Renal Carcinogenesis, Rat

  • Gordon C. Hard
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Renal tumors in the rat can be classified into three broad categories depending on whether their origin and cellular composition identify with mature epithelium, connective tissue, or primordial embryonic tissue (Table 8). The sole representative of the latter class, nephroblastoma, could be designated also as an epithelial kidney tumor in this species.


Renal Tumor National Toxicology Program Lipomatous Tumor Potassium Bromate Renal Carcinogenesis 
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  1. Ford SM, Hook JB (1984) Biochemical mechanisms of toxic nephropathies. Semin Nephrol 4:88–106Google Scholar
  2. Georgii A, Prechtel K Zobl H (1969) Sarkombildung durch Polyoma virus in der Niere von Rattcn. Z Krebsforsch 72: 1–11PubMedCrossRefGoogle Scholar
  3. Goodman DG, Ward 1M, Squire RA, Paxton MB, Reichardt WD, Chu KC. Linhart MS (1980) Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats. Toxicol Appl Pharmacol 55:433–447Google Scholar
  4. Hard GC (1984) High frequency, single-dose model of renal adenoma/carcinoma induction using dimethylnitrosamine in Crl:(W)BR rats. Carcinogenesis 5:1047–1050PubMedCrossRefGoogle Scholar
  5. Hard GC (1985) Differential renal tumor responsc to Nethylnitrosourea and dimethylnitrosamine in the Nb rat: basis for a new rodent model of nephroblastoma. Carcinogenesis 6:1551–1558PubMedCrossRefGoogle Scholar
  6. Hard GC (1987) Chemically-induced epithelial tumours and carcinogenesis of the renal parenchyma. In: Bach PH, Lock EA (eds) Nephrotoxicity in the experimental and clinical situation, part 1. Nijhoff. Dordrecht, pp 211–250CrossRefGoogle Scholar
  7. Hard GC (1990) Tumours of the kidney. renal pelvis and ureter. IARC Sci Publ 99:301–344PubMedGoogle Scholar
  8. Hard GC, Butler WH (1970) Cellular analysis of renal neoplasia: induction of renal tumors in dietaryconditioned rats by dimethylnitrosamine, with a reappraisal of morphological characteristics. Cancer Res 30:2796–2805PubMedGoogle Scholar
  9. Hard GC, Butler WH (1970) Cellular analysis of renal neoplasia: light microscope study of the development of interstitial lesions induced in the rat kidney by a single carcinogenic dose of dimethylnitrosamine. Cancer Res 30:2806–2815PubMedGoogle Scholar
  10. Hard GC, Butler WH (1971) Ultrastructural study of the development of interstitial lesions leading to mesenchymal neoplasia induced in the rat renal cortex by dimethylnitrosamine. Cancer Res 31:337–347PubMedGoogle Scholar
  11. Hard GC, Butler WH (197lb) Morphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine. Cancer Res 31: 1496–1505Google Scholar
  12. Hard GC, Noble RL (1981) Occurrence, transplantation, and histologic characteristics of nephroblastoma in the Nb hooded rat. Invest Urol 18:371–376PubMedGoogle Scholar
  13. Hard GC, Mackay RL, Kochhar OS (1984) Electron microscopic determination of the sequence of acute tubular and vascular injury induced in the rat kidney by a carcinogenic dose of dimethylnitrosamine. Lab Invest 50:659–672PubMedGoogle Scholar
  14. Hard GC, Rodgers IS, Baetcke KP, Richards WL, McGaughy RE, Valcovic LR (1993) Hazard evaluation of chemicals that cause accumulation of α2u-globulin, hyalinc droplet nephropathy, and tubule neoplasia in the kidneys of male rats. Environ Health Perspect 99:313–349PubMedGoogle Scholar
  15. Hard GC, Alden CL, Stula EF, Trump BF (1995) Proliferative lesions of the kidney in rats. In: Guides for toxicologic pathology. STP/ARP/AFIP, Washington DC, pp 1–19Google Scholar
  16. Hiasa Y, Ohshima M, Iwata C, Tanikate T (1979) Histopathological studies on renal tubular cell tumors in rats treated with N-ethyl-N-hydroxyethylnitrosamine. Gann 70:817–820PubMedGoogle Scholar
  17. Hinton DE, Heatfield BM, Lipsky MM, Trump BF (1980) Animal model of human disease: renal tubular carcinomas. Am J Pathol 100:317–320Google Scholar
  18. Johansson SL (1981) Carcinogenicity of analgesics: longterm treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine and paracetamol (acetamidophen). Int J Cancer 27:521–529PubMedCrossRefGoogle Scholar
  19. Kasai H, Nishimura S, Kurokawa Y, Hayashi Y (1987) Oral administration of the renal carcinogen, potassium bromate, specifically produces 8-hydroxydeoxyguanosine in rat target organ DNA. Carcinogenesis 8: 1959–1961PubMedCrossRefGoogle Scholar
  20. Kilham L, Low RJ, Conti SF, Dallenbach FD (1962) Intranuclear inclusions and neoplasms in the kidneys of wild rats. J Natl Cancer Inst 29:863–885PubMedGoogle Scholar
  21. Kirsten WH, Anderson DG, Platz CE, Crowell EB Jr (1962) Observations on the morphology and frequency of polyoma tumors in rats. Cancer Res 22:484–491PubMedGoogle Scholar
  22. Kurokawa Y, Hayashi Y, Maekawa A, Takahashi M, Kokubo T, Odashima S (1983) Carcinogenicity of potassium bromate administered orally to F344 rats. J Natl Cancer Inst 71:965–972PubMedGoogle Scholar
  23. Lipsky MM, Trump BF (1988) Chemically induced renal epithelial neoplasia in experimental animals. Intl Rev Exp Pathol 30:357–383Google Scholar
  24. McCoy GW (1909) A preliminary report on tumors found in wild rats. J Med Res 21:285–296PubMedGoogle Scholar
  25. Middle JG, Robinson G, Embleton MJ (1981) Naturally arising tumors of the inbred WAB/Not rat strain. I. Classification, age and sex distribution, and transplantation behavior. J Natl Cancer Inst 67:629–636PubMedGoogle Scholar
  26. Miller EC, Miller JA (1981) Searches for ultimate chemical carcinogens and their reactions with cellular macromolecules. Cancer 47:2327–2345PubMedCrossRefGoogle Scholar
  27. Murai T, Mori S, Machino S, Hosono M and others (1993) Induction of renal pelvic carcinoma by phenacetin in hydronephrosis-bearing rats of the SD/cShi strain. Cancer Res 53:4218–4223PubMedGoogle Scholar
  28. Nash JA, King LJ, Lock EA, Green T (1984) The metabolism and disposition of hexachloro-l:3-butadiene in the rat and its relevance to nephrotoxicity. Toxicol Appl Pharmacol 73:124–137PubMedCrossRefGoogle Scholar
  29. Nicoll JW, Swann PF, Pegg AE (1975) Effect of dimethylnitrosamine on persistence of methylated guanines in rat liver and kidney DNA. Nature 254:261–262PubMedCrossRefGoogle Scholar
  30. Nogueira E (1987) Rat renal carcinogenesis after chronic simultaneous exposure to lead acetate and Nnitrosodiethylamine. Virchows Arch (Cell Pathol) 53:365–374CrossRefGoogle Scholar
  31. Nogueira E, Bannasch P (1988) Cellular origin of rat renal oncocytoma. Lab Invest 59:337–343PubMedGoogle Scholar
  32. Nogueira E, Cardesa A, Mohr U (1993) Experimental models of renal carcinogenesis. Cancer Res Clin Oncol 119:190–198CrossRefGoogle Scholar
  33. Rosen VJ, Castanera TJ, Kimeldorf DJ, Jones DC (1961) Renal neoplasms in the irradiated and non-irradiated Sprague-Dawley rat. Am J Pathol 38:359–369PubMedGoogle Scholar
  34. Rosen VJ, Castanera TJ, Kimeldorf DJ, Jones DC (1962) Pancreatic islet cell tumors and renal tumors in the male rat following neutron exposure. Lab Invest 11:204–210PubMedGoogle Scholar
  35. Sai K, Takagi A, Umemura T, Hasegawa R, Kurokawa Y (1991) Relation of 8-hydroxydeoxyguanosine formation in rat kidney to lipid peroxidation, glutathione level and relative organ weight after a single administration of potassium bromate. Jpn J Cancer Res 82:165–169PubMedCrossRefGoogle Scholar
  36. Sanotskii VA. Erleksova EV (1964) Morphological changes in rats at long intervals after administration of Po210. Fed Proc 23:T785-T788 (translations)Google Scholar
  37. Singer B (1979) N-Nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis. J Natl Cancer lnst 62:1329–1339Google Scholar
  38. Singer B (1996) DNA damage: chemistry, repair, and mutagenic potential. Reg Toxical Pharmacol 23:2–13CrossRefGoogle Scholar
  39. Solé M, Cardesa A, Domingo J, Mohr U (1992) The carcinogenic effect of 2,2-dioxopropylnitrosamine on the renal pelvic epithelium of Sprague-Dawley rats, after chronic subcutaneous injections. J Cancer Res Clin Oncol 118:222–227PubMedCrossRefGoogle Scholar
  40. Swenberg JA, Short B, Borghoff S, Strasser J, Charbonneau M (1989) The comparative pathobiology of α2u-globulin nephropathy. Toxicol Appl Pharmacal 97:35–46CrossRefGoogle Scholar
  41. Toyokuni S, Sagripanti JL (1993) DNA single- and doublestrand breaks produced by ferric nitrilotriacetate in relation to renal tubular carcinogenesis. Carcinogenesis 14:223–227PubMedCrossRefGoogle Scholar
  42. Toyokuni S, Mori T, Dizdaroglu M 1994 DNA base modifications in renal chromatin of Wistar rats treated with a renal carcinogen, ferric nitrilotriacetate. Int J Cancer 57:123–128PubMedCrossRefGoogle Scholar
  43. Toyokuni S, Uchida K, Okamoto K, Hattori-Nakakuki Y, Hiai H, Stadtman ER 1994 Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate. Proc Natl Acad Sci USA 91:2616–2620PubMedCrossRefGoogle Scholar
  44. Umemura T, Sai K, Takagi A, Hasegawa R, Kurokawa Y (1990) Oxidative DNA damage, lipid peroxidation and nephrotoxicity induced in the rat kidney after ferric nitrilotriacetate administration. Cancer Lett 54:95–100PubMedCrossRefGoogle Scholar
  45. Woolley PG, Wherry WB (1911–1912) Notes on twentytwo spontaneous tumors in wild rats (R. norvegicus). J Med Res 25:205–215Google Scholar
  46. Zenser TV, Davis BB (1984) Enzyme systems involved in the formation of reactive metabolites in the renal medulla: cooxidation via prostaglandin H synthase. Fundam Appl Toxicol 4:922–929PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • Gordon C. Hard

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