Infarction, Kidney, Rat, Mouse
The gross appearance of renal infarcts is dependent upon their age (Sheehan and Davis 1958).During the first few hours after infarction the lesion is red and the overlying capsule is tense. Thecut surfaces of infarcts are characteristically triangular in shape, with the apex pointing toward the medulla. As the lesion ages, the color changes to gray centrally, and there may be a red rim at the margin. In approximately a week, the lesion becomes depressed below the capsular surface and progressively smaller and firmer. Old infarcts eventually lose their triangular shape and become linear. The size of the infarct is dependent upon the size of the obstructed vessel and the age of the lesion. In cases where there is a recurring embolic shower in the kidney, multiple acute and chronic infarcts may be present in the same animal.
KeywordsIschemic infarct acute or chronic infarct healed infarct
Unable to display preview. Download preview PDF.
- Heptinstall RH (1974) Infarction, cortical necrosis, and papillary necrosis, including the kidney of analgesic abuse. In: Pathology of the kidney, vol 1, 2nd edn. Little Brown, Boston, pp 221–272Google Scholar
- Jones DB (1984) Scanning and transmission electron microscopy of tubular changes in acute renal failure. In: Solez K, Whelton A (eds) Acute renal failure: correlations between morphology and function. Dekker, New York, pp 71–95Google Scholar
- Kreisberg JI, Bulger RE, Trump BF, Nagle BF (1976) Effects of transient hypotension on the structure and function of rat kidney. Virchows Arch [Cell Pathol] 22:121–33Google Scholar
- Levinsky NG, Alexander EA, Venkatachalam MA (1981) Acute renal failure. In: Brenner BM, Rector FC Jr (eds) The kidney, vol 1, 2nd edn. Saunders, Philadelphia, pp 1181–1236Google Scholar
- Maxie MG (1985) The urinary system. In: Jubb KVF, Kennedy PC, Palmer NP (eds) Pathology of domestic animals, vol 2,3rd edn. Academic, New York, pp 344–411Google Scholar
- Solez K, D’Agostini RJ, Stawowy L, Freedman MT, Scott WW Jr, Siegelman SS, Heptinstall RH (1977) Beneficial effect of propranolol in a histologically appropriate model of postischemic acute renal failure. Am J Pat hoi 88:163–192Google Scholar
- Svendsen UG (1985) The importance of thymus in the pathogenesis of the chronic phase of hypertension in mice following partial infarction of the kidney. Acta Pat hoi Microbiol Scand [A] 4:539–540Google Scholar
- Ward JM, Hamlin MH II, Ackerman LJ, Lattuada CP, Longfellow DG, Cameron TP (1983) Age-related neoplastic and degenerative lesions in aging male virginand ex-breeder ACI/segHapBR rats. J Gerontol 38:538- 548Google Scholar