Urinary System pp 179-198 | Cite as

Estrogen-Induced Malignant Tumor, Kidney, Golden Hamster

  • Antonio Llombart-Bosch
  • Amando Peydró-Olaya
Part of the Monographs on Pathology of Laboratory Animals book series (LABORATORY)


The neoplasm is initially unilateral and is made up of single or multiple nodules which displace local structures. Small nodules, whose size is on the macro- to microscopic border, are found mainly in the cortex or at the corticomedullary junction, between the sixth and eighth month of intoxication. Smaller lesions seen as 0.1- to 0.2-mm patches have been found after 3–4 months of treatment, coinciding with what we have designated tumorlets (Cortes-Vizcaino and LlombartBosch 1993). Eventually, large, bilateral multiple tumors arise in association with small neoplastic foci. The left kidney is more often involved and may weigh as much as 20 g. On cut section, the large confluent tumor masses are fleshy and solid with focal necrosis. Cysts of various sizes may be present, as are hemorrhagic foci.


Diethylstilbestrol (DES)-induced kidney tumor of the Syrian golden hamster estrogen(E2)-dependent renal tumor E2-induced nephroblastoma E2-induced clear cell carcinoma hormonal-dependent carcinoma 


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© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Antonio Llombart-Bosch
  • Amando Peydró-Olaya

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