Application of Transgenes and Transgenic Mice to Study Gene Activity from the Oocyte to the Early Embryo
Development is initiated during gametogenesis. The contribution of the oocyte has been precisely defined in a few species, such as in invertebrates, using genetic approaches (St Johnston and Nüsslein-Volhard 1992), and also in certain vertebrates, such as amphibians, using biochemical analyzes (Ruiz i Altaba and Melton 1990; Kessler and Melton 1994). However, the steps of embryogenesis that occur prior to gastrulation exhibit a surprisingly large diversity among the different zoologic groups. It is therefore impossible to extrapolate rules or strategies and, so far, no conserved developmental pathways have been found.
KeywordsEarly Embryo Preimplantation Embryo Yeast Artificial Chromosome Transient Expression Assay Preimplantation Development
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- Forlani S, Nicolas J (1996a) Gene activity in the preimplantation mouse embryo. In: Transgenic animals: generation and use. Harward academic publishers gmbh. Editor Houdebine JM. Amsterdam pp 345–359Google Scholar
- Hogan B, Costantini F, Lacy E (1986) Manipulating the mouse embryo. Cold Spring Harbor Laboratory Press, Cold Spring Habor, New YorkGoogle Scholar
- Hoppe PC (1985) Technique of fertilization in vitro. In: Dixon RL (ed) Reproductive toxicology. Raven Press, New York, pp 191–199Google Scholar
- Latham KE, Solter D (1991) Effect of egg composition on the developmental capacity of androgenetic mouse embryos [published erratum appears in Development 1992 Apr; 114(4):preceding table of contents]. Development 113: 561–568Google Scholar
- Maniatis T, Fritsch E, Sambrook J (1989) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor, New YorkGoogle Scholar
- Melanitou E, Simmler M C, Heard E, Rougeulle C, Avner P (1996) Selected methods related to the mouse as a model system. In: Kenneth WA (ed) Methods in molecular genetics: human molecular genetics. pp 439–469Google Scholar
- Paris D, Toyama K, Sinet PM, Kamoun P, London J (1995) A comparison between an inbred strain and hybrid lines to generate transgenic mice. Mouse Genome 93: 1038–1040Google Scholar
- Peterson KR, Clegg CH, Huxley C, Josephson BM, Haugen HS, Furukawa T, Stamatoyannopoulos G (1993) Transgenic mice containing a 248-kb yeast artificial chromosome carrying the human beta-globin locus display proper developmental control of human globin genes. Proc Natl Acad Sci USA 90: 7593–8597PubMedCrossRefGoogle Scholar
- Peterson KR, Li QL, Clegg CH, Furukawa T, Navas PA, Norton EJ, Kimbrough TG, Stamatoyannopoulos G (1995) Use of yeast artificial chromosomes (YACs) in studies of mammalian development: production of beta-globin locus YAC mice carrying human globin developmental mutants. Proc Natl Acad Sci USA 92: 5655–5659PubMedCrossRefGoogle Scholar
- Reik W, Howlett S, Surani M (1990) Imprinting by DNA methylation: from trans-genes to endogenous sequences. Development Suppl 99–106Google Scholar
- Rose M, Winston F, Hieter P (1990) Methods in yeast genetics: a course manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, New York.Google Scholar
- Surani MA, Kothary R, Allen ND, Singh PB (1990) Genome imprinting and development in the mouse. Development Suppl 89–98Google Scholar