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Urinary System pp 260-270 | Cite as

Acute Tubular Lesions, Kidney, Rat

  • Roger A. Owen
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

Mild or focal changes are undetectable grossly. Large, pale kidneys that are heavier than normal and that bulge under the capsule are characteristic of widespread tubular damage. On cut surface, a white band in the outer stripe of the outer medulla is characteristic of those compounds that affect the pars recta (Fig. 222), whereas cortical pallor occurs if the pars convoluta is the damaged segment. Papillary or medullary congestion may also be seen.

Keywords

Synonyms Acute tubular necrosis (ATN) nephrotoxic ATN acute tubular nephrosis acute toxic tubular nephrosis acute toxic tubular nephritis acute tubular degeneration 

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References

  1. Alden CL, Kanerva RL, Ridder G, Stone LC (1983) Renal effects of petroleum hydrocarbons. In: Mehlman MA (ed) Advances in modern environmental toxicology, vol 7. American Petroleum Institute, Washington DC, pp 107–120Google Scholar
  2. Alden CL, Parker RD, Eastman DF (1989) Development of an acute model for the study of chloromethanediphosphonate nephrotoxicity. Toxicol Pathol 17:27–32PubMedGoogle Scholar
  3. Alden CL, Burns JL, Parker RD, Englehart JL, Dennis VW (1990) Characterization of the early ultrastructural and biochemical events occurring in dichloromethane diphosphonate nephrotoxicity. Toxicol Pat hoi 18:661–666Google Scholar
  4. Appel GB, Neu HC (1977) The nephrotoxicity of antimicrobial agents, parts 1–3. N Engl J Med 296:663–670, 722–728, 784–787PubMedCrossRefGoogle Scholar
  5. Berndt WO (1983) Transport of citrinin by rat renal cortex. Arch Toxicol 54:35–40PubMedCrossRefGoogle Scholar
  6. Biber TUL, Mylle M, Baines AD, Gottschalk CW, Oliver J, MacDowell MC (1968) A study by micropuncture and microdissection of acute renal damage in rats. Am J Med 44:664–705PubMedCrossRefGoogle Scholar
  7. Carpenedo F, Luciani S, Scaravilli F, Palatini P, Santi R (1974) Nephrotoxic effects of atractyloside in rats. Arch Toxicol 32:169–180PubMedCrossRefGoogle Scholar
  8. Carroll R, Kovacs K, Tapp E (1965) The pathogenesis of glycerol-induced renal tubular necrosis. J Pathol Bacteriol 89:573–580PubMedCrossRefGoogle Scholar
  9. Cherian MG, Goyer RA, Delaquerriere-Richardson L (1976) Cadmium-metallothionein-induced nephropathy. Toxicol Appl Pharmacol 38:399–408PubMedCrossRefGoogle Scholar
  10. Cheville NF (1983) Cell pathology, 2nd edn. Iowa State University, Ames, pp 76–129Google Scholar
  11. Choie DD, Richter GW (1972) Lead poisoning: rapid formation of intranuclear inclusions. Science 177:1194–1195PubMedCrossRefGoogle Scholar
  12. Davies DJ, Kennedy A, Roberts C (1969) The excretion of renal cells following necrosis of the distal segment of the nephron by hexadimethrine bromide. Br J Exp Pathol 50:319–326PubMedGoogle Scholar
  13. Dekant W, Vamvakas S, Anders MW (1994) Formation and fate of nephrotoxic and cytotoxic glutathione Sconjugates: cysteine conjugate β-lyase pathway. Adv Pharmacol 27:115–162PubMedCrossRefGoogle Scholar
  14. Dobyan DC, Nagle RB, Bulger RE (1977) Acute tubular necrosis in the rat kidney following sustained hypotension: physiologic and morphologic observations. Lab Invest 37:411–422PubMedCrossRefGoogle Scholar
  15. Dobyan DC, Levi J, Jacobs C, Kosek J, Weiner MW (1980) Mechanisms of cis-platinum nephrotoxicity. II. Morphologic observations. J Pharmacol Exp Ther 213:551–556PubMedGoogle Scholar
  16. Donohoe JF, Venkatachalam MA, Bernard DB, Levinsky NG (1978) Tubular leakage and obstruction after renal ischemia: structural-functional correlations. Kidney Int 13:208–222PubMedCrossRefGoogle Scholar
  17. Evan AP, Dail WG Jr (1974) The effects of sodium chromate on the proximal tubules of the rat kidney: Fine structural damage and lysozymuria. Lab Invest 30:704–715PubMedGoogle Scholar
  18. Farber JL (1982) Biology of disease: membrane injury and calcium homeostasis in the pathogenesis of coagulative necrosis. Lab Invest 47:114–123PubMedGoogle Scholar
  19. Finckh ES (1957) Experimental acute tubular nephrosis following subcutaneous injection of glycerol. J Pathol Bacteriol 73:69–85CrossRefGoogle Scholar
  20. Fowler BA (1972) The morphologic effects of dieldrin and methyl mercuric chloride on pars recta segments of the rat kidney proximal tubules. Am J Pathol 69:163–178PubMedGoogle Scholar
  21. Fowler BA (1982) Ultrastructural and biochemicallocalization of organelle damage from nephrotoxic agents. In: Porter GA (ed) Nephrotoxic mechanisms of drugs and environmental toxins. Plenum, New York, pp 315–330Google Scholar
  22. Fowler BA, Hook GE, Lucier GW (1977) Tetrachlorodibenzo-p-dioxin induction of renal microsomal enzyme systems: ultrastructural effects on pars recta (S3) proximal tubule cells on the rat kidney. J Pharmacol Exp Ther 203:712–721PubMedGoogle Scholar
  23. Ganote CE, Petersen DR, Carone FA (1974a) The nature of D-serine induced nephrotoxicity. Am J Pathol 77:269–282PubMedGoogle Scholar
  24. Ganote CE, Reimer KA, Jennings RB (1974b) Acute mercuric chloride nephrotoxicity. Lab Invest 31:633–647PubMedGoogle Scholar
  25. Goldstein RS (1993) Biochemieal heterogeneity and site specific tubular injury. In: Hook JB, Goldstein RS (eds) Toxicology of the kidney series. Raven, New York, pp 201–245Google Scholar
  26. Goldstein RS, Mayor GH (1983) Mini review: the nephrotoxicity of cisplatin. Life Sci 32:685–690PubMedCrossRefGoogle Scholar
  27. Gould DH, Fettman MJ, Daxenbichler ME, Bartuska BM (1985) Functional and structural alterations of the rat kidney induced by the naturally occurring organonitrile 2S1-cyano-2-hydroxy-3,4-epithiobutane. Toxicol Appl Pharmacol 78:190–201PubMedCrossRefGoogle Scholar
  28. Goyer RA (1982) The nephrotoxic effects of lead. In: Bach PH, Bonner FW, Bridge JW, Lock EA (eds) Nephrotoxicity: assessment and pathogenesis. Wiley, New York, pp 338–348Google Scholar
  29. Gray JE (1977) Chronic progressive nephrosis in the albino rat. CRC Crit Rev Toxicol 5:115–144PubMedCrossRefGoogle Scholar
  30. Green CR, Ham KN, Tange JD (1969) Kidney lesions induced in rats by p-aminophenol. Br Med J 61:162–164CrossRefGoogle Scholar
  31. Haagsma BH, Pound A W (1979) Mercuric chlorideinduced renal tubular necrosis in the rat. Br J Exp Pathol 60:341–352PubMedGoogle Scholar
  32. Haagsma BH, Pound A W (1980) Mercuric chlorideinduced tubulo-necrosis in the rat kidney: the recovery phase. Br J Exp Pathol 61:229–241PubMedGoogle Scholar
  33. Haley DP (1982) Morphologic changes in uranyl nitrateinduced acute renal failure in saline- and water-drinking rats. Lab Invest 46:196–208PubMedGoogle Scholar
  34. Hard GC, Mackay RL, Kochhar OS (1984) Electron microscopic determination of the sequence of acute tubular and vascular injury induced in the rat kidney by a carcinogenic dose of dimethylnitrosamine. Lab Invest 50:659–672PubMedGoogle Scholar
  35. Heywood R (1981) Target organ toxicity. Toxicol Lett 8:349–358PubMedCrossRefGoogle Scholar
  36. Hinchman CA, Ballatori N (1990) Glutathione-degrading capacities of liver and kidney in different species. Biochem Pharmacol 40:1131–1135PubMedCrossRefGoogle Scholar
  37. Hottendorf GH (1982) Clinical versus experimental comparisons of amino glycoside nephrotoxicity. In: Fillastre JP (ed) Nephrotoxicity, ototoxicity of drugs. Proceedings of the 2nd International Symposium on Nephrotoxicity Antibiotics. University of Rouen, Rouen, pp 257–268Google Scholar
  38. Houghton DC, Harnett M, Campbell-Boswell M, Porter G, Bennett W (1976) A light and electron microscopic analysis of gentamicin nephrotoxicity in rats. Am J Pathol 82:589–612PubMedGoogle Scholar
  39. Ishmael J, Pratt I, Lock EA (1982) Necrosis of the pars recta (S3 segment) of the rat kidney produced by hexachloro-1,3-butadiene. J Pathol 138:99–113PubMedCrossRefGoogle Scholar
  40. Ishmael J, Pratt I, Lock EA (1984) Hexachloro-1,3-butadiene-induced renal tubular necrosis in the mouse. J Pathol 142: 195–203PubMedCrossRefGoogle Scholar
  41. Jones TC, Hunt RD (1983) Veterinary pathology, 5th edn. Lea and Febiger, Philadelphia, pp 1446–1502Google Scholar
  42. Kaltenbach JP, Ganote CE, Carone FA (1979) Renal tubular necrosis induced by compounds structurally related to D-serine. Exp Mol Pathol 30:209–214PubMedCrossRefGoogle Scholar
  43. Klos C, Koob M, Kramer C, Dekant W (1992) pAminophenol nephrotoxicity: biosynthesis of toxic glutathione conjugates. Toxieol Appl Pharmacol 115:98–106CrossRefGoogle Scholar
  44. Kluwe WM (1982) Mechanisms of acute nephrotoxicity: halogenated aliphatic hydrocarbons. In: Porter GA (ed) Nephrotoxic mechanisms of drugs and environmental toxins. Plenum, New York, pp 331–344Google Scholar
  45. Kosek JC, Mazze RI, Cousins MJ (1974) Nephrotoxicity of gentamicin. Lab Invest 30:48–57PubMedGoogle Scholar
  46. Lockard VG, Phillips RD, Wallace-Hayes A, Berndt WO, O’Neal RM (1980) Citrinin nephrotoxicity in rats: a light and electron microscopic study. Exp Mol Pathol 32:226–240PubMedCrossRefGoogle Scholar
  47. Madrazo A, Suzuki Y, Churg J (1969) Radiation nephritis:acute changes following high doses of radiation. Am J Pathol 54:507–527PubMedGoogle Scholar
  48. McDowell EM, Nagle RB, Zalme RC, McNeil JS, Flamenbaum W, Trump BF (1976) Studies on the pathophysiology of acute renal failure. I. Correlation of ultrastructure and function in the proximal tubule of the rat following administration of mercuric chloride. Virchows Arch B Cell Pathol 22:173–196PubMedGoogle Scholar
  49. McMurtry RJ, Mitchell JR (1977) Renal and hepatic necrosis after metabolic activation of 2-substituted furans and thiophenes, including furosemide and cephaloridine. Toxicol Appl Pharmacol 42:285–300PubMedCrossRefGoogle Scholar
  50. McMurtry RJ, Snodgrass WR, Mitchell JR (1978) Renal necrosis, glutathione depletion, and covalent binding after acetaminophen. Toxicol Appl Pharmacol 46:87–100PubMedCrossRefGoogle Scholar
  51. Merski JA (1981) Acute structural changes in renal tubular epithelium following administration of nitrilotriacetate. Food Cosmet Toxicol 19:463–470PubMedCrossRefGoogle Scholar
  52. Murray SM (1979) The morphology of serotonin-induced renal lesions in the rat. J Pathol 128:203–211PubMedCrossRefGoogle Scholar
  53. Nash JA, King LJ, Lock EA, Green T (1984) The metabolism and disposition of hexachloro-l,3-butadiene in the rat and its relevance to nephrotoxicity. Toxieol Appl Pharmacol 73:124–137CrossRefGoogle Scholar
  54. Newton JF, Pasino DA, Hook JB (1985) Acetaminophen nephrotoxicity: quantitation of renal metabolic activation in vivo. Toxicol Appl Pharmacol 78:39–46PubMedCrossRefGoogle Scholar
  55. Nouwen EJ, Verstrepen WA, Buyssens N, Zhu MQ, De Broe ME (1994) Hyperplasia, hypertrophy and phenotypic alterations in the distal nephron after acute proximal tubular injury in the rat. Lab Invest 70:479–493PubMedGoogle Scholar
  56. Oken DE, Landwehr DM, Kirschbaum BB (1982) The hemodynamic basis for experimental acute renal failure. In: Bach PH, Bonner FW, Bridges JW, Lock EA (eds) Nephrotoxicity: assessment and pathogenesis. Wiley, New York, pp 169–181Google Scholar
  57. Olbricht CHJ (1980) Experimental models of acute renal failure. Contrib Nephrol 19:110–123PubMedGoogle Scholar
  58. Owen RA, Heywood R (1980) Renal toxicity of aspirin to rats pre-treated with ethinyl oestradiol. Toxicol Lett 5:169–174CrossRefGoogle Scholar
  59. Owen RA, Heywood R (1983) Age-related susceptibility to aspirin-induced nephrotoxicity in female rats. Toxicol Lett 18:167–170PubMedCrossRefGoogle Scholar
  60. Patel R, McKenzie JK, McQueen EG (1964) Tamm-Horsfall urinary mucoprotein and tubular obstruction by casts in acute renal failure. Lancet 1:457–461PubMedCrossRefGoogle Scholar
  61. Payne BJ, Rhodes DC (1978) The acute nephrotoxicity of gold sodium thiomalate. Vet Pathol 15 [Suppl 5]:5–8PubMedGoogle Scholar
  62. Peterson DR, Carone FA (1979) Renal regeneration following D-serine induced acute tubular necrosis. Anat Rec 193:383–388PubMedCrossRefGoogle Scholar
  63. Potter CL, Gandolfi AJ, Nagle R, Clayton JW (1981) Effects of inhaled chlorotrifluoroethylene and hexafluoropropene on the rat kidney. Toxicol Appl Pharmacol 59:431–440PubMedCrossRefGoogle Scholar
  64. Reinhard MK, Hottendorf GH, Powell ED (1991) Differences in the sensitivity of Fischer and Sprague-Dawley rats to aminoglycoside nephrotoxicity. Toxicol Pathol 19:66–71PubMedGoogle Scholar
  65. Robbins SL, Cotran RS, Kumar V (1984) Pathologic basis of disease. Saunders, Philadelphia, pp 1–39Google Scholar
  66. Rush GF, Smith JH, Newton JF, Hook JB (1984) Chemically induced nephrotoxicity: role of metabolic activation. CRC Crit Rev Toxicol 13:99–160CrossRefGoogle Scholar
  67. Schubert GE (1976) Folic acid-induced acute renal failure in the rat: morphological studies. Kidney Int 10:S46-S50CrossRefGoogle Scholar
  68. Shimizu A, Yamanaka N (1993) Apoptosis and cell desquamation in repair process of ischemic tubular necrosis. Virchows Arch B Cell Pathol 64:171–180CrossRefGoogle Scholar
  69. Soderlund E, Dybing E, Nelson SD (1980) Nephrotoxicity and hepatotoxicity of Tris (2,3-dibromopropyl) phosphate in the rat. Toxicol Appl Pharmacol 56:171–181PubMedCrossRefGoogle Scholar
  70. Stein J (1982) Overview of pathophysiology of acute renal failure. In: Porter GA (ed) Nephrotoxic mechanisms of drugs and environmental toxins. Plenum, New York, pp 3–9Google Scholar
  71. Striker GE, Smuckler EA, Kohnen PW, Nagle RB (1968) Structural and functional changes in rat kidney during CCl4 intoxication. Am J Pathol 53:769–789PubMedGoogle Scholar
  72. Tarloff JB, Goldstein RS, Morgan DG, Hook JB (1989) Acetaminophen and p-aminophenol nephrotoxicity in aging male Sprague-Dawley and Fischer 344 rats. Fundam Appl Toxicol 12:78–91PubMedCrossRefGoogle Scholar
  73. Terracini B, Parker VH (1965) A pathological study on the toxicity of S-dichloro-vinyl-L-cysteine. Food Cosmet ToxicoI 3:67–74CrossRefGoogle Scholar
  74. Thelmo WL, Levine S (1978) Renal lesions induced by tilorone and an analog. Am J Pathol 91:355–360PubMedGoogle Scholar
  75. Thomas BL, Faith GC (1979) Renal tubular necrosis following cephalothin. Nephron 23:205–209PubMedCrossRefGoogle Scholar
  76. Trump BF (1995) Cell death is alive and well. Toxicol Pathol 23:617–621PubMedCrossRefGoogle Scholar
  77. Trump BF, Berezesky IK, Osornio-Vargas AR (1981) Cell death and the disease process. The role of calcium. In: Bowen I, Lockshin RA (eds) Cell death in biology and pathology. Chapman and Hall, New York, pp 209–242Google Scholar
  78. Tune BM (1975) Relationship between the transport and toxicity of cephalosporins in the kidney. J Infect Dis 132:189–194PubMedCrossRefGoogle Scholar
  79. Venkatachalam MA, Bernard DB, Donohoe JF, Levinsky NG (1978) Ischemic damage and repair in the rat proximal tubule: differences among the S1, S2 and S3 segments. Kidney Int 14:31–49PubMedCrossRefGoogle Scholar
  80. Venkatachalam MA, Kreisberg JI, Stein JH, Lifschitz MD (1983) Editorial: salvage of ischemic cells by impermeant solute and adenosine triphosphate. Lab Invest 49:1–3PubMedGoogle Scholar
  81. Verani RR, Brewer ED, Ince A, Gibson J, Bulger RE (1982) Proximal tubular necrosis associated with maleic acid administration to the rat. Lab Invest 46:79–88PubMedGoogle Scholar
  82. Wachsmuth ED, Thomann P (1982) Testing for renal tolerability: cefsulodin in rats and rabbits. In: Bach PH, Bonner FW, Bridges JW, Lock EA (eds) Nephrotoxicity: assessment and pathogenesis. Wiley, New York, pp 498–503Google Scholar
  83. Wedeen RP, Batuman V, Cheeks C, Marquet E, Sobel H (1983) Transport of gentamicin in rat proximal tubule. Lab Invest 48:212–223PubMedGoogle Scholar
  84. Weinberg JM, Johnson KJ, de la Iglesia FA, Allen ED (1989) Acute alterations of tissue Ca++ and lethal tubular cell injury during HgCl2 nephrotoxicity in the rat. Toxicol Pathol 17:483–493PubMedGoogle Scholar
  85. Whiting PH, Thomson AW, Blair JT, Simpson JG (1982) Experimental cyc1osporin A nephrotoxicity. Br J Exp Pathol 63:88–94PubMedGoogle Scholar
  86. Wilks MF, Gregg NJ, Bach PH (1994) Metal accumulation and nephron heterogeneity in mercuric chloride-induced acute renal failure. Toxicol Pathol 22:282–290PubMedCrossRefGoogle Scholar
  87. Zbinden G (1969) Experimental renal toxicity. In: Rouiller C, Muller AF (eds) The kidney: morphology, biochemistry, physiology. Academic, New York, pp 401–461Google Scholar

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© Springer-Verlag Berlin Heidelberg 1986

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  • Roger A. Owen

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