Urinary System pp 299-305 | Cite as

Diphenylthiazole-Induced Renal Cystic Disease, Rat

  • Frank A. Carone
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


Kidneys are bilaterally and symmetrically enlarged three- to fivefold (Fig. 253) after 4-8 weeks of diphenylthiazole feeding 1.03% in pelletized rat chow (Carone et al. 1974). Enlargement is most prominent in outer medulla and consists of dilated tubules arranged radially (Fig. 253). Renal microdissection reveals saccular and fusiform dilations of all collecting tubules in the outer medulla, with occasional distention of cortical collecting and distal tubules. Following drug withdrawal, gross renal changes return to normal in 4-8 weeks (Kanwar and Carone 1984).


Polycystic kidney disease (PKD) 


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  1. Carone FA, Rowland RG, Perlman SG, Ganote CR (1974) The pathogenesis of drug-induced renal cystic disease. Kidney Int 5:411–421PubMedCrossRefGoogle Scholar
  2. Carone FA, Stolarczyk J, Krumlovsky FA, Perlman SG, Roberts TH, Rowland RG (1975) The nature of a druginduced renal concentrating defect in rats. Lab Invest 31:658–664Google Scholar
  3. Carone FA, Bacallao R, Kanwar YS (1994) Biology of polycystic kidney disease. Lab Invest 70:437–448PubMedGoogle Scholar
  4. Carone FA, Nakamura S, Wand inger-Ness A, Christensen E, Kanwar YS, Bacallao R (1995) A putative polycystic breakpoint protein (PBP) antibody recognizes a matrix protein. XIII International Congress of Nephrology, Madrid, Spain, 2–6 July 1995Google Scholar
  5. Casey HW, Ayers KM, Robinson FR (1978) The urinary system. In: Benirschke K, Garner FN, Jones TC (eds) Pathology of laboratory animals, vol I. Springer, Berlin, Heidelberg, New York, Chap 3, pp 115–173CrossRefGoogle Scholar
  6. Dousa TP, Rowland RG, Carone FA (1973) Renal medullary adenylate cyclase in drug-induced nephrogenic diabetes insipidus. Proc Soc Exp Bioi Med 142:720–722Google Scholar
  7. Grantham JJ (1983) Polycystic kidney disease: a predominance of giant nephrons. Am J Physiol 244:F3-F10PubMedGoogle Scholar
  8. International Polycystic Kidney Disease Consortium (1995) Polycystic kidney disease: the complete structure of the PKD1 gene and its protein. Cell 81:289–298Google Scholar
  9. Iverson WO, Fetterman GH, Jacobson ER, Olsen JH, Senior DF, Schobert EE (1982) Polycystic kidney and liver disease in springbok: I. Morphology of the lesions. Kidney Int 22:146–155PubMedCrossRefGoogle Scholar
  10. Kanwar YS, Carone FA (1984) Reversible changes of tubular cell and basement membrane in drug-induced renal cystic disease. Kidney Int 25:35–43CrossRefGoogle Scholar
  11. Mandell J, Koch WK, Nidess R, Preminger GM, McFarland E (1983) Congenital polycystic kidney disease. Am J Pathol 113:112–114PubMedGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 1998

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  • Frank A. Carone

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