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Molekulare Grundlagen der Herzinsuffizienz

  • Chapter
Herz-Kreislauf-Erkrankungen

Part of the book series: Handbuch der Molekularen Medizin ((HDBMOLEK,volume 3))

Zusammenfassung

Die Herzinsuffizienz ist ein klinisches Syndrom, das durch die Unfähigkeit des Herzens gekennzeichnet ist, das vom Organismus benötigte Herzzeitvolumen bei ausreichendem enddiastolischem Ventrikeldruck zu fördern. Dieses Mißverhältnis von Angebot und Bedarf verursacht eine Aktivierung neurohumoraler Kompensationsmechanismen, die darauf gerichtet sind, eine ausreichende Organperfusion zu gewährleisten, letztlich aber zum beschleunigten Fortschreiten der Herzinsuffizienz beitragen. Die wichtigsten Symptome der Herzinsuffizienz sind Stauungserscheinungen im kleinen und großen Kreislauf (Rückwärtsversagen) sowie Zeichen der Minderperfusion von Organen (Vorwärtsversagen). Nach einem Vorschlag der New York Heart Association wird der Schweregrad der klinischen Symptomatik in 4 Klassen eingeteilt (NYHA I–IV; Tabelle 1.5.1).

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  1. Thomas Eschenhagen
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  2. Joachim Weil
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Eschenhagen, T., Weil, J. (1998). Molekulare Grundlagen der Herzinsuffizienz. In: Ganten, D., Ruckpaul, K. (eds) Herz-Kreislauf-Erkrankungen. Handbuch der Molekularen Medizin, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80360-4_5

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