Urinary System pp 238-243 | Cite as

Interstitial Nephritis, Mouse

  • Charles A. MontgomeryJr.
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


In acute interstitial nephritis, the kidney is enlarged and pale. If the disease is focal in distribution, the lesions may be seen as white or gray foci in the cortex. In the acute phase, a lesion near the capsular surface of the kidney may be elevated; in focal chronic interstitial nephritis the lesions are usually depressed. In diffuse chronic interstitial nephritis the kidneys are reduced in size and the surface is granular or nodular; the capsule is often adherent to the underlying renal parenchyma. If diffusely fibrotic, the kidney cuts with increased resistance. The cut surface may have a white zone at the corticomedullary junction. In some cases, cortical or medullary cysts may be present.


Acute interstitial nephritis chronic interstitial nephritis tubulointerstitial nephritis acute or chronic inflammation of the interstitium 


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© Springer-Verlag Berlin Heidelberg 1998

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  • Charles A. MontgomeryJr.

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