Abstract
The gross appearance of the kidney is normal in most studies of experimental renal papillary necrosis. In experiments where analgesics have been fed to rats for prolonged periods of up to 72 weeks, macroscopic cortical scars may be noted.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Abel JA (1971) Analgesic nephropathy - a review of the literature. Clin Pharmacol Ther 12:583–598
Abrahams C, Levinson C (1970) Ultrastructure of the renal papilla in experimentally induced analgesic nephritis in rats. S Afr Med J 44:63–65
Abrahams C, Rubenstein AH, Levin NW, Wunderlich U (1964) Experimentally induced analgesic nephritis in rat. Arch Pathol 78:222–230
Axelsen RA (1975) The induction of renal papillary necrosis in Gunn rats by analgesics and analgesic mixtures. Br J Exp Pathol 56:92–97
Axelsen RA (1976) Analgesic-induced renal papillary necrosis in the Gunn rat: the comparative nephrotoxicity of aspirin and phenacetin. J Pathol 120:145–150
Bach PH (1993) Experimental evidence and the biochemical basis for the role of analgesics in cancer. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 180–196
Bach PH, Bridges JW (1985) Chemically induced renal papillary necrosis and upper urothelial carcinoma, parts 1 and 2. CRC Crit Rev Toxicol 15:217–439
Beswick EP, Schatzki PF (1960) Experimental renal papillary necrosis. Arch Pathol 69:733–740
Björck S (1993) Paracetamol-induced renal tubular cell necrosis. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 174–179
Burry A, Cross R, Axelsen R (1977) Analgesic nephropathy and the renal concentrating mechanism. Pathol Ann 12(2):1–13
Carro-Ciampi G (1978) Phenacetin abuse: a review. Toxicology 10:311–339
Duggin GG (1980) Mechanisms in the development of analgesic nephropathy. Kidney Int 18:553–561
Edwards KDG, Curtis EA, Stoker LM (1971) One-day renal function testing in normal rats and in cases of experimentally-induced analgesic nephropathy, nephrocalcinosis and nephrotic syndrome. Nephron 8:235–245
Hanzlik PJ, Scott RW, Reycraft JL (1917) The salicylates. VIII. Salicyl oedema. Arch Intern Med 20:329–340
Hardy TL (1970) N-phenyl anthranilic acid: an agent for inducing and studying renal papillary necrosis in the rat. Br J Exp Pathol 51:348–355
Haschek H (ed) (1973) Problems on phenacetin abuse. Facta, Vienna
Isaka H, Yoshii H, Otsuji A, Koike M, Nagai Y, Koura M, Sugiyasu K, Kanabayashi T (1979) Tumours of Sprague-Dawley rats induced by long-term feeding of phenacetin. Gann 70:29–36
Johansson SL (1991) Carcinogenicity of analgesics: longterm treatment of Sprague-Dawley rats with phenacetin, phenazone, caffeine, and paracetamol (acetaminophen). Int J Cancer 27:521–529
Kennedy A, Saluga PG (1970) Urinary cytology in experimental toxic renal injury. Ann Rheum Dis 29:546–552
Kimberly RP, Bowden RE, Keier HK, Plotz PH (1978) Reduction of renal function by newer nonsteroidal antiinflammatory drugs. Am J Med 64:804–807
Kincaid-Smith (ed) (1978) Analgesic nephropathy. Kidney Int 13:1–113
Kleinknecht D (1993) Diseases of the kidney caused by non-steroidal anti-inflammatory drugs. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 160–173
Markovic B (1971) Rescherches experimentales sur le role de la phenacetine dans la pathogenese des nephropathies interstielles chroniques. Arch Union Med Balk 9:591–598
McMurtry RJ, Snodgrass WR, Mitchell JR (1978) Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. Toxicol Appl Pharmacol 46:87- 100
McCredie M (1993) Analgesics as human carcinogens - clinical and epidemiological evidence. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 197–210
Mitchell JR, McMurtry RJ, Statham CN, Nelson SD (1977) Molecular basis for several drug-induced nephropathies. Am J Med 62:518–526
Molland EA (1978) Experimental renal papillary necrosis. Kidney Int 13:5–14
Mudge GH, Gemborys MW, Duggin GG (1978) Covalent binding of metabolites of acetaminophen to kidney protein and depletion of renal glutathione. J Pharmacol Exp Ther 206:218–226
Murray T, Goldberg M (1975) Analgesic abuse and renal disease. Annu Rev Med 26:537–550
Nanra RS (1976) Pathology, aetiology and pathogenesis of analgesic nephropathy. Aust NZ J Med 6 [SuppI1]:33–37
Nanra RS (1980) Clinical and pathological aspects of analgesic nephropathy. Br J Clin Pharmacol 10 [Suppl 2]:359S-368S
Nanra RS (1983) Renal effects of antityretic analgesics. Am J Med 75:70–81
Nanra RS (1993a) Analgesic nephropathy in the 1990s – an Australian perspective. Kidney Int 44 [Suppl 42]:S86- S92
Nanra RS (1993b) Analgesic-induced renal disease. In: Schrier RW, Gottschalk CW (eds) Diseases of the kidney, vol 2, 5th edn. Little Brown, Boston, pp 1104- 1129
Nanra RS, Kincaid-Smith P (1970) Papillary necrosis in rats caused by aspirin and aspirin-containing mixtures. Br Med J 3:559–561
Nanra RS, Kincaid-Smith P (1972) Chronic effect of analgesic on the kidney. Prog Biochem Pharmacol 7:285–323
Nanra RS, Kincaid-Smith P (1993) Experimental evidence for nephrotoxicity of analgesics. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 17–31
Nanra RS, Chirawong P, Kincaid-Smith P (1973) Medullary ischaemia in experimental analgesic nephropathy - the pathogenesis of renal papillary necrosis. Aust NZ J Med 3:580–586
Nanra RS, Daniel V, Howard M (1980) Analgesic nephropathy induced by common proprietary mixtures. Med J Aust 1:486–487
Nanra RS, Daniel V, Howard M, Gupta JW (1981) Physiological changes in experimental analgesic nephropathy. Proceedings of the VIlth International Congress on Nephrology, 1981, Athens (abstr DK 020)
Nanra RS, Daniel V, Howard M, Murugesu R, White KH (1982) Uroepithehal hyperplasia and carcinoma in experimental analgesic nephropathy. Proceedings of the VllIth International Congress on Nephrology, 1982, Athens (abstr DK 021)
Prescott LF (1966) The nephrotoxicity of analgesics. J Pharm Pharmacol 18:331–353
Prescott LF (1982) Analgesic nephropathy. A reassessment of the role of phenacetin and other analgesics. Drugs 23:75–149
Pugliese F, Cinotti GA (1993) Biochemistry and pharmacology of non-steroidal anti-inflammatory drugs and renal prostaglandins. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 133–146
Rosner I (1974) Nephropathies experimentales aux analgesiques. Therapie 29:483–505
Rosner I (1976) Experimental analgesic nephropathy. CRC Crit Rev Toxicol 4:331–352
Sheehan HL, Davis JC (1959) Renal ischemia with good reflow. J Pathol Bacteriol 78:351–377
Shelley JH (1967) Phenacetin, through the looking glass. Clin Pharmacol Ther 8:427–471
Steele TW, Edwards KDG (1970) Abnormalities of urinary concentrating, acidifying and sodium conserving abilities induced by excessive analgesic intake of rats. Aust Ann Med 19:412–413
Williams GM, Weisburger JH (1986) Chemical carcinogens. In: Klassen CD, Amdur MO, Doull J (eds) Casarett and Doull’s toxicology: the basic science of poisons, 3rd edn. McMillan, New York, pp 99–173
Winchester IF (1981) Georgetown University symposium of analgesics. Aspirin and acetaminophen. Arch Intern Med 141:273–406
Wiseman EH, Reinert H (1975) Anti-inflammatory drugs and renal papillary necrosis. Agents Actions 5:322–325
Wizgird JP, French SW, Coulson W (1965) Pathogenesis of serum-induced papillary necrosis. Arch Pathol 79:57- 64
Zambraski EJ, Dunn MJ (1993) Effects of non-steroidal anti-inflammatory drugs on renal function. In: Stewart JH (ed) Analgesic and NSAID-induced kidney disease. Oxford University Press, New York, pp 147–159
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Nanra, R.S. (1998). Experimental Renal Effects of Analgesics, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_27
Download citation
DOI: https://doi.org/10.1007/978-3-642-80335-2_27
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80337-6
Online ISBN: 978-3-642-80335-2
eBook Packages: Springer Book Archive