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Urinary System pp 271-278 | Cite as

Juxtaglomerular Cell Hyperplasia, Induced, Laboratory Animals

  • Roger A. Owen
  • Sylvain Molon-Noblot
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Juxtaglomerular cell hyperplasia is not visible grossly.

Keywords

Synonyms Juxtaglomerular cell hypertrophy/hyperplasia juxtaglomerular epithelioid cell hyperplasia juxtaglomerular granular cell hyperplasia 

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References

  1. Albassam M, Baker K, Clarke D, Walker R, Smith G (1994) Juxtaglomerular changes in normotensive cynomologous monkeys treated with CI-992, a human renin inhibitor. Vet Patho1 31:583 (abstr 37)Google Scholar
  2. Barajas L, Powers K, Carretero 0, Scicli AG, Inagami T (1986) Immunocytochemical localization of renin and kallikrein in the rat renal cortex. Kidney Int 29:965–970PubMedCrossRefGoogle Scholar
  3. Berka JLA, Alcorn D, Ryan GB, Skinner SL (1992) Renin processing studied by immunogold localization of prorenin and renin in granular juxtaglomerular cells in mice treated with enalapril. Cell Tissue Res 268:141–148PubMedCrossRefGoogle Scholar
  4. Brunner HR, Nussberger J, Waeber B (1990) Various approaches to blockade of the renin angiotensin system: persistent renin response. J Hypertens Suppl [Suppl 8]:S149-S153CrossRefGoogle Scholar
  5. Cantin M, Aranjo-Nascimento MF, Benchimol S, Desormeaux Y (1977) Metaplasia of smooth muscle cells into juxtaglomerular cells in the juxtaglomerular apparatus, arteries, and arterioles of the ischemic (endocrine) kidney. Am J Pathol 87:581–602PubMedGoogle Scholar
  6. Christensen JA, Bohle A, Mikeler E, Taugner R (1989) Renin-positive granulated Goormaghtigh’s cells. Immunohistochemical and electron microscopic studies on biopsies from patients with pseudo-Bartter’s syndrome. Cell Tissue Res 255:149–153PubMedCrossRefGoogle Scholar
  7. Cogan MG, Xie MH, Liu FY, Wong PC, Timmennans PB (1991) Effects of DuP 753 on proximal nephron and renal transport. Am J Hypertens 4:315S-320SPubMedGoogle Scholar
  8. Davis JO, Freeman RH (1976) Mechanisms regulating renin release. Physiol Rev 56:1–56PubMedGoogle Scholar
  9. Dominick MA, Bobrowski WF, Metz AL, Gough A W, MacDonald JR (1990) Ultrastructural juxtaglomerular cell changes in normotensive rats treated with quinapril, an inhibitor of angiotensin-converting enzyme. Toxicol.Pathol 18:396–406PubMedCrossRefGoogle Scholar
  10. Donaubauer HH, Mayer D (1988) Acute, subchronic and chronic toxicity of the new angiotensin converting enzyme inhibitor ramipril. Arzneimittelforschung 38:14–20PubMedGoogle Scholar
  11. Gibson RE, Thorpe HH, Cartwright ME, Frank JD, Schorn TW, Bunting PB (1991) Angiotensin receptor subtypes in the renal cortex of rat and Rhesus monkey. Am J Physiol 261:F512-F518PubMedGoogle Scholar
  12. Gomez RA, Chevalier RL, Everett AD, Elwood JP, Peach MJ, Lynch KR, Carey RM (1990) Recruitment of renin gene-expressing cells in adult rat kidneys. Am J Physiol 259:F660-F665PubMedGoogle Scholar
  13. Herblin WF, Chiu AT, McCall DE, Ardecky RJ, Carini DJ, Duncia JV (1991) Angiotensin II receptor heterogeneity. Am J Hypertens 4:299S-302SPubMedGoogle Scholar
  14. Jackson DG, Jones HB (1995) Histopathological and ultrastructural changes in the juxtaglomerular apparatus of the rat following administration of ZENECA ZD6888 (2-ethyl-5,6,7,8-tetrahydro-4- [(2’ -(1H -tetrazol-5-yl) biphenyl-4-y-I)-methoxy] quinoline), an angiotensin II antagonist. Toxicol Pathol 23:7–15PubMedCrossRefGoogle Scholar
  15. Keeton TK, Campbell WB (1980) The pharmacologic alteration of renin release. Pharmacol Rev 32:81–227PubMedGoogle Scholar
  16. Kirchheim H, Ehmke H, Persson P (1990) Role of blood pressure in control of renin release. Acta Physiol Scand [Suppl] 591:40–47Google Scholar
  17. Laragh JH (1991) Renin system blockade as a therapeutic strategy. Past, present, and future. Am J Hypertens 4:273S-274SPubMedGoogle Scholar
  18. La Rocca PT, Squibb RE, Powell ML, Szot RJ, Black HE, Schwartz E (1986) Acute and subchronic toxicity of a nonsulfhydryl angiotensin-converting enzyme inhibitor. Toxicol Appl Pharmacol 82:104–111PubMedCrossRefGoogle Scholar
  19. Latta H (1973) Ultrastructure of the glomerulus and juxtaglomerular apparatus. In: Handbook of physiology. Renal physiology. Am Physiol Soc, Washington DC, pp 1–29Google Scholar
  20. MacDonald JR, Susick RL Jr, Pegg DO, Dominick MA (1992) Renal structure and function in rats after suprapharmacologic doses of quinapril, an angiotensinconverting enzyme inhibitor. J Cardiovasc Pharmacol 19:282–289PubMedCrossRefGoogle Scholar
  21. Owen RA, Molon-Noblot S, Hubert MF, Kindt MV, Keenan KP, Eydelloth RS (1994a) The morphology of juxtaglomerular cell hyperplasia and hypertrophy in normotensive rats and monkeys given an angiotensin II receptor antagonist. Toxicol Pathol 22:606–619PubMedCrossRefGoogle Scholar
  22. Owen RA, Molon-Noblot S, Hubert MF, Siegl PKS, Eydelloth RS, Keenan KP (1994b) Juxtaglomerular cell hypertrophy and hyperplasia induced in Rhesus monkeys by angiotensin II receptor antagonists. Lab Invest 71:543–551PubMedGoogle Scholar
  23. Skinner SL, McCubbin JW, Page IH (1964) Control of renin secretion. Circ Res 15:64–76PubMedGoogle Scholar
  24. Taugner R, Hackenthal E (1989) Long-term modulation of renin synthesis and secretion. In: Taugner R, Hackenthal E (eds) Juxtaglomerular apparatus. Springer, Berlin Heidelberg New York, pp 221–224Google Scholar
  25. Waldherr R (1989) Pathology of the human juxtaglomerular apparatus. In: Taugner R, Hackenthal E (eds) Juxtaglomerular apparatus. Springer, Berlin Heidelberg New York, pp 241–254Google Scholar
  26. Wurfer K, Hackenthal E, Metz R, Nobiling R, Simon T, Taugner R (1988) Interzonal and intrazonal heterogeneities in the renin status of the pre glomerular arteriole in five species. Histochemistry 89:283–287PubMedCrossRefGoogle Scholar
  27. Zaki FO, Keirn OR, Takii Y, Inagami T (1982) Hyperplasia of juxtaglomerular cells and renin localization in kidney of normotensive animals given captopril. Ann Clin Lab Sci 12:200–215PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Roger A. Owen
  • Sylvain Molon-Noblot

There are no affiliations available

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