Pleiotrope Zytostatikaresistenz (Multidrug resistance) und Hochdosischemotherapie

  • Thomas Licht
Part of the Handbuch der Molekularen Medizin book series (HDBMOLEK, volume 2)


Die Behandlung der meisten lokal beschränkten Malignóme basiert derzeit auf operativen oder radiotherapeutischen Verfahren. Die zytostatische Chemotherapie kommt in der Regel zum Einsatz, wenn die Erkrankungen weit fortgeschritten oder, wie im Fall hämatopoetischer Neoplasien oder kleinzelliger Bronchialkarzinome, schon primär generalisiert sind. Neuere Therapiemodalitäten, wie die gentherapeutische Korrektur der zugrundeliegenden genetischen Defekte, haben sich noch nicht als Standardtherapien etabliert. Manche bösartigen Erkrankungen können durch eine zytostatische Polychemotherapie geheilt werden. Zu diesen zählen verschiedene Erkrankungen des hämatopoeti- schen Systems, insbesondere akute myeloische und lymphatische Leukämien, der Morbus Hodgkin und hochmaligne oder intermediäre Non-Hodg- kin-Lymphome sowie einige solide Tumoren.


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  • Thomas Licht

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