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Pharmacokinetics of Fluoroquinolones in Experimental Animals

  • Chapter
Quinolone Antibacterials

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 127))

Abstract

Absorption, distribution, metabolism and excretion (ADME) are important processes which not only characterize the pharmacokinetics of an antibacterial agent but also influence significantly its antibacterial efficacy at the focus of infection. During the developmental process of an antimicrobial agent, infection models in experimental animals bridge the gap between the in vitro and clinical evaluation of an anti-infective agent. However, some restrictions exist, which, if ignored, will compromise the conclusions drawn from the data generated in animal models of infections. One of the major drawbacks in the use of animal models may be the differences in pharmacokinetics of a drug between animals and humans. It is well documented that animals eliminate drugs faster than humans (Boxenbaum 1982; Dedrick 1973; Mordenti 1985,1986; Sawada et al. 1984). These differences can be overcome, for example, by repeated fractional dosing or continuous infusion. The species-specific differences in the routes of excretion present difficulties, and in drug metabolism these difficulties cannot be overcome.

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Authors
  1. A. Dalhoff
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  2. T. Bergan
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Editors and Affiliations

  1. Bayer AG Geschäftsbereich Pharma Pharma-Forschungszentrum, Institut für Klinische Pharmakologie, Geb. 429, D-42096, Wuppertal, Germany

    J. Kuhlmann

  2. Institut für Medizinische Mikrobiologie und Virologie, Christian-Albrechts-Universität, D-24105, Brunswiker Str. 4, Kiel, Germany

    A. Dalhoff

  3. Bayer AG Geschäftsbereich Pharma Pharma-Forschungszentrum, Institut für Chemotherapie, Geb. 405, D-42096, Wuppertal, Germany

    H.-J. Zeiler

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Dalhoff, A., Bergan, T. (1998). Pharmacokinetics of Fluoroquinolones in Experimental Animals. In: Kuhlmann, J., Dalhoff, A., Zeiler, HJ. (eds) Quinolone Antibacterials. Handbook of Experimental Pharmacology, vol 127. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80364-2_6

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  • DOI: https://doi.org/10.1007/978-3-642-80364-2_6

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