Chloroform Nephrosis, Male Mouse
The kidneys of male mice of susceptible strains exposed to toxic concentrations of chloroform (HCCl3) are acutely swollen and pale with a granular appearance. Often, in survivors, the kidneys have white capsular mottling and cortical streaks due to calcification of necrotic tubules (Deringer et al. 1953). Kidneys are somewhat enlarged, as confirmed by increased renal weight in chloroform-treated male mice (Ahmadizadeh et al. 1984).
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