Advertisement

Urinary System pp 416-420 | Cite as

Undifferentiated Carcinoma, Urinary Bladder, Rat

  • Greg P. Sykes
  • Edwin F. Stula
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Undifferentiated carcinoma of the urinary bladder has been reported in five studies (Fukushima et al. 1976; Kunze and Schauer 1977; Goodman et al. 1979; NIH 1979; Deerberg et al. 1985), although specifics regarding its gross appearance were not given. Since this neoplasm is generally more invasive than other bladder neoplasms, it is more likely to present as a solid mass infiltrating the bladder wall rather than a papillary or plaque-like lesion limited to the mucosa. All six of the cases reported by Deerberg et al. (1985) had metastases to the lung or lymph nodes; no metastasis was observed in the other studies.

Keywords

Small cell carcinoma giant cell carcinoma spindle cell carcinoma anaplastic carcinoma 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Blomjous CE, Vos W, De Voogt HJ, Van der Valk P, Meijer CJ (1989) Small cell carcinoma of the urinary bladder. A clinicopathologic, morphometric, immunohistochemical, and ultrastructural study of 18 cases. Cancer 64:1347–1357PubMedCrossRefGoogle Scholar
  2. Chomette G, Tranbaloc P, De Frejacques C, Auriol M (1984) Non-transitional cell malignant tumors of the bladder. Anatomopathological study. Prog Clin Bioi Res 162(A):75–80Google Scholar
  3. Cohen SM (1983) Pathology of experimental bladder cancer in rodents. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 2. CRC Press, Boca Raton, pp 2–40Google Scholar
  4. Deerberg F, Rehm S, Jostmeyer HH (1985) Spontaneous urinary bladder tumors in DAlHan rats: a feasible model of human bladder cancer. J Nat! Cancer Inst 75:1113- 1121PubMedGoogle Scholar
  5. Friedell GH, Nagy GK, Cohen SM (1983) Pathology of human bladder cancer and related lesions. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, voll. CRC Press, Boca RatonGoogle Scholar
  6. Frith CH, Farmer JH, Greenman DL, Shaw GW (1980) Biologic and morphologic characteristics of urinary bladder neoplasms induced in BALB/C female mice with 2-acetylaminofiuorene. J Environ Pathol Toxicol 3:103–119PubMedGoogle Scholar
  7. Fukushima S, Hirose M, Tsuda H, Shirai T, Hirao K (1976) Histological classification of urinary bladder cancers in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann 67:81–90PubMedGoogle Scholar
  8. Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48:237–248PubMedCrossRefGoogle Scholar
  9. Hicks RM, Wakefield JS, Vlasov NN, Pliss GB (1976) Tumours of the urinary bladder. IARC Sci PubI 6:103–134Google Scholar
  10. Hirose M, Fukushima S, Hananouchi M, Shirai T, Ogiso T (1976) Different susceptibilities of the urinary bladder epithelium of animal species to three nitroso compounds. Gann 67:175–189PubMedGoogle Scholar
  11. Ito N, Hiasa Y, Tarnai A, Okajima E, Kitamura H (1969) Histogenesis of urinary bladder tumors induced by Nbutyl- N-(4-hydroxybutyl)nitrosamine in rats. Gann 60:401–410PubMedGoogle Scholar
  12. Kahn HJ, Huang SN, Hanna WM, Baumal R, Phillips MJ (1984) Immunohistochemical localization of epidermal and Mallory body cytokeratin in undifferentiated epithelial tumors. Comparison with ultrastructural features. Am J Clin Pat hoI 81:184–191Google Scholar
  13. Kunze E, Chowaniec J (1990) Tumours of the urinary bladder. In: IARC Sci Publ 99:353Google Scholar
  14. Kunze E, Schauer A (1977) Morphology, classification and histogenesis of N -butyl-N -(4-hydroxybutyl)nitrosamineinduced carcinomas in the urinary bladder of rats. Z Krebsforsch 88:273–289Google Scholar
  15. Mazzucchelli L, Kraft R, Gerber H, Egger C, Studer UE, Zimmermann A (1992) Carcinosarcoma of the urinary bladder: a distinct variant characterized by small cell undifferentiated carcinoma with neuroendocrine features. Virchows Arch A Pathol Anat Histopathol 421:477–483PubMedCrossRefGoogle Scholar
  16. Mills SE, Wolfe JT. Weiss MA, Swanson PE and others (1987) Small cell undifferentiated carcinoma of the Urinary bladder: a light microscopic, immunocytochemical, and ultrastructural study of 12 cases. Am J Surg Pathol 11:606–617CrossRefGoogle Scholar
  17. Mostofi FK, Sobin LH, Torloni H (1973) Histological typing of urinary bladder tumors. WHO, Geneva, pp 29–31 NIH (1979) Bioassay of p-cresidine for possible carcinogenicity. Publ no 79–1397. National Cancer Institute, BethesdaGoogle Scholar
  18. Pamukcu AM, Price JM, Bryan GT (1976) Naturally occurring and bracken-fern-induced bovine urinary bladder tumors. Clinical and morphological characteristics. Vet Pathol 13:110–122PubMedGoogle Scholar
  19. Ramaekers F, Huysmans A, Moesker 0, Schaart G, Herman C, Vooijs P (1985) Cytokeratin expression during neoplastic progression of human transitional cell carcinomas as detected by a monoclonal and polyclonal antibody. Lab Invest 52:31–38PubMedGoogle Scholar
  20. Siegelbaum MH, Edmonds P, Seidmon EJ (1986) Use of immunohistochemistry for identification of primary lymphoma of the bladder. J UroI 136:1074–1076Google Scholar
  21. Young RH (1987) Carcinosarcoma of the urinary bladder. Cancer 59:1333–1339PubMedCrossRefGoogle Scholar
  22. Young RH, Eble IN (1991) Unusual forms of carcinoma of the urinary bladder. Hum Pathol 22:948–965PubMedCrossRefGoogle Scholar
  23. Young RH, Wick MR, Mills SE (1988) Sarcomatoid carcinoma of the urinary bladder. A clinicopathologic analysis of 12 cases and review of the literature. Am J Clin Pathol 90:653–661PubMedGoogle Scholar
  24. Zukerberg LR, Harris NL, Young RH (1991) Carcinoma of the urinary bladder simulating malignant lymphoma: a report of five cases. Am J Surg PathoI 15:569–576CrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Greg P. Sykes
  • Edwin F. Stula

There are no affiliations available

Personalised recommendations