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Interstitial Nephritis, Mouse

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Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

Abstract

In acute interstitial nephritis, the kidney is enlarged and pale. If the disease is focal in distribution, the lesions may be seen as white or gray foci in the cortex. In the acute phase, a lesion near the capsular surface of the kidney may be elevated; in focal chronic interstitial nephritis the lesions are usually depressed. In diffuse chronic interstitial nephritis the kidneys are reduced in size and the surface is granular or nodular; the capsule is often adherent to the underlying renal parenchyma. If diffusely fibrotic, the kidney cuts with increased resistance. The cut surface may have a white zone at the corticomedullary junction. In some cases, cortical or medullary cysts may be present.

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Authors
  1. Charles A. Montgomery Jr.
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Editors and Affiliations

  1. Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street,N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. American Health Foundation, One Dana Drive, Valhalla, NY, USA

    Gordon C. Hard BVSc., Ph.D., DSc., FRCPath., FRCVS, FAToxSci. (Director of Administration and Senior Toxicologist) (Director of Administration and Senior Toxicologist)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

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© 1998 Springer-Verlag Berlin Heidelberg

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Montgomery, C.A. (1998). Interstitial Nephritis, Mouse. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_19

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  • DOI: https://doi.org/10.1007/978-3-642-80335-2_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80337-6

  • Online ISBN: 978-3-642-80335-2

  • eBook Packages: Springer Book Archive

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