Fragrances have been used by mankind more than 3000 years, judging from the perfume container discovered in an ancient ruin in India and from a fresco showing ladies enjoying perfume in Egypt. They will surely also be used in the future since they are a kind of art, and at the same time are a part of our daily necessities such as cosmetics, toiletries and food. Some fragrances, however, have been demonstrated to be allergenic, and responsible for causing cosmetic dermatitis. Therefore discovering these “trouble making” fragrances was the first stage. Replacing them with alternative fragrances was then necessary at the second stage. This combination project has been carried out in Japan since 1970. This is a short report on the history of the project.
KeywordsContact Dermatitis Patch Test Linalool Oxide Citronellyl Acetate Musk Ketone
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