Urinary System pp 431-438 | Cite as

Calcium Oxalate Urolithiasis, Rat

  • Saeed R. Khan
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The gross appearance of kidneys, ureters, and bladder depends upon the severity of the disease. In calcium oxalate nephrolithiasis, kidneys become grossly enlarged and stippled with yellowish white flecks on their external surfaces and on cut sections (Andrus et al. 1960; Tawashi et al. 1980; Lyon et al. 1966). Hydronephrosis with crystalline sediments and concretions in calyceal fornices and the renal pelvis is common (Andrus et al. 1960). Renal papillary tips may be encrusted with glistening whitish crystalline deposits. Calculi may be present in ureters and bladder. When present in the ureter, calculi cause ureteral obstruction and hydroureter. The most frequent site of obstruction is the junction between the ureter and bladder. There is considerable variation in size, shape, and texture of calculi. They may be single or multiple, sand-like or large, smooth or nodulous or with sharp edges. They are generally hard and heavy and white to yellow.


Urinary stone disease urinary lithiasis nephrolithiasis kidney stone disease 


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  1. Andrus SB, Gershoff SN, Faragalla FF, Prien EL (1960) Production of calcium oxalate renal calculi in vitamin B6- deficientrats. Study of the influence of urine pH. Lab Invest 9:7–27PubMedGoogle Scholar
  2. Cheng L (1980) Urinary tract calculi in man and laboratory animals: incidence, composition, and etiology. J Environ Pathol Toxicol 4:317–349PubMedGoogle Scholar
  3. Coburn SP, Packett LV Jr (1962) Calcium, phosphorus and citrate interactions in oxalate urolithiasis produced with a low-phosphorus diet in rats. J Nutr 76:385–392PubMedGoogle Scholar
  4. Finlayson B (1974) Symposium on renal lithiasis. Renal lithiasis in review. Urol Clin North Am 1:181–212PubMedGoogle Scholar
  5. Finlayson B, Khan SR, Hackett RL (1984) Mechanisms of stone formation - an overview. Scan Electron Microsc 1984(3):1419–1425Google Scholar
  6. Gershoff SN, Faragalla FF, Nelson DA, Andrus SB (1959) Vitamin B6 deficiency and oxalate nephrocalcinosis in the cat. Am] Med 27:72–82CrossRefGoogle Scholar
  7. Gustafsson BE, Norman A (1962) Urinary calculi in germfree rats. J Exp Med 116:273–284 Khan SR (1991) Pathogenesis of oxalate urolithiasis: lessons from experimental studies with rats. Am J Kid Dis 17:398–401Google Scholar
  8. Khan SR (1995a) Experimental calcium oxalate nephrolithiasis and the formation of human urinary stones. Scan Micros 9:89–101Google Scholar
  9. Khan SR (1995b) Calcium oxalate crystal interaction with renal tubular epithelium, mechanism of crystal adhesion and its impact on stone development. Urol Res 23:71–79PubMedCrossRefGoogle Scholar
  10. Khan SR, Hackett RL (1985) Calcium oxalate urolithiasis in the rat: Is it a model for human stone disease? A review of recent literature. Scan Electron Microsc 85 (II):759–774Google Scholar
  11. Khan SR, Finlayson B, Hackett RL (1979a) Histologic study of the early events in oxalate induced intranephronic calculosis. Invest Urol17:199–202PubMedGoogle Scholar
  12. Khan SR, Finlayson B, Hackett RL (1979b) Scanning electron microscopy of calcium oxalate crystal formation in experimental nephrolithiasis. Lab Invest 41:504–510PubMedGoogle Scholar
  13. Khan SR, Finlayson B, Hackett RL (1982) Experimental calcium oxalate nephrolithiasis in the rat. Role of the renal papilla. Am J Pathol 107:59–69PubMedGoogle Scholar
  14. Khan SR, Hackett RL, Thomas WC Jr, Finlayson B (1984) Kinetics of calcium oxalate encrustation on plastic foreign bodies in rat urinary bladders. In: Ryall RL, Brockis JG, Marshall VQ, Finlayson B (eds) Urinary stone. Churchill Livingstone, Edinburgh, pp 363–371Google Scholar
  15. Lyon ES, Borden TA, Vermeulen CW (1966) Experimental oxalate lithiasis produced with ethylene glycol. Invest Urol4:143–151PubMedGoogle Scholar
  16. McIntosh GH (1978) Urolithiasis in animals. Aust Vet J 54:267–271PubMedCrossRefGoogle Scholar
  17. McIntosh GH, Belling GB, Bulman FH (1979) Experimental oxalate urolith formation in rats. Aust J Exp Biol Med Sci 57:251–259PubMedCrossRefGoogle Scholar
  18. Nath R, Thind SK, Murthy MSR, Talwar HS, Farooqui S (1984) Molecular aspects of idiopathic urolithiasis. Mol Aspects Med 7:1–176PubMedCrossRefGoogle Scholar
  19. Rushton HG, Spector M (1982) Effects of magnesium deficiency on intra tubular calcium oxalate formation and crystalluria in hyperoxaluric rats. J Urol127:598–604PubMedGoogle Scholar
  20. Tawashi R, Cousineau M, Sharkawi M (1980) Calcium oxalate crystal formation in the kidneys of rats injected with 4-hydroxy-L-proline. Urol Res 8:121- 127PubMedCrossRefGoogle Scholar
  21. Werness PG, Knox FG, Smith LH (1981) Low phosphate diet in rats: a model for calcium oxalate urolithiasis. In: Smith LH, Robertson WG, Finlayson B (eds) Urolithiasis: clinical and basic research. Plenum, New York, pp 731–734Google Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • Saeed R. Khan

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