Application of Transgenes and Transgenic Mice to Study Gene Activity from the Oocyte to the Early Embryo

  • Sylvie Forlani
  • Lucile Montfort
  • Jean-François Nicolas
Part of the Springer Lab Manual book series (SLM)


Development is initiated during gametogenesis. The contribution of the oocyte has been precisely defined in a few species, such as in invertebrates, using genetic approaches (St Johnston and Nüsslein-Volhard 1992), and also in certain vertebrates, such as amphibians, using biochemical analyzes (Ruiz i Altaba and Melton 1990; Kessler and Melton 1994). However, the steps of embryogenesis that occur prior to gastrulation exhibit a surprisingly large diversity among the different zoologic groups. It is therefore impossible to extrapolate rules or strategies and, so far, no conserved developmental pathways have been found.


Early Embryo Preimplantation Embryo Yeast Artificial Chromosome Transient Expression Assay Preimplantation Development 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Sylvie Forlani
    • 1
  • Lucile Montfort
    • 1
  • Jean-François Nicolas
    • 1
  1. 1.Unité de Biologie moléculaire du Développement, URA 1947 du Centre National de la Recherche ScientifiqueInstitut PasteurParis Cedex 15France

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