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Tumorerkrankungen pp 186–198Cite as

Bispezifische Antikörper — Werkzeuge zur T-Zell Rekrutierung

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Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 2))

Zusammenfassung

Seit der Entdeckung monoklonaler Antikörper durch Köhler u. Milstein [1975] werden diese in einer Vielzahl von Therapieversuchen eingesetzt [Brennan et al. 1985, Paulus 1985]. Bispezifische Antikörper bilden eine neue Generation von Antikörpern und erkennen im Gegensatz zu herkömmlichen Antikörpern 2 unterschiedliche Antigene. Sie lassen sich aufgrund dieser Eigenschaft vielfältig in der Tumortherapie einsetzen [Staerz u. Bevan 1986].

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  1. Heribert Bohlen
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  2. Oliver Manzke
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  3. Hans Tesch
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  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, D-13122, Berlin-Buch, Deutschland

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Bohlen, H., Manzke, O., Tesch, H. (1998). Bispezifische Antikörper — Werkzeuge zur T-Zell Rekrutierung. In: Ganten, D., Ruckpaul, K. (eds) Tumorerkrankungen. Handbuch der Molekularen Medizin, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80362-8_9

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