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Urinary System pp 331–368Cite as

Hyperplasia, Urinary Bladder, Rat

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Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Hyperplasia of the transitional cell epithelium of the urinary bladder is a common phenomenon seen under various conditions and in different strains of rats of both sexes. Development of urothelial hyperplasia appears understandable when it is realized that very slowly renewing transitional cell epithelium is capable of intensive proliferation in response to appropriate stimuli. Pathogenetically, two main types of hyperplastic lesions need to be distinguished, differing in their prospective biologic behavior. Preneoplastic urothelial hyperplasia is initiated by specific effects of carcinogens, progressively advances to a frank tumor growth, and thus plays a key role as an important developmental and transitional stage during initiation and promotion of multistep carcinogenesis of the bladder. Regenerative and reactive hyperplasia are produced by a wide variety of nongenotoxic and nonmutagenic agents affecting the urothelial cells in different ways, followed by an overcompensatory cell replication. This type of hyperplasia is reversible and returns to normal once the causative agent is withdrawn, thus lacking a preneoplastic potential.

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Authors
  1. Ekkehard Kunze
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Editors and Affiliations

  1. Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street,N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. American Health Foundation, One Dana Drive, Valhalla, NY, USA

    Gordon C. Hard BVSc., Ph.D., DSc., FRCPath., FRCVS, FAToxSci. (Director of Administration and Senior Toxicologist) (Director of Administration and Senior Toxicologist)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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Kunze, E. (1998). Hyperplasia, Urinary Bladder, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_34

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