Urinary System pp 409-416 | Cite as

Adenocarcinoma, Urinary Bladder, Rat

  • Edwin F. Stula
  • Greg P. Sykes
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The gross features of primary adenocarcinoma of the urinary bladder of the rat have not been adequately described. Only five cases have been reported; one induced with bracken fern (Pamukcu et al. 1976a) and four with N-butyl-N(4-hydroxybutyl)nitrosamine (BBN) (Kunze and Schauer 1977).


Urinary Bladder Transitional Cell Carcinoma Urinary Bladder Cancer Spindle Cell Carcinoma Inverted Papilloma 
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  1. Alroy J, Roganovic D, Banner BF, Jacobs JB, Merk FB, Ucci AA, Kiwan PWL, Coon JS IV, Miller A W III (1981) Primary adenocarcinomas of the human urinary bladder: histochemical, immunological and ultrastructural studies. Virchows Arch Pat hoi Anat 393:165–181Google Scholar
  2. Anderstrom C, Johansson SL, von Schultz L (1983) Primary adenocarcinoma of the urinary bladder: a clinicopathologic and prognostic study. Cancer 52:1273- 1280PubMedCrossRefGoogle Scholar
  3. Bennett JK, Wheatley JK, Walton KN (1984) Ten-year experience with adenocarcinoma of the bladder. J Urol 131:262–263PubMedGoogle Scholar
  4. Birt DF, Julius AD, Hasegawa R, St. John M, Cohen SM (1987) Effect of L-tryptophan excess and vitamin B6 deficiency on rat urinary bladder cancer promotion. Cancer Res 47:1244–1250Google Scholar
  5. Bonser GM, Jull JW (1956) The histological changes in the mouse bladder following surgical implantation of paraffin wax pellets containing various chemicals. J Pathol Bacteriol 72:489–495CrossRefGoogle Scholar
  6. Boorman GA, Hollander CF (1973) Spontaneous lesions in the female WAG/Rij (Wistar) rat. J GerontoI 28:152- 159Google Scholar
  7. Boorman GA, Hollander CF (1974) High incidence of spontaneous urinary bladder and ureter tumors in the brown Norway rat. J Natl Cancer Inst 52:1005–1008PubMedGoogle Scholar
  8. Brobst DF, Olson C (1963) Neoplastic and proliferative lesions of the bovine urinary bladder. Am J Vet Res 24:105–110PubMedGoogle Scholar
  9. Burnett AL, Epstein N, Marshal FF (1991) Adenocarcinoma of urinary bladder: classification and management. Urology 37:315–322PubMedCrossRefGoogle Scholar
  10. Chin NW, Marinescu AM, Fani KF (1992) Composite adenocarcinoma and carcinoid tumor of urinary bladder. Urology 40:249–252PubMedCrossRefGoogle Scholar
  11. Chomette G, Tranbaloc P, De Frejacques C, Auriol M (1984) Non-transitional cell malignant tumors of the bladder. Anatomopathological study. Prog Clin Bioi Res 162(A):75–80Google Scholar
  12. Clemente CD (ed) (1985) Anatomy of the human body. Gray’s anatomy, 29th edn. Lea and Febiger, Philadelphia, p 1517Google Scholar
  13. Cohen SM (1983) Pathology of experimental bladder cancer in rodents. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 2. CRC Press, Boca RatonGoogle Scholar
  14. Coleman GL, Barthold SW, Osbaldiston GW, Foster SJ, Jonas AM (1977) Pathological changes during aging in barrier-reared Fischer 344 male rats. J GerontoI32:258- 278Google Scholar
  15. Conzelman GM Jr, Moulton JE, Flanders LE 3rd, Springer K, Crout DW (1969) Induction of transitional cell carcinomas of the urinary bladder in monkeys fed 2- naphthylamine. J Natl Cancer Inst 42:825–836PubMedGoogle Scholar
  16. Deerberg F, Rehm S, Jostmeyer HH (1985) Spontaneous urinary bladder tumors in DA/Han rats: a feasible model of human bladder cancer. J Natl Cancer Inst 75:1113- 1121PubMedGoogle Scholar
  17. Druckrey H, Preussmann R, Ivankovic S, Schmidt CH, Mennel HD, Stahl KW (1964) Selektive Erzeugung von Blasenkrebs an Ratten durch dibutyl- und N-butyl- Nbutanol(4)-nitrosamin. Z Krebsforsch 66:280–290PubMedCrossRefGoogle Scholar
  18. EI-Bolkainy MN (1983) Schistosomiasis and bladder cancer. In: Bryan GT, Cohen SM (eds) The pathology of bladder cancer, vol 1. CRC Press, Boca RatonGoogle Scholar
  19. Erttirk E, Cohen SM, Price JM, Bryan GT (1969) Pathogenesis, histology, and transplant ability of urinary bladder carcinomas induced in albino rats by oral administration of N-[4-(5-nitro-2furyl)-2-thiazolyl] formamide. Cancer Res 29:2219–2228Google Scholar
  20. Federal Register Propoxur (1995) (Baygon, Sendran): proposed decision not to initiate a special review. Fed Reg 60:3210 (1113/95) Google Scholar
  21. Flaks B, Flaks A, Shaw AP (1985) Induction by paracetamol of bladder and liver tumours in the rat. Effects on hepatocyte fine structure. Acta Pathol Microbiol Immunol Scand 93:367–377Google Scholar
  22. Foot NC (1944) Glandular metaplasia of the epithelium of the urinary tract. Southern Med J 37:137–142CrossRefGoogle Scholar
  23. Frith CH (1979) Morphologic classification of inflammatory, nonspecific, and proliferative lesions of the urinary bladder of mice. Invest UroI 16:435–444Google Scholar
  24. Fujii H, Cunha GR, Norman JT (1982) The induction of adenocarcinomatous differentiation in neoplastic bladder epithelium by an embryonic prostatic inductor. J UroI 128:858–861Google Scholar
  25. Fukushima S, Hirose M, Tsuda H, Shirai T, Hirao K (1976) Histological classification of urinary bladder cancers in rats induced by N-butyl-N-(4-hydroxybutyl)nitrosamine. Gann 67:81–90PubMedGoogle Scholar
  26. Fukushima S, Inoue T, Uwagawa S, Shibata MA, Ito N (1989) Co-carcinogenic effects of NaHC03 on 0- phenylphenol-induced rat bladder carcinogenesis. Carcinogenesis 10:1635–1640PubMedCrossRefGoogle Scholar
  27. Goodman DG, Ward JM, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging F344 rats. Toxicol Appl Pharmacol 48:237–248PubMedCrossRefGoogle Scholar
  28. Gordon NS, Sinclair RA, Snow RM (1990) Pelvic lipomatosis with cystitis cystica, cystitis glandularis and adenocarcinoma of the bladder: first reported case. Aust NZ J Surg 60:229–232Google Scholar
  29. Grignon DJ, Ro JY, Ayala AG, Johnson DE (1991a) Primary signet-ring cell carcinoma of the urinary bladder. Am J Clin Pathol 95:13–20PubMedGoogle Scholar
  30. Grignon DJ, Ro JY, Ayala AG, Johnson DE, Ordonez NG (1991b) Primary adenocarcinoma of the urinary bladder. A clinicopathologic analysis of 72 cases. Cancer 67:2165–2172PubMedCrossRefGoogle Scholar
  31. Hasegawa R, Fukushima S, Furukawa F, Takahashi M, Ito N (1986) Aberrant colonic epithelium in the bladder: report of a case. J Urol 136:901–902PubMedGoogle Scholar
  32. Hasegawa R, Fukushima S, Hirose M, Seki K, Takahashi M, Furuizawa F, Toyoda K, Ito N (1987) Histochemical demonstration of colonic type mucin in glandular metaplasia and adenocarcinoma of the human urinary bladder. Acta Pathol Jpn 37:1097–1103PubMedGoogle Scholar
  33. Heyns CF, De Kock ML, Kirsten PH, van Velden DJ (1991) Pelvic lipomatosis associated with cystitis glandularis and adenocarcinoma of the bladder. J Urol 145:364–366PubMedGoogle Scholar
  34. Hicks RM, Chowaniec J (1978) Experimental induction, histology, and ultrastructure of hyperplasia and neoplasia of the urinary bladder epithelium. Int Rev Exp Pathol 18:199–280PubMedGoogle Scholar
  35. Hicks RM, Wakefield JSTJ, Vlasov NN, Pliss GB (1976) Tumours of the urinary bladder. IARC Sci Publ 6:103–134PubMedGoogle Scholar
  36. Hicks RM, Wright R, Wakefield JSTJ (1982) The induction of rat bladder cancer by 2-naphthylamine. Br J Cancer 46:646–661PubMedCrossRefGoogle Scholar
  37. Hirono I, Shibuya C, Fushimi K, Haga M (1970) Studies on the carcinogenic properties of bracken, Pteridium aquilinum. J Natl Cancer Inst 45:179–188PubMedGoogle Scholar
  38. Hirono I, Also S, Hosaka S, Yamaji T, Haga M (1983) Induction of mammary cancer in CD rats fed bracken diet. Carcinogenesis 4:885–887PubMedCrossRefGoogle Scholar
  39. Hirose M, Fukushima S, Hananouchi M, Shirai T, Ogiso T (1976) Different susceptibilities of the urinary bladder epithelium of animal species to three nitroso compounds. Gann 67:175–189PubMedGoogle Scholar
  40. Ito N, Hiasa Y, Tarnai A, Okajima E, Kitamura H (1969) Histogenesis of urinary bladder tumors induced by Nbutyl- N-(4-hydroxybutyl)nitrosamine in rats. Gann 60:401–410PubMedGoogle Scholar
  41. Jarrett WF, McNeil PE, Grimshaw WT, Selman IE, McIntyre WI (1978) High incidence area of cattle cancer with a possible interaction between an environmental carcinogen and a papilloma virus. Nature 274:215–217PubMedCrossRefGoogle Scholar
  42. Kimura ET, Fort FL, Buratto B, Tekeli S, Kersterson JW, Heyman lA, Cusick PK (1984) Carcinogenic evaluation of estazolam via diet in CD strain Sprague-Dawley rats and B6C3FI mice for 2 years. Fundam Appl Toxicol 4:827–842PubMedCrossRefGoogle Scholar
  43. Kroes R, Garbis-Berkvens JM, de Vries T, van Nesselrooy HJ (1981) Histopathological profile of a Wistar rat stock including a survey of the literature. J Gerontol 36:259–279PubMedGoogle Scholar
  44. Kunze E, Chowaniec J (1990) Tumours of the urinary bladder. IARC Sci Publ 99:351Google Scholar
  45. Kunze E, Schauer A (1977) Morphology, classification and histogenesis of bladder cancer. Z Krebsforsch 88:273–289CrossRefGoogle Scholar
  46. Lijinsky W, Saavedra JE, Reuber MD (1981) Induction of carcinogenesis in Fischer rats by methylalkylnitrosamines. Cancer Res 41:1288–1292PubMedGoogle Scholar
  47. MacKenzie WF, Garner FM (1973) Comparison of neoplasms in six sources of rats. J Natl Cancer Inst 50:1243–1257Google Scholar
  48. Maekawa A, Odashima S (1975) Spontaneous tumors in ACI/N rats. J Natl Cancer Inst 55:1437–1445PubMedGoogle Scholar
  49. Maita K, Hirano M, Harada T, Mitsumori K, Yoshida A, Takahashi K, Nakashima N, Kitazawa T, Enomoto A, Inui K, Shirasu Y (1988) Mortality, major cause of moribundity, and spontaneous tumors in CD-1 mice. Toxicol PathoI16:340–349Google Scholar
  50. Marceau N (1990) Cell lineages and differentiation programs in epidermal, urothelial and hepatic tissues and their neoplasms. Lab Invest 63:4–20PubMedGoogle Scholar
  51. McIntosh JF, Worley G Jr (1955) Adenocarcinoma arising in exstrophy of the bladder: report of two cases and review of the literature. J Urol 73:820–829PubMedGoogle Scholar
  52. Mostofi FK, Davis CJ Jr (1984) Epithelial abnormalities of the urinary bladder. Prog Clin Bioi Res 162(A):81–93Google Scholar
  53. Mostofi FK, Sesterhenn IA (1984) Pathology of epithelial tumors and carcinoma in situ of bladder. Prog Clin Bioi Res 162(A):55–74Google Scholar
  54. Mostofi FK, Sobin LH, Torloni H (1974) Histological typing of urinary bladder tumors. WHO, Geneva Newbould M, McWilliam U (1990) A study of vesical adenocarcinoma, intestinal metaplasia and related lesions using mucin histochemistry. Histopathology 17:225–230Google Scholar
  55. NIH (1977) Bioassay of nitrilotriacetic acid and iiitrilotriacetic acid, trisodium salt, monohydrate for possible carcinogenicity. Publ no 77–806. National Cancer Institute, BethesdaGoogle Scholar
  56. NIH (1978a) Bioassay of o-anisidine hydrochloride for possible carcinogenicity. Publ no 78–1339. National Cancer Institute, BethesdaGoogle Scholar
  57. NIH (1978b) Bioassay of 4-amino-2-nitrophenol for possible carcinogenicity. Publ no 78–1344. National Cancer Institute, BethesdaGoogle Scholar
  58. NIH (1979a) Bioassay of o-toluidine for possible carcinogenicity. Publ no 79–1709. National Cancer Institute, BethesdaGoogle Scholar
  59. NIH (1979b) Bioassay of N-nitrosodiphenylamiirie for possible carcinogenicity. Publ no 79–1720. National Cancer Institute, BethesdaGoogle Scholar
  60. NIH (1979c) Bioassay of p-quinone dioxime for possible carcinogenicity. Publ no 79–1735. National Cancer Institute, BethesdaGoogle Scholar
  61. NIH (1983a) Carcinogenesis bioassay of allyl isothiocyanate in F344/N rats and B6C3FI mice (gavage study). Publ no 83–1790. National Toxicology Program, Research Triangle ParkGoogle Scholar
  62. NIH (1983b) Carcinogenesis bioassay of melamine in F3441N rats and B6C3FI mice (feed study). Publ no 83- 2501. National Toxicology Program, Research Triangle ParkGoogle Scholar
  63. Osborne CA, Low DG, Perman V, Barnes DM (1968) Neoplasms ofthe canine and feline urinary bladder: incidence, etiologic factors, occurrence and pathologic features. Am J Vet Res 29:2041–2055PubMedGoogle Scholar
  64. Pamukcu AM (1974) Tumours of the urinary bladder. Bull World Health Organ 50:43–52PubMedGoogle Scholar
  65. Pamukcu AM, Price JM (1969) Induction of intestinal and urinary bladder cancer in rats by feeding bracken fern (Pteris aquilina). J Natl Cancer Inst 43:275–281PubMedGoogle Scholar
  66. Pamukcu AM, Erttirk E, Yalciner S, Bryan GT (1976a) Histogenesis of urinary bladder cancer induced in rats by bracken fern. Invest UroI14:213–218PubMedGoogle Scholar
  67. Pamukcu AM, Price JM, Bryan GT(1976b) Naturally occurring and bracken-fern-induced bovine urinary bladder tumors. Clinical and morphological characteristics. Vet Pathol 13:110–122PubMedGoogle Scholar
  68. Pamukcu AM, Yalciner S, Hatcher JF, Bryan GT (1980) Quercetin, a rat intestinal and bladder carcinogen present in bracken fern (Pteridium aquilinum). Cancer Res 40:3468–3472PubMedGoogle Scholar
  69. Pauli BU, Alroy J, Weinstein RS (1983) The ultrastructure and pathobiology of urinary bladder cancer. In: Bryan GT, Cohen SM (eds) Pathology of bladder cancer, vol 2. CRC Press, Boca RatonGoogle Scholar
  70. Prejean JD, Peckham JC, Casey AE, Griswald DP, Weisburger EK, Weisburger JH (1973) Spontaneous tumors in Sprague-Dawley rats and Swiss mice. Cancer Res 33:2768–2773PubMedGoogle Scholar
  71. Raghavan D, Russel PJ, Brown JL (1992) Experimental models of histogenesis and tumor cell heterogeneity in bladder cancer. Semin Surg Oncol 8:279–284PubMedCrossRefGoogle Scholar
  72. Roe FJC (1964) An illustrated classification often proliferative and neoplastic changes in mouse bladder epithet lium in response to prolonged irritation. J Urol 36:238- 253CrossRefGoogle Scholar
  73. Satake T, Matsuyama M (1986) Neoplastic nature of argyrophil cells in urachal adenocarcinoma. Acta Pathol Jpn 36:1587–1592PubMedGoogle Scholar
  74. Schardein JL, Fitzgerald JE, Kaump DH (1968) Spontaneous tumors in Holtzman-source rats of various ages. Pathol Vet 5:238–252PubMedGoogle Scholar
  75. Schubert GE, Pavkovic MB, Bethke-Bedurftig BA (1982) Tubular urachal remnants in adult bladders. J Urol 127:40–42PubMedGoogle Scholar
  76. Stula EF, Barnes JR, Sherman H, Reinhardt CF, Zapp JA Jr (1978) Urinary bladder tumors in dogs from 4,4’methylene- bis(2-chloroaniline) (MOCA). J Environ Pathol Toxicol 1:31–50PubMedGoogle Scholar
  77. Tamano S, Hagiwara A, Suzuki E, Okada M, Shirai T, Fukushima S (1991) Time- and dose-dependent induction of invasive urinary bladder cancers by N-ethyl-N-(4-hydroxybutyl)nitrosamine in B6C3F1 mice. Jpn J Cancer Res 82:650–656PubMedCrossRefGoogle Scholar
  78. Thompson SW, Huseby RA, Fox MA, Davis CL, Hunt RD (1961) Spontaneous tumors in the Sprague-Dawley rat. J Natl Cancer Inst 27:1037–1057PubMedGoogle Scholar
  79. Trillo AA, Kuchler LL, Wood AC, Prater T (1981) Adenocarcinonia of the urinary bladder: histologic, cytologic and ultrastructural features in a case. Acta Cytol 25:285–290PubMedGoogle Scholar
  80. Ward JM, Goodman DG, Squire RA, Chu KC, Linhart MS (1979) Neoplastic and nonneoplastic lesions in aging (C57BLl6NxC3H/HeN)FI (B6C3FI) mice. J Nat! Cancer Inst 63:849–854PubMedGoogle Scholar
  81. Ward JM, Hamlin MH 2nd, Ackerman LJ, Lattuada CP, Longfellow DO, Cameron TP (1983) Age-related neoplastic and degenerative lesions in aging male virgin and ex-breeder ACIIsegHapBR rats. J GerontoI 38:538–548Google Scholar
  82. Walsh KM, Poteracki J (1994) Spontaneous neoplasms in control Wistar rats. Fundam Appl Toxicol 22:65–72PubMedCrossRefGoogle Scholar
  83. Witters S, Baert-Van Damme L (1987) Bladder exstrophy complicated by adenocarcinoma. Eur Urol 13:415–416PubMedGoogle Scholar
  84. Young RH, Eble IN (1991) Unusual forms of carcinoma of the urinary bladder. Hum Pathol 22:948–965PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Edwin F. Stula
  • Greg P. Sykes

There are no affiliations available

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