Skip to main content
SpringerLink
Log in

Immune Mechanisms in Injury to Glomeruli and Tubulointerstitial Tissue

  • Chapter
Urinary System

Part of the book series: Monographs on Pathology of Laboratory Animals ((LABORATORY))

  • 517 Accesses

Abstract

At the beginning of this century, the idea took shape that human glomerular diseases are caused by immunologic mechanisms. Since that time, many attempts have been made to induce glomerular diseases and elucidate the pathogenetic mechanisms involved. The study of these experimental models has given an insight into the pathophysiology and underlying immunological mechanisms of renal disease and glomerular disease in particular (Furness and Harris 1994).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Adams S, Leblanc P, Datta SK (1991) Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens. Proc Natl Acad Sci USA 88:11271–11275

    CAS  Google Scholar 

  • Adler S (1992) Integrin receptors in the glomerulus. Potential role in glomerular injury. Am J Physiol 262:F697-F704

    PubMed  CAS  Google Scholar 

  • Adler S, Chen X (1992) Anti-FxlA antibody recognizes a β1-integrin on glomerular epithelial cells and inhibits adhesion and growth. Am J Physiol 262:F770-F776

    PubMed  CAS  Google Scholar 

  • Allison MEM, Wilson C, Gottschalk CW (1974) Pathophysiology of experimental glomerulonephritis in rats. J Clin Invest 53:1402–1423

    PubMed  CAS  Google Scholar 

  • Alvarez RJ, Sun MJ, Haverty TP, Iozzo RV, Myers JC, Neilson EG (1992) Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int 41:14–23

    PubMed  CAS  Google Scholar 

  • Andres GA, McCluskey RT (1975) Tubular and interstitial renal disease due to immunologic mechanisms. Kidney Int 7:271–289

    PubMed  CAS  Google Scholar 

  • Andres GA, Morgan C, Hsu KC, Rifkind, RA, Seegal BC (1962) Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody. The basement membranes and cisternae of visceral epithelial cells in nephritic rat glomeruli. J Exp Med 115:929–936

    PubMed  CAS  Google Scholar 

  • Aoki I, Aoki A, Otani M, Miyagi Y, Misugi K, Ishii N, Hagiwara E, Tani K, Okubo T, Ishigatsubo Y (1992) A correlation between IgG class antibody production and glomerulonephritis in the murine chronic graft-versushost reaction. Clin Immunol Immunopathol 63:34–38

    PubMed  CAS  Google Scholar 

  • Arhelger RB, Gronvall JA, Carr OB Jr, Brunson JG (1963) Electron microscopic localizations of nephrotoxic serum in rabbit glomeruli with ferritin-conjugated antibody. Lab Invest 12:33–37

    PubMed  CAS  Google Scholar 

  • Arisz L, Noble B, Milgrom M, Brentjens JR, Andres GA (1979) Experimental chronic serum sickness in rats. A model of immune complex glomerulonephritis and systemic immune complex deposition. Int Arch Allergy Appl Immunol 60:80–88

    PubMed  CAS  Google Scholar 

  • Aten J, Bruijn JA, Veninga A, de Heer E, Weening JJ (1988a) Anti-laminin autoantibodies and mercuryinduced glomerulopathy. Kidney Int 33:309–309 (abstr)

    Google Scholar 

  • Aten J, Bruijn JA, Veninga A, de Heer E, Weening JJ (1988b) Anti-laminin autoantibodies and mercuryinduced membranous glomerulopathy in the DZB rat. Kidney Int 34:556–556 (abstr)

    Google Scholar 

  • Aten J, Bosman CB, de Heer E, Hoedemaeker PJ, Weening JJ (1988c) Cyclosporin A induces long-term unresponsiveness in mercuric chloride-induced autoimmune glomerulonephritis. Clin Exp Immunol 73:307–311

    PubMed  CAS  Google Scholar 

  • Aten J, Veninga A, de Heer E, Hoedemaeker PJ, Nieuwenhuis P, Rozing J, Weening JJ (1991) Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur J Immunol 21:611–616

    PubMed  CAS  Google Scholar 

  • Aten J, Stet RJ, Wagenaar-Hilbers JP, Weening JJ, Fleuren GJ, Nieuwenhuis P (1992a) Glomerulopathy induced by graft-versus-host reaction in the rat. Requirement of donor CD4+ T lymphocytes and MHC class II incompatibility at the lymphoid compartment. Scand J Immunol 35:93–105

    PubMed  CAS  Google Scholar 

  • Aten J, Veninga A, Bruijn JA, Prins FA, de Heer E, Weening JJ (1992b) Antigenic specificities of glomerular-bound autoantibodies in membranous glomerulopathy induced by mercuric chloride. Clin Immunol Immunopathol 63:89–102

    PubMed  CAS  Google Scholar 

  • Baelde HJ, Bergijk EC, Bruijn JA (1990) Isolation and characterization of mouse glomerular basement membrane. J Clin Lab Immunol 33:17–20

    PubMed  CAS  Google Scholar 

  • Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW (1986a) Glomerulonephritis induced by monoclonal anti-Thy-l.l antibodies. A sequential histological and ultrastructural study in the rat. Lab Invest 55:680–687

    PubMed  CAS  Google Scholar 

  • Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW (1986b) Acute glomerulonephritis after intravenous injection of monoclonal anti-thymocyte antibodies in the rat. Immunol Lett 12:109–113

    PubMed  CAS  Google Scholar 

  • Bagchus WM, Jeunink MF, Elema JD (1990) The mesangium in anti-Thy-l nephritis. Influx of macrophages, mesangial cell hypercellularity, and macromolecular accumulation. Am J Pathol 137:215–223

    PubMed  CAS  Google Scholar 

  • Barabas AZ, Lannigan R (1974) Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. II. Early glomerular lesions. Br J Exp Pathol 55:282–290

    PubMed  CAS  Google Scholar 

  • Bariety J, Druet P, Laliberte F, Sapin C (1971) Glomerulonephritis with y and βIC-globulin deposits induced in rats by mercuric chloride. Am J Pathol 65:293–302

    PubMed  CAS  Google Scholar 

  • Bergijk EC, Munaut C, Baelde JJ, Prins F, Foidart JM, Hoedemaeker PJ, Bruijn JA (1992) A histologic study of the extracellular matrix during the development of glomerulosclerosis in murine chronic graft-versus-host disease. Am J Pathol 140:1147–1156

    PubMed  CAS  Google Scholar 

  • Bloom RD, Florquin S, Singer GG, Brennan DC, Rubin Kelley V (1992) Pivotal role for colony stimulating factor 1 (CSF-1) in the induction of lupus nephritis. J Am Soc Nephro1 3:576 (abstr)

    Google Scholar 

  • Bolton WK, Sturgill BC (1978) Bovine serum albumin chronic serum sickness nephropathy in rats. Br J Exp Pathol 59:167–177

    PubMed  CAS  Google Scholar 

  • Bolton WK, Tucker FL, Sturgill BC (1984) New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens. J Clin Invest 73:1263–1276

    PubMed  CAS  Google Scholar 

  • Border WA, Ruoslahti E (1990) Transforming growth factor-β1 induces extracellular matrix formation in glomerulonephritis. Cell Differ Dev 32:425–431

    PubMed  CAS  Google Scholar 

  • Border W A, Ruoslahti E (1992) Transforming growth factor-~ in disease: the dark side of tissue repair. J Clin Invest 90:1–7

    PubMed  CAS  Google Scholar 

  • Border WA, Adler SG, Wang H, Kamil ES, Ward HJ, Cohen H (1983) The pathologic and therapeutic implications of electrical charge in immune complex glomerulonephritis. In: Lambert PP, Bergmann P, Beauwens R (eds) The pathogenicity of cationic proteins. Raven, New York, pp 394–396

    Google Scholar 

  • Border WA, Okuda S, Nakamura T (1989) Extracellular matrix and glomerular disease. Semin Nephrol 9:307–317

    PubMed  CAS  Google Scholar 

  • Border W A, Okuda S, Languino LR, Ruoslahti E (1990a) Transforming growth factor-beta regulates production of proteoglycans by mesangial cells. Kidney Int 37:689–695

    PubMed  CAS  Google Scholar 

  • Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E (1990b) Suppression of experimental glomerulonephritis by antiserum against transforming growth factor ~1. Nature 346:371–374

    PubMed  CAS  Google Scholar 

  • Border WA, Noble NA, Yamamoto T, Tomooka S, Kagami S (1992) Antagonists of transforming growth factor-β: a novel approach to treatment of glomerulonephritis and prevention of glomerulosclerosis. Kidney Int 41:566–570

    PubMed  CAS  Google Scholar 

  • Boswell JM, Yui MA, Burt DW, Kelley VE (1988) Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis. J Immunol 141:3050–3054

    PubMed  CAS  Google Scholar 

  • Brentjens JR, Noble B, Andres GA (1982) Immunologically mediated lesions of kidney tubules and interstitium in laboratory animals and in man. Springer Semin Immunopathol 5:357–378

    PubMed  CAS  Google Scholar 

  • Brinkman K, Termaat RM, de Jong J, van den Brink HG, Berden JM, Smeenk RJT (1989) Cross-reactive binding patterns of monoclonal antibodies to DNA are often caused by DNA/anti-DNA immune complexes. Res Immunol 140:595–612

    PubMed  CAS  Google Scholar 

  • Brinkman K, Termaat R, Berden JH, Smeenk RJ (1990) Anti-DNA antibodies and lupus nephritis: the complexity of crossreactivity. Immunol Today 11:232–234

    PubMed  CAS  Google Scholar 

  • Bruijn JA, Oemar BS, Ehrich JH, Foidart JM, Fleuren GJ (1987) Anti-basement membrane glomerulopathy in experimental trypanosomiasis. J Immunol 139:2482–2488

    PubMed  CAS  Google Scholar 

  • Bruijn JA, van Elven EH, Hogendoorn PC, Corver WE, Hoedemaeker PJ, Fleuren GJ (1988) Murine chronic graft -versus-host disease as a model for lupus nephritis.Am J Pathol 130:639–641

    CAS  Google Scholar 

  • Bruijn JA, Van Elven EH, Corver WE, Oudshoorn-Snoek M, Fleuren GJ (1989a) Genetics of experimental lupus nephritis: non-H-2 factors determine susceptibility for renal involvement in murine chronic graft-versus-host disease. Clin Exp Immunol 76:284–289

    PubMed  CAS  Google Scholar 

  • Bruijn JA, van Elven EH, Hogendoorn PC, Corver WE, Hoedemaeker PJ, Fleuren GJ (1989b) Systemic lupus erythematosus (mice). In: Capen CC, Jones TC, Migaki G (eds) Handbook: animal models of human disease. Registry of Comparative Pathology, Armed Forces Institute of Pathology, Washington DC, pp 356–359

    Google Scholar 

  • Bruijn JA, Hoedemaeker PJ, Fleuren GJ (1989c) Pathogenesis of anti-basement membrane glomerulopathy and immune-complex glomerulonephritis: dichotomy dissolved. Lab Invest 61:480–488

    PubMed  CAS  Google Scholar 

  • Bruijn JA, Hogendoorn PC, Corver WE, van den Broek LJ, Hoedemaeker PJ, Fleuren GJ (1990a) Pathogenesis of experimental lupus nephritis: a role for anti-basement membrane and anti-tubular brush border antibodies in murine chronic graft-versus-host disease. Clin Exp Immunol 79:115–122

    PubMed  CAS  Google Scholar 

  • Bruijn JA, van Leer EH, Baelde HJ, Corver WE, Hogendoorn PC, Fleuren GJ (1990b) Characterization and in vivo transfer of nephritogenic autoantibodies directed against dipeptidyl peptidase IV and laminin in experimental lupus nephritis. Lab Invest 63:350–359

    PubMed  CAS  Google Scholar 

  • Bruijn JA, Bergijk EC, de Heer E, Fleuren GJ, Hoedemaeker PJ (1992) Induction and progression of experimental lupus nephritis: exploration of a pathogenetic pathway. Kidney Int 41:5–13

    PubMed  CAS  Google Scholar 

  • Cameron JS (1979) Pathogenesis and treatment of membranous nephropathy. Kidney Int 15:88–103

    PubMed  CAS  Google Scholar 

  • Cattell V, Cook T, Moncada S (1990) Glomeruli synthesize nitrite in experimental nephrotoxic nephritis. Kidney Int 38: 1056–1060

    PubMed  CAS  Google Scholar 

  • Chan HM, Zhu LF, Zhong R, Grant D, Goyer RA, Cherian MG (1993) Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol Appl Pharmacol 123:89–96

    PubMed  CAS  Google Scholar 

  • Chapo JA, Grande JP, Killen PD (1992) Transcriptional regulation of collagen IV gene expression during renal development. J Am Soc Nephrol 3:627 (abstr)

    Google Scholar 

  • Cheng IK, Dorsch SE, Hall BM (1988) The regulation of autoantibody production in Heymann’s nephritis by T lymphocyte subsets. Lab Invest 59:780–788

    PubMed  CAS  Google Scholar 

  • Cochrane CG, Unanue ER, Dixon FJ (1965) A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis. J Exp Med 122:99–116

    PubMed  CAS  Google Scholar 

  • Cole EH, Glynn MF, Laskin CA, Sweet J, Mason N, Levy GA (1990) Ancrod improves survival in murine systemic lupus erythematosus. Kidney Int 37:29–35

    PubMed  CAS  Google Scholar 

  • Cosio FG (1992) Cell-matrix adhesion receptors: relevance to glomerular pathology. Am J Kidney Dis 20:294–305

    PubMed  CAS  Google Scholar 

  • Couser WG, Sal ant DJ (1980) In situ immune complex formation and glomerular injury. Kidney Int 17:1–13

    PubMed  CAS  Google Scholar 

  • Couser WG, Salant DJ (1982) Immunopathogenesis of glomerular capillary wall injury in nephrotic states. In: Brenner BM, Stein JH (eds) Nephrotic syndrome. Churchill Livingstone, New York, pp 62–80

    Google Scholar 

  • Couser WG, Stilmant MM, Darby C (1976) Autologous immune complex nephropathy. I. Sequential study of immune complex deposition, ultrastructural changes, proteinuria, and alterations in glomerular sialoprotein. Lab Invest 34:23–30

    PubMed  CAS  Google Scholar 

  • Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62:1275–1287

    PubMed  CAS  Google Scholar 

  • de Heer E, Daha MR, van Es LA (1985) The autoimmune response in active Heymann’s nephritis in Lewis rats is regulated by T-Iymphocyte subsets. Cell Immunol 92:254–264

    PubMed  Google Scholar 

  • de Heer E, van Leer EHG, de Roo GM, Baelde JJ, Bruijn JA, Hoedemaeker PJ (1992) Autoamplification of systemic autoimmunity by anti-CD26 autoantibodies in experimental lupus nephritis in mice. J Am Soc Nephrol 3:582–582 (abstr)

    Google Scholar 

  • de Heer E, Davidoff A, van der Wal A, van Geest M, Paul LC (1994) Chronic renal allograft rejection in the rat. Transplantation-induced antibodies against basement membrane antigens. Lab Invest 70:494–502

    PubMed  Google Scholar 

  • Diamond JR (1992) The role of reactive oxygen species in animal models of glomerular disease. Am J Kidney Dis 19:292–300

    PubMed  CAS  Google Scholar 

  • Diaz-Gallo C, Rubin Kelly V (1992) IFN-gamma induces a tubular cell surface molecule which reduces proliferation of aut ore active kidney-infiltrating T-cells. J Am Soc Nephro1 3:582 (abstr)

    Google Scholar 

  • Dixon FJ (1962) Tissue injury produced by antigenantibody complexes. In: Graber P, Miescher P (eds) Mechanism of cell and tissue damage produced by immune reactions. 2nd International Symposium on Immunopathology. Schwabe, Basel, p 71

    Google Scholar 

  • Dixon FJ, Vazquez JJ, Weigle WO, Cochrane CG (1958) Pathogenesis of serum sickness. Arch Pathol 65:18–28

    CAS  Google Scholar 

  • Dixon FJ, Feldman JD, Vazquez JJ (1961) Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113:899–920

    PubMed  CAS  Google Scholar 

  • Druet E, Sapin C, Günther E, Feingold N, Druet P (1977) Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control. Eur J Immunol 7:348–351

    PubMed  CAS  Google Scholar 

  • Druet P, Ayed K, Bariety J, Bernandin JF, Druet E, Girard JF, Hinglais N, Sapin C (1978) Glomerulonéphrite immunes experiment ales indrites par Ie bichlorure de mercure chez Ie rat. In: Hamburger J, Crosnier J, FunckErentano JL (eds) Actualités néphrologiques de I’Hôpital Necker, Paris. Flammarion, Paris, pp 245–264

    Google Scholar 

  • Druet E, Sapin C, Fournie G, Mandet C, GUnther E, Druet P (1982) Genetic control of susceptibility to mercuryinduced immune nephritis in various strains of rat. Clin Immunol Immunopathol 25:203–212

    PubMed  CAS  Google Scholar 

  • el Nahas AM (1992) Growth factors and glomerular sclerosis. Kidney Int Suppl 36:S15-S20

    PubMed  Google Scholar 

  • el Nahas AM, Bassett AH, Cope GH, Le Carpentier JE (1991) Role of growth hormone in the development of experimental renal scarring. Kidney Int 40:29–34

    PubMed  Google Scholar 

  • Emancipator SN, Gallo GR, Lamm ME (1983) Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science 155:1432–1434

    Google Scholar 

  • Esnault VL, Mathieson PW, Thiru S, Oliveira DB, MartinLockwood C (1992) Autoantibodies to myeloperoxidase in Brown Norway rats treated with mercuric chloride. Lab Invest 67:114–120

    PubMed  CAS  Google Scholar 

  • Fan PY, Ruiz P, Pisetsky DS, Coffman TM, Spurney RF (1992) The effects of short-term treatment with the PGE1 analogue misoprostol on inflammatory mediator production in murine lupus nephritis. J Am Soc Nephrol 3:586 (abstr)

    Google Scholar 

  • Feenstra K, Lee RVD, Greben HA, Arends A, Hoedemaeker PJ (1975) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level. Lab Invest 32:235–242

    PubMed  CAS  Google Scholar 

  • Fennell RH Jr, Pardo VM (1967) Experimental glomerulonephritis in rats. Lab Invest 17:481–488

    PubMed  Google Scholar 

  • Fish AJ, Michael AF, Vernier RL, Good RA (1966) Acute serum sickness nephritis in the rabbit. An immune deposit disease. Am J Pathol 49:997–488

    PubMed  CAS  Google Scholar 

  • Fish AJ, Carmody KM, Michael AF (1979) Spatial orientation and distribution of antigens within human glomerular basement membrane. J Lab Clin Med 94:447–457

    PubMed  CAS  Google Scholar 

  • Fleuren GJ (1976) Studies on pathogenesis and treatment of experimental immune complex glomerulonephritis. Roos and Roos, Arnhem

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ (1981) Experimental antibasement membrane renal disease: a linear glomerular and tubular immunofluorescence pattern caused by antibodies directed against endothelial antigens. In: Zurrukzoglu W, Papadimitriou M, Pyrpassopoulos M, Sion M, Zamboulis C (eds) Nephrology. 8th International Congress on Nephrology (Athens, June 1981). Karger, Basel

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ (1982) Localization en microscopie immuno-electronique des antigenes impliques dans la fixation lineaire Ie long des membranes basales dans un modele homologue chez Ie rat. Nephrologie 3:93 (abstr)

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ, de Vries L, Nieuwenhuis P (1982) Reaction greffe contre hote chez Ie rat: developpement d’anticorps anti-rein. Nephrologie 3:93(abstr)

    Google Scholar 

  • Fleuren GJ, Hoedemaeker PJ, de Vries L, Nieuwenhuis P (1983) Graft-versus-host reaction in rats: development of anti-kidney antibodies and glomerulonephritis. Nieren Hochdruck Krankh 12:361

    Google Scholar 

  • Floege J, Johnson RJ, Gordon K, Iida H, Pritzl P, Yoshimura A, Campbell C, Alpers CE, Couser WG (1991) Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Kidney Int 40:477–488

    PubMed  CAS  Google Scholar 

  • Floege J, Johnson RJ, Gordon K, Yoshimura A, Campbell C, lruela-Arispe L, Alpers CE, Couser WG (1992) Altered glomerular extracellular matrix synthesis in experimental membranous nephropathy. Kidney Int 42:573–585

    PubMed  CAS  Google Scholar 

  • Florquin S, Goldman M (1994) T cell subsets in glomerular diseases. Springer Semin Immunopathol 16:71–80

    PubMed  CAS  Google Scholar 

  • Florquin S, Abramowicz D, de Heer E, Bruijn JA, Doutrelepont JM, Goldman M, Hoedemaeker PJ (1991) Renal immunopathology in murine host-versus-graft disease. Kidney Int 40:852–861

    PubMed  CAS  Google Scholar 

  • Florquin S, Amraoui Z, Dubois C, Decuyper J, Goldman M (1994) The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin Binduced shock in mice. J Exp Med 180:1153–1158

    PubMed  CAS  Google Scholar 

  • Fogel MA, Boyd CD, Leardkamolkarn V, Abrahamson DR, Minto A WM, Salant DJ (1991) Glomerular basement membrane expansion in passive Heymann nephritis. Absence of increased synthesis of type IV collagen, laminin, or fibronectin. Am J Pathol 138:465–475

    PubMed  CAS  Google Scholar 

  • Freundlich B, Bomalaski JS, Neilson E, Jimenez SA (1986) Regulation of fibroblast proliferation and collagen synthesis by cytokines. Immunol Today 7:303–307

    CAS  Google Scholar 

  • Fukatsu A, Brentjens JR, Killen PD, Kleinman HK, Martin GR, Andres GA (1987) Studies on the formation of glomerular immune deposits in Brown Norway rats injected with mercuric chloride. Clin Immunol Immunopathol 45:35–47

    PubMed  CAS  Google Scholar 

  • Funabiki K, Horikoshi S, Tomino Y, Nagai Y, Koide H (1990) Immunohistochemical analysis of extracellular components in the glomerular sclerosis of patients with glomerulonephritis. Clin Nephrol 34:239–246

    PubMed  CAS  Google Scholar 

  • Furness PN, Harris K (1994) An evaluation of experimental models of glomerulonephritis. Int J Exp Pathol 75:9–22

    PubMed  CAS  Google Scholar 

  • Germuth FG Jr (1953) A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J Exp Med 97:257–282

    PubMed  Google Scholar 

  • Germuth FG Jr, Rodriguez E (1973) Immunopathology of the renal glomerulus. Little Brown, Boston

    Google Scholar 

  • Germuth FG Jr, Senterfit LB, Pollack AD (1967a) Immune complex disease: I. Experimental acute and chronic glomerulonephritis. Johns Hopkins Med J 120:225–251

    PubMed  Google Scholar 

  • Germuth FG Jr, Kelemen WA, Pollack AD (1967b) Immune complex disease. II. The role of circulatory dynamics and glomerular filtration in the development of experimental glomerulonephritis. Johns Hopkins Med J 120:252–261

    PubMed  Google Scholar 

  • Gleichmann E, Pals ST, Rolink AG, Radaszkiewics T, Gleichmann H (1984) Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases. Immunol Today 5:324–332

    Google Scholar 

  • Golbus SM, Wilson CB (1979) Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall. Kidney Int 16:148–157

    PubMed  CAS  Google Scholar 

  • Goldman M (1990) Cytokines in the pathophysiology of systemic lupus erythematosus. Autoimmunity 8:173–179

    PubMed  CAS  Google Scholar 

  • Grond J, Weening JJ (1990) Mesangial cell injury glomerulosclerosis and therapeutic intervention. Contrib Nephrol 81:229–239

    PubMed  CAS  Google Scholar 

  • Guery JC, Druet P (1990) A spontaneous hybridoma producing autoanti-idiotypic antibodies that recognize a Vkappa-associated idiotope in mercury-induced autoimmunity. Eur J Immunol 20:1027–1031

    PubMed  CAS  Google Scholar 

  • Guery JC, Hedrich HJ, Mercier P, Reetz IC, Mandet C, Mahieu P, Neilson EG, Druet P (1989) Mapping of a gene for the Mr 48,000 tubular basement membrane antigen in the rat. Immunogenetics 29:350–354

    PubMed  CAS  Google Scholar 

  • Gunnia UB, Amenta PS, Seibold JR, Thomas TJ (1991) Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. Kidney Int 39:882–890

    PubMed  CAS  Google Scholar 

  • Haakenstad AO, Striker GE, Mannik M (1983) Removal of glomerular immune complex deposits by excell antigen in chronic mouse model of immune complex disease. Lab Invest 48:323–331

    PubMed  CAS  Google Scholar 

  • Diaz-Gallo C, Rubin Kelly V (1992) IFN-gamma induces a tubular cell surface molecule which reduces proliferation of aut ore active kidney-infiltrating T-cells. J Am Soc Nephro1 3:582 (abstr)

    Google Scholar 

  • Harmon WE, Grupe WE, Parkman R (1980) Control of autologous immune complex nephritis. I. Suppression of the disease in the presence of T-cell sensitization. J Immunol 124:1034–1038

    PubMed  CAS  Google Scholar 

  • Henry GA, Jarnot BM, Steinhoff MM, Bigazzi PE (1988) Mercury-induced renal autoimmunity in the MAXX rat. Clin Immunol Immunopathol 49:187–203

    PubMed  CAS  Google Scholar 

  • Heymann W, Lund HZ (1951) Nephrotic syndrome in rats. Pediatrics 7:691–706

    PubMed  CAS  Google Scholar 

  • Heymann W, Hackel DB, Harwood S, Wilson SG, Hunter JL (1959) Production of nephrotic syndrome in rats by Freund’s adjuvant and rat kidney suspensions. Proc Soc xp Bioi Med 100:660–664

    CAS  Google Scholar 

  • Heymann W, Hunter JL, Hackel DB (1962a) Experimental auto-immune nephrosis in rats. III. J Immunol 88:135–141

    PubMed  CAS  Google Scholar 

  • Heymann W, Hunter JL, Hackel DB, Cuppage F (1962b) Transfer of experimental auto-immune nephrosis in rats. Proc Soc Exp Bioi Med 111:568–573

    CAS  Google Scholar 

  • Hill GS (1992) Systemic lupus erythematosus and mixed connective tissue disease. In: Heptinstall RH (ed) Pathology of the kidney. Little Brown, Boston, pp 871–950

    Google Scholar 

  • Hines WH, Mann RA, Kelly CJ, Neilson EG (1990) Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigenspecific T cell cytokine. J Immunol 144:75–83

    PubMed  CAS  Google Scholar 

  • Hirose S, Tokushige K, Kinoshita K, Nozawa S, Saito J, Nishimura H, Shirai T (1991) Contribution of the gene linked to the T cell receptor beta chain gene complex of NZW mice to the autoimmunity of (NZB x NZW)FJ mice. Eur J Immunol 21:823–826

    PubMed  CAS  Google Scholar 

  • Hirsch F, Couderc J, Sapin C, Fournie G, Druet P (1982) Polyclonal effect of HgCI2 in the rat, its possible role in an experimental autoimmune disease. Eur J Immunol 12:620–625

    PubMed  CAS  Google Scholar 

  • Hockenbery DM (1992) The bcl-2 oncogene and apoptosis. Semin Immunol 4:413–420

    PubMed  CAS  Google Scholar 

  • Hoedemaeker PJ (1972) Een vorm van experimentele glomerulonefritis in de rat. Ned Tijdschr Geneeskd 116:1802 (abstr)

    Google Scholar 

  • Hoedemaeker PJ, Weening JJ (1989) Relevance of experimental models for human nephropathology. Kidney Int 35:1015–1025

    PubMed  CAS  Google Scholar 

  • Hoedemaeker PJ, Feenstra K, Nijkeuter A, Arends A (1972) Ultrastructural localization of heterologous nephrotoxic antibody in glomerular basement membrane of the rat. Lab Invest 26:610–613

    PubMed  CAS  Google Scholar 

  • Hoedemaeker PJ, Fleuren GJ, Weening JJ (1984) Etiologic factors in immunologically mediated glomerulonephritis. In: Robinson RR (ed) Nephrology. Proceedings of the 9th International Congress on Nephrology (Los Angeles). Springer, Berlin Heidelberg New York

    Google Scholar 

  • Hogendoorn PC, Bruijn JA, van den Broek LJ, de Heer E, Foidart JM, Hoedemaeker PJ, Fleuren GJ (1988) Antibodies to purified renal tubular epithelial antigens contain activity against laminin fibronectin, and type IV collagen. Lab Invest 58:278–286

    PubMed  CAS  Google Scholar 

  • Hogendoorn PC, Ter Braak BPM, Bruijn JA (1991) Experimentallupus nephritis: basement membrane charge alterations. Path Res Pract 187:699 (abstr)

    Google Scholar 

  • Hogendoorn PC, Ter Braak BPM, Smeenk RJT, Bruijn JA (1992) Glomerular basement membrane charge alteration in experimental lupus nephritis is related to antihistone antibody production. J Am Soc Nephrol 3:594 (abstr)

    Google Scholar 

  • Holdsworth SR, Tipping PG (1991) Cell-mediated immunity in glomerulonephritis. In: Pusey CD (ed) Immunology of renal diseases. Kluwer, Dordrecht, pp 62–80

    Google Scholar 

  • Hultman P, Enestrom S (1989) Mercury induced B-cell activation and antinuclear antibodies in mice. J Clin Lab Immunol 28:143–150

    PubMed  CAS  Google Scholar 

  • Hyman LR, Colvin RB, Steinberg AD (1976a) Immunopathogenesis of autoimmune tubulointerstitial nephripathogenesis tubulointerstitial nephritis. I. Demonstration of differential susceptibility in strain KK and strain XIII guinea pigs. J Immunol 116:327–335

    PubMed  CAS  Google Scholar 

  • Hyman LR, Steinberg AD, Colvin RB, Bernard EF (1976b) Immunopathogenesis of autoimmune tubulointerstitial nephritis. II. Role of an immune response gene linked to the major histocompatibility complex. J Immunol 117:1894–1897

    PubMed  CAS  Google Scholar 

  • Icard P, Pelletier L, Val MC, Mandet C, Pasquier R, Michel A, Druet P (1993) Evidence for a role of antilaminin-producing B cell clones that escape tolerance in the pathogenesis of HgCI2-induced membranous nephropathy. Nephrol Dial Transplant 8:122–128

    PubMed  CAS  Google Scholar 

  • Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E (1993) Glomerulosclerosis induced by in vivo transfection of transforming growth factor-p or plateletderived growth factor gene into the rat kidney. J Clin Invest 92:2597–2601

    PubMed  CAS  Google Scholar 

  • Izui S, McConahey PJ, Theofilopoulos AN, Dixon FJ (1979) Assocition of circulating retroviral gp70-antigp70 immune complexes with murine systemic lupus erythematosus. J Exp Med 149:1099–1116

    PubMed  CAS  Google Scholar 

  • Jacob CO, McDevitt HO (1988) Tumour necrosis factoralpha in murine autoimmune “lupus” nephritis. Nature 331:356–358

    PubMed  CAS  Google Scholar 

  • Jacob CO, van der Meide PH, McDevitt HO (1987) In vivo treatment of (NZB x NZW)Fllupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med 166:798–803

    PubMed  CAS  Google Scholar 

  • Kay CF (1940) The mechanism by which experimental nephritis is produced in rabbits injected with nephrotoxic duck serum. J Exp Med 72:559–572

    PubMed  CAS  Google Scholar 

  • Kay CF (1942) The mechanism of a form of glomerulonephritis: nephrotoxic nephritis in rabbits. Am J Med Sci 204:483–490

    Google Scholar 

  • Kelley VE, Winkelstein A. Izui S, Dixon FJ (1981) Prostaglandin El inhibits T-cell proliferation and renal disease in MRL/l mice. Clin Immunol Immunopathol 21:190–213

    PubMed  CAS  Google Scholar 

  • Kerjaschki D (1990) The pathogenesis of membranous glomerulonephritis: from morphology to molecules. Virchows Arch B Cell Pathol 58:253–271

    CAS  Google Scholar 

  • Kerjaschki D (1992) Molecular pathogenesis of membranous nephropathy. Kidney Int 41:1090–1105

    PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79:5557–5561

    PubMed  CAS  Google Scholar 

  • Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157:667–686

    PubMed  CAS  Google Scholar 

  • Kher KK (1983) Tolerance to autologous immune complex nephritis: evidence for suppression of 201C;B201D; cell response. Kidney Int 23:185 (abstr)

    Google Scholar 

  • Kiberd BA (1991) Murine lupus nephritis. A structurefunction study. Lab Invest 65:51–60

    PubMed  CAS  Google Scholar 

  • Kiberd BA (1992) Interleukin-6 in murine lupus nephritis. J Am Soc Nephro1 3:598 (abstr)

    Google Scholar 

  • Killen PD, Long R, DeMeester CA, O’Brien E (1990) Transcriptional regulation of collagen IV genes. Kidney Int 37:220(abstr)

    Google Scholar 

  • Kim Y, Butkowski R, Burke B, Kleppel MM, Crosson J, Katz A, Michael AF (1991) Differential expression of basement membrane collagen in membranous nephropathy. Am J Pathol 139:1381–1388

    PubMed  CAS  Google Scholar 

  • Kirtland HH III, Mohler DN, Horowitz DA (1980) Methyldopa inhibition of suppressor-lymphocyte function. A proposed cause of autoimmune hemolytic anemia. N Engl J Med 302:825–832

    PubMed  CAS  Google Scholar 

  • Kitani A, Hara M, Hirose T, Harigai M, Suzuki K, Kawakami M, Kawaguchi Y, Hidaka T, Kawagoe M, Nakamura H (1992) Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression. Clin Exp Immunol 88:75–83

    PubMed  CAS  Google Scholar 

  • Klassen J, McCluskey RT, Milgrom F (1971) Nonglomerular renal disease produced in rabbits by immunization with homologous kidney. Am J Pathol 63:333–358

    PubMed  CAS  Google Scholar 

  • Kondo Y, Shigematsu H (1972) Cellular aspects of rabbit Masugi nephritis. I. Cell kinetics in recoverable glomerulonephritis. Virchows Arch Cell Patho1 10:40–50

    CAS  Google Scholar 

  • Kuncio GS, Neilson EG, Haverty T (1991) Mechanisms of tubulointerstitial fibrosis. Kidney Int 39:550–556

    PubMed  CAS  Google Scholar 

  • Lehman DH, Marquardt H, Wilson CB, Dixon FJ (1974a) Specificity of autoantibodies to tubular and glomerular basement membranes induced in guinea pigs. J Immunol 112:241–248

    PubMed  CAS  Google Scholar 

  • Lehman DH, Wilson CB, Dixon FJ (1974b) Interstitial nephritis in rats immunized with heterologous tubular basement membrane. Kidney Int 5:187–195

    PubMed  CAS  Google Scholar 

  • Lewis RM, Armstrong MY, Andre-Schwartz J, Muftuoglu A, Beldotti L, Schwartz RS (1968) Chronic allogenic disease. I. Development of glomerulonephritis. J Exp Med 128:653–679

    PubMed  CAS  Google Scholar 

  • Linker-Israeli M (1992) Cytokine abnormalities in human lupus. Clin Immunol Immunopathol 63:10–12

    PubMed  CAS  Google Scholar 

  • Litwin A, Bash JA, Adams LE, Donovan RJ, Hess EV (1979) Immunoregulation of Heymann’s nephritis. I. Induction of suppressor cells. J Immunol 122:1029–1034

    PubMed  CAS  Google Scholar 

  • Lockwood CM, Mason DW, Bowman C (1983) Suppressor cell function in mercuric chloride-induced autoimmune nephritis in the Brown-Norway rat. Kidney Int 24:406(abstr)

    Google Scholar 

  • Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, Couser WG (1992) Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Am J Pathol 141:85–98

    PubMed  CAS  Google Scholar 

  • Mannik M, Striker GE (1980) Removal of glomerular deposits of immune complexes in mice by administration of excell antigen. Lab Invest 42:483--489

    PubMed  CAS  Google Scholar 

  • Masugi M (1933) Ober das Wesen der spezifischen Veranderungen der Niere und der Leber durch das Nephrotoxin bzw. das Hepatotoxin. Beitr Pathol Anat Allg Pathol 91:82–112

    Google Scholar 

  • Masugi M, Sato Y (1934) Ober die allergische Gewebsreaktion der Niere. Zugleich ein experimenteller Beitrag zur Pathogenese der diffusen Glomerulonephritis und der Periarteritis Nodosa. Virchows Arch Pathol Anat 293:615–664

    Google Scholar 

  • Mathieson PW, Stapleton KJ, Oliveira DB, Lockwood CM (1991) Immunoregulation of mercuric chloride-induced autoimmunity in Brown Norway rats: a role for CD8+ T cells revealed by in vivo depletion studies. Eur J Immunol 21:2105–2109

    PubMed  CAS  Google Scholar 

  • Mathieson PW, Thiru S, Oliveira DBG (1992) Mercuric chloride-treated Brown Norway rats develop widespread tissue injury including necrotizing vasculitis. Lab Invest 67:121–129

    PubMed  CAS  Google Scholar 

  • Matsumoto K (1990) Production of interleukin-1 by glomerular macrophages in nephrotoxic serum nephritis. Am J Nephrol 10:502–506

    PubMed  CAS  Google Scholar 

  • Mauer SM, Sutherland DER, Howard RJ, Fish AJ, Najarian JS, Michael AF (1973) The glomerular mesangium. III. Acute immune mesangial injury: a new model of glomerulonephritis. J Exp Med 137:553–570

    PubMed  CAS  Google Scholar 

  • Mendrick DL, Noble B, Brentjens JR, Andres GA (1980) Antibody mediated injury to proximal tubules in Heymann nephritis. Kidney Int 18:328–343

    PubMed  CAS  Google Scholar 

  • Mendrick DL, Rennke HG, Cotran RS, Springer TA, Abbas AK (1983) Methods in laboratory investigation. Monoclonal antibodies against rat glomerular antigens: production and specificity. Lab Invest 49:107–117

    PubMed  CAS  Google Scholar 

  • Merritt SE, Killen PD, Phan SH, Wiggins RC (1990) Analysis of α1 (I) procollagen β-1 (IV) collagen, and ~actin mRNA in glomerulus and cortex of rabbits with experimental anti-glomerular basement membrane disease. Evidence for early extraglomerular collagen biosynthesis. Lab Invest 63:762–769

    PubMed  CAS  Google Scholar 

  • Miettinen A, Tömroth T, Tikannen I, Virtanen I, Linder E (1980) Heymann nephritis induced by kidney brush border glycoproteins. Lab Invest 43:547–555

    PubMed  CAS  Google Scholar 

  • Mirtcheva J, Pfeiffer C, Bruijn JA, Jacquesmart F, Gleichmann E (1989) Immunological alterations inducible by mercury compounds. III. H- 2A acts as an immune response and H-2E as an immune suppression locus for HgC12-induced antinucleolar autoantibodies. Eur J Immunol 19:2257–2261

    PubMed  CAS  Google Scholar 

  • Molina A, Sanchez-Madrid F, Bricio T, Martin A, Barat A, Alvarez V, Mampaso F (1994) Prevention of mercuric chloride-induced nephritis in the Brown Norway rat by treatment with antibodies against the a4 integrin. J Immunol 153:2313–2320

    PubMed  CAS  Google Scholar 

  • Morita H, Maeda K, Obayashi M, Shinzato T, Nakayama A, Fujita Y, Takai I, Kobayakawa H, Inoue I, Sugiyama S, Asai J, Nakashima I, Isobe KI (1992) Induction of irreversible glomerulosclerosis in the rat by repeated injections of a monoclonal anti-Thy-1.1 antibody. Nephron 60:92–99

    PubMed  CAS  Google Scholar 

  • Mountz JD, Edwards CK 3rd (1992) Murine models of autoimmunity: T-cell and B-cell defects. Curr Opin Rheumatol 4:612–620

    PubMed  CAS  Google Scholar 

  • Munaut C, Bergijk EC, Baelde 11, Noäl A, Foidart 1M, Bruijn lA (1992) A molecular biologic study of extracellular matrix components during the development of glomerulosclerosis in murine chronic graftversus-host disease. Lab Invest 67:580–587

    CAS  Google Scholar 

  • Nakamura T, Ebihara I, Shirato I, Tomino Y, Koide H (1991) Increased steady-state levels of mRNA coding for extracellular matrix components in kidneys of NZB/W Fl mice. Am 1 Pathol 139:437–450

    CAS  Google Scholar 

  • Nakamura T, Miller D, Ruoslahti E, Border WA (1992) Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-β1 Kidney Int 41:1213–1221

    CAS  Google Scholar 

  • Natori Y, Shindo N, Natori Y (1994) Proteinuria induced by anti-dipeptidyl peptidase IV (gpI08): role of circulating and glomerular antigen. Clin Exp Immunol 95:327–332

    PubMed  CAS  Google Scholar 

  • Neilson EG (1989) Pathogenesis and therapy of interstitial nephritis. Kidney Int 35:1257–1270

    PubMed  CAS  Google Scholar 

  • Noble B, Olson KA, Milgrom M, Albini B (1980) Tissue deposition of immune complexes in mice receiving daily injections of bovine serum albumin. Clin Exp Immunol 42:255–262

    PubMed  CAS  Google Scholar 

  • Oite T, Batsford SR, Mihatsch Ml, Takamiya H, Vogt A (1982) Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted cationized antigen. J Exp Med 155:460–474

    PubMed  CAS  Google Scholar 

  • O’Meara YM, Natori Y, Minto A W, Goldstein DJ, Manning EC, Salant Dl (1992) Nephrotoxic antiserum identifies a β1-integrin on rat glomerular epithelial cells. Am J Physiol 262:F1083-F1091

    PubMed  Google Scholar 

  • Okuda S, Languino LR, Ruoslahti E, Border WA (1990) Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest 86:453–462

    PubMed  CAS  Google Scholar 

  • Okuda S, Nakamura T, Yamamoto T, Ruoslahti E, Border W A (1991) Dietary protein restriction rapidly reduces transforming growth factor-β1 expression in experimental glomerulonephritis. Proc Nat! Acad Sci USA 88:9765–9769

    CAS  Google Scholar 

  • Orlando RA, Kerjaschki D, Kurihara H, Biemesderfer D, Farquhar MG (1992) gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc Nat! Acad Sci USA 89:6698–6702

    Google Scholar 

  • Paul LC, Rennke HG, Milford EL, Carpenter CB (1984) Thy-l.1 in glomeruli of rat kidneys. Kidney Int 25:771–777

    PubMed  CAS  Google Scholar 

  • Pelletier L, Galceran M, Pasquier R, Ronco P, Verroust P, Bariety J, Druet P (1987a) Down modulation of Heymann’s nephritis by mercuric chloride. Kidney Int 32:227–232

    PubMed  CAS  Google Scholar 

  • Pelletier L, Pasquier R, Rossert J, Druet P (1987b) HgC12 induces nonspecific immunosuppression in Lewis rats. Eur J Immunol 17:49–54

    PubMed  CAS  Google Scholar 

  • Peterson OW, Gushwa LC, Wilson CB, Blantz RC (1989) Tubuloglomerular feedback activity after glomerular immune injury. Am J Physiol 257:F67-F71

    PubMed  CAS  Google Scholar 

  • Polak L, Barnes J, Turk JL (1968) The genetic control of contact sensitization to inorganic metal compounds in guinea-pigs. Immunology 14:707–711

    PubMed  CAS  Google Scholar 

  • Prouvost-Danon A, Abadie A, Sapin C, Basin H, Druet P (1981) Induction of IgE synthesis and potentiation of anti-ovalbumin IgE antibody response by HgCl2 in the rat. J Immunol 126:699–702

    PubMed  CAS  Google Scholar 

  • Quiza CG, Leenaerts PL, Hall BM (1991) Induction of unresponsiveness to Heymann’s nephritis: inhibited by monoclonal antibody to CD4 but not to CD8. Cell Immunol 133:456–467

    PubMed  CAS  Google Scholar 

  • Rennke HG, Klein PS, Sandstrom DJ, Mendrick DL (1994) Cell-mediated immune injury in the kidney: acute nephritis induced in the rat by azobenzenearsonate. Kidney Int 45:1044–1056

    PubMed  CAS  Google Scholar 

  • Rolink AG, Gleichmann H, Gleichmann E (1983) Diseases caused by reactions ofT lymphocytes to incompatible structures of the major histocompatibility complex. VII. Immune-complex glomerulonephritis. J Immunol 130:209–215

    PubMed  CAS  Google Scholar 

  • Rothbard S, Watson RF (1969) Comparison of reactions of antibodies to rat collagen and to rat kidney in the basement membranes of rat renal glomeruli. J Exp Med 129:1145–1161

    PubMed  CAS  Google Scholar 

  • Roubinian JR, Papoian R, Talal N (1977) Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW Fl mice. J Immunol 118:1524–1529

    PubMed  CAS  Google Scholar 

  • Saito A, Pietromonaco SAK, Farquhar M (1994) Complete cloning and sequencing of rat gp330/megalin, a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 91:9725–9729

    CAS  Google Scholar 

  • Sal ant DJ, Belok S, Madaio MP, Couser WG (1980) A new role for complement in experimental membranous nephropathy in rats. J Clin Invest 66:1339–1350

    PubMed  CAS  Google Scholar 

  • Sanchez-Crespo M, Alonso F, Barat A, Egido J (1982) Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. Clin Exp Immunol 49:631–638

    PubMed  CAS  Google Scholar 

  • Sapin C, Druet E, Druet P (1977) Induction of antiglomerular basement membrane antibodies in the Brown Norway rat by mercuric chloride. Clin Exp Immunol 49:631–638

    Google Scholar 

  • Sapin C, Druet P, Mandet C (1980) Induction of susceptibility to HgCl2 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible Fl hybrids. Eur J Immunol l0:371–374

    Google Scholar 

  • Schmiedeke TM, Stockl FW, Weber R, Sugisaki Y, Batsford SR, Vogt A (1989) Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J Exp Med 169:1879–1894

    PubMed  CAS  Google Scholar 

  • Schneeberger EE, Grupe WE (1976) The ultrastructure of the glomerular slit diaphragm in autologous immune complex nephritis. Lab Invest 34:298–305

    PubMed  CAS  Google Scholar 

  • Schrijver G, Assmann KJ, Bogman MJ, Robben HC, de Waal RM, Koene RA (1988) Antiglomerular basement membrane nephritis in the mouse. Study on the role of complement in the heterologous phase. Lab Invest 59:484–491

    PubMed  CAS  Google Scholar 

  • Schrijver G, Schalkwijk J, Robben JC, Assmann KJ, Koene RA (1989) Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase. J Exp Med 169:1435–1448

    PubMed  CAS  Google Scholar 

  • Schrijver G, Bogman MJ, Assmann KJ, de Waal RM, Robben HC, Van Gasteren H, Koene RA (1990) AntiGBM nephritis in the mouse: role of granulocytes in the heterologous phase. Kidney Int 38:86–95

    PubMed  CAS  Google Scholar 

  • Senterfit LB, Germuth FG Jr (1969) Significance of mesangial localization of immune complexes in rabbits developing arteritis in the absence of glomerulonephritis (GLN). Fed Proc 28:421 (abstr)

    Google Scholar 

  • Shibata S, Nagasawa T, Naruse T, Miyakawa Y (1967) Glomerulonephritis induced in rats by antiserum against a glycoprotein rat kidney - a new experimental model of glomerulonephritis. Jpn J Exp Med 37:337–353

    PubMed  CAS  Google Scholar 

  • Shibata S, Miyakawa Y, Naruse T, Nagasawa T, Takuma T (1969) A glycoprotein that induces nephrotoxic antibody: its isolation and purification from rat glomerular basement membrane. J Immunol 102:593–601

    PubMed  CAS  Google Scholar 

  • Shibata S, Nagasawa T, Miyakawa Y, Naruse T (1971) Nephritogenic glycoprotein: 1. Proliferative glomerulonephritis induced in rats by a single injection of the soluble glycoprotein isolated from homologous glomerular basement membrane. J Immunol 106:1284–1294

    PubMed  CAS  Google Scholar 

  • Shigematsu H (1970) Glomerular events during the initial phase of rat Masugi nephritis. Virchows Arch Cell pathol 5:187–200

    CAS  Google Scholar 

  • Shimizu Y, van Seventer GA, Horgan KJ, Shaw S (1990) Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol 145:59–67

    PubMed  CAS  Google Scholar 

  • Singh AK (1992) IL-4 causes up-regulation of an autoreactive VH gene that frequently encodes for antiDNA antibodies in lupus mice. J Am Soc Nephrol 3:615(abstr)

    Google Scholar 

  • Slikkerveer A (1992) Bismuth: biokinetics, toxicity and experimental therapy of overdosage. Pasmans, The Hague

    Google Scholar 

  • Slikkerveer A, Schroijen VJ, de Wolff FA, Bruijn JA (1992) Reversible nephrotoxicity after overdosage with colloidal bismuth subcitrate. J Am Soc Nephrol 3:729(abstr)

    Google Scholar 

  • Stebley RW (1962) Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund’s complete adjuvant. J Exp Med 116:253–272

    Google Scholar 

  • Stebley RW (1963) Glomerulonephritis induced in monkeys by injections of heterologous glomerular basement membrane and Freund’s adjuvant. Nature 197:1173–1176

    Google Scholar 

  • Stebley RW (1967) Studies on autoimmune nephritis in sheep and rats. IV. The relative efficacy of heterologous, homologous and autologous glomerular basement membrane (GBM) in inducing nephritis. Fed Proc 26:531 (abstr)

    Google Scholar 

  • Stebley RW, Rudofsky U (1966) Studies on autoimmune nephritis in rats. I. Nephritis induced in rats by injections of human glomerular basement membrane (HGBM) and Freund’s adjuvant (FA). Clin Res 14:449 (abstr)

    Google Scholar 

  • Stebley RW, Rudofsky U (1971) Renal tubular disease and autoantibodies against tubular basement membrane induced in guinea pigs. J Immunol 107:589–594

    Google Scholar 

  • Steinberg AD, Huston DP, Taurog JD, Cowdery JS, Raveché ES (1981) The cellular and genetic basis of murine lupus. Immunol Rev 55:121–154

    PubMed  CAS  Google Scholar 

  • Sugisaki T, Yoshida T, McCluskey RT, Andres GA, Klassen J (1980) Autoimmune cell-mediated tubulointerstitial nephritis induced in Lewis rats by renal antigens. Clin Immunol Immunopathol 15:33–43

    PubMed  CAS  Google Scholar 

  • Susani M, Schulze M, Exner M, Kerjaschki D (1994) Antibodies to glycolipids activate complement and promote proteinuria in passive Heymann nephritis. Am J Pathol 144:807–819

    PubMed  CAS  Google Scholar 

  • Suzuki M, Hatakeyama A, Kameoka J, Tamate E, Yusa A, Kurosawa K, Saito T, Sasaki T, Yoshinaga K (1991) Anti-DNA idiotypes deposited in renal glomeruli of patients with lupus nephritis. Am J Kidney Dis 18:232–239

    PubMed  CAS  Google Scholar 

  • Takahashi S, Nose M, Sasaki J, Yamamoto T, Kyogoku M (1991) IgG3 production in MRL/1pr mice is responsible for development of lupus nephritis. J Immunol 147:515–519

    PubMed  CAS  Google Scholar 

  • Termaat RM, Brinkman K, Nossent JC, Swaak AJ, Smeenk RJT, Berden JHM (1990) Anti-heparan sulphate reactivity in sera from patients with systemic lupus erythematosus with renal or non-renal manifestations. Clin Exp Immunol 82:268–274

    PubMed  CAS  Google Scholar 

  • Theofilopoulos AN, Dixon FJ (1980) Immune complexes in human diseases. A review. Am J Pathol 100:529–594

    PubMed  CAS  Google Scholar 

  • Tipping PG, Holdsworth SR (1986) The participation of macrophages glomerular procoagulant activity and factor VIII in glomerular fibrin deposition. Studies on antiGBM antibody-induced glomerulonephritis in rabbits. Am J Patho1 124:10–17

    CAS  Google Scholar 

  • Tipping PG, Lowe MG, Holdsworth SR (1988) Glomerular macrophages express augmented procoagulant activity in experimental fibrin-related glomerulonephritis in rabbits. J Clin Invest 82:1253–1259

    PubMed  CAS  Google Scholar 

  • Tipping PG, Leong TW, Holdsworth SR (1991a) Tumor necrosis factor production by glomerular macrophages in anti-glomerular basement membrane glomerulonephritis in rabbits. Lab Invest 65:272–279

    PubMed  CAS  Google Scholar 

  • Tipping PG, Lowe MG, Holdsworth SR (1991b) Glomerular interleukin 1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis. Kidney Int 39:103–110

    PubMed  CAS  Google Scholar 

  • Treurniet RA, Bergijk EC, Baelde JJ, de Heer E, Bruijn JA (1992) Sex difference in the development of chronic graft versus host disease-induced experimental lupus nephritis. J Am Soc Nephrol 3:619 (abstr)

    Google Scholar 

  • Treurniet RA, Bergijk EC, Baelde JJ, de Heer E, Hoedemaeker PJ, Bruijn JA (1993) Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis. Clin Exp Immunol 91:442–448

    PubMed  CAS  Google Scholar 

  • Umland SP, Razac S, Nahrebne DK, Seymour BW (1992) Effects of in vivo administration of interferon (IFN)- gamma, anti-IFN-gamma, or anti-interleukin-4 monoclonal antibodies in chronic autoimmune graftversus-host disease. Clin Immunol Immunopathol 63:66–73

    PubMed  CAS  Google Scholar 

  • Unanue ER, Dixon FJ, Feldman JD (1967) Experimental allergic glomerulonephritis induced in the rabbit with homologous renal antigens. J Exp Med 125:163–176

    PubMed  CAS  Google Scholar 

  • van Dam AP, Meilof JF, van den Brink HG, Smeenk RJ (1990) Fine specificities of anti-nuclear antibodies in murine models of graft-versus-host disease. Clin Exp Immunol 81:31–38

    PubMed  Google Scholar 

  • van Damme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest 38:502–510

    PubMed  Google Scholar 

  • van den Broek MF, de Heer E, van Bruggen MC, de Roo G, Kleiverda K, Eulderink F, van den Berg WB (1993) Immunomodulation of streptococcal cell wall-induced arthritis. Identification of inflammatory cells and regulatory T cell subsets by mercuric chloride and in vivo CD8 depletion. Eur J Immunol 22:3091–3095

    Google Scholar 

  • van der Meide PH, de Labie MC, Botman CA, van Bennekom WP, Olsson T, Aten J, Weening JJ (1993) Mercuric chloride down-regulates T cell interferongamma production in Brown Norway but not in Lewis rats: role of glutathione. Eur J Immunol 23:675–681

    PubMed  Google Scholar 

  • van Leer EH, de Roo GM, Bruijn JA, Hoedemaeker PJ, de Heer E (1993) Synergistic effects of anti-gp330 and antidipeptidyl peptidase type IV antibodies in the induction of glomerular damage. Exp Nephrol 1:292–300

    PubMed  Google Scholar 

  • van Rappard-van der Veen FM, Rolink AG, Gleichmann E (1982) Diseases caused by reactions of T lymphocytes towards incompatible structures of the major histocompatibility complex. VI. Autoantibodies characteristic of systemic lupus erythematosus induced by abnormal T-B cell cooperation across I-E. J Exp Med 155:1555–1560

    Google Scholar 

  • van Velthuysen M (1994) African Trypanosomiasis in mice. A model of glomerular disease. Pasmans, The Hague

    Google Scholar 

  • van Velthuysen M, Bruijn JA, van Leer EH, Fleuren GJ (1992) Pathogenesis of Trypanosomiasis-induced glomerulonephritis in mice. Nephrol Dial Transplant 7:507–515

    PubMed  Google Scholar 

  • van Velthuysen M, Veninga A, Bruijn JA, de Heer E, Fleuren GJ (1993) Susceptibility for infection-related glomerulopathy depends on non-MHC genes. Kidney Int 43:623–629

    PubMed  Google Scholar 

  • van Velthuysen M, Mayen AE, van Rooijen N, Fleuren GJ, de Heer E, Bruijn JA (1994a) T-cells and macrophages in Trypanosoma brucei-related glomerulopathy. Infect Imm 62:3230–3235

    Google Scholar 

  • van Velthuysen M, Mayen AE, Prins FA, de Heer E, Bruijn JA, Fleuren GJ (1994b) Phagocytosis by glomerular endothelial cells in infection-related glomerulopathy. Nephrol Dial Transplant 9:1077–1083

    PubMed  Google Scholar 

  • van Zwieten MJ, Leber PD, Bhan AK, McCluskey RT (1977) Experimental cell-mediated interstitial nephritis induced with exogenous antigens. J Immunol 118:589–593

    PubMed  Google Scholar 

  • Vissers MC, Fantone JC, Wiggins R, Kunkel SL (1989) Glomerular basement membrane-containing immune complexes stimulate tumor necrosis factor and interleukin-1 production by human monocytes. Am J Pathol 134:1–6

    PubMed  CAS  Google Scholar 

  • Vlahakos D, Foster MH, Ucci AA, Barrett KJ, Datta SK, Madaio MP (1992a) Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. J Am Soc Nephrol 2:1345–1354

    PubMed  CAS  Google Scholar 

  • Vlahakos DV, Foster MH, Adams S, Katz M, Ucci AA, Barrett KJ, Datta SK, Madaio MP (1992b) Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int 41:1690–1700

    PubMed  CAS  Google Scholar 

  • Vogt A, Batsford SR (1983) Interaction of cationic antigens with GBM: pathogenic implications. In: Lambert PP, Bergmann P, Beauwens R (eds) The pathogenicity of cationic proteins. Raven, New York, pp 102–111

    Google Scholar 

  • Vogt A, Bockhorn H, Kozima K, Sasaki M (1968) Electron microscopic localization of the nephrotoxic antibody in the glomeruli of the rat after intravenous application of purified nephritogenic antibody-ferritin conjugates. J Exp Med 127:867–878

    PubMed  CAS  Google Scholar 

  • Vogt A, Schmidt HU, Takamiya H, Batsford S (1980) In situ immune complex nephritis and basic proteins. Proc Eur Dial Transplant Assoc 17:613–620

    PubMed  CAS  Google Scholar 

  • Wardle EN (1991) Cell biology and glomerulonephritis. Nephron 59:529–532

    PubMed  CAS  Google Scholar 

  • Weening JJ (1984) Autoimmune reactions and glomerulonephritis caused by heavy metals and other toxins. In: Hayes AW, Schnell RC, Miya TS (eds) Developments in the science and practice of toxicology. Elsevier, New York, pp 211–218

    Google Scholar 

  • Weening JJ, Fleuren GJ, Hoedemaeker PJ (1978) Demonstration of antinuclear antibodies in mercuric chlorideinduced glomerulopathy in the rat. Lab Invest 39:405–411

    PubMed  CAS  Google Scholar 

  • Weening JJ, Grond J, van der Top D, Hoedemaeker PJ (1980) Identification of the nuclear antigen involved in mercury-induced glomerulopathy in the rat. Invest Cell Pathol 3:129–134

    PubMed  CAS  Google Scholar 

  • Weening JJ, Hoedemaeker PJ, Bakker WW (1981) Immunoregulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat. Clin Exp Immunol 45:64–71

    PubMed  CAS  Google Scholar 

  • Wilson CB, Dixon FJ (1970) Antigen quantitation in experimental immune complex glomerulonephritis. I. Acute serum sickness. J Immunol 105:279–290

    PubMed  CAS  Google Scholar 

  • Wilson CB, Gushwa LC, Peterson OW, Tucker BJ, Blantz RC (1981) Glomerular immune injury in the rat: effect of antagonists of histamine activity. Kidney Int 20:628–635

    PubMed  CAS  Google Scholar 

  • Wolf G, Neilson EG (1991) Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia. Kidney Int 39:401–420

    PubMed  CAS  Google Scholar 

  • Wolf G, Neilson EG (1992) Increases in levels of collagen types I and IV messenger ribonucleic acid in murine kidneys after treatment with cyclosporin. Nephron 60:87–91

    PubMed  CAS  Google Scholar 

  • Yanase K, Cizman B, Foster MH, Smith RM, Peachey LD, Jarett L, Madaio MP (1992) Ultrastructural localization of anti-DNA antibody (Ab) transport into the nuclei of cultured mesangial cells. J Am Soc Nephro1 3:623 (abstr)

    Google Scholar 

  • Yap HK, Lee BW, Ng SC, Seah CC, Wong SC, Jordan SC (1992) Endothelial cell activation by sera from patients with systemic lupus erythematosus. J Am Soc Nephrol 3:668 (abstr)

    Google Scholar 

  • Yokoyama H, Takabatake T, Takaeda M, Wad a T, Naito T, Ikeda K, Goshima S, Takasawa K, Tomosugi N, Kobayashi K, Kida H (1992) Up-regulated MHC-class II expression and gamma-IFN and soluble IL-2R in lupus nephritis. Kidney Int 42:755–763

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. Jan A. Bruijn
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Emile de Heer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Philip J. Hoedemaeker
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Harvard Medical School, ILSI Research Foundation, 1126 Sixteenth Street,N.W., Washington, DC, 20036, USA

    Thomas Carlyle Jones D.V.M., D.Sc. (Professor of Comparative Pathology Emeritus) (Professor of Comparative Pathology Emeritus)

  2. American Health Foundation, One Dana Drive, Valhalla, NY, USA

    Gordon C. Hard BVSc., Ph.D., DSc., FRCPath., FRCVS, FAToxSci. (Director of Administration and Senior Toxicologist) (Director of Administration and Senior Toxicologist)

  3. Medizinische Hochschule Hannover, Institut für Experimentelle Pathologie, Konstanty-Gutschow-Strasse 8, 30625, Hannover, Germany

    Ulrich Mohr M.D. (Professor of Experimental Pathology) (Professor of Experimental Pathology)

Rights and permissions

Reprints and permissions

Copyright information

© 1986 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Bruijn, J.A., de Heer, E., Hoedemaeker, P.J. (1986). Immune Mechanisms in Injury to Glomeruli and Tubulointerstitial Tissue. In: Jones, T.C., Hard, G.C., Mohr, U. (eds) Urinary System. Monographs on Pathology of Laboratory Animals. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80335-2_15

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80335-2_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80337-6

  • Online ISBN: 978-3-642-80335-2

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation