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Mechanismen der Entstehung fremdstoffbedingter Krebsformen

  • Michael Schwarz
  • Karl Walter Bock
Chapter
Part of the Handbuch der Molekularen Medizin book series (HDBMOLEK, volume 2)

Zusammenfassung

Aufgrund epidemiologischer Befunde wird geschätzt, daß bei der Entstehung von über 70% der Krebserkrankungen beim Menschen exogene Faktoren eine Rolle spielen. Unter diesen sind chemische Risikofaktoren vermutlich die bedeutsamsten [Doli u. Peto 1981]. Von der WHO werden derzeit etwa 50 Chemikalien oder Chemikaliengemische als eindeutig kanzerogen für den Menschen aufgelistet [IARC 1987]. Der Elimination dieser Risikofaktoren kommt neben therapeutischen Maßnahmen entscheidende Bedeutung zu. Im folgenden Beitrag wird nach einem kurzen historischen Abriß ein Mehrschrittmodell der Kanzerogenese entwickelt, anhand dessen die verschiedenartigen Wirkungen chemischer Krebsrisikofaktoren abgehandelt werden.1 Auf Möglichkeiten zur Quantifizierung der mit einer Exposition verbundenen kanzerogenen Risiken wird abschließend eingegangen.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Michael Schwarz
  • Karl Walter Bock

There are no affiliations available

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