Nephronophthisis is an inherited progressive nephropathy of CBA/CaH-kd (also called kdkd) mice that results in an atypical end-stage kidney disease characterized by massively dilatated tubules, mononuclear interstitial infiltrate, and minimal interstitial fibrosis.
KeywordsKidney disease of mice
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- Kelly CJ, Korngold R, Mann R, Clayman M, Haverty T, Neilson EG (1986) Spontaneous interstitial nephritis in kdkd mice. II. Characterization of a tubular antigenspecific, H-2K-restricted Lyt-2+ effector T cell that mediates destructive tubulointerstitial injury. J Immunol 136:526–531PubMedGoogle Scholar