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Are Major Components of Fragrances a Problem?

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Fragrances

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Abstract

The fragrance mix (FM), or perfume mix, as introduced for screening by Larsen [1] in 1977, contains eight basic constituents of perfumes commonly used at that time (eugenol, isoeugenol, oak moss, geraniol, hydroxycitronellal, α-amyl cinnamic aldehyde, cinnamic alcohol, and cinnamic aldehyde). Originally formulated at 16% in petrolatum (pet., 2% of each constituent), it frequently produced irritant reactions; therefore the FM was lowered to 8%. With this mix, the response rate in dermatological patients presently ranges worldwide from 4% to 11%: Germany, from 7.5% [2] to 11.2% [3]; Denmark, 5.5% [4]; Belgium 8.3% (A. Dooms-Goossens, personal communication); Portugal, 4.2% (329 children) [5]; Sweden, 5.6% [6]; and in Europe as a whole, 7.8% (2455 patients at eight centres [7]).

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Authors
  1. P. J. Frosch
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Editors and Affiliations

  1. Städtische Kliniken Dortmund, Hautklinik and Department of Dermatology, University of Witten/Herdecke, Beurhausstraße 40, D-44137, Dortmund, Germany

    Peter J. Frosch

  2. Gentofte Hospital, Department of Dermatology, University of Copenhagen, Niels Andersen Vej 65, DK-2900, Hellerup, Denmark

    Jeanne Duus Johansen

  3. St. John’s Institute of Dermatology, St. Thomas’ Hospital, SEI 7EH, London, England

    Ian R. White

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© 1998 Springer-Verlag Berlin Heidelberg

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Frosch, P.J. (1998). Are Major Components of Fragrances a Problem?. In: Frosch, P.J., Johansen, J.D., White, I.R. (eds) Fragrances. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80340-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-80340-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80342-0

  • Online ISBN: 978-3-642-80340-6

  • eBook Packages: Springer Book Archive

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