Skip to main content

Oncocytoma, Kidney, Rat

  • Chapter
Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The oncocytoma is usually not visible with the naked eye but is only detected under the microscope.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ahn YS (1993) Metabolische Aberrationen und Proliferationskinetik während der Entstehung epithelialer Nierentumoren der Ratte. Thesis, University of Heidelberg

    Google Scholar 

  • Ahn YS, Rempel A, Zerban H, Bannasch P (1994) Overexpression of glucose transporter isoform GLUTI and hexokinase I in rat renal oncocytic tubules and oncocytomas. Virchows Arch B (Cell Pathol) 425:63- 68

    CAS  Google Scholar 

  • Alanen KA, Ekfors TO, Lipasti JA, Nurmi MJ (1984) Renal oncocytoma: the incidence of 18 surgical and 12 autopsy cases. Histopathology 8:731–737

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Schacht U (1968) Nitrosamin-induzierte tubuläre Glykogenspeicherung und Geschwulstbildung in der Rattenniere. Virchows Arch B (Cell Pathol) 1:95- 97

    Google Scholar 

  • Bannasch P, Zerban H (1990) Animal models and renal carcinogenesis. In: Eble IN (ed) Tumors and tumor-like conditions of the kidneys and ureters. Churchill Livingstone, New York, pp 1–34

    Google Scholar 

  • Bannaseh P, Zerban H (1994) Pre neoplastic and neoplastic lesions of the kidneys of the rat. In: Bannasch P, Gössner W (eds) Pathology of neoplasia and pre neoplasia in rodents.Schattauer, Stuttgart, pp 82–107

    Google Scholar 

  • Bannasch P, Schacht U, Storch E (1974) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. I. Induktion und Histologie der Tumoren. Z Krebsforsch 81:311–331

    Article  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1978a) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. II. TubuIäre Glykogenose und die Genese von klar- oder acidophilzelligen Tumoren. Z Krebsforsch 92:63–86

    Article  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1978b) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosomorpholin-vergifteten Ratten. III. Onkocytentubuli und Onkocytome. Z Krebsforsch 92:87–104

    Article  CAS  Google Scholar 

  • Bannasch P, Mayer D, Krech R (1979) Neoplastische und präneoplastische Veränderungen bei Ratten nach einmaliger oraler Applikation von N-Nitrosomorpholin. J Cancer Res Clin Oneol 94:233–248

    Article  CAS  Google Scholar 

  • Bannasch P, Krech R, Zerban H (1980) Morphogenese und Mikromorphologie epithelialer Nierentumoren bei Nitrosormorpholin-vergifteten Ratten. IV. Tubuläre Lasionen und basophile Tumoren. J Cancer Res Clin Oncol 98:243–265

    Article  PubMed  CAS  Google Scholar 

  • Bannasch P, Zerban H, Hacker HJ (1986) Oncocytoma, kidney, rat. In: Jones TC, MohrU, Hunt RD (eds) Monographs on pathology of laboratory animals, urinary system. Springer, Berlin Heidelberg New York, pp 49–60

    Google Scholar 

  • Barnes CA, Beckman EN (1983) Renal oncocytoma and its congeners. Am J Clin Pathol 79:312–318

    PubMed  CAS  Google Scholar 

  • Blessing MH, Wienert G (1973) Onkozytom der Niere (Klinische und pathologisch-anatomische Befunde). Zentralbl Allg Pathol 117:227–234

    PubMed  CAS  Google Scholar 

  • Chemeris G, Loktionov A, Rempel A, Schwarz M, Bannasch P (1995) Elevated content of p53 protein in the absence of p53 gene mutations as a possible prognostic marker for human renal cell tumors. Virchows Arch B (Cell Pat hoi) 426:563–569

    CAS  Google Scholar 

  • Chen KTK (1983) Multifocal renal oncocytoma. J Urol 30:546–547

    Google Scholar 

  • Choi H, Almagro VA, McManus JT, Norback DH, Jacobs SC (1983) Renal oncocytoma. A clinicopathologic study. Cancer 51:1887–1896

    Article  PubMed  CAS  Google Scholar 

  • Dietrich DR, Swenberg JA (1991) Pre neoplastic lesions in rodent kidney induced spontaneously or by nongenotoxic agents: predictive nature and comparison to lesions induced by genotoxic carcinogens. Mutat Res 248:239–260

    Article  PubMed  CAS  Google Scholar 

  • Eble IN, Hull MT (1984) Morphologic features of renal oncocytoma: a light and electron microscopic study. Hum PathoI 15:1054–1061

    Article  CAS  Google Scholar 

  • Eker R, Mossige J, Johannessen JV, Aars H (1981) Hereditary renal adenomas and adenocarcinomas in rats. Diagn Histopathol 4:99–110

    PubMed  CAS  Google Scholar 

  • Evarts RP, Brown CA, Mostafa MH (1982) Production of kidney tumors in rats with low dose of dimethylnitrosamine after partial hepatectomy. J Natl Cancer Inst 68:293–298

    PubMed  CAS  Google Scholar 

  • Fischer R (1961) Uber den histochemischen Nachweis oxydativer Enzyme in Onkozyten verschiedener Organe. Virchows Arch Pathol Anat 334:445–452

    Article  CAS  Google Scholar 

  • Forland M, Bannayan GA (1983) Minimal-change lesion nephrotic syndrome with renal oncocytoma. Am J Med 75:715–720

    Article  PubMed  CAS  Google Scholar 

  • Gray JE, Van Zwieten MJ, Hollander CF (1982) Earlylight microscopic changes of chronic progressivenephrosis in several strains of aging laboratory rats. J GerontoI 37:142–150

    CAS  Google Scholar 

  • Gusek W (1975) Die Ultrastruktur Cycasin-induzierter ierenadenome. Virchows Arch A Pathol Anat Histol 365:221–237

    Article  PubMed  CAS  Google Scholar 

  • Gusek W, Mestwerdt W (1969) Cycasin-induzierte Nierentumoren bei der Wistarratte unter besonderer Berücksichtigung der Adenome. Beitr Pathol Anat 139:199–218

    PubMed  CAS  Google Scholar 

  • Hamperl H (1962) Onkocyten und Onkocytome. VirchowsArch Pathol Anat 355:452–483

    Article  Google Scholar 

  • Harrison RH, Baird JM, Kowierschke SW (1981) Renal oncocytoma: ten-year follow-up. Urology 17:596–599

    Article  PubMed  CAS  Google Scholar 

  • Hunt HA, Tudball CF, Sutherland RC, Westmore DD (1983) Bilateral renal oncocytomas: a case report. J Urol 129:122G-1221

    Google Scholar 

  • Jasmin G, Cha JW (1969) Renal adenomas induced in rats by dimethylnitrosamine. Arch Pathol 87:267–278

    PubMed  CAS  Google Scholar 

  • Klein HJ, Schiimmelfeder N, Hübner G (1966) Zur Histochemie und Ultrastruktur der Onkocyten. Zentralbl Allg Pathol 08:444–445

    Google Scholar 

  • Klein MJ, Valensi QJ (1976) Proximal tubular adenoma of kidney with so-called oncocytic features. A clinicopathologic study of 3 cases of a rarely reported neoplasm. Cancer 38:906–914

    Article  PubMed  CAS  Google Scholar 

  • Kovacs G, Welter C, Wilkens L, Blin N, Deriese W (1989) Renal oncocytoma: a phenotypic and genotypic entity of renal parenchymal tumors. Am J Pathol 134:967–971

    PubMed  CAS  Google Scholar 

  • Krech R, Bannasch P (1979) Mucopolysaccharidose interstitieller Zellen während der Genese epithelialer Nierentumoren. Verh Dtsch Ges PathoI 63:393–397

    CAS  Google Scholar 

  • Krech R, Zerban H, Bannasch P (1981) Mitochondrial anomalies in renal oncocytes induced in rat by Nnitrosomorpholine.Eur J Cell Bioi 25:331–339

    CAS  Google Scholar 

  • Lieber MM (1984) Renal oncocytoma. In: Javadpour N (ed) Cancer of the kidney. Thieme-Stratton, Stuttgart, pp 139–148

    Google Scholar 

  • Lieber MM, Tomera KM, Farrow GM (1981) Renal oncocytoma. J Urol 25:481–485

    Google Scholar 

  • Maatman TJ, Novick AC, Tancinco BF, Vesoulis Z, Levin HS, Montie JE, Montague DK (1984) Renal oncocytoma: a diagnostic and therapeutic dilemma. J Urol 132:878–881

    PubMed  CAS  Google Scholar 

  • Maldague P (1966) Radiocancérisation expérimental durein par les rayons X chez Ie rat. Les radiocancérs du rein. Pathol Eur 1:321–409

    PubMed  CAS  Google Scholar 

  • Mayer D, Weber E, Kadenbach B, Bannasch P (1989) Immunocytochemical demonstration of cytochromec-oxidase as a marker for renal oncocytes and oncocytomas. Toxicol Pathol 17:46–49

    PubMed  CAS  Google Scholar 

  • Meister P, Rabes H (1973) Nierentumoren durch Diethylnitrosamin nach partieller Leberresektion: Morphologie und Wachstumsverhalten. Z Krebsforsch 80:169–178

    Article  CAS  Google Scholar 

  • Merino MJ, Livolsi V A (1982) Oncocytomas of the kidney.Cancer 50:1852–1856

    CAS  Google Scholar 

  • Murphy WM, Beckwith JB, Farrow GM (eds) (1994) Tumors of the kidney, bladder, and related urinary structures. Atlas of tumor pathology. Armed Forces Institute of Pathology, ashington DC, pp 1–326

    Google Scholar 

  • Nogueira E (1987) Rat renal carcinogenesis after chronic simultaneous exposure to lead acetate and Nnitrosodiethylamine.Virchows Arch B (Cell Pathol) 53:365–374

    CAS  Google Scholar 

  • Nogueira E, Bannasch P (1988) Cellular origin of rat renal oncocytoma. Lab Invest 59:337–343

    PubMed  CAS  Google Scholar 

  • Nogueira E, Cardesa A, Mohr U (1993) Experimental models of kidney tumors. J Cancer Res Clin Oncol 119:190–198

    Article  PubMed  CAS  Google Scholar 

  • Nogueira E, Klimek F, Weber E, Bannasch P (1989) Collecting duct origin of rat renal clear cell tumors. Virchows Arch B (Cell Pathol) 57:275

    Article  CAS  Google Scholar 

  • Ortmann M, Vierbuchen M, Koller G, Fischer R (1988a) Renal oncocytoma. 1. Cytochrome c oxidase in normal and neoplastic renal tissue as detected by immunohistochemistry - a valuable aid to distinguish oncocytomas from renal cell carcinomas. Virchows Arch B (Cell Pathol) 56:165–173

    Article  CAS  Google Scholar 

  • Ortmann M, Vierbuchen M, Fischer R (1988b) Renal oncocytoma. II. Lectin and immunohistochemical features indicating an origin from the collecting duct. Virchows Arch B (Cell Pathol) 56:175–184

    Article  CAS  Google Scholar 

  • Pearse AGE (1968) Histochemistry, vol 1, 3rd edn. Little Brown, Boston

    Google Scholar 

  • Rosen VJ Jr, Castanera TJ, Kimmeldorf DJ, Jones DC (1961) Renal neoplasms in the irradiated and nonirradiated Sprague-Dawley rat. Am J Pathol 38:359- 369

    PubMed  CAS  Google Scholar 

  • Starkel S (1993) Karzinome und Onkozytome der Niere. Fischer, Stuttgart

    Google Scholar 

  • Starkel S, Pannen B, Thoenes W, Steart PV, Wagner S, Drenckhahn D (1988) Intercalated cells as a probable source for the development of rcnal oncocytoma. Virchows Arch B (Cell Pathol) 56:185–189

    Article  Google Scholar 

  • Tallini G, Ladanyi M, Rosai J. Jhanwar SC (1994) Analysis of nuclear and mitochondrial DNA alterations in thyroid and renal oncocytic tumors. Cytogenet Cell Genet 66:253–259

    CAS  Google Scholar 

  • Tandler B, Hoppel CL (1973) Mitochondria. Academic, New York

    Google Scholar 

  • Tandler B, Shipkey FH (1964) Ultrastructure of Warthin’s tumor. 1. Mitochondria. J Ultrastruct Res 11:292- 305

    Article  CAS  Google Scholar 

  • Tandler B, Hutter RVP, Erlandson RA (1970) Ultrastructure of oncocytoma of the parotid gland. Lab Invest 23:567–580

    PubMed  CAS  Google Scholar 

  • Thoenes W, Störkel S, Rumpelt HJ (1986) Histopathology and classification of renal cell tumors (adenomas. oncocytomas and carcinomas). The basic cytological and histopathological elements and their use for diagnostics. Pathol Res Pract 181:125–143

    Article  PubMed  CAS  Google Scholar 

  • Tsuda H, Hacker HI. Katayama H. Masui T, Ito N. Bannasch P (1986) Correlative histochemical studies on preneoplastic and neoplastic lesions in the kidney of rats treated with nitrosamines. Virchows Arch B (Cell Pathol) 51:385–404

    Article  CAS  Google Scholar 

  • Velasquez G, Glass TA, D’Souza VJ, Formanek AG (1984) Multiple oncocytomas and renal carcinoma. AJR 142:123–124

    PubMed  CAS  Google Scholar 

  • van der Walt JD, Reid HAS, Risdon RA, Shaw HF (1983) Renal oncocytoma. A review of the literature and report of an unusual multicentric case. Virchows Arch Pathol Anat 398:291–304

    Article  Google Scholar 

  • Warfel KA, Eble IN (1982) Renal oncocytomatosis. JUral 27:79–80

    Google Scholar 

  • Welter C. Kovacs G, Seitz G, Blin N (1989) Alteration of mitochondrial DNA in human oncocytomas. Genes Chrom Cancer 1:79–82

    Google Scholar 

  • Woodard BH, Tannenbaum ST, Mossier JA (1981) Multicentric renal oncocytoma. J Urol 26:247–248

    Google Scholar 

  • Yu GSM, Rendler S, Herskowitz A, Molnar JJ (1980) Renal oncocytoma: report of five cases and review of literature. Cancer 45:1010–1018

    Article  Google Scholar 

  • Zerban H, Nogueira E, Riedasch G, Bannasch P (1987) Renal oncocytoma: origin from the collecting duct. Virchows Arch B (Cell Pathol) 52:375–387

    Article  CAS  Google Scholar 

  • Zhang G, Monda L, Wasserman NF, Fraley EE (1985) Bilateral renal oncocytoma: report of 2 cases and literature review. J Urol 133:84–86

    PubMed  CAS  Google Scholar 

  • Zippel L (1942) Zur Kenntnis der Onkocyten. Virchows Arch B (Cell Pathol) 308:360–382

    Article  Google Scholar 

  • Zollinger HU (1953) Durch chronische Bleivergiftung erzeugte Nierenadenome und -carcinome bei Ratten und ihre Beziehung zu den entsprechenden Neubildungen des Menschen. Virchows Arch B (Cell Pathol) 323:694–710

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bannasch, P., Zerban, H., Ahn, Y.S., Hacker, H.J. (1998). Oncocytoma, Kidney, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80335-2_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80337-6

  • Online ISBN: 978-3-642-80335-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics