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Experimental Renal Effects of Analgesics, Rat

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Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

The gross appearance of the kidney is normal in most studies of experimental renal papillary necrosis. In experiments where analgesics have been fed to rats for prolonged periods of up to 72 weeks, macroscopic cortical scars may be noted.

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References

  • Abel JA (1971) Analgesic nephropathy - a review of the literature. Clin Pharmacol Ther 12:583–598

    PubMed  CAS  Google Scholar 

  • Abrahams C, Levinson C (1970) Ultrastructure of the renal papilla in experimentally induced analgesic nephritis in rats. S Afr Med J 44:63–65

    PubMed  CAS  Google Scholar 

  • Abrahams C, Rubenstein AH, Levin NW, Wunderlich U (1964) Experimentally induced analgesic nephritis in rat. Arch Pathol 78:222–230

    PubMed  CAS  Google Scholar 

  • Axelsen RA (1975) The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures. Br J Exp Pathol 56:92–97

    PubMed  CAS  Google Scholar 

  • Axelsen RA (1976) Analgesic-induced renal papillary necrosis in the Gunn rat: the comparative nephrotoxicity of aspirin and phenacetin. J Pathol 120:145–150

    Article  PubMed  CAS  Google Scholar 

  • Bach PH (1993) Experimental evidence and the biochemical basis for the role of analgesics in cancer. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 180–196

    Google Scholar 

  • Bach PH, Bridges JW (1985) Chemically induced renal papillary necrosis and upper urothelial carcinoma, parts 1 and 2. CRC Crit Rev Toxicol 15:217–439

    Article  CAS  Google Scholar 

  • Beswick EP, Schatzki PF (1960) Experimental renal papillary necrosis. Arch Pathol 69:733–740

    PubMed  CAS  Google Scholar 

  • Björck S (1993) Paracetamol-induced renal tubular cell necrosis. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 174–179

    Google Scholar 

  • Burry A, Cross R, Axelsen R (1977) Analgesic nephropathy and the renal concentrating mechanism. Pathol Ann 12(2):1–13

    Google Scholar 

  • Carro-Ciampi G (1978) Phenacetin abuse: a review. Toxicology 10:311–339

    Article  PubMed  CAS  Google Scholar 

  • Duggin GG (1980) Mechanisms in the development of analgesic nephropathy. Kidney Int 18:553–561

    Article  PubMed  CAS  Google Scholar 

  • Edwards KDG, Curtis EA, Stoker LM (1971) One-day renal function testing in normal rats and in cases of experimentally-induced analgesic nephropathy, nephrocalcinosis and nephrotic syndrome. Nephron 8:235–245

    Article  PubMed  CAS  Google Scholar 

  • Hanzlik PJ, Scott RW, Reycraft JL (1917) The salicylates. VIII. Salicyl oedema. Arch Intern Med 20:329–340

    Article  CAS  Google Scholar 

  • Hardy TL (1970) N-phenyl anthranilic acid: an agent for inducing and studying renal papillary necrosis in the rat. Br J Exp Pathol 51:348–355

    PubMed  CAS  Google Scholar 

  • Haschek H (ed) (1973) Problems on phenacetin abuse. Facta, Vienna

    Google Scholar 

  • Isaka H, Yoshii H, Otsuji A, Koike M, Nagai Y, Koura M, Sugiyasu K, Kanabayashi T (1979) Tumours of Sprague-Dawley rats induced by long-term feeding of phenacetin. Gann 70:29–36

    PubMed  CAS  Google Scholar 

  • Johansson SL (1991) Carcinogenicity of analgesics: longterm treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine, and paracetamol (acetaminophen). Int J Cancer 27:521–529

    Article  Google Scholar 

  • Kennedy A, Saluga PG (1970) Urinary cytology in experimental toxic renal injury. Ann Rheum Dis 29:546–552

    Article  PubMed  CAS  Google Scholar 

  • Kimberly RP, Bowden RE, Keier HK, Plotz PH (1978) Reduction of renal function by newer nonsteroidal antiinflammatory drugs. Am J Med 64:804–807

    Article  PubMed  CAS  Google Scholar 

  • Kincaid-Smith (ed) (1978) Analgesic nephropathy. Kidney Int 13:1–113

    Google Scholar 

  • Kleinknecht D (1993) Diseases of the kidney caused by non-steroidal anti-inflammatory drugs. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 160–173

    Google Scholar 

  • Markovic B (1971) Rescherches experimentales sur le role de la phenacetine dans la pathogenese des nephropathies interstielles chroniques. Arch Union Med Balk 9:591–598

    Google Scholar 

  • McMurtry RJ, Snodgrass WR, Mitchell JR (1978) Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. Toxicol Appl Pharmacol 46:87- 100

    Article  PubMed  CAS  Google Scholar 

  • McCredie M (1993) Analgesics as human carcinogens - clinical and epidemiological evidence. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 197–210

    Google Scholar 

  • Mitchell JR, McMurtry RJ, Statham CN, Nelson SD (1977) Molecular basis for several drug-induced nephropathies. Am J Med 62:518–526

    Article  PubMed  CAS  Google Scholar 

  • Molland EA (1978) Experimental renal papillary necrosis. Kidney Int 13:5–14

    Article  PubMed  CAS  Google Scholar 

  • Mudge GH, Gemborys MW, Duggin GG (1978) Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. J Pharmacol Exp Ther 206:218–226

    PubMed  CAS  Google Scholar 

  • Murray T, Goldberg M (1975) Analgesic abuse and renal disease. Annu Rev Med 26:537–550

    Article  PubMed  CAS  Google Scholar 

  • Nanra RS (1976) Pathology, aetiology and pathogenesis of analgesic nephropathy. Aust NZ J Med 6 [SuppI1]:33–37

    Google Scholar 

  • Nanra RS (1980) Clinical and pathological aspects of analgesic nephropathy. Br J Clin Pharmacol 10 [Suppl 2]:359S-368S

    PubMed  Google Scholar 

  • Nanra RS (1983) Renal effects of antityretic analgesics. Am J Med 75:70–81

    PubMed  CAS  Google Scholar 

  • Nanra RS (1993a) Analgesic nephropathy in the 1990s – an Australian perspective. Kidney Int 44 [Suppl 42]:S86- S92

    Google Scholar 

  • Nanra RS (1993b) Analgesic-induced renal disease. In: Schrier RW, Gottschalk CW (eds) Diseases of the kidney, vol 2, 5th edn. Little Brown, Boston, pp 1104- 1129

    Google Scholar 

  • Nanra RS, Kincaid-Smith P (1970) Papillary necrosis in rats caused by aspirin and aspirin-containing mixtures. Br Med J 3:559–561

    Article  PubMed  CAS  Google Scholar 

  • Nanra RS, Kincaid-Smith P (1972) Chronic effect of analgesic on the kidney. Prog Biochem Pharmacol 7:285–323

    PubMed  CAS  Google Scholar 

  • Nanra RS, Kincaid-Smith P (1993) Experimental evidence for nephrotoxicity of analgesics. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 17–31

    Google Scholar 

  • Nanra RS, Chirawong P, Kincaid-Smith P (1973) Medullary ischaemia in experimental analgesic nephropathy - the pathogenesis of renal papillary necrosis. Aust NZ J Med 3:580–586

    Article  CAS  Google Scholar 

  • Nanra RS, Daniel V, Howard M (1980) Analgesic nephropathy induced by common proprietary mixtures. Med J Aust 1:486–487

    PubMed  CAS  Google Scholar 

  • Nanra RS, Daniel V, Howard M, Gupta JW (1981) Physiological changes in experimental analgesic nephropathy. Proceedings of the VIlth International Congress on Nephrology, 1981, Athens (abstr DK 020)

    Google Scholar 

  • Nanra RS, Daniel V, Howard M, Murugesu R, White KH (1982) Uroepithehal hyperplasia and carcinoma in experimental analgesic nephropathy. Proceedings of the VllIth International Congress on Nephrology, 1982, Athens (abstr DK 021)

    Google Scholar 

  • Prescott LF (1966) The nephrotoxicity of analgesics. J Pharm Pharmacol 18:331–353

    Article  PubMed  CAS  Google Scholar 

  • Prescott LF (1982) Analgesic nephropathy. A reassessment of the role of phenacetin and other analgesics. Drugs 23:75–149

    Article  PubMed  CAS  Google Scholar 

  • Pugliese F, Cinotti GA (1993) Biochemistry and pharmacology of non-steroidal anti-inflammatory drugs and renal prostaglandins. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 133–146

    Google Scholar 

  • Rosner I (1974) Nephropathies experimentales aux analgesiques. Therapie 29:483–505

    PubMed  CAS  Google Scholar 

  • Rosner I (1976) Experimental analgesic nephropathy. CRC Crit Rev Toxicol 4:331–352

    PubMed  CAS  Google Scholar 

  • Sheehan HL, Davis JC (1959) Renal ischemia with good reflow. J Pathol Bacteriol 78:351–377

    Article  PubMed  CAS  Google Scholar 

  • Shelley JH (1967) Phenacetin, through the looking glass. Clin Pharmacol Ther 8:427–471

    PubMed  CAS  Google Scholar 

  • Steele TW, Edwards KDG (1970) Abnormalities of urinary concentrating, acidifying and sodium conserving abilities induced by excessive analgesic intake of rats. Aust Ann Med 19:412–413

    Google Scholar 

  • Williams GM, Weisburger JH (1986) Chemical carcinogens. In: Klassen CD, Amdur MO, Doull J (eds) Casarett and Doull’s toxicology: the basic science of poisons, 3rd edn. McMillan, New York, pp 99–173

    Google Scholar 

  • Winchester IF (1981) Georgetown University symposium of analgesics. Aspirin and acetaminophen. Arch Intern Med 141:273–406

    Article  Google Scholar 

  • Wiseman EH, Reinert H (1975) Anti-inflammatory drugs and renal papillary necrosis. Agents Actions 5:322–325

    Article  PubMed  CAS  Google Scholar 

  • Wizgird JP, French SW, Coulson W (1965) Pathogenesis of serum-induced papillary necrosis. Arch Pathol 79:57- 64

    PubMed  CAS  Google Scholar 

  • Zambraski EJ, Dunn MJ (1993) Effects of non-steroidal anti-inflammatory drugs on renal function. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 147–159

    Google Scholar 

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© 1998 Springer-Verlag Berlin Heidelberg

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Nanra, R.S. (1998). Experimental Renal Effects of Analgesics, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_27

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  • DOI: https://doi.org/10.1007/978-3-642-80335-2_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80337-6

  • Online ISBN: 978-3-642-80335-2

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