Advertisement

Urinary System pp 199-224 | Cite as

Immune Mechanisms in Injury to Glomeruli and Tubulointerstitial Tissue

  • Jan A. Bruijn
  • Emile de Heer
  • Philip J. Hoedemaeker
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)

Abstract

At the beginning of this century, the idea took shape that human glomerular diseases are caused by immunologic mechanisms. Since that time, many attempts have been made to induce glomerular diseases and elucidate the pathogenetic mechanisms involved. The study of these experimental models has given an insight into the pathophysiology and underlying immunological mechanisms of renal disease and glomerular disease in particular (Furness and Harris 1994).

Keywords

Lupus Nephritis Glomerular Basement Membrane Immune Complex Glomerulonephritis Heymann Nephritis Masugi Nephritis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Adams S, Leblanc P, Datta SK (1991) Junctional region sequences of T-cell receptor beta-chain genes expressed by pathogenic anti-DNA autoantibody-inducing helper T cells from lupus mice: possible selection by cationic autoantigens. Proc Natl Acad Sci USA 88:11271–11275Google Scholar
  2. Adler S (1992) Integrin receptors in the glomerulus. Potential role in glomerular injury. Am J Physiol 262:F697-F704PubMedGoogle Scholar
  3. Adler S, Chen X (1992) Anti-FxlA antibody recognizes a β1-integrin on glomerular epithelial cells and inhibits adhesion and growth. Am J Physiol 262:F770-F776PubMedGoogle Scholar
  4. Allison MEM, Wilson C, Gottschalk CW (1974) Pathophysiology of experimental glomerulonephritis in rats. J Clin Invest 53:1402–1423PubMedGoogle Scholar
  5. Alvarez RJ, Sun MJ, Haverty TP, Iozzo RV, Myers JC, Neilson EG (1992) Biosynthetic and proliferative characteristics of tubulointerstitial fibroblasts probed with paracrine cytokines. Kidney Int 41:14–23PubMedGoogle Scholar
  6. Andres GA, McCluskey RT (1975) Tubular and interstitial renal disease due to immunologic mechanisms. Kidney Int 7:271–289PubMedGoogle Scholar
  7. Andres GA, Morgan C, Hsu KC, Rifkind, RA, Seegal BC (1962) Electron microscopic studies of experimental nephritis with ferritin-conjugated antibody. The basement membranes and cisternae of visceral epithelial cells in nephritic rat glomeruli. J Exp Med 115:929–936PubMedGoogle Scholar
  8. Aoki I, Aoki A, Otani M, Miyagi Y, Misugi K, Ishii N, Hagiwara E, Tani K, Okubo T, Ishigatsubo Y (1992) A correlation between IgG class antibody production and glomerulonephritis in the murine chronic graft-versushost reaction. Clin Immunol Immunopathol 63:34–38PubMedGoogle Scholar
  9. Arhelger RB, Gronvall JA, Carr OB Jr, Brunson JG (1963) Electron microscopic localizations of nephrotoxic serum in rabbit glomeruli with ferritin-conjugated antibody. Lab Invest 12:33–37PubMedGoogle Scholar
  10. Arisz L, Noble B, Milgrom M, Brentjens JR, Andres GA (1979) Experimental chronic serum sickness in rats. A model of immune complex glomerulonephritis and systemic immune complex deposition. Int Arch Allergy Appl Immunol 60:80–88PubMedGoogle Scholar
  11. Aten J, Bruijn JA, Veninga A, de Heer E, Weening JJ (1988a) Anti-laminin autoantibodies and mercuryinduced glomerulopathy. Kidney Int 33:309–309 (abstr)Google Scholar
  12. Aten J, Bruijn JA, Veninga A, de Heer E, Weening JJ (1988b) Anti-laminin autoantibodies and mercuryinduced membranous glomerulopathy in the DZB rat. Kidney Int 34:556–556 (abstr)Google Scholar
  13. Aten J, Bosman CB, de Heer E, Hoedemaeker PJ, Weening JJ (1988c) Cyclosporin A induces long-term unresponsiveness in mercuric chloride-induced autoimmune glomerulonephritis. Clin Exp Immunol 73:307–311PubMedGoogle Scholar
  14. Aten J, Veninga A, de Heer E, Hoedemaeker PJ, Nieuwenhuis P, Rozing J, Weening JJ (1991) Susceptibility to the induction of either autoimmunity or immunosuppression by mercuric chloride is related to the major histocompatibility complex class II haplotype. Eur J Immunol 21:611–616PubMedGoogle Scholar
  15. Aten J, Stet RJ, Wagenaar-Hilbers JP, Weening JJ, Fleuren GJ, Nieuwenhuis P (1992a) Glomerulopathy induced by graft-versus-host reaction in the rat. Requirement of donor CD4+ T lymphocytes and MHC class II incompatibility at the lymphoid compartment. Scand J Immunol 35:93–105PubMedGoogle Scholar
  16. Aten J, Veninga A, Bruijn JA, Prins FA, de Heer E, Weening JJ (1992b) Antigenic specificities of glomerular-bound autoantibodies in membranous glomerulopathy induced by mercuric chloride. Clin Immunol Immunopathol 63:89–102PubMedGoogle Scholar
  17. Baelde HJ, Bergijk EC, Bruijn JA (1990) Isolation and characterization of mouse glomerular basement membrane. J Clin Lab Immunol 33:17–20PubMedGoogle Scholar
  18. Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW (1986a) Glomerulonephritis induced by monoclonal anti-Thy-l.l antibodies. A sequential histological and ultrastructural study in the rat. Lab Invest 55:680–687PubMedGoogle Scholar
  19. Bagchus WM, Hoedemaeker PJ, Rozing J, Bakker WW (1986b) Acute glomerulonephritis after intravenous injection of monoclonal anti-thymocyte antibodies in the rat. Immunol Lett 12:109–113PubMedGoogle Scholar
  20. Bagchus WM, Jeunink MF, Elema JD (1990) The mesangium in anti-Thy-l nephritis. Influx of macrophages, mesangial cell hypercellularity, and macromolecular accumulation. Am J Pathol 137:215–223PubMedGoogle Scholar
  21. Barabas AZ, Lannigan R (1974) Induction of an autologous immune complex glomerulonephritis in the rat by intravenous injection of heterologous anti-rat kidney tubular antibody. II. Early glomerular lesions. Br J Exp Pathol 55:282–290PubMedGoogle Scholar
  22. Bariety J, Druet P, Laliberte F, Sapin C (1971) Glomerulonephritis with y and βIC-globulin deposits induced in rats by mercuric chloride. Am J Pathol 65:293–302PubMedGoogle Scholar
  23. Bergijk EC, Munaut C, Baelde JJ, Prins F, Foidart JM, Hoedemaeker PJ, Bruijn JA (1992) A histologic study of the extracellular matrix during the development of glomerulosclerosis in murine chronic graft-versus-host disease. Am J Pathol 140:1147–1156PubMedGoogle Scholar
  24. Bloom RD, Florquin S, Singer GG, Brennan DC, Rubin Kelley V (1992) Pivotal role for colony stimulating factor 1 (CSF-1) in the induction of lupus nephritis. J Am Soc Nephro1 3:576 (abstr)Google Scholar
  25. Bolton WK, Sturgill BC (1978) Bovine serum albumin chronic serum sickness nephropathy in rats. Br J Exp Pathol 59:167–177PubMedGoogle Scholar
  26. Bolton WK, Tucker FL, Sturgill BC (1984) New avian model of experimental glomerulonephritis consistent with mediation by cellular immunity. Nonhumorally mediated glomerulonephritis in chickens. J Clin Invest 73:1263–1276PubMedGoogle Scholar
  27. Border WA, Ruoslahti E (1990) Transforming growth factor-β1 induces extracellular matrix formation in glomerulonephritis. Cell Differ Dev 32:425–431PubMedGoogle Scholar
  28. Border W A, Ruoslahti E (1992) Transforming growth factor-~ in disease: the dark side of tissue repair. J Clin Invest 90:1–7PubMedGoogle Scholar
  29. Border WA, Adler SG, Wang H, Kamil ES, Ward HJ, Cohen H (1983) The pathologic and therapeutic implications of electrical charge in immune complex glomerulonephritis. In: Lambert PP, Bergmann P, Beauwens R (eds) The pathogenicity of cationic proteins. Raven, New York, pp 394–396Google Scholar
  30. Border WA, Okuda S, Nakamura T (1989) Extracellular matrix and glomerular disease. Semin Nephrol 9:307–317PubMedGoogle Scholar
  31. Border W A, Okuda S, Languino LR, Ruoslahti E (1990a) Transforming growth factor-beta regulates production of proteoglycans by mesangial cells. Kidney Int 37:689–695PubMedGoogle Scholar
  32. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E (1990b) Suppression of experimental glomerulonephritis by antiserum against transforming growth factor ~1. Nature 346:371–374PubMedGoogle Scholar
  33. Border WA, Noble NA, Yamamoto T, Tomooka S, Kagami S (1992) Antagonists of transforming growth factor-β: a novel approach to treatment of glomerulonephritis and prevention of glomerulosclerosis. Kidney Int 41:566–570PubMedGoogle Scholar
  34. Boswell JM, Yui MA, Burt DW, Kelley VE (1988) Increased tumor necrosis factor and IL-1 beta gene expression in the kidneys of mice with lupus nephritis. J Immunol 141:3050–3054PubMedGoogle Scholar
  35. Brentjens JR, Noble B, Andres GA (1982) Immunologically mediated lesions of kidney tubules and interstitium in laboratory animals and in man. Springer Semin Immunopathol 5:357–378PubMedGoogle Scholar
  36. Brinkman K, Termaat RM, de Jong J, van den Brink HG, Berden JM, Smeenk RJT (1989) Cross-reactive binding patterns of monoclonal antibodies to DNA are often caused by DNA/anti-DNA immune complexes. Res Immunol 140:595–612PubMedGoogle Scholar
  37. Brinkman K, Termaat R, Berden JH, Smeenk RJ (1990) Anti-DNA antibodies and lupus nephritis: the complexity of crossreactivity. Immunol Today 11:232–234PubMedGoogle Scholar
  38. Bruijn JA, Oemar BS, Ehrich JH, Foidart JM, Fleuren GJ (1987) Anti-basement membrane glomerulopathy in experimental trypanosomiasis. J Immunol 139:2482–2488PubMedGoogle Scholar
  39. Bruijn JA, van Elven EH, Hogendoorn PC, Corver WE, Hoedemaeker PJ, Fleuren GJ (1988) Murine chronic graft -versus-host disease as a model for lupus nephritis.Am J Pathol 130:639–641Google Scholar
  40. Bruijn JA, Van Elven EH, Corver WE, Oudshoorn-Snoek M, Fleuren GJ (1989a) Genetics of experimental lupus nephritis: non-H-2 factors determine susceptibility for renal involvement in murine chronic graft-versus-host disease. Clin Exp Immunol 76:284–289PubMedGoogle Scholar
  41. Bruijn JA, van Elven EH, Hogendoorn PC, Corver WE, Hoedemaeker PJ, Fleuren GJ (1989b) Systemic lupus erythematosus (mice). In: Capen CC, Jones TC, Migaki G (eds) Handbook: animal models of human disease. Registry of Comparative Pathology, Armed Forces Institute of Pathology, Washington DC, pp 356–359Google Scholar
  42. Bruijn JA, Hoedemaeker PJ, Fleuren GJ (1989c) Pathogenesis of anti-basement membrane glomerulopathy and immune-complex glomerulonephritis: dichotomy dissolved. Lab Invest 61:480–488PubMedGoogle Scholar
  43. Bruijn JA, Hogendoorn PC, Corver WE, van den Broek LJ, Hoedemaeker PJ, Fleuren GJ (1990a) Pathogenesis of experimental lupus nephritis: a role for anti-basement membrane and anti-tubular brush border antibodies in murine chronic graft-versus-host disease. Clin Exp Immunol 79:115–122PubMedGoogle Scholar
  44. Bruijn JA, van Leer EH, Baelde HJ, Corver WE, Hogendoorn PC, Fleuren GJ (1990b) Characterization and in vivo transfer of nephritogenic autoantibodies directed against dipeptidyl peptidase IV and laminin in experimental lupus nephritis. Lab Invest 63:350–359PubMedGoogle Scholar
  45. Bruijn JA, Bergijk EC, de Heer E, Fleuren GJ, Hoedemaeker PJ (1992) Induction and progression of experimental lupus nephritis: exploration of a pathogenetic pathway. Kidney Int 41:5–13PubMedGoogle Scholar
  46. Cameron JS (1979) Pathogenesis and treatment of membranous nephropathy. Kidney Int 15:88–103PubMedGoogle Scholar
  47. Cattell V, Cook T, Moncada S (1990) Glomeruli synthesize nitrite in experimental nephrotoxic nephritis. Kidney Int 38: 1056–1060PubMedGoogle Scholar
  48. Chan HM, Zhu LF, Zhong R, Grant D, Goyer RA, Cherian MG (1993) Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol Appl Pharmacol 123:89–96PubMedGoogle Scholar
  49. Chapo JA, Grande JP, Killen PD (1992) Transcriptional regulation of collagen IV gene expression during renal development. J Am Soc Nephrol 3:627 (abstr)Google Scholar
  50. Cheng IK, Dorsch SE, Hall BM (1988) The regulation of autoantibody production in Heymann’s nephritis by T lymphocyte subsets. Lab Invest 59:780–788PubMedGoogle Scholar
  51. Cochrane CG, Unanue ER, Dixon FJ (1965) A role of polymorphonuclear leukocytes and complement in nephrotoxic nephritis. J Exp Med 122:99–116PubMedGoogle Scholar
  52. Cole EH, Glynn MF, Laskin CA, Sweet J, Mason N, Levy GA (1990) Ancrod improves survival in murine systemic lupus erythematosus. Kidney Int 37:29–35PubMedGoogle Scholar
  53. Cosio FG (1992) Cell-matrix adhesion receptors: relevance to glomerular pathology. Am J Kidney Dis 20:294–305PubMedGoogle Scholar
  54. Couser WG, Sal ant DJ (1980) In situ immune complex formation and glomerular injury. Kidney Int 17:1–13PubMedGoogle Scholar
  55. Couser WG, Salant DJ (1982) Immunopathogenesis of glomerular capillary wall injury in nephrotic states. In: Brenner BM, Stein JH (eds) Nephrotic syndrome. Churchill Livingstone, New York, pp 62–80Google Scholar
  56. Couser WG, Stilmant MM, Darby C (1976) Autologous immune complex nephropathy. I. Sequential study of immune complex deposition, ultrastructural changes, proteinuria, and alterations in glomerular sialoprotein. Lab Invest 34:23–30PubMedGoogle Scholar
  57. Couser WG, Steinmuller DR, Stilmant MM, Salant DJ, Lowenstein LM (1978) Experimental glomerulonephritis in the isolated perfused rat kidney. J Clin Invest 62:1275–1287PubMedGoogle Scholar
  58. de Heer E, Daha MR, van Es LA (1985) The autoimmune response in active Heymann’s nephritis in Lewis rats is regulated by T-Iymphocyte subsets. Cell Immunol 92:254–264PubMedGoogle Scholar
  59. de Heer E, van Leer EHG, de Roo GM, Baelde JJ, Bruijn JA, Hoedemaeker PJ (1992) Autoamplification of systemic autoimmunity by anti-CD26 autoantibodies in experimental lupus nephritis in mice. J Am Soc Nephrol 3:582–582 (abstr)Google Scholar
  60. de Heer E, Davidoff A, van der Wal A, van Geest M, Paul LC (1994) Chronic renal allograft rejection in the rat. Transplantation-induced antibodies against basement membrane antigens. Lab Invest 70:494–502PubMedGoogle Scholar
  61. Diamond JR (1992) The role of reactive oxygen species in animal models of glomerular disease. Am J Kidney Dis 19:292–300PubMedGoogle Scholar
  62. Diaz-Gallo C, Rubin Kelly V (1992) IFN-gamma induces a tubular cell surface molecule which reduces proliferation of aut ore active kidney-infiltrating T-cells. J Am Soc Nephro1 3:582 (abstr)Google Scholar
  63. Dixon FJ (1962) Tissue injury produced by antigenantibody complexes. In: Graber P, Miescher P (eds) Mechanism of cell and tissue damage produced by immune reactions. 2nd International Symposium on Immunopathology. Schwabe, Basel, p 71Google Scholar
  64. Dixon FJ, Vazquez JJ, Weigle WO, Cochrane CG (1958) Pathogenesis of serum sickness. Arch Pathol 65:18–28Google Scholar
  65. Dixon FJ, Feldman JD, Vazquez JJ (1961) Experimental glomerulonephritis. The pathogenesis of a laboratory model resembling the spectrum of human glomerulonephritis. J Exp Med 113:899–920PubMedGoogle Scholar
  66. Druet E, Sapin C, Günther E, Feingold N, Druet P (1977) Mercuric chloride-induced anti-glomerular basement membrane antibodies in the rat: genetic control. Eur J Immunol 7:348–351PubMedGoogle Scholar
  67. Druet P, Ayed K, Bariety J, Bernandin JF, Druet E, Girard JF, Hinglais N, Sapin C (1978) Glomerulonéphrite immunes experiment ales indrites par Ie bichlorure de mercure chez Ie rat. In: Hamburger J, Crosnier J, FunckErentano JL (eds) Actualités néphrologiques de I’Hôpital Necker, Paris. Flammarion, Paris, pp 245–264Google Scholar
  68. Druet E, Sapin C, Fournie G, Mandet C, GUnther E, Druet P (1982) Genetic control of susceptibility to mercuryinduced immune nephritis in various strains of rat. Clin Immunol Immunopathol 25:203–212PubMedGoogle Scholar
  69. el Nahas AM (1992) Growth factors and glomerular sclerosis. Kidney Int Suppl 36:S15-S20PubMedGoogle Scholar
  70. el Nahas AM, Bassett AH, Cope GH, Le Carpentier JE (1991) Role of growth hormone in the development of experimental renal scarring. Kidney Int 40:29–34PubMedGoogle Scholar
  71. Emancipator SN, Gallo GR, Lamm ME (1983) Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science 155:1432–1434Google Scholar
  72. Esnault VL, Mathieson PW, Thiru S, Oliveira DB, MartinLockwood C (1992) Autoantibodies to myeloperoxidase in Brown Norway rats treated with mercuric chloride. Lab Invest 67:114–120PubMedGoogle Scholar
  73. Fan PY, Ruiz P, Pisetsky DS, Coffman TM, Spurney RF (1992) The effects of short-term treatment with the PGE1 analogue misoprostol on inflammatory mediator production in murine lupus nephritis. J Am Soc Nephrol 3:586 (abstr)Google Scholar
  74. Feenstra K, Lee RVD, Greben HA, Arends A, Hoedemaeker PJ (1975) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. I. The natural history: a histologic and immunohistologic study at the light microscopic and the ultrastructural level. Lab Invest 32:235–242PubMedGoogle Scholar
  75. Fennell RH Jr, Pardo VM (1967) Experimental glomerulonephritis in rats. Lab Invest 17:481–488PubMedGoogle Scholar
  76. Fish AJ, Michael AF, Vernier RL, Good RA (1966) Acute serum sickness nephritis in the rabbit. An immune deposit disease. Am J Pathol 49:997–488PubMedGoogle Scholar
  77. Fish AJ, Carmody KM, Michael AF (1979) Spatial orientation and distribution of antigens within human glomerular basement membrane. J Lab Clin Med 94:447–457PubMedGoogle Scholar
  78. Fleuren GJ (1976) Studies on pathogenesis and treatment of experimental immune complex glomerulonephritis. Roos and Roos, ArnhemGoogle Scholar
  79. Fleuren GJ, Hoedemaeker PJ (1981) Experimental antibasement membrane renal disease: a linear glomerular and tubular immunofluorescence pattern caused by antibodies directed against endothelial antigens. In: Zurrukzoglu W, Papadimitriou M, Pyrpassopoulos M, Sion M, Zamboulis C (eds) Nephrology. 8th International Congress on Nephrology (Athens, June 1981). Karger, BaselGoogle Scholar
  80. Fleuren GJ, Hoedemaeker PJ (1982) Localization en microscopie immuno-electronique des antigenes impliques dans la fixation lineaire Ie long des membranes basales dans un modele homologue chez Ie rat. Nephrologie 3:93 (abstr)Google Scholar
  81. Fleuren GJ, Hoedemaeker PJ, de Vries L, Nieuwenhuis P (1982) Reaction greffe contre hote chez Ie rat: developpement d’anticorps anti-rein. Nephrologie 3:93(abstr)Google Scholar
  82. Fleuren GJ, Hoedemaeker PJ, de Vries L, Nieuwenhuis P (1983) Graft-versus-host reaction in rats: development of anti-kidney antibodies and glomerulonephritis. Nieren Hochdruck Krankh 12:361Google Scholar
  83. Floege J, Johnson RJ, Gordon K, Iida H, Pritzl P, Yoshimura A, Campbell C, Alpers CE, Couser WG (1991) Increased synthesis of extracellular matrix in mesangial proliferative nephritis. Kidney Int 40:477–488PubMedGoogle Scholar
  84. Floege J, Johnson RJ, Gordon K, Yoshimura A, Campbell C, lruela-Arispe L, Alpers CE, Couser WG (1992) Altered glomerular extracellular matrix synthesis in experimental membranous nephropathy. Kidney Int 42:573–585PubMedGoogle Scholar
  85. Florquin S, Goldman M (1994) T cell subsets in glomerular diseases. Springer Semin Immunopathol 16:71–80PubMedGoogle Scholar
  86. Florquin S, Abramowicz D, de Heer E, Bruijn JA, Doutrelepont JM, Goldman M, Hoedemaeker PJ (1991) Renal immunopathology in murine host-versus-graft disease. Kidney Int 40:852–861PubMedGoogle Scholar
  87. Florquin S, Amraoui Z, Dubois C, Decuyper J, Goldman M (1994) The protective role of endogenously synthesized nitric oxide in staphylococcal enterotoxin Binduced shock in mice. J Exp Med 180:1153–1158PubMedGoogle Scholar
  88. Fogel MA, Boyd CD, Leardkamolkarn V, Abrahamson DR, Minto A WM, Salant DJ (1991) Glomerular basement membrane expansion in passive Heymann nephritis. Absence of increased synthesis of type IV collagen, laminin, or fibronectin. Am J Pathol 138:465–475PubMedGoogle Scholar
  89. Freundlich B, Bomalaski JS, Neilson E, Jimenez SA (1986) Regulation of fibroblast proliferation and collagen synthesis by cytokines. Immunol Today 7:303–307Google Scholar
  90. Fukatsu A, Brentjens JR, Killen PD, Kleinman HK, Martin GR, Andres GA (1987) Studies on the formation of glomerular immune deposits in Brown Norway rats injected with mercuric chloride. Clin Immunol Immunopathol 45:35–47PubMedGoogle Scholar
  91. Funabiki K, Horikoshi S, Tomino Y, Nagai Y, Koide H (1990) Immunohistochemical analysis of extracellular components in the glomerular sclerosis of patients with glomerulonephritis. Clin Nephrol 34:239–246PubMedGoogle Scholar
  92. Furness PN, Harris K (1994) An evaluation of experimental models of glomerulonephritis. Int J Exp Pathol 75:9–22PubMedGoogle Scholar
  93. Germuth FG Jr (1953) A comparative histologic and immunologic study in rabbits of induced hypersensitivity of the serum sickness type. J Exp Med 97:257–282PubMedGoogle Scholar
  94. Germuth FG Jr, Rodriguez E (1973) Immunopathology of the renal glomerulus. Little Brown, BostonGoogle Scholar
  95. Germuth FG Jr, Senterfit LB, Pollack AD (1967a) Immune complex disease: I. Experimental acute and chronic glomerulonephritis. Johns Hopkins Med J 120:225–251PubMedGoogle Scholar
  96. Germuth FG Jr, Kelemen WA, Pollack AD (1967b) Immune complex disease. II. The role of circulatory dynamics and glomerular filtration in the development of experimental glomerulonephritis. Johns Hopkins Med J 120:252–261PubMedGoogle Scholar
  97. Gleichmann E, Pals ST, Rolink AG, Radaszkiewics T, Gleichmann H (1984) Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases. Immunol Today 5:324–332Google Scholar
  98. Golbus SM, Wilson CB (1979) Experimental glomerulonephritis induced by in situ formation of immune complexes in glomerular capillary wall. Kidney Int 16:148–157PubMedGoogle Scholar
  99. Goldman M (1990) Cytokines in the pathophysiology of systemic lupus erythematosus. Autoimmunity 8:173–179PubMedGoogle Scholar
  100. Grond J, Weening JJ (1990) Mesangial cell injury glomerulosclerosis and therapeutic intervention. Contrib Nephrol 81:229–239PubMedGoogle Scholar
  101. Guery JC, Druet P (1990) A spontaneous hybridoma producing autoanti-idiotypic antibodies that recognize a Vkappa-associated idiotope in mercury-induced autoimmunity. Eur J Immunol 20:1027–1031PubMedGoogle Scholar
  102. Guery JC, Hedrich HJ, Mercier P, Reetz IC, Mandet C, Mahieu P, Neilson EG, Druet P (1989) Mapping of a gene for the Mr 48,000 tubular basement membrane antigen in the rat. Immunogenetics 29:350–354PubMedGoogle Scholar
  103. Gunnia UB, Amenta PS, Seibold JR, Thomas TJ (1991) Successful treatment of lupus nephritis in MRL-lpr/lpr mice by inhibiting ornithine decarboxylase. Kidney Int 39:882–890PubMedGoogle Scholar
  104. Haakenstad AO, Striker GE, Mannik M (1983) Removal of glomerular immune complex deposits by excell antigen in chronic mouse model of immune complex disease. Lab Invest 48:323–331PubMedGoogle Scholar
  105. Diaz-Gallo C, Rubin Kelly V (1992) IFN-gamma induces a tubular cell surface molecule which reduces proliferation of aut ore active kidney-infiltrating T-cells. J Am Soc Nephro1 3:582 (abstr)Google Scholar
  106. Harmon WE, Grupe WE, Parkman R (1980) Control of autologous immune complex nephritis. I. Suppression of the disease in the presence of T-cell sensitization. J Immunol 124:1034–1038PubMedGoogle Scholar
  107. Henry GA, Jarnot BM, Steinhoff MM, Bigazzi PE (1988) Mercury-induced renal autoimmunity in the MAXX rat. Clin Immunol Immunopathol 49:187–203PubMedGoogle Scholar
  108. Heymann W, Lund HZ (1951) Nephrotic syndrome in rats. Pediatrics 7:691–706PubMedGoogle Scholar
  109. Heymann W, Hackel DB, Harwood S, Wilson SG, Hunter JL (1959) Production of nephrotic syndrome in rats by Freund’s adjuvant and rat kidney suspensions. Proc Soc xp Bioi Med 100:660–664Google Scholar
  110. Heymann W, Hunter JL, Hackel DB (1962a) Experimental auto-immune nephrosis in rats. III. J Immunol 88:135–141PubMedGoogle Scholar
  111. Heymann W, Hunter JL, Hackel DB, Cuppage F (1962b) Transfer of experimental auto-immune nephrosis in rats. Proc Soc Exp Bioi Med 111:568–573Google Scholar
  112. Hill GS (1992) Systemic lupus erythematosus and mixed connective tissue disease. In: Heptinstall RH (ed) Pathology of the kidney. Little Brown, Boston, pp 871–950Google Scholar
  113. Hines WH, Mann RA, Kelly CJ, Neilson EG (1990) Murine interstitial nephritis. IX. Induction of the nephritogenic effector T cell repertoire with an antigenspecific T cell cytokine. J Immunol 144:75–83PubMedGoogle Scholar
  114. Hirose S, Tokushige K, Kinoshita K, Nozawa S, Saito J, Nishimura H, Shirai T (1991) Contribution of the gene linked to the T cell receptor beta chain gene complex of NZW mice to the autoimmunity of (NZB x NZW)FJ mice. Eur J Immunol 21:823–826PubMedGoogle Scholar
  115. Hirsch F, Couderc J, Sapin C, Fournie G, Druet P (1982) Polyclonal effect of HgCI2 in the rat, its possible role in an experimental autoimmune disease. Eur J Immunol 12:620–625PubMedGoogle Scholar
  116. Hockenbery DM (1992) The bcl-2 oncogene and apoptosis. Semin Immunol 4:413–420PubMedGoogle Scholar
  117. Hoedemaeker PJ (1972) Een vorm van experimentele glomerulonefritis in de rat. Ned Tijdschr Geneeskd 116:1802 (abstr)Google Scholar
  118. Hoedemaeker PJ, Weening JJ (1989) Relevance of experimental models for human nephropathology. Kidney Int 35:1015–1025PubMedGoogle Scholar
  119. Hoedemaeker PJ, Feenstra K, Nijkeuter A, Arends A (1972) Ultrastructural localization of heterologous nephrotoxic antibody in glomerular basement membrane of the rat. Lab Invest 26:610–613PubMedGoogle Scholar
  120. Hoedemaeker PJ, Fleuren GJ, Weening JJ (1984) Etiologic factors in immunologically mediated glomerulonephritis. In: Robinson RR (ed) Nephrology. Proceedings of the 9th International Congress on Nephrology (Los Angeles). Springer, Berlin Heidelberg New YorkGoogle Scholar
  121. Hogendoorn PC, Bruijn JA, van den Broek LJ, de Heer E, Foidart JM, Hoedemaeker PJ, Fleuren GJ (1988) Antibodies to purified renal tubular epithelial antigens contain activity against laminin fibronectin, and type IV collagen. Lab Invest 58:278–286PubMedGoogle Scholar
  122. Hogendoorn PC, Ter Braak BPM, Bruijn JA (1991) Experimentallupus nephritis: basement membrane charge alterations. Path Res Pract 187:699 (abstr)Google Scholar
  123. Hogendoorn PC, Ter Braak BPM, Smeenk RJT, Bruijn JA (1992) Glomerular basement membrane charge alteration in experimental lupus nephritis is related to antihistone antibody production. J Am Soc Nephrol 3:594 (abstr)Google Scholar
  124. Holdsworth SR, Tipping PG (1991) Cell-mediated immunity in glomerulonephritis. In: Pusey CD (ed) Immunology of renal diseases. Kluwer, Dordrecht, pp 62–80Google Scholar
  125. Hultman P, Enestrom S (1989) Mercury induced B-cell activation and antinuclear antibodies in mice. J Clin Lab Immunol 28:143–150PubMedGoogle Scholar
  126. Hyman LR, Colvin RB, Steinberg AD (1976a) Immunopathogenesis of autoimmune tubulointerstitial nephripathogenesis tubulointerstitial nephritis. I. Demonstration of differential susceptibility in strain KK and strain XIII guinea pigs. J Immunol 116:327–335PubMedGoogle Scholar
  127. Hyman LR, Steinberg AD, Colvin RB, Bernard EF (1976b) Immunopathogenesis of autoimmune tubulointerstitial nephritis. II. Role of an immune response gene linked to the major histocompatibility complex. J Immunol 117:1894–1897PubMedGoogle Scholar
  128. Icard P, Pelletier L, Val MC, Mandet C, Pasquier R, Michel A, Druet P (1993) Evidence for a role of antilaminin-producing B cell clones that escape tolerance in the pathogenesis of HgCI2-induced membranous nephropathy. Nephrol Dial Transplant 8:122–128PubMedGoogle Scholar
  129. Isaka Y, Fujiwara Y, Ueda N, Kaneda Y, Kamada T, Imai E (1993) Glomerulosclerosis induced by in vivo transfection of transforming growth factor-p or plateletderived growth factor gene into the rat kidney. J Clin Invest 92:2597–2601PubMedGoogle Scholar
  130. Izui S, McConahey PJ, Theofilopoulos AN, Dixon FJ (1979) Assocition of circulating retroviral gp70-antigp70 immune complexes with murine systemic lupus erythematosus. J Exp Med 149:1099–1116PubMedGoogle Scholar
  131. Jacob CO, McDevitt HO (1988) Tumour necrosis factoralpha in murine autoimmune “lupus” nephritis. Nature 331:356–358PubMedGoogle Scholar
  132. Jacob CO, van der Meide PH, McDevitt HO (1987) In vivo treatment of (NZB x NZW)Fllupus-like nephritis with monoclonal antibody to gamma interferon. J Exp Med 166:798–803PubMedGoogle Scholar
  133. Kay CF (1940) The mechanism by which experimental nephritis is produced in rabbits injected with nephrotoxic duck serum. J Exp Med 72:559–572PubMedGoogle Scholar
  134. Kay CF (1942) The mechanism of a form of glomerulonephritis: nephrotoxic nephritis in rabbits. Am J Med Sci 204:483–490Google Scholar
  135. Kelley VE, Winkelstein A. Izui S, Dixon FJ (1981) Prostaglandin El inhibits T-cell proliferation and renal disease in MRL/l mice. Clin Immunol Immunopathol 21:190–213PubMedGoogle Scholar
  136. Kerjaschki D (1990) The pathogenesis of membranous glomerulonephritis: from morphology to molecules. Virchows Arch B Cell Pathol 58:253–271Google Scholar
  137. Kerjaschki D (1992) Molecular pathogenesis of membranous nephropathy. Kidney Int 41:1090–1105PubMedGoogle Scholar
  138. Kerjaschki D, Farquhar MG (1982) The pathogenic antigen of Heymann nephritis is a membrane glycoprotein of the renal proximal tubule brush border. Proc Natl Acad Sci USA 79:5557–5561PubMedGoogle Scholar
  139. Kerjaschki D, Farquhar MG (1983) Immunocytochemical localization of the Heymann nephritis antigen (GP330) in glomerular epithelial cells of normal Lewis rats. J Exp Med 157:667–686PubMedGoogle Scholar
  140. Kher KK (1983) Tolerance to autologous immune complex nephritis: evidence for suppression of 201C;B201D; cell response. Kidney Int 23:185 (abstr)Google Scholar
  141. Kiberd BA (1991) Murine lupus nephritis. A structurefunction study. Lab Invest 65:51–60PubMedGoogle Scholar
  142. Kiberd BA (1992) Interleukin-6 in murine lupus nephritis. J Am Soc Nephro1 3:598 (abstr)Google Scholar
  143. Killen PD, Long R, DeMeester CA, O’Brien E (1990) Transcriptional regulation of collagen IV genes. Kidney Int 37:220(abstr)Google Scholar
  144. Kim Y, Butkowski R, Burke B, Kleppel MM, Crosson J, Katz A, Michael AF (1991) Differential expression of basement membrane collagen in membranous nephropathy. Am J Pathol 139:1381–1388PubMedGoogle Scholar
  145. Kirtland HH III, Mohler DN, Horowitz DA (1980) Methyldopa inhibition of suppressor-lymphocyte function. A proposed cause of autoimmune hemolytic anemia. N Engl J Med 302:825–832PubMedGoogle Scholar
  146. Kitani A, Hara M, Hirose T, Harigai M, Suzuki K, Kawakami M, Kawaguchi Y, Hidaka T, Kawagoe M, Nakamura H (1992) Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression. Clin Exp Immunol 88:75–83PubMedGoogle Scholar
  147. Klassen J, McCluskey RT, Milgrom F (1971) Nonglomerular renal disease produced in rabbits by immunization with homologous kidney. Am J Pathol 63:333–358PubMedGoogle Scholar
  148. Kondo Y, Shigematsu H (1972) Cellular aspects of rabbit Masugi nephritis. I. Cell kinetics in recoverable glomerulonephritis. Virchows Arch Cell Patho1 10:40–50Google Scholar
  149. Kuncio GS, Neilson EG, Haverty T (1991) Mechanisms of tubulointerstitial fibrosis. Kidney Int 39:550–556PubMedGoogle Scholar
  150. Lehman DH, Marquardt H, Wilson CB, Dixon FJ (1974a) Specificity of autoantibodies to tubular and glomerular basement membranes induced in guinea pigs. J Immunol 112:241–248PubMedGoogle Scholar
  151. Lehman DH, Wilson CB, Dixon FJ (1974b) Interstitial nephritis in rats immunized with heterologous tubular basement membrane. Kidney Int 5:187–195PubMedGoogle Scholar
  152. Lewis RM, Armstrong MY, Andre-Schwartz J, Muftuoglu A, Beldotti L, Schwartz RS (1968) Chronic allogenic disease. I. Development of glomerulonephritis. J Exp Med 128:653–679PubMedGoogle Scholar
  153. Linker-Israeli M (1992) Cytokine abnormalities in human lupus. Clin Immunol Immunopathol 63:10–12PubMedGoogle Scholar
  154. Litwin A, Bash JA, Adams LE, Donovan RJ, Hess EV (1979) Immunoregulation of Heymann’s nephritis. I. Induction of suppressor cells. J Immunol 122:1029–1034PubMedGoogle Scholar
  155. Lockwood CM, Mason DW, Bowman C (1983) Suppressor cell function in mercuric chloride-induced autoimmune nephritis in the Brown-Norway rat. Kidney Int 24:406(abstr)Google Scholar
  156. Lovett DH, Johnson RJ, Marti HP, Martin J, Davies M, Couser WG (1992) Structural characterization of the mesangial cell type IV collagenase and enhanced expression in a model of immune complex-mediated glomerulonephritis. Am J Pathol 141:85–98PubMedGoogle Scholar
  157. Mannik M, Striker GE (1980) Removal of glomerular deposits of immune complexes in mice by administration of excell antigen. Lab Invest 42:483--489PubMedGoogle Scholar
  158. Masugi M (1933) Ober das Wesen der spezifischen Veranderungen der Niere und der Leber durch das Nephrotoxin bzw. das Hepatotoxin. Beitr Pathol Anat Allg Pathol 91:82–112Google Scholar
  159. Masugi M, Sato Y (1934) Ober die allergische Gewebsreaktion der Niere. Zugleich ein experimenteller Beitrag zur Pathogenese der diffusen Glomerulonephritis und der Periarteritis Nodosa. Virchows Arch Pathol Anat 293:615–664Google Scholar
  160. Mathieson PW, Stapleton KJ, Oliveira DB, Lockwood CM (1991) Immunoregulation of mercuric chloride-induced autoimmunity in Brown Norway rats: a role for CD8+ T cells revealed by in vivo depletion studies. Eur J Immunol 21:2105–2109PubMedGoogle Scholar
  161. Mathieson PW, Thiru S, Oliveira DBG (1992) Mercuric chloride-treated Brown Norway rats develop widespread tissue injury including necrotizing vasculitis. Lab Invest 67:121–129PubMedGoogle Scholar
  162. Matsumoto K (1990) Production of interleukin-1 by glomerular macrophages in nephrotoxic serum nephritis. Am J Nephrol 10:502–506PubMedGoogle Scholar
  163. Mauer SM, Sutherland DER, Howard RJ, Fish AJ, Najarian JS, Michael AF (1973) The glomerular mesangium. III. Acute immune mesangial injury: a new model of glomerulonephritis. J Exp Med 137:553–570PubMedGoogle Scholar
  164. Mendrick DL, Noble B, Brentjens JR, Andres GA (1980) Antibody mediated injury to proximal tubules in Heymann nephritis. Kidney Int 18:328–343PubMedGoogle Scholar
  165. Mendrick DL, Rennke HG, Cotran RS, Springer TA, Abbas AK (1983) Methods in laboratory investigation. Monoclonal antibodies against rat glomerular antigens: production and specificity. Lab Invest 49:107–117PubMedGoogle Scholar
  166. Merritt SE, Killen PD, Phan SH, Wiggins RC (1990) Analysis of α1 (I) procollagen β-1 (IV) collagen, and ~actin mRNA in glomerulus and cortex of rabbits with experimental anti-glomerular basement membrane disease. Evidence for early extraglomerular collagen biosynthesis. Lab Invest 63:762–769PubMedGoogle Scholar
  167. Miettinen A, Tömroth T, Tikannen I, Virtanen I, Linder E (1980) Heymann nephritis induced by kidney brush border glycoproteins. Lab Invest 43:547–555PubMedGoogle Scholar
  168. Mirtcheva J, Pfeiffer C, Bruijn JA, Jacquesmart F, Gleichmann E (1989) Immunological alterations inducible by mercury compounds. III. H- 2A acts as an immune response and H-2E as an immune suppression locus for HgC12-induced antinucleolar autoantibodies. Eur J Immunol 19:2257–2261PubMedGoogle Scholar
  169. Molina A, Sanchez-Madrid F, Bricio T, Martin A, Barat A, Alvarez V, Mampaso F (1994) Prevention of mercuric chloride-induced nephritis in the Brown Norway rat by treatment with antibodies against the a4 integrin. J Immunol 153:2313–2320PubMedGoogle Scholar
  170. Morita H, Maeda K, Obayashi M, Shinzato T, Nakayama A, Fujita Y, Takai I, Kobayakawa H, Inoue I, Sugiyama S, Asai J, Nakashima I, Isobe KI (1992) Induction of irreversible glomerulosclerosis in the rat by repeated injections of a monoclonal anti-Thy-1.1 antibody. Nephron 60:92–99PubMedGoogle Scholar
  171. Mountz JD, Edwards CK 3rd (1992) Murine models of autoimmunity: T-cell and B-cell defects. Curr Opin Rheumatol 4:612–620PubMedGoogle Scholar
  172. Munaut C, Bergijk EC, Baelde 11, Noäl A, Foidart 1M, Bruijn lA (1992) A molecular biologic study of extracellular matrix components during the development of glomerulosclerosis in murine chronic graftversus-host disease. Lab Invest 67:580–587Google Scholar
  173. Nakamura T, Ebihara I, Shirato I, Tomino Y, Koide H (1991) Increased steady-state levels of mRNA coding for extracellular matrix components in kidneys of NZB/W Fl mice. Am 1 Pathol 139:437–450Google Scholar
  174. Nakamura T, Miller D, Ruoslahti E, Border WA (1992) Production of extracellular matrix by glomerular epithelial cells is regulated by transforming growth factor-β1 Kidney Int 41:1213–1221Google Scholar
  175. Natori Y, Shindo N, Natori Y (1994) Proteinuria induced by anti-dipeptidyl peptidase IV (gpI08): role of circulating and glomerular antigen. Clin Exp Immunol 95:327–332PubMedGoogle Scholar
  176. Neilson EG (1989) Pathogenesis and therapy of interstitial nephritis. Kidney Int 35:1257–1270PubMedGoogle Scholar
  177. Noble B, Olson KA, Milgrom M, Albini B (1980) Tissue deposition of immune complexes in mice receiving daily injections of bovine serum albumin. Clin Exp Immunol 42:255–262PubMedGoogle Scholar
  178. Oite T, Batsford SR, Mihatsch Ml, Takamiya H, Vogt A (1982) Quantitative studies of in situ immune complex glomerulonephritis in the rat induced by planted cationized antigen. J Exp Med 155:460–474PubMedGoogle Scholar
  179. O’Meara YM, Natori Y, Minto A W, Goldstein DJ, Manning EC, Salant Dl (1992) Nephrotoxic antiserum identifies a β1-integrin on rat glomerular epithelial cells. Am J Physiol 262:F1083-F1091PubMedGoogle Scholar
  180. Okuda S, Languino LR, Ruoslahti E, Border WA (1990) Elevated expression of transforming growth factor-β and proteoglycan production in experimental glomerulonephritis. Possible role in expansion of the mesangial extracellular matrix. J Clin Invest 86:453–462PubMedGoogle Scholar
  181. Okuda S, Nakamura T, Yamamoto T, Ruoslahti E, Border W A (1991) Dietary protein restriction rapidly reduces transforming growth factor-β1 expression in experimental glomerulonephritis. Proc Nat! Acad Sci USA 88:9765–9769Google Scholar
  182. Orlando RA, Kerjaschki D, Kurihara H, Biemesderfer D, Farquhar MG (1992) gp330 associates with a 44-kDa protein in the rat kidney to form the Heymann nephritis antigenic complex. Proc Nat! Acad Sci USA 89:6698–6702Google Scholar
  183. Paul LC, Rennke HG, Milford EL, Carpenter CB (1984) Thy-l.1 in glomeruli of rat kidneys. Kidney Int 25:771–777PubMedGoogle Scholar
  184. Pelletier L, Galceran M, Pasquier R, Ronco P, Verroust P, Bariety J, Druet P (1987a) Down modulation of Heymann’s nephritis by mercuric chloride. Kidney Int 32:227–232PubMedGoogle Scholar
  185. Pelletier L, Pasquier R, Rossert J, Druet P (1987b) HgC12 induces nonspecific immunosuppression in Lewis rats. Eur J Immunol 17:49–54PubMedGoogle Scholar
  186. Peterson OW, Gushwa LC, Wilson CB, Blantz RC (1989) Tubuloglomerular feedback activity after glomerular immune injury. Am J Physiol 257:F67-F71PubMedGoogle Scholar
  187. Polak L, Barnes J, Turk JL (1968) The genetic control of contact sensitization to inorganic metal compounds in guinea-pigs. Immunology 14:707–711PubMedGoogle Scholar
  188. Prouvost-Danon A, Abadie A, Sapin C, Basin H, Druet P (1981) Induction of IgE synthesis and potentiation of anti-ovalbumin IgE antibody response by HgCl2 in the rat. J Immunol 126:699–702PubMedGoogle Scholar
  189. Quiza CG, Leenaerts PL, Hall BM (1991) Induction of unresponsiveness to Heymann’s nephritis: inhibited by monoclonal antibody to CD4 but not to CD8. Cell Immunol 133:456–467PubMedGoogle Scholar
  190. Rennke HG, Klein PS, Sandstrom DJ, Mendrick DL (1994) Cell-mediated immune injury in the kidney: acute nephritis induced in the rat by azobenzenearsonate. Kidney Int 45:1044–1056PubMedGoogle Scholar
  191. Rolink AG, Gleichmann H, Gleichmann E (1983) Diseases caused by reactions ofT lymphocytes to incompatible structures of the major histocompatibility complex. VII. Immune-complex glomerulonephritis. J Immunol 130:209–215PubMedGoogle Scholar
  192. Rothbard S, Watson RF (1969) Comparison of reactions of antibodies to rat collagen and to rat kidney in the basement membranes of rat renal glomeruli. J Exp Med 129:1145–1161PubMedGoogle Scholar
  193. Roubinian JR, Papoian R, Talal N (1977) Effects of neonatal thymectomy and splenectomy on survival and regulation of autoantibody formation in NZB/NZW Fl mice. J Immunol 118:1524–1529PubMedGoogle Scholar
  194. Saito A, Pietromonaco SAK, Farquhar M (1994) Complete cloning and sequencing of rat gp330/megalin, a distinctive member of the low density lipoprotein receptor gene family. Proc Natl Acad Sci USA 91:9725–9729Google Scholar
  195. Sal ant DJ, Belok S, Madaio MP, Couser WG (1980) A new role for complement in experimental membranous nephropathy in rats. J Clin Invest 66:1339–1350PubMedGoogle Scholar
  196. Sanchez-Crespo M, Alonso F, Barat A, Egido J (1982) Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. Clin Exp Immunol 49:631–638PubMedGoogle Scholar
  197. Sapin C, Druet E, Druet P (1977) Induction of antiglomerular basement membrane antibodies in the Brown Norway rat by mercuric chloride. Clin Exp Immunol 49:631–638Google Scholar
  198. Sapin C, Druet P, Mandet C (1980) Induction of susceptibility to HgCl2 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible Fl hybrids. Eur J Immunol l0:371–374Google Scholar
  199. Schmiedeke TM, Stockl FW, Weber R, Sugisaki Y, Batsford SR, Vogt A (1989) Histones have high affinity for the glomerular basement membrane. Relevance for immune complex formation in lupus nephritis. J Exp Med 169:1879–1894PubMedGoogle Scholar
  200. Schneeberger EE, Grupe WE (1976) The ultrastructure of the glomerular slit diaphragm in autologous immune complex nephritis. Lab Invest 34:298–305PubMedGoogle Scholar
  201. Schrijver G, Assmann KJ, Bogman MJ, Robben HC, de Waal RM, Koene RA (1988) Antiglomerular basement membrane nephritis in the mouse. Study on the role of complement in the heterologous phase. Lab Invest 59:484–491PubMedGoogle Scholar
  202. Schrijver G, Schalkwijk J, Robben JC, Assmann KJ, Koene RA (1989) Antiglomerular basement membrane nephritis in beige mice. Deficiency of leukocytic neutral proteinases prevents the induction of albuminuria in the heterologous phase. J Exp Med 169:1435–1448PubMedGoogle Scholar
  203. Schrijver G, Bogman MJ, Assmann KJ, de Waal RM, Robben HC, Van Gasteren H, Koene RA (1990) AntiGBM nephritis in the mouse: role of granulocytes in the heterologous phase. Kidney Int 38:86–95PubMedGoogle Scholar
  204. Senterfit LB, Germuth FG Jr (1969) Significance of mesangial localization of immune complexes in rabbits developing arteritis in the absence of glomerulonephritis (GLN). Fed Proc 28:421 (abstr)Google Scholar
  205. Shibata S, Nagasawa T, Naruse T, Miyakawa Y (1967) Glomerulonephritis induced in rats by antiserum against a glycoprotein rat kidney - a new experimental model of glomerulonephritis. Jpn J Exp Med 37:337–353PubMedGoogle Scholar
  206. Shibata S, Miyakawa Y, Naruse T, Nagasawa T, Takuma T (1969) A glycoprotein that induces nephrotoxic antibody: its isolation and purification from rat glomerular basement membrane. J Immunol 102:593–601PubMedGoogle Scholar
  207. Shibata S, Nagasawa T, Miyakawa Y, Naruse T (1971) Nephritogenic glycoprotein: 1. Proliferative glomerulonephritis induced in rats by a single injection of the soluble glycoprotein isolated from homologous glomerular basement membrane. J Immunol 106:1284–1294PubMedGoogle Scholar
  208. Shigematsu H (1970) Glomerular events during the initial phase of rat Masugi nephritis. Virchows Arch Cell pathol 5:187–200Google Scholar
  209. Shimizu Y, van Seventer GA, Horgan KJ, Shaw S (1990) Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin. J Immunol 145:59–67PubMedGoogle Scholar
  210. Singh AK (1992) IL-4 causes up-regulation of an autoreactive VH gene that frequently encodes for antiDNA antibodies in lupus mice. J Am Soc Nephrol 3:615(abstr)Google Scholar
  211. Slikkerveer A (1992) Bismuth: biokinetics, toxicity and experimental therapy of overdosage. Pasmans, The HagueGoogle Scholar
  212. Slikkerveer A, Schroijen VJ, de Wolff FA, Bruijn JA (1992) Reversible nephrotoxicity after overdosage with colloidal bismuth subcitrate. J Am Soc Nephrol 3:729(abstr)Google Scholar
  213. Stebley RW (1962) Glomerulonephritis induced in sheep by injections of heterologous glomerular basement membrane and Freund’s complete adjuvant. J Exp Med 116:253–272Google Scholar
  214. Stebley RW (1963) Glomerulonephritis induced in monkeys by injections of heterologous glomerular basement membrane and Freund’s adjuvant. Nature 197:1173–1176Google Scholar
  215. Stebley RW (1967) Studies on autoimmune nephritis in sheep and rats. IV. The relative efficacy of heterologous, homologous and autologous glomerular basement membrane (GBM) in inducing nephritis. Fed Proc 26:531 (abstr)Google Scholar
  216. Stebley RW, Rudofsky U (1966) Studies on autoimmune nephritis in rats. I. Nephritis induced in rats by injections of human glomerular basement membrane (HGBM) and Freund’s adjuvant (FA). Clin Res 14:449 (abstr)Google Scholar
  217. Stebley RW, Rudofsky U (1971) Renal tubular disease and autoantibodies against tubular basement membrane induced in guinea pigs. J Immunol 107:589–594Google Scholar
  218. Steinberg AD, Huston DP, Taurog JD, Cowdery JS, Raveché ES (1981) The cellular and genetic basis of murine lupus. Immunol Rev 55:121–154PubMedGoogle Scholar
  219. Sugisaki T, Yoshida T, McCluskey RT, Andres GA, Klassen J (1980) Autoimmune cell-mediated tubulointerstitial nephritis induced in Lewis rats by renal antigens. Clin Immunol Immunopathol 15:33–43PubMedGoogle Scholar
  220. Susani M, Schulze M, Exner M, Kerjaschki D (1994) Antibodies to glycolipids activate complement and promote proteinuria in passive Heymann nephritis. Am J Pathol 144:807–819PubMedGoogle Scholar
  221. Suzuki M, Hatakeyama A, Kameoka J, Tamate E, Yusa A, Kurosawa K, Saito T, Sasaki T, Yoshinaga K (1991) Anti-DNA idiotypes deposited in renal glomeruli of patients with lupus nephritis. Am J Kidney Dis 18:232–239PubMedGoogle Scholar
  222. Takahashi S, Nose M, Sasaki J, Yamamoto T, Kyogoku M (1991) IgG3 production in MRL/1pr mice is responsible for development of lupus nephritis. J Immunol 147:515–519PubMedGoogle Scholar
  223. Termaat RM, Brinkman K, Nossent JC, Swaak AJ, Smeenk RJT, Berden JHM (1990) Anti-heparan sulphate reactivity in sera from patients with systemic lupus erythematosus with renal or non-renal manifestations. Clin Exp Immunol 82:268–274PubMedGoogle Scholar
  224. Theofilopoulos AN, Dixon FJ (1980) Immune complexes in human diseases. A review. Am J Pathol 100:529–594PubMedGoogle Scholar
  225. Tipping PG, Holdsworth SR (1986) The participation of macrophages glomerular procoagulant activity and factor VIII in glomerular fibrin deposition. Studies on antiGBM antibody-induced glomerulonephritis in rabbits. Am J Patho1 124:10–17Google Scholar
  226. Tipping PG, Lowe MG, Holdsworth SR (1988) Glomerular macrophages express augmented procoagulant activity in experimental fibrin-related glomerulonephritis in rabbits. J Clin Invest 82:1253–1259PubMedGoogle Scholar
  227. Tipping PG, Leong TW, Holdsworth SR (1991a) Tumor necrosis factor production by glomerular macrophages in anti-glomerular basement membrane glomerulonephritis in rabbits. Lab Invest 65:272–279PubMedGoogle Scholar
  228. Tipping PG, Lowe MG, Holdsworth SR (1991b) Glomerular interleukin 1 production is dependent on macrophage infiltration in anti-GBM glomerulonephritis. Kidney Int 39:103–110PubMedGoogle Scholar
  229. Treurniet RA, Bergijk EC, Baelde JJ, de Heer E, Bruijn JA (1992) Sex difference in the development of chronic graft versus host disease-induced experimental lupus nephritis. J Am Soc Nephrol 3:619 (abstr)Google Scholar
  230. Treurniet RA, Bergijk EC, Baelde JJ, de Heer E, Hoedemaeker PJ, Bruijn JA (1993) Gender-related influences on the development of chronic graft-versus-host disease-induced experimental lupus nephritis. Clin Exp Immunol 91:442–448PubMedGoogle Scholar
  231. Umland SP, Razac S, Nahrebne DK, Seymour BW (1992) Effects of in vivo administration of interferon (IFN)- gamma, anti-IFN-gamma, or anti-interleukin-4 monoclonal antibodies in chronic autoimmune graftversus-host disease. Clin Immunol Immunopathol 63:66–73PubMedGoogle Scholar
  232. Unanue ER, Dixon FJ, Feldman JD (1967) Experimental allergic glomerulonephritis induced in the rabbit with homologous renal antigens. J Exp Med 125:163–176PubMedGoogle Scholar
  233. van Dam AP, Meilof JF, van den Brink HG, Smeenk RJ (1990) Fine specificities of anti-nuclear antibodies in murine models of graft-versus-host disease. Clin Exp Immunol 81:31–38PubMedGoogle Scholar
  234. van Damme BJC, Fleuren GJ, Bakker WW, Vernier RL, Hoedemaeker PJ (1978) Experimental glomerulonephritis in the rat induced by antibodies directed against tubular antigens. V. Fixed glomerular antigens in the pathogenesis of heterologous immune complex glomerulonephritis. Lab Invest 38:502–510PubMedGoogle Scholar
  235. van den Broek MF, de Heer E, van Bruggen MC, de Roo G, Kleiverda K, Eulderink F, van den Berg WB (1993) Immunomodulation of streptococcal cell wall-induced arthritis. Identification of inflammatory cells and regulatory T cell subsets by mercuric chloride and in vivo CD8 depletion. Eur J Immunol 22:3091–3095Google Scholar
  236. van der Meide PH, de Labie MC, Botman CA, van Bennekom WP, Olsson T, Aten J, Weening JJ (1993) Mercuric chloride down-regulates T cell interferongamma production in Brown Norway but not in Lewis rats: role of glutathione. Eur J Immunol 23:675–681PubMedGoogle Scholar
  237. van Leer EH, de Roo GM, Bruijn JA, Hoedemaeker PJ, de Heer E (1993) Synergistic effects of anti-gp330 and antidipeptidyl peptidase type IV antibodies in the induction of glomerular damage. Exp Nephrol 1:292–300PubMedGoogle Scholar
  238. van Rappard-van der Veen FM, Rolink AG, Gleichmann E (1982) Diseases caused by reactions of T lymphocytes towards incompatible structures of the major histocompatibility complex. VI. Autoantibodies characteristic of systemic lupus erythematosus induced by abnormal T-B cell cooperation across I-E. J Exp Med 155:1555–1560Google Scholar
  239. van Velthuysen M (1994) African Trypanosomiasis in mice. A model of glomerular disease. Pasmans, The HagueGoogle Scholar
  240. van Velthuysen M, Bruijn JA, van Leer EH, Fleuren GJ (1992) Pathogenesis of Trypanosomiasis-induced glomerulonephritis in mice. Nephrol Dial Transplant 7:507–515PubMedGoogle Scholar
  241. van Velthuysen M, Veninga A, Bruijn JA, de Heer E, Fleuren GJ (1993) Susceptibility for infection-related glomerulopathy depends on non-MHC genes. Kidney Int 43:623–629PubMedGoogle Scholar
  242. van Velthuysen M, Mayen AE, van Rooijen N, Fleuren GJ, de Heer E, Bruijn JA (1994a) T-cells and macrophages in Trypanosoma brucei-related glomerulopathy. Infect Imm 62:3230–3235Google Scholar
  243. van Velthuysen M, Mayen AE, Prins FA, de Heer E, Bruijn JA, Fleuren GJ (1994b) Phagocytosis by glomerular endothelial cells in infection-related glomerulopathy. Nephrol Dial Transplant 9:1077–1083PubMedGoogle Scholar
  244. van Zwieten MJ, Leber PD, Bhan AK, McCluskey RT (1977) Experimental cell-mediated interstitial nephritis induced with exogenous antigens. J Immunol 118:589–593PubMedGoogle Scholar
  245. Vissers MC, Fantone JC, Wiggins R, Kunkel SL (1989) Glomerular basement membrane-containing immune complexes stimulate tumor necrosis factor and interleukin-1 production by human monocytes. Am J Pathol 134:1–6PubMedGoogle Scholar
  246. Vlahakos D, Foster MH, Ucci AA, Barrett KJ, Datta SK, Madaio MP (1992a) Murine monoclonal anti-DNA antibodies penetrate cells, bind to nuclei, and induce glomerular proliferation and proteinuria in vivo. J Am Soc Nephrol 2:1345–1354PubMedGoogle Scholar
  247. Vlahakos DV, Foster MH, Adams S, Katz M, Ucci AA, Barrett KJ, Datta SK, Madaio MP (1992b) Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. Kidney Int 41:1690–1700PubMedGoogle Scholar
  248. Vogt A, Batsford SR (1983) Interaction of cationic antigens with GBM: pathogenic implications. In: Lambert PP, Bergmann P, Beauwens R (eds) The pathogenicity of cationic proteins. Raven, New York, pp 102–111Google Scholar
  249. Vogt A, Bockhorn H, Kozima K, Sasaki M (1968) Electron microscopic localization of the nephrotoxic antibody in the glomeruli of the rat after intravenous application of purified nephritogenic antibody-ferritin conjugates. J Exp Med 127:867–878PubMedGoogle Scholar
  250. Vogt A, Schmidt HU, Takamiya H, Batsford S (1980) In situ immune complex nephritis and basic proteins. Proc Eur Dial Transplant Assoc 17:613–620PubMedGoogle Scholar
  251. Wardle EN (1991) Cell biology and glomerulonephritis. Nephron 59:529–532PubMedGoogle Scholar
  252. Weening JJ (1984) Autoimmune reactions and glomerulonephritis caused by heavy metals and other toxins. In: Hayes AW, Schnell RC, Miya TS (eds) Developments in the science and practice of toxicology. Elsevier, New York, pp 211–218Google Scholar
  253. Weening JJ, Fleuren GJ, Hoedemaeker PJ (1978) Demonstration of antinuclear antibodies in mercuric chlorideinduced glomerulopathy in the rat. Lab Invest 39:405–411PubMedGoogle Scholar
  254. Weening JJ, Grond J, van der Top D, Hoedemaeker PJ (1980) Identification of the nuclear antigen involved in mercury-induced glomerulopathy in the rat. Invest Cell Pathol 3:129–134PubMedGoogle Scholar
  255. Weening JJ, Hoedemaeker PJ, Bakker WW (1981) Immunoregulation and anti-nuclear antibodies in mercury-induced glomerulopathy in the rat. Clin Exp Immunol 45:64–71PubMedGoogle Scholar
  256. Wilson CB, Dixon FJ (1970) Antigen quantitation in experimental immune complex glomerulonephritis. I. Acute serum sickness. J Immunol 105:279–290PubMedGoogle Scholar
  257. Wilson CB, Gushwa LC, Peterson OW, Tucker BJ, Blantz RC (1981) Glomerular immune injury in the rat: effect of antagonists of histamine activity. Kidney Int 20:628–635PubMedGoogle Scholar
  258. Wolf G, Neilson EG (1991) Molecular mechanisms of tubulointerstitial hypertrophy and hyperplasia. Kidney Int 39:401–420PubMedGoogle Scholar
  259. Wolf G, Neilson EG (1992) Increases in levels of collagen types I and IV messenger ribonucleic acid in murine kidneys after treatment with cyclosporin. Nephron 60:87–91PubMedGoogle Scholar
  260. Yanase K, Cizman B, Foster MH, Smith RM, Peachey LD, Jarett L, Madaio MP (1992) Ultrastructural localization of anti-DNA antibody (Ab) transport into the nuclei of cultured mesangial cells. J Am Soc Nephro1 3:623 (abstr)Google Scholar
  261. Yap HK, Lee BW, Ng SC, Seah CC, Wong SC, Jordan SC (1992) Endothelial cell activation by sera from patients with systemic lupus erythematosus. J Am Soc Nephrol 3:668 (abstr)Google Scholar
  262. Yokoyama H, Takabatake T, Takaeda M, Wad a T, Naito T, Ikeda K, Goshima S, Takasawa K, Tomosugi N, Kobayashi K, Kida H (1992) Up-regulated MHC-class II expression and gamma-IFN and soluble IL-2R in lupus nephritis. Kidney Int 42:755–763PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1986

Authors and Affiliations

  • Jan A. Bruijn
  • Emile de Heer
  • Philip J. Hoedemaeker

There are no affiliations available

Personalised recommendations