Skip to main content

Fremdstoffmetabolismus und Krebs: Molekular-epidemiologische Forschung

  • Chapter
Book cover Tumorerkrankungen

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 2))

  • 97 Accesses

Zusammenfassung

Chemische Substanzen (Abb. 4.2.1) können Mutationen auslösen (Tumorinitiation) oder das Wachstum mutierter Zellen stimulieren (Tumorpromotion). Die meisten Krebserkrankungen lassen sich auf chemische Umwelteinflüsse zurückführen [Doll u. Peto 1981].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Alexandrie EX, Sundberg MI, Seidegård J, Tornling G, Rannung A (1994) Genetic susceptibility to lung cancer with special emphasis on CYP1A1 and GSTM1: a study on host factors in relation to age at onset, gender and histological cancer types. Carcinogenesis 15: 1785–1790

    PubMed  CAS  Google Scholar 

  • Ames BN, Dunston WE, Yamasaki E, Lee FD (1973) Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection. Proc Natl Acad Sci USA 70: 2281–2285

    PubMed  CAS  Google Scholar 

  • Ayesh R, Idle JR, Ritchie JC, Crothers MJ, Hetzel MR (1984) Metabolic oxidation phenotypes as markers for susceptibility to lung cancer. Nature 312: 169–171

    PubMed  CAS  Google Scholar 

  • Badawi AF, Hirvonen A, Bell DA, Lang NP, Kadlubar FF (1995) Role of aromatic amine acetyltransferases, NATI and NAT2, in carcinogen-DNA-adduct formation in the human urinary bladder. Cancer Res 55: 5230–5237

    PubMed  CAS  Google Scholar 

  • Bale AE, Nebert DW, Mride OW (1987) Subchromosomal localization of the dioxin-inducible PI-450 locus (CYP1) and description of two RFLPs detected with a 3’P 1–450 cDNA probe. Cytogenet Cell Genet 46: 574–575

    Google Scholar 

  • Bell DA, Taylor JA, Paulson DF, Robertson CN, Mohler JL, Lucier GW (1993) Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase M1 (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85: 1159–1164

    PubMed  CAS  Google Scholar 

  • Bell DA, Badawi AF, Lang NP, Illett KF, Kadlubar FF, Hirvonen A (1995a) Polymorphism in the N-acetyltransferase 1 (NATI) polyadenylation signal: association of NAT1*10 allele with higher N-acetylation activity in bladder and colon tissue. Cancer Res 55: 5226–5229

    Google Scholar 

  • Bell DA, Stephens EA, Castranio T, Umbach DM, Watson M, Deakin M, Elder J, Hendrickse C, Duncan H, Strange RC (1995b) Polyadenylation polymorphism in the acetyl-transferase 1 gene (NAT1) increases risk of colorectal cancer. Cancer Res 55: 3537–3542

    PubMed  CAS  Google Scholar 

  • Benitez J, Ladero JM, Fernández-Gundin MJ, Llerena A, Cobaleda J, Martinez C, Muñoz JJ, Vargaz E, Prados J, González-Rozas F, Rodrigues-Molina J, Usón AC (1990) Polymorphic oxidation of debrisoquine in bladder cancer. Ann Med 22: 157–160

    PubMed  CAS  Google Scholar 

  • Benitez J, Ladero JM, Jara C, Carrillo JA, Cobaleda J, Llerena A, Vargas E, Muñoz JJ (1991) Polymorphic oxidation of debrisoquine in lung cancer. Eur J Cancer 27: 161–166

    Google Scholar 

  • Benowitz NL, Jacob P, Perez-Stable E (1996) CYP2D6 phenotype and the metabolism of nicotine and cotinine. Pharmacogenetics 6: 239–242

    PubMed  CAS  Google Scholar 

  • Bertram JS, Kolonel LN, Meyskens FL (1987) Rationale and strategies for chemoprevention of cancer in humans. Cancer Res 47: 3012–3031

    PubMed  CAS  Google Scholar 

  • Bicho MP, Breitenfeld L, Carvalho AA, Manso CF (1988) Acetylation phenotypes in patients with bladder carcinoma. Ann Genet 31: 167–171

    PubMed  CAS  Google Scholar 

  • Bock KW (1991) Role of UDP-glucuronosyltransferases in chemical carcinogenesis. Crit Rev Biochem Mol Biol 26: 129–150

    PubMed  CAS  Google Scholar 

  • Boobis AR, Lynch AM, Murray S, Torre R de la, Solans A, Farre M, Segura J, Gooderham NJ, Davies DS (1994) CYP1A2-catalyzed conversion of dietary heterocyclic amines to their proximate carcinogens is their major route of metabolism in humans. Cancer Res 54: 89–94

    PubMed  CAS  Google Scholar 

  • Bosma PJ, Chowdhury JR, Bakker C, Gantla S, Boer A de, Oostra BA, Lindhout D, Tytgat GNJ, Jansen PLM, Oude Elferink RPJ, Chowdhury NR (1995) The genetic basis of the reduced expression of bilirubin UDP-glucuronosyl-transferase 1 in Gilbert’s syndrome. N Engl J Med 333: 1171–1175

    PubMed  CAS  Google Scholar 

  • Breslow NE, Day NE (1980) Statistical methods in cancer research, vol 1. The analysis of case-control studies. I ARC Sci Publ 32: 1–350

    Google Scholar 

  • Breslow NE, Day NE (1987) Statistical methods in cancer research, vol 2. The design and analysis of cohort studies. I ARC Sci Publ 82: 1–406

    Google Scholar 

  • Brockmoller J, Roots I (1994) Assessment of liver metabolic function Clinical implications. Clin Pharmakokinet 27: 216–248

    CAS  Google Scholar 

  • Brockmoller J, Gross D, Kerb R, Drakoulis N, Roots I (1992) Correlation between trans-stilbene oxide-glutathione conjugation activity and the deletion mutation in the glutathione-S-transferase class Mu gene detected by polymerase chain reaction. Biochem Pharmacol 43: 647–650

    PubMed  CAS  Google Scholar 

  • Brockmoller J, Kerb R, Drakoulis N, Nitz M, Roots I (1993) Genotype and phenotype of glutathione S-transferase class N isoenzymes N and O in lung cancer patients and controls. Cancer Res 53: 1004–1009

    CAS  Google Scholar 

  • Brockmoller J, Kerb R, Drakoulis N, Staffeldt B, Roots I (1994) Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study. Cancer Res 54: 4103–4111

    PubMed  CAS  Google Scholar 

  • Brockmoller J, Cascorbi I, Kerb R, Roots I (1996) Combined genetical analysis of arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, and cytochrome enzymes as heritable modulators of bladder cancer risk. Cancer Res 56: 3915–3925

    PubMed  CAS  Google Scholar 

  • Bryant MS, Skipper PL, Tannenbaum ST, Maclure M (1987) Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers. Cancer Res 47: 602–608

    PubMed  CAS  Google Scholar 

  • Buehler BA, Delimont, D, Van Waes M, Finell RH (1990) Prenatal prediction of risk of the fetal hydantoin syndrome. N Engl J Med 322: 1567–1572

    PubMed  CAS  Google Scholar 

  • Butler MA, Iwasaki M, Guengerich FP, Kadlubar FF (1989) Human cytochrome P-450PA (P-450IA2), the phenacetin-O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines. Proc Natl Acad Sci USA 86: 7696–7700

    PubMed  CAS  Google Scholar 

  • Caporaso N, Goldstein A (1995) Cancer genes: single and susceptibility: exposing the difference. Pharmacogenetics 5: 59–63

    PubMed  CAS  Google Scholar 

  • Caporaso N, Hayes RB, Dosemeci M, Hoover R, Ayesh R, Hetzel M, Idle JR (1989) Lung cancer risk, occupational exposure, and the debrisoquine metabolic phenotype. Cancer Res 49: 3675–3679

    PubMed  CAS  Google Scholar 

  • Carmella SG, Akerbar S, Hecht SS (1993) Metabolism of the tobacco-specific nitrosamine 4-(methyl nitrosamino)-l-(3-pyridyl)-l-butanone in smoker’s urine. Cancer Res 53: 721–724

    PubMed  CAS  Google Scholar 

  • Carriere V, Goasduff T, Ratanasavanh D, Morel F, Gautier J-C, Guillouzo A, Beaune P, Berthou F (1993) Both cytochromes P450 2E1 and 1A1 are involved in the metabolism of chlorzoxazone. Chem Res Toxicol 6: 852–857

    PubMed  CAS  Google Scholar 

  • Cartwright RA, Glashan RW, Rogers HJ, Ahmod RA, Barham-Hall D, Higgins E, Kahn MA (1982) The role of N-acetyltransferase in bladder carcinogenesis: a pharmacogenetic epidemiological approach to bladder cancer. Lancet II: 842–845

    Google Scholar 

  • Cartwright RA, Philip PA, Rogers HJ, Glashan RW (1984) Genetically determined debrisoquine oxidation capacity in bladder cancer. Carcinogenesis 5: 1191–1192

    PubMed  CAS  Google Scholar 

  • Cascorbi I, Drakoulis N, Brockmoller J, Maurer A, Sperling K, Roots I (1995) Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am J Hum Genet 57: 581–592

    PubMed  CAS  Google Scholar 

  • Cascorbi I, Brockmoller J, Mrozikiewicz PM, Bauer S, Loddenkemper R, Roots I (1996a) Homozygous rapid arylamine N-acetyltransferase (NAT2) genotype as susceptibility factor for lung cancer. Cancer Res 56: 3961–3966

    PubMed  CAS  Google Scholar 

  • Cascorbi I, Brockmoller J, Roots I (1996b) A C4887A polymorphism in exon 7 of human CYP1A1: population frequency, mutation linkages, and the impact to lung cancer susceptibility. Cancer Res 56: 4965–4969

    PubMed  CAS  Google Scholar 

  • Case RAM, Hosker ME, Monald DB, Pearson JT (1954) Tumors of the urinary bladder in workmen engaged in the manufacture and use of cartain dyestuff intermediates in the British chemical industry. Part 1. The role of aniline, benzidine, alpha-napthylamine and beta-naphthylamine. Br J Ind Med 11: 75–104

    PubMed  CAS  Google Scholar 

  • Chen H, Sandler DP, Taylor JA, Shore DL, Liu E, Bloomfield CD, Bell DA (1996) Increased risk for myelodysplasia syndromes in individuals with glutathione transferase theta 1 (GSTT1) gene defect. Lancet 347: 295–297

    PubMed  CAS  Google Scholar 

  • Cheng TJ, Christiani DC, Xu X, Wain JC, Wiencke JK, Kelsey KT (1995) Glutathione S-transferase mu genotype, diet, and smoking as determinants of sister chromatid exchange frequency in lymphocytes. Cancer Epidemiol Biomarkers Prev 4: 535–542

    PubMed  CAS  Google Scholar 

  • Cholerton S, Arpanahi A, Mracken N, Boustead C, Taber H, Johnstone E, Leathart J, Daly AK, Idle JR (1994) Poor metabolizers of nicotine and CYP2D6 polymorphism. Lancet 343: 62–63

    PubMed  CAS  Google Scholar 

  • Clifford SC, Neal DE, Lunec J (1996) High level expression of the multidrug resistance (MDR1) gene in the normal bladder urothelium: a potential involvement in protection against carcinogens? Carcinogenesis 17: 601–604

    PubMed  CAS  Google Scholar 

  • Conney AH (1982) Induction of microsomal enzymes by foreign chemicals and carcinogenesis by polycyclic aromatic hydrocarbons: GHA Clowes memorial lecture. Cancer Res 42: 4857–4917

    Google Scholar 

  • Conney AH, Pantuck EJ, Hsiao KC, Garland WA, Anderson KE, Alvarez AP, Kappas, A (1976) Enhanced phenacetin metabolism in human subjects fed charcoal-broiled beef. Clin Pharmacol Ther 20: 633–642

    PubMed  CAS  Google Scholar 

  • Crespi CL, Penman BW, Gelboin HV, Gonzalez FJ (1991) A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P450 2D6. Carcinogenesis 12: 1197–1201

    PubMed  CAS  Google Scholar 

  • Crofts F, Taioli E, Trachman J, Cosma GN, Currie D, Toniolo P, Garte SJ (1994) Functional significance of different human CYP1A1 genotypes. Carcinogenesis 15: 2961–2963

    PubMed  CAS  Google Scholar 

  • Daly AK, Thomas DJ, Cooper J, Pearson WR, Neal DE, Idle JR (1993) Homozygous deletion of gene for glutathione S-transferase M1 in bladder cancer. BMJ 307: 481–482

    PubMed  CAS  Google Scholar 

  • Daly AK, Brockmoller J, Broly F, Eichelbaum M, Evans WE, Gonzalez FJ, Huang JD, Idle JR, Ingelman-Sundberg M, Ishizaki T, Jacqz-Aigrain E, Meyer UA, Nebert D, Steen V, Wolf CR, Zanger UM (1996) Nomenclature for human CYP2D6 alleles. Pharmacogenetics 6: 193–201

    PubMed  CAS  Google Scholar 

  • Doll R, Peto R (1981) The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today. J Natl Cancer Inst 66: 1192–1308

    Google Scholar 

  • Drakoulis N, Cascorbi I, Brockmoller J, Gross CR, Roots I (1994) Polymorphisms in the human CYP1A1 gene as susceptibility factors for lung cancer: exon-7 mutation (4889 A to G), and a T to C mutation in the 3’-flanking region. Clin Invest 72: 240–248

    CAS  Google Scholar 

  • Duche JC, Joanne C, Barre J, Cremoux H de, Dalphin JC, Depierre A, Brochard P, Tillement JP, Bechtel P (1991) Lack of relationship between the polymorphism of debrisoquine oxidation and lung cancer. Br J Clin Pharmacol 31: 533–536

    PubMed  CAS  Google Scholar 

  • Eichelbaum M, Spannbrucker N, Steincke B, Dengler H (1979) Defective N-oxidation of spartein in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 16: 183–187

    PubMed  CAS  Google Scholar 

  • Evans DAP (1992) N-Acetyltransferase. In: Kalow W (ed) Pharmacogenetics of drug metabolism. Pergamon Press, Oxford New York, pp 95–178

    Google Scholar 

  • Evans DAP, Eze LC, Whibley EJ (1983) The association of the slow acetylator phenotype with bladder cancer. J Med Genet 20: 330–333

    PubMed  CAS  Google Scholar 

  • Fernandez-Salguero P, Pineau T, Hilbert DM, Mhail T, Lee SS, Kimura S, Nebert DW, Rudikoff S, Ward JM, Gonzalez FJ (1995) Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268: 638–639

    Google Scholar 

  • Fleming CM, Persad R, Kaisary A, Smith P, Adedoyin A, Porter J, Wilkinson GR, Branch RA (1994) Low activity of dapsone N-hydroxylation as a susceptibility risk factor in aggressive bladder cancer. Pharmacogenetics 4: 199–207

    PubMed  CAS  Google Scholar 

  • Gaedigk A, Spielberg SP, Grant DM (1994) Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions. Pharmacogenetics 4: 142–153

    PubMed  CAS  Google Scholar 

  • Gold LS, Slone TH, Stern BR, Manley NB, Ames BN (1992) Rodent carcinogens: setting priorities. Science 258: 261–265

    PubMed  CAS  Google Scholar 

  • Gooderham NJ, Murray S, Lynch AM, Edwards RJ, Yadollahi-Farsani M, Bratt C, Rich KJ, Zhao K, Murray BP, Bhadresa S, Crosbie SJ, Boobis AR, Davies DS (1996) Heterocyclic amines: evaluation of their role in diet associated human cancer. Br J Clin Pharmacol 42: 91–98

    PubMed  CAS  Google Scholar 

  • Gorrod JW, Jenner P, Keysell GR, Mikhael BR (1974) Oxidative metabolism of nicotine by cigarette smokers with cancer of the urinary bladder. J Natl Cancer Inst 52: 1421–1424

    PubMed  CAS  Google Scholar 

  • Green VJ, Pirmohamed M, Kitteringham NR, Gaedigk A, Grant DM, Boxer M, Burchell B, Park BK (1995) Genetic analysis of microsomal epoxide hydrolase in patients with carbamazepine hypersensitivity. Biochem Pharmacol 50: 1353–1359

    PubMed  CAS  Google Scholar 

  • Greenwald P (1994) Experience from clinical trials in cancer prevention. Ann Med 26: 73–80

    PubMed  CAS  Google Scholar 

  • Grinberg-Funes RA, Singh VN, Perera FP, Bell DA, Young TL, Dickey C, Wang LW, Santella RM (1994) Polycyclic aromatic hydrocarbon – DNA adducts in smokers and their relationship to micronutrient levels and the glutathione-S-transferase M1 genotype. Carcinogenesis 15: 2449–2454

    PubMed  CAS  Google Scholar 

  • Guengerich FP, Kim D-H, Iwasaki M (1991) Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem Res Toxicol 4: 168–179

    PubMed  CAS  Google Scholar 

  • Guggenmoos-Holzman I, Wernecke K-D (1996) Medizinische Statistik. Blackwell, Oxford London, S 1–220

    Google Scholar 

  • Hanssen H-P, Agarwal DP, Goedde HW, Bucher H, Huland H, Brachmann W, Ovenbeck R (1985) Association of N-

    Google Scholar 

  • acetyltransferase polymorphism and environmental factors with bladder carcinogenesis. Eur Urol 11: 263–266

    Google Scholar 

  • Hassett C, Aicher L, Sidhu JS, Omiecinski CJ (1994) Human microsomal epoxide hydrolase: genetic polymorphism functional expression in vitro of amino acid variants. Hum Mol Genet 3: 421–428

    PubMed  CAS  Google Scholar 

  • Hayashi SI, Watanabe J, Kawajiri K (1991) Genetic polymorphisms in the 5’-flanking region change translational regulation of the human cytochrome P450IIE1 gene. J Biochem 110: 559–565

    PubMed  CAS  Google Scholar 

  • Hayashi SI, Watanabe J, Kawajiri K (1992) High susceptibility to lung cancer analyzed in terms of combined genotypes of P4501A1 and mu-class glutathione S-transferase genes. Jpn J Cancer Res 83: 866–870

    PubMed  CAS  Google Scholar 

  • Hayes JD, Pulford DJ (1995) The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol 30: 445–600

    PubMed  CAS  Google Scholar 

  • Hayes RB, Bi W, Rothman N, Broly F, Caporaso N, Feng P, You X, Yin S, Woosley RL, Meyer UA (1993) N-Acetylation phenotype and genotype and risk of bladder cancer in benzidine-exposed workers. Carcinogenesis 14: 675–678

    PubMed  CAS  Google Scholar 

  • Hecht SS, Chung FL, Richie JP, Akerkar SA, Borukhova A, Skowronski L, Carmella SG (1995) Effects of watercress consumption on metabolism of a tobacco-specific lung carcinogen in smokers. Cancer Epidemiol Biomarkers Prev 4: 877–884

    PubMed  CAS  Google Scholar 

  • Heckbert SR, Weiss NS, Hornung SK, Eaton DL, Motulsky AG (1992) Glutathione S-transferase and epoxide hydrolase activity in human leucocytes in relation to risk of lung cancer and other smoking-related cancers. J Natl Cancer Inst 84: 414–422

    PubMed  CAS  Google Scholar 

  • Hein DW (1988) Acetylator genotype and arylamine induced carcinogenesis. Biochem Biophys Acta 948: 37–66

    PubMed  CAS  Google Scholar 

  • Hein DW, Rustan TD, Ferguson RJ, Doll MA, Gray K (1994) Metabolic activation of aromatic and heterocyclic N-hydroxyarylamines by wild-type and mutant recombinant human NAT1 and NAT2 acetyltransferases. Arch Toxicol 68: 129–133

    PubMed  CAS  Google Scholar 

  • Hennekens CH, Buring JE, Manson JE, Stampfer M, Rosner B, Cook NR, Belanger C, Lotte F, Gaziano JM, Ridker PM, Willett W, Peto R (1996) Lack of effect of long-term supplementation with beta carotene on the incidence of malignant neoplasms and cardiovascular disease. N Engl J Med 334: 1189–1190

    Google Scholar 

  • Hill AB (1967) Statistical evidence and interference. In: Hill AB (ed) Principles of medical statistics. Oxford University Press, Oxford, pp 302–325

    Google Scholar 

  • Hirvonen A, Husgafvel-Pursiainen K, Anttila S, Vainio H (1993) The GSTM1 null genotype as a potential risk modifier for squamous cell carcinoma of the lung. Carcinogenesis 14: 1479–1481

    PubMed  CAS  Google Scholar 

  • Hirvonen A, Nylund L, Kociba P, Husgafvel-Pursianinen K, Vainio H (1994) Modulation of urinary mutagenicity by genetically determined carcinogen metabolism in smokers. Carcinogenesis 15: 813–815

    PubMed  CAS  Google Scholar 

  • Idle JR (1991) Is environmental carcinogenesis modulated by host polymorphism? Mutat Res 247: 259–266

    PubMed  CAS  Google Scholar 

  • Illet KF, David BM, Detchon P et al. (1987) Acetylation phenotype in colorectal carcinoma. Cancer Res 47: 1466–1469

    Google Scholar 

  • Ishikawa T (1992) The ATP-dependent glutathione S-conjugate export pump. Trends Biochem Sci 17: 463–468

    PubMed  CAS  Google Scholar 

  • Izzotti A, De Flora S, Petrilli GL, Gallagher J, Rojas M, Alexandrov K, Bartsch H, Lewtas J (1995) Cancer biomarkers in human atherosclerotic lesions: detection of DNA adducts. Cancer Epidemiol Biomarkers Prev 4: 105–110

    PubMed  CAS  Google Scholar 

  • Jones AL, Hagen M, Coughtrie MWH, Roberts RC, Glatt H (1995) Human platelet phenolsulfotransferase: NA cloning, stable expression in V79 cells and identification of a novel allelic variant of the phenol-sulfating form. Biochem Biophys Res Commun 208: 855–862

    PubMed  CAS  Google Scholar 

  • Joseph P, Jaiswal A (1994) NAD(P)H:quinone oxidoreductasel (DT diaphorase) specifically prevents the formation of benzo[a]pyrene quinone-DNA adducts generated by cytochrome P450 1A2 and P450 reductase. Proc Natl Acad Sci USA 91: 8413–8417

    PubMed  CAS  Google Scholar 

  • Jounaidi Y, Hyrailles V, Gervot L, Maurel P (1996) Detection of a CYP3A5 allelic variant: a candidate for the polymorphic expression of the protein. Biochem Biophys Res Commun 221: 466–470

    PubMed  CAS  Google Scholar 

  • Kaisary A, Smith P, Jaczq E, Mllister CB, Wilkinson GR, Ray WA, Branch RA (1987) Genetic predisposition to bladder cancer: ability to hydroxylate debrisoquine and mephenytoin as risk factors. Cancer Res 47: 5488–5493

    PubMed  CAS  Google Scholar 

  • Karakaya AE, Cok I, Sardas S, Gogus O, Sardas OS (1986) N-Acetyltransferase phenotype of patients with bladder cancer. Hum Toxicol 5: 333–335

    PubMed  CAS  Google Scholar 

  • Kato S, Bowman ED, Harrington AM, Blomeke B, Shields PG (1995) Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. J Natl Cancer Inst 87: 861–862

    Google Scholar 

  • Kawajiri K, Nakachi K, Imai K, Watanabe J, Hayashi S-I (1993) The CYP1A1 gene and cancer susceptibility. Crit Rev Oncol Hematol 14: 77–87

    PubMed  CAS  Google Scholar 

  • Kawajiri K, Watanabe J, Eguchi H, Hayashi S-I (1995) Genetic polymorphisms of drug-metabolizing enzymes and lung cancer susceptibility. Pharmacogenetics 5: S70-S73

    PubMed  CAS  Google Scholar 

  • Kellerman G, Shaw CR, Luy ten-Keller man M (1973) Aryl-hydrocarbon hydroxylase inducibility and bronchogenic carcinoma. N Engl J Med 289: 934–937

    Google Scholar 

  • Ketley JN, Habig WH, Jakoby WB (1975) Binding of nonsubstrate ligands to the glutathione S-transferases. J Biol Chem 250: 8670–8673

    PubMed  CAS  Google Scholar 

  • Kerb R, Brockmoller J, Reum T, Roots I (1997) Deficiency of glutathione S-transferases M1 and T 1 as heritable factors of increased cutaneous UV-sensitivity. J Invest Dermatol 108: 229–232

    PubMed  CAS  Google Scholar 

  • Kihara M, Kihara M, Noda K (1994) Lung cancer risk of GSTM1 null genotype is dependent on the extent of tobacco smoke exposure. Carcinogenesis 15: 415–418

    PubMed  CAS  Google Scholar 

  • Kim RB, O’Shea D, Wilkinson GR (1995) Interindividual variability of chlorzoxazone 6-hydroxylation in men and women and its relationship to CYP2E1 genetic polymorphisms. Clin Pharmacol Ther 57: 645–555

    PubMed  CAS  Google Scholar 

  • Koob M, Dekant W (1991) Bioactivation of xenobiotics by formation of toxic glutathione conjugates. Chem Biol Interact 77: 107–139

    PubMed  CAS  Google Scholar 

  • Koop DR (1992) Oxidative and reductive metabolism by cytochrome P450 2E1. FASEB J 6: 724–730

    PubMed  CAS  Google Scholar 

  • Kouri RE, Minney CE, Slomianry DJ, Snodgrass DR, Wray N, Memore TL (1982) Positive correlation between high aryl hydrocarbon hydroxylase activity and primary lung cancer as analysed in cryopreserved lymphozytes. Cancer Res 42: 5030–5037

    PubMed  CAS  Google Scholar 

  • Kramer MS (1988) Clinical epidemiology and biostatistics. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Kronbach T, Mathys D, Umeno M, Gonzalez FJ, Meyer UA (1989) Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4. Mol Pharmacol 36: 89

    PubMed  CAS  Google Scholar 

  • Ladero JM, Kwok CK, Jara C, Fernandez L, Silmi AM, Tapia D, Uson AC (1985) Hepatic acetylator phenotype in bladder cancer patients. Ann Clin Res 17: 96–99

    PubMed  CAS  Google Scholar 

  • Ladero JM, Gonzalez JF, Benitez J et al. (1991) Acetylator polymorphism in human colorectal carcinoma. Cancer Res 51: 2098–2100

    PubMed  CAS  Google Scholar 

  • Lafuente A, Pujol F, Carretero P, Villa JP, Cuchi A (1993) Human glutathione S-transferase N (GSTN) deficiency as a marker for the susceptibility to bladder and larynx cancer among smokers. Cancer Lett 68: 49–54

    PubMed  CAS  Google Scholar 

  • Lang NP, Chu DZ, Hunter CF et al. (1986) Role of aromatic amine acetyltransferase in human colorectal cancer. Arch Surg 121: 1259–1261

    PubMed  CAS  Google Scholar 

  • Law MR, Hetzel MR, Idle JR (1989) Debrisoquine metabolism and genetic predisposition to lung cancer. Br J Cancer 59: 686–688

    PubMed  CAS  Google Scholar 

  • Lemeshow S, Hosmer DW, Klar J, Lwanga SK (1990) Adequacy of sample size in health studies. Wiley & Sons, Chichester, pp 1–239

    Google Scholar 

  • Levin ML (1953) The occurrence of lung cancer in man. Acta Unio Internat Contra Cancrum 9: 531–541

    CAS  Google Scholar 

  • Lewalter J, Korallus U (1985) Blood protein conjugates and acetylation of aromatic amines. New findings on biological monitoring. Int Arch Occup Environ Health 56: 179–196

    PubMed  CAS  Google Scholar 

  • Lin HJ, Han C-Y, Bernstein DA, Hsiao W, Lin BK, Hardy S (1994) Ethnic distribution of the glutathione transferyse Mu 1–1 (GSTM1) null genotype in 1473 individuals and application to bladder cancer susceptibility. Carcinogenesis 15: 1077–1081

    PubMed  CAS  Google Scholar 

  • Lindberg RL, Negishi M (1989) Alteration of mouse cytochrome P450coh substrate specificity by mutation of a single amino-acid residue. Nature 339: 632–634

    PubMed  CAS  Google Scholar 

  • Lindpaintner K, Pfeffer MA, Kreutz R, Stampfer MJ, Grodstein F, Lotte F, Buring J, Hennekens CH (1995) A prospective evaluation of an angiotensin-converting-enzyme gene polymorphism and the risk of ischemic heart disease. N Engl J Med 332: 706–711

    PubMed  CAS  Google Scholar 

  • Llerena A, Edman G, Cobaleda J, Benitez J, Schalling D, Bertilsson L (1993) Relationship between personality and debrisoquine hydroxylation capacity. Acta Psychiatr Scand 87: 23–28

    PubMed  CAS  Google Scholar 

  • London SJ, Daly AK, Fairbrother KS, Holmes C, Carpenter CL, Navidi WC, Idle JR (1995) Lung cancer risk in African-Americans in relation to a race-specific CYP1A1 polymorphism. Cancer Res 55: 6035–6037

    PubMed  CAS  Google Scholar 

  • Lower G (1983) Molecular epidemiology of arylamine-induced urinary bladder cancer: some theoretical considerations. In: Weber WW, Hein DW, Litwin A, Lower GM (eds) Relationship of acetylator status to isoniazid toxicity, lupus erythematosus and bladder cancer. Fedn Proc 42: 3086–3097

    Google Scholar 

  • Lower GM, Nilsson T, Nelson CE, Wolf H, Gamsky TW, Bryan GT (1979) N-Acetyltransferase phenotype and risk in urinary bladder cancer: approaches in molecular epidemiology. Preliminary results in Sweden and Denmark. Environ Health Perspect 29: 71–79

    Google Scholar 

  • Mannervik B, Awasthi YC, Yoard PG, Hayes JD, Dillio C, Ketterer B, Listowsky I, Morgenstern R, Muramatsu M, Pearson WR, Pickett CB, Sato K, Widersten M, Wolf CR (1992) Nomenclature for human glutathione transferases. Biochem J 282: 305–308

    PubMed  CAS  Google Scholar 

  • Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22: 719–748

    PubMed  CAS  Google Scholar 

  • McGlynn K, Rosvold EA, Lustbader ED, Hu Y, Clapper ML, Zhou T, Wild CP, Xia X-L, Baffoe-Bonnie A, Ofori-Adjei D, Chen G-C, London WT, Shen F-M, Buetow KH (1995) Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin Bl. Proc Natl Acad Sci USA 92: 2384–2387

    PubMed  CAS  Google Scholar 

  • McWilliams JE, Sanderson BJS, Harris EL, Richert-Boe KE, Henner WD (1995) Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk. Cancer Epidemiol Biomarkers Prev 4: 589–594

    PubMed  CAS  Google Scholar 

  • Miller ME, Cosgriff JM (1983) Acetylator phenotype in human bladder cancer. J Urol 130: 65–66

    PubMed  CAS  Google Scholar 

  • Miller EC, Miller JA (1983) Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules. Cancer 47: 2327–2345

    Google Scholar 

  • Minchin RF, Kadlubar FF, Illett KF (1993) Role of acetylation in colorectal cancer. Mutat Res 200: 35–42

    Google Scholar 

  • Miners JO, Mackenzie PI (1991) Drug glucuronidation in humans. Pharmacol Ther 51: 347–369

    PubMed  CAS  Google Scholar 

  • Mommsen S, Aagaard J (1986) Susceptibility in urinary bladder cancer: acetyltransferase phenotypes and related risk factors. Cancer Lett 32: 199–205

    PubMed  CAS  Google Scholar 

  • Nakachi K, Imai K, Hayashi S, Kawajiri K (1993) Polymorphisms of the CYP1A1 and glutathione S-transferase genes associated with susceptibility to lung cancer in relation to cigarette dose in a Japanese population. Cancer Res 53: 2994–2999

    PubMed  CAS  Google Scholar 

  • Nazar-Steward V, Motulsky AG, Eaton DL, White E, Hornung SK, Leng Z-T, Stapleton P, Weiss NS (1993) The glutathione S-transferase N polymorphism as a marker for susceptibility to lung carcinoma. Cancer Res 53: 2313–2318

    Google Scholar 

  • Nebert DW (1994) Drug-metabolizing enzymes in ligand-modulated transcription. Biochem Pharmacol 47: 25–37

    PubMed  CAS  Google Scholar 

  • Nelson DR, Koymans L, Kamataki T, Stegeman J, Feyereisen R, Waxman DJ, Waterman MR, Gotoh O, Coon MJ, Wstabrook RW, Gunsalus IC, Nebert DW (1996) P450 superfamily: update on new sequences, gene mapping, accession numbers and nomenclature. Pharmacogenetics 6: 1–42

    PubMed  CAS  Google Scholar 

  • Neumann H-G, Albrecht O, Dorp C van, Zwirner-Baier I (1995) Macromolecular adducts caused by environmental chemicals. Clin Chem 41: 1835–1840

    PubMed  CAS  Google Scholar 

  • Okey AB, Riddick DA, Harper PA (1994) Molecular biology of the aromatic hydrocarbon (dioxin) receptor. Trends Pharmacol Sci 15: 226–232

    PubMed  CAS  Google Scholar 

  • Okkels H, Sigsgaard T, Wolf H, Autrup H (1996) Glutathione S-transferase mu as a risk factor in bladder tumors. Pharmacogenetics 6: 251–256

    PubMed  CAS  Google Scholar 

  • Owens IS, Ritter JK (1992) The novel bilirubin/phenol UDP-glucuronosyltransferase UGT1 gene locus: implications for multiple familial hyperbilirubinaemia phenotypes. Pharmacogenetics 2: 93–108

    PubMed  CAS  Google Scholar 

  • Paigen B, Gurtoo HL, Minowada J, Houton L, Vincent R, Paigen K, Parker NB, Ward E, Hayner NT (1977) Questionable relation of aryl hydrocarbon hydroxylase to lung cancer risk. N Engl J Med 297: 346–350

    PubMed  CAS  Google Scholar 

  • Pearson WR, Vorachek WR, Xu S-J, Berger R, Hart I, Vannais D, Patterson D (1993) Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am J Hum Genet 53: 220–233

    PubMed  CAS  Google Scholar 

  • Peluso M, Castegnaro M, Malaveille C, Friesen M, Garren L, Hautefeuille A, Vineis P, Kadlubar F, Bartsch H (1991) 32 Postlabeling analysis of urinary mutagens from smokers of black tobacco implicates 2-amino-l-methyl-6-phenylimidazo[4,5-b]pyridine (PP) as a major DNA-damaging agent. Carcinogenesis 12: 713–717

    Google Scholar 

  • Pemble S, Schroeder KR, Spencer SR, Meyer DJ, Hallier E, Bolt HM, Ketterer B, Taylor JB (1994) Human glutathione S-transferase theta (GSTT1): NA cloning and the characterization of a genetic polymorphism. Biochem J 300: 271–276

    PubMed  CAS  Google Scholar 

  • Perera FP, Weinstein IB (1982) Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. J Chron Dis 35: 581–600

    PubMed  CAS  Google Scholar 

  • Pero RW, Olsson A, Berglund G, Janzon L, Larsson SA, Elmstahl S (1993) The Malmo biological bank. J Intern Med 233: 63–67

    PubMed  CAS  Google Scholar 

  • Probst MR, Blum M, Fasshauer I, D’Orazio D, Meyer UA, Wild D (1992) The role of the human acetylation polymorphism in the metabolic activation of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ). Carcinogenesis 13: 1713–1717

    PubMed  CAS  Google Scholar 

  • Probst-Hensch N, Haile RW, Ingles SA, Longnecker MP, Han C-Y, Lin BK, Lee DB, Sakamoto GT, Frankl HD, Lee ER, Lin HJ (1995) Acetylation polymorphism and prevalence of colorectal adenomas. Cancer Res 55: 2017–2020

    PubMed  CAS  Google Scholar 

  • Prochaska HJ, Talalay P (1988) Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver. Cancer Res 48: 4776–4782

    PubMed  CAS  Google Scholar 

  • Rehn L (1895) Blasengeschwülste bei Fuchsin-Arbeitern. Arch Klin Chir 50: 588–590

    Google Scholar 

  • Risch A, Wallace DMA, Bathers S, Sim E (1995) Slow N-acetylation genotype is a susceptibilty factor in occupational and smoking related bladder cancer. Hum Mol Genet 4: 231–236

    PubMed  CAS  Google Scholar 

  • Roots I, Brockmöller J (1996) Pharmakogenetik. In: Rietbrock N, Staib AH, Loew D (Hrsg) Klinische Pharmakologie, 3. Aufl. Steinkopf, Darmstadt, S 101–120

    Google Scholar 

  • Roots I, Drakoulis N, Ploch M, Heinemeyer G, Loddenkemper R, Minks T, Nitz M, Otte F, Koch M (1988) Debrisoquine hydroxylation phenotype, acetylation phenotype, and ABO blood groups as genetic host factors of lung cancer risk. Klin Wochenschr [Suppl 11] 66: 87–97

    PubMed  Google Scholar 

  • Roots I, Drakoulis N, Brockmöller J, Janicke I, Cuprunov M, Ritter J (1989) Hydroxylation and acetylation phenotypes as genetic risk factors in certain malignancies. In: Kato R, Estabrook RW, Cayen MN (eds) Xenobiotic metabolism and disposition. Taylor & Francis, London, pp 499–506

    Google Scholar 

  • Roots I, Drakoulis N, Brockmöller J (1992) Polymorphic enzymes and cancer risk: concepts, methodology and data review. In: Kalow W (ed) Pharmacogenetics of drug metabolism. Pergamon Press, Oxford New York, pp 815–841

    Google Scholar 

  • Rost KL, Roots I (1994) Accelerated caffeine metabolism after omeprazole treatment is indicated by urinary metabolite ratios – coincidence with plasma clearance and breath test. Clin Pharmacol Ther 55: 402–411

    PubMed  CAS  Google Scholar 

  • Rost KL, Brösicke H, Brockmöller J, Scheffler M, Helge H, Roots I (1992) Increase of cytochrome P450IA2 activity by omeprazole: evidence by the 13C-[N-3-methyl]-caffeine breath test in poor and extensive metabolizers of S-mephenytoin. Clin Pharmacol Ther 52: 170–180

    PubMed  CAS  Google Scholar 

  • Rostami-Hodjegans A, Nurminen S, Jackson PR, Tucker GT (1996) Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment. Pharmacogenetics 6: 121–150

    Google Scholar 

  • Rosvold EA, Mlynn KA, Lustbader ED, Buetow KH (1995) Identification of an NAD(P)H:quinone oxidoreductase polymorphism and its association with lung cancer and smoking Pharmacogenetics 5: 199–206

    PubMed  CAS  Google Scholar 

  • Rothman KJ (1986) Modern epidemiology. Little, Brown & Co, Boston

    Google Scholar 

  • Ruffalo RL, Thompson JF (1982) Cimetidine and acetylcysteine as antidote for acetaminophen overdose. South Med J 75: 954–962

    PubMed  CAS  Google Scholar 

  • Ryberg D, Kure E, Lystad S, Skaug V, Stangeland L, Mercy I, Borrensen A-L, Haugen A (1994) P53 mutations in lung tumors: relationship to putative susceptibility markers for cancer. Cancer Res 54: 1551–1555

    PubMed  CAS  Google Scholar 

  • Sackett DL (1979) Bias in analytic research. J Chron Dis 32: 51–63

    PubMed  CAS  Google Scholar 

  • Sato K, Kitahara A, Yin Z, Ebina T, Saroh K, Tsuda H, Ito N, Dempo K (1984) Molecular forms of glutathione-S-transferase and UDP-glucuronyltransferase as hepatic preneoplastic marker enzymes. Ann NY Acad Sci 47: 213 Schlesselman JJ (1982) Case-control studies – Design, conduct, analysis. Oxford University Press, Oxford, pp 1–354

    Google Scholar 

  • Schroder KR, Wiebel FA, Reich S, Dannappel D, Bolt HM, Hallier E (1995) Glutathione-S-transferase (GST) theta polymorphism influences background SCE rate. Arch Toxicol 69: 505–507

    PubMed  CAS  Google Scholar 

  • Schuetz JD, Beach DL, Guzelian PS (1994) Selective expression of cytochrome P450 CYP3A NAs in embryonic and adult human liver. Pharmacogenetics 4: 11–20

    PubMed  CAS  Google Scholar 

  • Schuetz EG, Schinkel AH, Relling MV, Schuetz JD (1996) P-glycoprotein: a major determinant of rifampicin-inductible expression of cytochrome P4503A in mice and humans. Proc Natl Acad Sci USA 93: 4001–4005

    PubMed  CAS  Google Scholar 

  • Schulte PA (1988) The role of genetic factors in bladder cancer. Cancer Detect Prev 11: 379–388

    PubMed  CAS  Google Scholar 

  • Seidegard J, De Pierre JW, Pero RW (1985) Hereditary interindividual differences in the glutathione transferase activity towards trans-stilbene oxide in resting human mononuclear leukocytes are due to a particular isozyme(s). Carcinogenesis 6: 1211–1216

    PubMed  CAS  Google Scholar 

  • Seidegard J, Pero RW, Miller DG, Beattie EJ (1986) A glutathione transferase in human leukocytes as a marker for the susceptibility to lung cancer. Carcinogenesis 7: 751–753

    PubMed  CAS  Google Scholar 

  • Seidegard J, Vorachek WR, Pero RW, Pearson WR (1988) Hereditary differences in the expression of the human glutathione transferase active on trans-stilbene oxide are due to a gene deletion. Proc Natl Acad Sci USA 85: 7293–7297

    PubMed  CAS  Google Scholar 

  • Seidegrd J, Pero RW, Markowitz MM, Roush G, Miller DG, Beattie EJ (1990) Isoenzyme(s) of glutathione transferase (class Mu) as a marker for the susceptibility to lung cancer: a follow up study. Carcinogenesis 11: 33–36

    Google Scholar 

  • Sesardic D, Boobis AR, Murray BP, Murray S, Segura J, Torre R de la, Davies DS (1990) Furafylline is a potent and selective inhibitor of cytochrome P450 1A2 in man. Br J Clin Pharmacol 20: 651–653

    Google Scholar 

  • Shaw GL, Falk RT, Deslauriers J, Frame JN, Nesbitt JC, Pass HI, Issaq HJ, Hoover RN, Tucker MA (1994) Debrisoquine metabolism and lung cancer risk. Cancer Epidemiol Biomarkers Prev 4: 41–48

    Google Scholar 

  • Shields PG, Bowman ED, Harrington AM, Doan VT, Weston A (1993) Polycyclic aromatic hydrocarbon-DNA adducts in human lung and cancer susceptibility genes. Cancer Res 53: 3486–3492

    PubMed  CAS  Google Scholar 

  • Shimada T, Iwasaki M, Martin MV, Guengerich FP (1989) Human liver microsomal cytochrome P-450 enzymes involved in the bioactivation of procarcinogens detected by umu gene response in Salmonella typhimurium TAI 535/ Kl002. Cancer Res 49: 3218–3228

    PubMed  CAS  Google Scholar 

  • Sinha R, Rothman N, Brown ED, Mark SD, Hoover RN, Caporaso NE, Levander OA, Knize MG, Lang NP, Kadlubar FF (1994) Pan-fried meat containing high levels of heterocyclic aromatic amines but low levies of polycyclic aromatic hydrocarbons induces cytochrome P4501A2 activity in humans. Cancer Res 54: 6154–6159

    PubMed  CAS  Google Scholar 

  • Smigel K (1996) Beta carotene fails to prevent cancer in two major studies, CARET intervention stopped. J Natl Cancer Inst 88: 145

    PubMed  CAS  Google Scholar 

  • Spielberg SP, Gordon GB, Blake DA, Goldstein DA, Herlong HF (1981) Predisposition to phenytoin hepatotoxicity assessed in vitro. N Engl J Med 305: 722–727

    PubMed  CAS  Google Scholar 

  • Spitzer WO, Horwitz SM (1991) Selected nonexperimental methods: an orientation. In: Troidl H, Spitzer WO, Meek B, Mulder DS, Mneally MF, Wechsler AS, Balch CM (Hrsg) Principles and practice of research strategies for surgical investigators, 2nd edn. Springer, Berlin Heidelberg New York, pp 104–113

    Google Scholar 

  • Spurr NK, Gough AC, Stevenson K, Wolf CR (1987) Msplpolymorphism detected with a NA probe for the P-450 I family on chromosome 15. Nucleic Acids Res 15: 5901

    PubMed  CAS  Google Scholar 

  • Sugimura T, Sato S (1983) Mutagens – carcinogens in foods. Cancer Res [Suppl] 43: 2415s-2421s

    CAS  Google Scholar 

  • Talaska G, AI Juburi AZ, Kadlubar FF (1991) Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-l)-4-aminobiphenyl as a major adduct. Proc Natl Acad Sci USA 88: 5350–5354

    PubMed  CAS  Google Scholar 

  • Talaska G, Schamer M, Skipper P, Tannenbaum S, Caporaso N, Kadlubar F, Bartsch H, Vineis P (1993) Carcinogen-DNA adducts in exfoliated urothelial cells: techniques for noninvasive human monitoring. Environ Health Perspect 99: 289–291

    PubMed  CAS  Google Scholar 

  • Tang BK, Zhou Y, Kadar D, Kalow W (1994) Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements. Pharmacogenetics 4: 117–124

    PubMed  CAS  Google Scholar 

  • Thier R, Taylor JB, Pemble SE, Humphreys WG, Persmark M, Ketterer B, Guengerich FP (1993) Expression of mammalian glutathione S-transferase 5–5 in Salmonella typhimurium TAI535 leads to base-pair mutations upon exposure to dihalomethanes. Proc Natl Acad Sci USA 90: 8576–8580

    PubMed  CAS  Google Scholar 

  • Traver RD, Horikoshi T, Danenberg KD, Stadlbauer THW, Danenberg PV, Ross D, Gibson NW (1992) NAD(P)H: Quinone oxidoreductase gene expression in human colon carcinoma cells: characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity. Cancer Res 52: 797–802

    PubMed  CAS  Google Scholar 

  • Vatsis KP, Weber WW, Bell DA, Dupret J-M, Evans DAP, Grant DM, Hein DW, Lin HJ, Meyer UA, Relling MV, Sim E, Suzuki T, Yamazoe Y (1995) Nomenclature of N-acetyl-transferases. Pharmacogenetics 5: 1–17

    PubMed  CAS  Google Scholar 

  • Vaury C, Laine R, Noguiez P, Coppet P de, Jaulin C, Praz F, Pompon D, Amor-Gueret M (1995) Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription. Cancer Res 55: 5520–5523

    PubMed  CAS  Google Scholar 

  • Vineis P, Caporaso N, Tannenbaum SR, Skipper PL, Glogowski J, Bartsch H, Coda M, Talaska G, Kadlubar F (1990) Acetylation phenotype, carcinogen-hemoglobin adducts, and cigarette smoking. Cancer Res 50: 3002–3004

    PubMed  CAS  Google Scholar 

  • Vineis P, Bartsch H, Caporaso N, Harrington AM, Kadlubar FF, Landi MT, Malaveille C, Shields PG, Skipper P, Talaska G, Tannenbaum SR (1994) Genetically based N-acetyl-transferase metabolic polymorphism and low-level environmental exposure to carcinogens. Nature 369: 154–156

    PubMed  CAS  Google Scholar 

  • Vogelstein B, Kinzler KW (1992) Carcinogens leave fingerprints. Nature 355: 209–210

    PubMed  CAS  Google Scholar 

  • Ward E, Paigen B, Steenland K, Vincent R, Mnowada J, Gurtoo HL, Sartori P, Havens MB (1978) Aryl hydrocarbon hydroxylase in persons with lung or laryngeal cancer. Int J Cancer 22: 384–389

    PubMed  CAS  Google Scholar 

  • Watkins PB (1990) Role of cytochrome P450 in drug metabolism and hepato toxicity. Semin Liver Dis 10: 235–250

    PubMed  CAS  Google Scholar 

  • Weinshilboum R, Aksoy I (1991) Sulfatation pharmacogenetics in humans. Chem Biol Interact 92: 233–246

    Google Scholar 

  • Wiencke JK, Kelsey KT, Lamela RA, Toscano WA (1990) Human glutathione S-transferase deficiency as a marker of susceptibility to epoxide-induced cytogenetic damage. Cancer Res 50: 1585–1590

    PubMed  CAS  Google Scholar 

  • Wiencke JK, Pemble S, Ketterer B, Kelsey KT (1995) Gene deletion of glutathione S-transferase I: Correlation with induced genetic damage and potential role in endogenous mutagenesis. Cancer Epidemiol Biomarkers Prev 4: 253–259

    PubMed  CAS  Google Scholar 

  • Willett WC (1994) Diet and health: what should we eat? Science 264: 532–537

    PubMed  CAS  Google Scholar 

  • Willett WC, Stampfer MJ, Colditz GA, Rosner BA, Speizer FE (1990) Relation of meat, fat, and fiber intake to the risk of colon cancer in a prospective study among women. N Engl J Med 323: 1664–1672

    PubMed  CAS  Google Scholar 

  • Woodhouse KW, Adams PC, Clothier A, Mucklow JC, Rawlings MD (1982) N-Acetylation phenotype in bladder cancer. Hum Toxicol 1: 443–445

    PubMed  CAS  Google Scholar 

  • Yang CS, Brady JE, Hong JY (1992) Dietary effects on cytochromes P450, xenobiotic metabolism and toxicity. FASEB J 6: 737–744

    PubMed  CAS  Google Scholar 

  • Yu MC, Skipper PL, Taghizadeh K, Tannenbaum SR, Chan KK, Henderson BE, Ross RK (1994) Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black and Asian men in Los Angeles, California. J Natl Cancer Inst 86: 712–716

    PubMed  CAS  Google Scholar 

  • Yu MC, Ross RK, Chan KK, Henderson BE, Skipper PL, Tannenbaum SR, Coetzee GA (1995) Glutathione S-transferase M1 genotype affects aminobiphenyl-hemoglobin adduct levels in white, black and Asian smokers and nonsmokers. Cancer Epidemiol Biomarkers Prev 4: 861–864

    PubMed  CAS  Google Scholar 

  • Zhong S, Howie AF, Ketterer B, Taylor J, Hayes JD, Beckett GJ, Wathen CG, Wolf CR, Spurr NK (1991) Glutathione S-transferase mu locus: use of genotyping and phenotyping assays to assess association with lung cancer susceptibility. Carcinogenesis 12: 1533–1537

    PubMed  CAS  Google Scholar 

  • Zhong S, Wyllie AH, Barnes D, Wolf CR, Spurr NK (1993) Relationship between the GSTM1 genetic polymorphism and susceptibility to bladder, breast and colon cancer. Carcinogenesis 14: 1821–1824

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Brockmöller, J. (1998). Fremdstoffmetabolismus und Krebs: Molekular-epidemiologische Forschung. In: Ganten, D., Ruckpaul, K. (eds) Tumorerkrankungen. Handbuch der Molekularen Medizin, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80362-8_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80362-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80363-5

  • Online ISBN: 978-3-642-80362-8

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics