Renal Carcinogenesis, Rat
Renal tumors in the rat can be classified into three broad categories depending on whether their origin and cellular composition identify with mature epithelium, connective tissue, or primordial embryonic tissue (Table 8). The sole representative of the latter class, nephroblastoma, could be designated also as an epithelial kidney tumor in this species.
KeywordsRenal Tumor National Toxicology Program Lipomatous Tumor Potassium Bromate Renal Carcinogenesis
Unable to display preview. Download preview PDF.
- Ford SM, Hook JB (1984) Biochemical mechanisms of toxic nephropathies. Semin Nephrol 4:88–106Google Scholar
- Goodman DG, Ward 1M, Squire RA, Paxton MB, Reichardt WD, Chu KC. Linhart MS (1980) Neoplastic and nonneoplastic lesions in aging Osborne-Mendel rats. Toxicol Appl Pharmacol 55:433–447Google Scholar
- Hard GC, Butler WH (197lb) Morphogenesis of epithelial neoplasms induced in the rat kidney by dimethylnitrosamine. Cancer Res 31: 1496–1505Google Scholar
- Hard GC, Alden CL, Stula EF, Trump BF (1995) Proliferative lesions of the kidney in rats. In: Guides for toxicologic pathology. STP/ARP/AFIP, Washington DC, pp 1–19Google Scholar
- Hinton DE, Heatfield BM, Lipsky MM, Trump BF (1980) Animal model of human disease: renal tubular carcinomas. Am J Pathol 100:317–320Google Scholar
- Lipsky MM, Trump BF (1988) Chemically induced renal epithelial neoplasia in experimental animals. Intl Rev Exp Pathol 30:357–383Google Scholar
- Sanotskii VA. Erleksova EV (1964) Morphological changes in rats at long intervals after administration of Po210. Fed Proc 23:T785-T788 (translations)Google Scholar
- Singer B (1979) N-Nitroso alkylating agents: formation and persistence of alkyl derivatives in mammalian nucleic acids as contributing factors in carcinogenesis. J Natl Cancer lnst 62:1329–1339Google Scholar
- Woolley PG, Wherry WB (1911–1912) Notes on twentytwo spontaneous tumors in wild rats (R. norvegicus). J Med Res 25:205–215Google Scholar