Skip to main content
SpringerLink
Log in

Interdependenz von Adhäsionsverlust und Apoptose als tragendes Prinzip der Gewebshomöostase und deren Störung in der Neoplasie

  • Chapter
Tumorerkrankungen

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 2))

  • 99 Accesses

Zusammenfassung

Zellen multizellularer Organismen verfügen über Programme der gezielten Selbstelimination. Dabei werden Proteasen aktiviert, die bereits als inaktive Vorstufen vorliegen. Diese Proteasen katalysieren einerseits intrazellulare Signalkaskaden, andererseits bewirken sie die Degradation von intrazellularen Makromolekülen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Bates RC, Buret A, Helden DF van, Horton MA, Burns GF (1994) Apoptosis induced by inhibition of cellular contact. J Cell Biol 125: 403–415

    Article  PubMed  CAS  Google Scholar 

  • Bates RC, Lincz LF, Burns GF (1995) Involvement of integrins in cell survival. Cancer Metastasis Rev 14: 191–203

    Article  PubMed  CAS  Google Scholar 

  • Bazil V, Horejsi V (1992) Shedding of the CD44 adhesion molecule from leukocytes induced by anti-CD44 monoclonal antibody simulating the effect of a natural receptor ligand. J Immunol 149: 747–753

    PubMed  CAS  Google Scholar 

  • Bellgrau D, Gold D, Selawry H, Moore J, Franzusoff A, Duke RC (1995) A role for the CD95 ligand in preventing graft rejection. Nature 377: 630–632

    Article  PubMed  CAS  Google Scholar 

  • Boldin MP, Varfolomeev EE, Pancer Z, Mett IL, Camonis JH (1995) A novel protein that interacts with the death domain of Fas/APO-1 contains a sequence motif related to the death domain. J Biol Chem 270: 7795–7798

    Article  PubMed  CAS  Google Scholar 

  • Boudreau N, Sympson CJ, Werb Z, Bissell MJ (1995) Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix. Science 267: 891–893

    Article  PubMed  CAS  Google Scholar 

  • Brooks PC, Montgomery AM, Rosenfeld M, Reisfeld RA, Hu T, Klier G, Cheresh DA (1994) Integrin avb3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79: 1157–1164

    Article  PubMed  CAS  Google Scholar 

  • Burridge K, Chrzanowska-Wodnicka M (1996) Focal adhesion, contractility, and signaling. Annu Rev Cell Dev Biol 12: 463–519

    Article  PubMed  CAS  Google Scholar 

  • Chinnaiyan AM, O’Rourke K, Tewari M, Dixit VM (1995) FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 81: 505–512

    Article  PubMed  CAS  Google Scholar 

  • Frisch SM, Francis H (1994) Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 124: 619–626

    Article  PubMed  CAS  Google Scholar 

  • Frisch SM, Vuori K, Ruoslahti E (1996) Control of adhesion-dependent cell survival by focal adhesion kinase. J Cell Biol 134: 793–799

    Article  PubMed  CAS  Google Scholar 

  • Griffith TS, Brunner T, Fletcher SM, Green DR, Ferguson TA (1995) Fas ligand-induced apoptosis as a mechanism of immune previlege. Science 270: 1189–1192

    Article  PubMed  CAS  Google Scholar 

  • Gruss HJ, Dower SK (1995) Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas. Blood 85: 3378–3404

    PubMed  CAS  Google Scholar 

  • Giinthert AR, Strater J, Reyher U von, Henne C, Joos S, Koretz K, Moldenhauer G, Krammer PH, Moller P (1996) Early detachment of colon carcinoma cells during CD95(APO-l/Fas)-mediated apoptosis. I. De-adhesion from hyaluronate by shedding of CD44. J Cell Biol 134: 1089–1096

    Article  Google Scholar 

  • Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Jameshima M, Hase A, Seto Y, Nagata S (1991) The polypeptide encoded by the NA for human cell surface antigen Fas can mediate apoptosis. Cell 66: 233–243

    Article  PubMed  CAS  Google Scholar 

  • Kerr JFR, Wyllie AH, Currie AR (1972) Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239–257

    Article  PubMed  CAS  Google Scholar 

  • Keshav S, Lawson L, Chung LP, Stein M, Perry VH, Gordon S (1990) Tumor necrosis factor NA localized to Paneth cells of normal murine intestinal epithelium by in situ hybridization. J Exp Med 171: 327–332

    Article  PubMed  CAS  Google Scholar 

  • Kischkel FC, Hellbardt S, Behrmann I, Germer M, Pawlita M, Krammer PH, Peter ME (1995) Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins (CAP) form a death-inducing signalling complex (DISC) with the receptor. EMBO J 14: 5579–5588

    PubMed  CAS  Google Scholar 

  • Leibovitz A, Stinson JC, Mombs W, III, Moy CE, Mazur KC, Mabry ND (1976) Classification of human colorectal adenocarcinoma cell lines. Cancer Res 36: 4561–4569

    Google Scholar 

  • Leithauser F, Dhein J, Mechtersheimer G, Koretz K, Briiderlein S, Henne C, Schmidt A, Debatin KM, Krammer PH, Moller P (1993) Constitutive and induced expression of APO-1, a new member of the nerve growth factor/tumor necrosis factor receptor superfamily, in normal and neoplastic cells. Lab Invest 69: 415–429

    PubMed  CAS  Google Scholar 

  • Lynch DH, Ramsdell F, Alderson MR (1995) Fas and Fa in the homeostatic regulation of immune response. Immunol Today 16: 569–574

    Article  PubMed  CAS  Google Scholar 

  • Martin SJ, Green DR (1995) Protease activation during apoptosis: death by a thousand cuts? Cell 82: 349–352

    Article  PubMed  CAS  Google Scholar 

  • Meredith JE Jr, Frazeli B, Schwartz MA (1993) The extracellular matrix as a cell survival factor. Mol Biol Cell 4: 953–961

    PubMed  CAS  Google Scholar 

  • Möller P, Koretz K, Leithäuser F, Brüderlein S, Henne C, Quentmeier A, Krammer PH (1994) Expression of APO-1 (CD95), a member of the NGF/TNF receptor superfamily, in normal and neoplastic colon epithelium. Int J Cancer 57: 371–377

    Article  PubMed  Google Scholar 

  • Möller P, Walczak H, Riedl S, Sträter J, Krammer HP (1996) Paneth cells express high levels of CD95 ligand transcripts. A unique property among gastrointestinal epithelia. Am J Pathol 149: 9–13

    PubMed  Google Scholar 

  • Montgomery AM, Reisfeld RA, Cheresh DA (1994) Integrin avb3 rescues melanoma cells from apoptosis in three dimensional dermal collagen. Proc Natl Acad Sci USA 91: 8856–8860

    Article  PubMed  CAS  Google Scholar 

  • O’Connell J, O’Sullivan GC, Collins JK, Shanahaqn F (1996) The Fas counterattack: Fas-mediated T cell killing by colon carcinoma cells expressing Fas ligand. J Exp Med 184: 1075–1082

    Google Scholar 

  • Owen-Schaub LB, Radinsky R, Kruzel E, Berry K, Yonehara S (1994) Anti-Fas on nonhematopoietic tumors: levels of Fas/Apo-1 and bcl-2 are not predictive of biological responsiveness. Cancer Res 54: 1580–1586

    PubMed  CAS  Google Scholar 

  • Owens LV, XU L, Craven RJ, Dent GA, Weiner TM, Kornberg L, Liu ET, Cance WG (1995) Overexpression of the focal adhesion kinase (p125FAK) in invasive human tumors. Cancer Res 55: 2752–2755

    PubMed  CAS  Google Scholar 

  • Raff M (1992) Social controls on cell survival and death. Nature 356: 397–400

    Article  PubMed  CAS  Google Scholar 

  • Reyher U von, Sträter J, Barth T, Günthert AR, Moldenhauer G, Krammer PH, Möller P (1997a) CD95(APO-l/Fas)-triggering causes detachment of adherent colon carcinoma cells due to selective depletion of surface integrins by membrane blebbing. Submitted

    Google Scholar 

  • Reyher U von, Sträter J, Kittstein W, Gschwendt M, Krammer PH, Möller P (1997b) Colon carcinoma cells use different mechanisms to escape CD95-mediated apoptosis. Submitted

    Google Scholar 

  • Ruoslahti E, Reed JC (1994) Anchorage dependence, integrins and apoptosis. Cell 77: 477–478

    Article  PubMed  CAS  Google Scholar 

  • Ruoslahti E, Noble NA, Kagami S, Border WA (1994) Integrins. Kidney Int 45: s17-s22 Schmauder-Chock EA, Chock SP, Patchen ML (1994) Ultra-structural localization of tumor necrosis factor-a. Histochem J 26: 142–151

    Article  Google Scholar 

  • Stanger BZ, Leder P, Lee TH, Kim E, Seed B (1995) RIP: a novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell death. Cell 81: 513–523

    Article  PubMed  CAS  Google Scholar 

  • Sträter J, Wedding U, Barth TFE, Koretz K, Elsing C, Möller P (1996) Rapid onset of apoptosis in vitro follows disruption of bl-integrin/matrix interactions in human colonic crypt cells. Gastroenterology 110: 1776–1784

    Article  PubMed  Google Scholar 

  • Sträter J, Wellisch I, Riedl S, Walczak H, Koretz K, Tandara A, Krammer PH, Möller P (1997) CD95(APO-l/Fas)-mediated apoptosis in colon epithelial cells: a possible pathogenic role of the CD95/CD95 ligand-system in ulcerative colitis. Gastroenterology 113: 160–167

    Article  PubMed  Google Scholar 

  • Suda T, Takahashi T, Goldstein P, Nagata S (1993) Molecular cloning and expression of the Fas ligand, a novel member of the tumor necrosis factor family. Cell 75: 1169–1178

    Article  PubMed  CAS  Google Scholar 

  • Tan X, Hsueh W, Gonzalez-Crussi F (1993) Cellular localization of tumor necrosis factor (TNF)-a transcripts in normal bowel and in necrotizing enterocolitis: TNF gene expression by Paneth cells, intestinal eosinophils, and macrophages. Am J Pathol 142: 1858–1865

    PubMed  CAS  Google Scholar 

  • Tanaka M, Suda T, Takahashi T, Nagata S (1995) Expression of the functional soluble form of human Fas ligand in activated lymphocytes. EMBO J 14: 1129–1135

    PubMed  CAS  Google Scholar 

  • Tanaka M, Suda T, Haze K, Nakanura N, Sato K, Kimura F, Motoyoshi K, Mizuki M, Tagawa S, Ohga S, Hatake K, Drummond AH, Nagata S (1996) Fas ligand in human serum. Nat Med 2: 317–322

    Article  PubMed  CAS  Google Scholar 

  • Trauth BC, Klas C, Peters AMJ, Matzku S, Môller P, Falk W, Debatin K-M, Krammer PH (1989) Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245: 301–305

    Article  PubMed  CAS  Google Scholar 

  • White K, Grether ME, Abrams JM, Young L, Farrell K, Steller H (1994) Genetic control of programmed cell death in drosophila. Science 264: 677–683

    Article  PubMed  CAS  Google Scholar 

  • Wyllie A (1980) Glucocorticoid-induced thymocyte apoptosis is associated with endogenous nuclease activation. Nature 284: 555–556

    Article  PubMed  CAS  Google Scholar 

  • Yonehara S, Ishii A, Yonehara M (1989) A cell-killing monoclonal antibody (anti-Fas) to a cell surface antigen codownregulation with the receptor of tumor necrosis factor. J Exp Med 169: 1747–1756

    Article  PubMed  CAS  Google Scholar 

  • Xu L, Owens LV, Sturge GC, Yang X, Liu ET et al. (1996) Attenuation of the expression of the focal adhesion kinase induces apoptosis in tumor cells. Cell Growth Differ 7: 413–418

    PubMed  CAS  Google Scholar 

  • Zhang Z, Vuori K, Reed JC, Ruoslahti E (1995) The α-5β-l integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression. Proc Natl Acad Sci USA 92: 6161–6165

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Ulrike von Reyher
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Jörn Sträter
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Peter Möller
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin (MDC), Robert-Rössle-Str. 10, D-13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

von Reyher, U., Sträter, J., Möller, P. (1998). Interdependenz von Adhäsionsverlust und Apoptose als tragendes Prinzip der Gewebshomöostase und deren Störung in der Neoplasie. In: Ganten, D., Ruckpaul, K. (eds) Tumorerkrankungen. Handbuch der Molekularen Medizin, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80362-8_7

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80362-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80363-5

  • Online ISBN: 978-3-642-80362-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation