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Urinary System pp 306-309 | Cite as

Spontaneous Hydronephrosis, Rat

  • Robert R. Maronpot
Chapter
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Cases of mild to moderate hydronephrosis are easily recognized on a midsagittally (Fig. 256) or transversely (Fig. 257) sliced kidney by dilation of the pelvocalyceal system. Distortion of the normal surface contour is usually not seen in moderately affected kidneys. However, the moderately hydronephrotic kidney may be slightly longer and wider than normal. While the amount of cortical tissue is normal, there is gross loss of medullary and papillary tissue associated with the pelvocalyceal dilation characteristic of moderate hydronephrosis. The decrease in renal tissue associated with moderate hydronephrosis may be accompanied by an increase, rather than the expected decrease, in kidney weight (Henderson et al. 1982).

Keywords

Renal Pelvis Renal Papilla Hydronephrotic Kidney Unilateral Hydronephrosis Impaired Glomerular Filtration Rate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Astarabadi T, Bell ET (1962) Spontaneous hydronephrosis in albino rats. Nature (Lond) 195:392–393CrossRefGoogle Scholar
  2. Burek JO (1978) Pathology of aging rats. CRC, West Palm Beach, pp 97–98Google Scholar
  3. Burton OS, Maronpot RR, Howard FL III (1979) Frequency of hydronephrosis in Wi star rats. Lab Anim Sci 29:642–644PubMedGoogle Scholar
  4. Claesson G, Josephson S, Robertson B (1983) Experimental partial ureteric obstruction in newborn rats. IV. Do the morphological effects progress continuously? J Urol 130:1217–1222PubMedGoogle Scholar
  5. Cohen BJ, De Bruin RW, Kort WJ (1970) Heritable hydronephrosis in a mutant strain of Brown Norway rats. Lab Anim Care 20:489–493PubMedGoogle Scholar
  6. Feldman JO, Woda BA (1980) Pathology and tumor incidence in aged Lewis and BN rats. Clin Immunol Immunopathol 15:331–343PubMedCrossRefGoogle Scholar
  7. Friedman J, Hoyer JR, McCormick B, Lewy JE (1979) Congenital unilateral hydronephrosis in the rat. Kidney Int 15:567–571PubMedCrossRefGoogle Scholar
  8. Fujita K, Fujita HM, Ohtawara y, Suzuki K, Tajima A, Aso Y (1979) Hydronephrosis in ACIIN rats. Lab Anim 13:325–327PubMedCrossRefGoogle Scholar
  9. 394.
    Henderson IW, Oliver lA Milne CM, Balment RJ (1982) Incidence and some functional characteristics of hydro- nephrosis in Brattleboro rats. Ann NY Acad Sci :21- 29Google Scholar
  10. Heptinstall RH (1974) Pathology of the kidney, 2nd edn. Little Brown, BostonGoogle Scholar
  11. Humes HD, Dieppa RA, Brenner BM (1980) Glomerular dynamics in rats with hereditary hydronephrosis. Invest Urol 18:46–51PubMedGoogle Scholar
  12. Jones TC, Hunt RD (1983) Veterinary pathology. Lea and Febiger, Philadelphia, Chap 24Google Scholar
  13. Josephson S (1983) Experimental obstructive hydronephrosis in newborn rats. III. Long-term effects on renal function. J Urol 129:396–400PubMedGoogle Scholar
  14. Lozzio BB, Chernoff AI, Machado ER, Lozzio CB (1967) Hereditary renal disease in a mutant strain of rats. Science 156:1742–1744PubMedCrossRefGoogle Scholar
  15. Lozzio BB, McDonald TP, Lange RD (1971) Erythropoietin formation in rats bearing congenital hydronephrosis. Isr J Med Sci 7:1001–1006PubMedGoogle Scholar
  16. Marshall FF, Garcia-Bunuel R, Beisel DS (1978) Hydronephrosis, renal agenesis, and associated genitourinary anomalies in ACI rats. Urology 11:58–61PubMedCrossRefGoogle Scholar
  17. McCormack KM, Hook JB, Gibson JE (1981) Developmental anomalies of the kidney: a review of normal and aberrant renal development. In: Hook JB (ed) Toxicology of the kidney. Raven, New YorkGoogle Scholar
  18. Mori S, Hosono M, Machino S, Nakai S, Makino S, Nakao H, Takeuchi Y, Takeda R, Murai T, Fukushima S (1994) Induction of the renal pelvic and ureteral carcinomas by N-butyl-N-(4-hydroxybutyl)nitrosamine in SD/cShi rats with spontaneous hydronephrosis. Toxicol Pathol 22:373–380PubMedCrossRefGoogle Scholar
  19. O’Donoghue PN, Wilson MS (1977) Hydronephrosis in male rats. Lab Anim 11:193–194PubMedCrossRefGoogle Scholar
  20. Sellers AL, Rosenfeld S, Friedman NB (1960) Spontaneous hydronephrosis in the rat. Proc Soc Exp BioI Med 104:512–515Google Scholar
  21. Suki W, Eknoyan G, Rector FC Jr, Seldin OW (1966) Patterns of nephron perfusion in acute and chronic hydronephrosis. J Clin Invest 45:122–131PubMedCrossRefGoogle Scholar
  22. Susie D, Sparks JC, Kentera D (1975) The reninangiotensin system in rats with hereditary hydronephrosis. Pflugers Arch 358:265–274CrossRefGoogle Scholar
  23. Tauchi K, Suzuki K, Imamichi T (1980) Establishment of a strain of a rat having extremely high incidence of congenital hydronephrosis and its morphological characteristics. Cong Anom 20:1–6Google Scholar
  24. Woo DC, Hoar RM (1972) “Apparent hydronephrosis” as a normal aspect of renal development in late gestation of rats: the effect of methyl salicylate. Teratology :191- 196Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1998

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  • Robert R. Maronpot

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