Skip to main content

Effect of Experimental Diabetes Mellitus, Kidney, Rat

  • Chapter
Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

Diabetic rat kidneys are larger than those of normal rats of corresponding age. The capsutar surface is usually smooth. A fine granulation can occur in late stages. The cut surfaces are brownish red.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Artacho-Perula E, Roldan-Villalobos R, Salcedo-Leal J, Vaamonde-Lemos R (1993) Stereo logical estimates of volume-weighted mean glomerular volume in streptozotocin-diabetic rats. Lab Invest 68:56–61

    PubMed  CAS  Google Scholar 

  • Bell RH Jr, Borjesson BA, Wolf PL, Fernandez-Cruz L, BrimmJE, Lee S, Sayers HJ, Orloff MJ (1984) Quantitative morphological studies of aging changes in the kidney of the Lewis rats. Renal Physiol 7:176–184

    PubMed  Google Scholar 

  • Cohen MP, Klein CV (1979) Glomerulopathy in rats with streptozotocin diabetes. Accumulation of glomerular basement membrane analgous to human diabetic nephropathy. J Exp Med 149:623–631

    Article  PubMed  CAS  Google Scholar 

  • Haley DP, Bulger RE (1983) The aging male rat: structure and function of the kidney. Am J Anat 167:1–13

    Article  PubMed  CAS  Google Scholar 

  • Hasslacher C, Reichenbacher R, Gechter F, Timpl R (1984) Glomerular basement membrance synthesis and serum concerntration of type IV collagen in streptozotocin-diabetic rats. Diabetologia 26:150–154

    Article  PubMed  CAS  Google Scholar 

  • Hirose K, Osterby R, Nozawa M, Gundersen HJG (1982) Development of glomerular lesions in experimental long-term diabetes in the rat. Kidney Int 21:689–695

    Article  PubMed  CAS  Google Scholar 

  • Hostetter TH, Troy JL, Brenner BM (1981) Glomerular hemodynamics in experimental diabetes mellitus. Kidney Int 19:410–415

    Article  PubMed  CAS  Google Scholar 

  • Jensen PK, Sandahl Christiansen J, Steven K, Parving HH (1981) Renal function in streptozotocin-diabetic rats. Diabetologia 21:409–414

    Article  PubMed  CAS  Google Scholar 

  • Kern TS, Engerman RL (1990) Arrest of glomerulopathy in diabetic dogs by improved glycaemic control. Diabetologia 33:522–525

    Article  PubMed  CAS  Google Scholar 

  • Kimura K, Tojo A, Nanba S, Matsuoka H, Sugimoto T (1990) Morphometric analysis of the arteriolar diameters in experimental nephropathies: application of microvascular casts. Virchows Arch (A) 417:319–323

    Article  CAS  Google Scholar 

  • Leegwater DC, Kuper CF (1984) Evaluation of histological changes in the kidneys of the alloxan diabetic rat by means of factor analysis. Food Chern Thoxicol 22:551- 557

    Article  CAS  Google Scholar 

  • Michels LD, O’Donnell MP, Keane WF (1984) Glomerular hemodynamic and structural correlations in long-term experimental diabetic rats. J Lab Clin Med 103:840–847

    PubMed  CAS  Google Scholar 

  • Morita T, Churg J (1983) Mesangiolysis. Kidney Int 24:1–9

    Article  CAS  Google Scholar 

  • Nyengaard JR, Rasch R (1993) The impact of experimental diabetes mellitus in rats on glomerular capillary number and sizes. Diabetologia 36:189–194

    Article  PubMed  CAS  Google Scholar 

  • Rasch R, Holck P (1991) Macula densa morphology in diabetic rats with and without hyperglycemia and in non diabetic hyperglycemic rats. Lab Invest 64:392–399

    PubMed  CAS  Google Scholar 

  • Risteli J, Draeger KE, Regitz G, Neubauer HP (1982) Increase in circulating basement membrane antigens in diabetic rats and effects of insulin treatment. Diabetologia 23:266–269

    Article  PubMed  CAS  Google Scholar 

  • Steffes MW, Mauer SM (1984) Diabetic glomerulopathy in man and experimental animal models. Int Rev Exp Pathol 26:147–175

    PubMed  CAS  Google Scholar 

  • Steffes MW, Vernier RL, Brown DM, Basgen JM, Mauer SM (1982) Diabetic glomerulopathy in the uninephrectomized rat resists amelioration following islet transplantation. Diabetologia 23:347–353

    Article  PubMed  CAS  Google Scholar 

  • Volkmann P, Wehner H (1986) Renal vessel changes in diabetic KK-mice. Virchows Arch [A] 409:669–678

    Article  CAS  Google Scholar 

  • Wehner H (1977) Morphologie der diabetischen Nephropathie. Munch Med Wochenschr 119:489–492

    CAS  Google Scholar 

  • Wehner H, Petri M (1983) Glomerular alterations in experimental diabetes of the rat. Pathol Res Pract 176:145- 157

    Article  PubMed  CAS  Google Scholar 

  • Wehner H, Höhn D, Faix-Schade U, Huber H, Walzer P (1972) Glomerular changes in mice with spontaneous hereditary diabetes. Lab Invest 27:331–340

    PubMed  CAS  Google Scholar 

  • Wehner H, Kösters W, Strauch M, Staudenmeier M (1980) Effect of islet transplantation on the glomerular changes in streptozotocin-diabetic rats. Virchows Arch (A) 388:137–154

    CAS  Google Scholar 

  • Wehner H, Nelischer G (1991) Morphometric investigations on intrarenal vessels of streptozotocin-diabetic rats. Virchows Arch (A) 419:231–235

    Article  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Wehner, H. (1986). Effect of Experimental Diabetes Mellitus, Kidney, Rat. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_26

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80335-2_26

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80337-6

  • Online ISBN: 978-3-642-80335-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics