Abstract
In this chapter, we illustrate how an understanding of chemistry can help solve practical allergy problems:
-
Chemical analysis can identify the actual allergen, which need not be the primary chemical constituent of a product, but may be a contaminant arising in the synthesis or production of the product or one formed during its storage and handling.
-
The physicochemical parameters affect the bioavailability and hence the allergenic properties of a given molecule.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Ducombs G, Benezra C, Talaga P et al (1990) Patch testing with the “sesquiterpene lactone mix”: a marker for contact allergy to Compositae and other sesquiterpene lactone containing plants. Contact Dermatitis 22:249 – 252
Dooms-Goossens A, Morren M (1992) Results of routine patch testing with a corticosteroid series in 2073 patients. Contact Dermatitis 26:189–191
Dooms-Goossens A, Bruze M, Buysse L, Fregert S, Gruvberger B, Stals H (1995) Contact allergy to allylglycidylether present as an impurity in 3-glycidyloxypropyltrimethoxy- silane, a fixing additive in silicone and polyurethane resins. Contact Dermatitis 33:17–19
Smook GA (1992) Handbook for pulp and paper technologists, 2nd edn. Wilde, Vancouver, pp 36–44
Ekman R, Holmbom B (1989) Analysis by gas chromatography of the wood extractives in pulp and water samples from mechanical pulping of spruce. Nord Pulp Pap Res J 4:16–24
Karlberg A-T, Bohlinder K, Boman A, Hacksell U, Hermansson J, Jacobsson S, Nilsson JLG (1988) Identification of 15-hydroperoxyabietic acid as a contact allergen in Portuguese colophony. J Pharm Pharmacol 40:42–47
Karlberg A-T, Boman A, Hacksell U, Jacobsson S, Nilsson, JLG (1988) Contact allergy to dehydroabietic acid derivatives isolated from Portuguese colophony. Contact Dermatitis 19:166–174
Hausen BM, Krohn K, Budianto E (1990) Contact allergy to colophony. VII. Sensitization studies with oxidation products of abietic and related acids. Contact Dermatitis 23: 352–358.
Gäfvert E, Nilsson U, Karlberg A-T, Magnusson K, Nilsson ILG (1992) Rosin allergy: identification of a dehydroabietic acid peroxide with allergenic properties. Arch Dermatol Res 284:409–413
Krohn K, Budantio E, Flörke U, Hausen BM (1992) Untersuchung der allergenen Prinzipen aus Kolophonium: Autoxidation, Synthese und Sensibilisierung. Liebigs Ann Chem 911–919
Hausen BM, Börries M, Budianto E, Krohn K (1993) Contact allergy to colophony. IX. Sensitization studies with further products isolated after oxidative degradation of resin acids and colophony. Contact Dermatitis 29:234–240
Gäfvert E, Shao LP, Karlberg A-T, Nilsson U, Nilsson JLG. (1994) Contact allergy to resin acid hydroperoxides. Hapten binding via free radicals and epoxides. Chem Res Toxicol 7:260–266
Khan L, Saeed MA (1994) 13/?, 14/?-dihydroxy-13a-isopropylabietic acid, an elicitor of contact allergy. J Pharm Sei 83:909–910
Shao LP, Gäfvert E, Nilsson U, Karlberg A-T, Nilsson JLG (1995) 15-Hydroperoxy dehydroabietic acid - a contact allergen in colophony from pinus species. Phytochemistry 4:853–857
Karlberg A-T (1991) Air oxidation increases the allergenic potential of tall oil rosin. Gum rosin contact allergens also identified in tall oil rosin. Am J Contact Dermatitis 2:43–49
Ehrin E, Karlberg A-T (1990) Detection of rosin (colophony) components in technical products using an HPLC technique. Contact Dermatitis 23:359–366
Karlberg A-T, Liden C (1992) Colophony (rosin) in newspaper may contribute to hand eczema. Br J Dermatol 126:161–165
Karlberg A-T, Gâfvert E, Lidén C (1995) Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons. J Am Acad Dermatol 33:427–432
Klecak G (1985) The Freund’s complete adjuvant test and the open epicutaneous test. Curr Probl Dermatol 185:152–157
Boman A, Karlberg A-T, Wahlberg JE (1988) Experiences with Freund’s complete adjuvant test (FCAT) when screening for contact allergens in colophony. Contact Dermatitis 18:25–29
Lidén C, Karlberg A-T (1992) Colophony in paper as a cause of hand eczema. Contact Dermatitis 26:272–273
Karlberg A-T, Gâfvert E, Meding B, Stenberg B (1996) Airborne contact dermatitis from unexpected exposure to rosin (colophony). Contact Dermatitis 35:272–278
Karlberg A-T, Magnusson K, Nilsson U (1994) Influence of an anti-oxidant on the formation of allergenic compounds during auto-oxidation of d-limonene. Ann Occup Hyg 38:199–207
Karlberg A-T, Magnusson K, Nilsson U (1992) Air oxidation of d-limonene (the citrus solvent) creates potent allergens. Contact Dermatitis 26:332–340
Karlberg A-T, Shao LP, Nilsson U, Gâfvert E, Nilsson JLG (1994) Hydroperoxides in oxidized d-limonene identified as potent contact allergens. Arch Dermatol Res 286:97–103
Karlberg A-T, Dooms-Goossens A (1997) Contact allergy to oxidized d-limonene - the citrus solvent. Contact Dermatitis 36:201–206
Meding B, Barregard L, Marcus K (1994) Hand eczema in car mechanics. Contact Dermatitis 30:129–134
Strazdins E (1989) Paper sizes and sizing. In: Zinkel DF, Russel J (eds) Naval stores. Production - chemistry - utilization. Pulp Chemicals Association, New York, pp 575–624
Burke RE (1989) Rosin-based printing inks. In: Zinkel DF, Russel J (eds) Naval stores. Production - chemistry - utilization. Pulp Chemicals Association, New York, pp 665–700
Wherry RW (1989) Other uses for rosin. In: Zinkel DF, Russel J (eds) Naval stores. Production - chemistry - utilization. Pulp Chemicals Association, New York, pp 701–714
Karlberg A-T, Gâfvert E, Hagelthorn G, Nilsson JLG (1988) Maleopimaric acid - a potent sensitizer in modified rosin. Contact Dermatitis 22:193–201
Gâfvert E, Shao LP, Karlberg A-T, Nilsson JLG (1995) Maleopimaric acid - a contact allergen in fumaric acid-modified rosin used for paper size. Nordic Pulp Paper Res J 10:139–144
Gâfvert E (1994) Allergenic components in modified and unmodified rosin. Chemical characterization and studies of allergenic activity. Acta Dermatol Venereol Suppl (Stockh) 184
Gâfvert E, Bordalo O, Karlberg A-T (1996) Patch testing with allergens from modified rosin (colophony) discloses additional cases of contact allergy. Contact Dermatitis 35:290–298
Tsuchiya S, Kondo M, Okamoto K, Takase Y (1985) The cumulative contact enhancement test. Curr Probl Dermatol 14:208–219
Lepoittevin J-P (1995) Les “MIX”: du fondamental à la clinique. Le point de vue du chimiste. In: GERDA (ed) Progrès en dermato-allergologie, vol 1. Médiscript, Viterne, pp 185–192
Andersen KE, Burrows D, White IR (1995) Allergens from the standard series. In: Rycroft RJG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg New York, pp 416–458
Paulsen E (1992) Compositae dermatitis: a survey. Contact Dermatitis 26:76–86
English JSC, Norris P, White IR, Cronin E (1989) Variability in the clinical patterns of compositae dermatitis. Br J Dermatol 121 [Suppl 34]:27
Benezra C, Ducombs G, Sell Y, Foussereau J (1985) Plant contact dermatitis. Decker, Toronto
Franot C, Benezra C, Lepoittevin JP (1993) Synthesis and interaction studies of 13C labeled lactone derivatives with a model protein using 13C NMR. Biorg Med Chem 1:389–397
Stampf JL, Schlewer G, Ducombs G, Foussereau J, Benezra C (1978) ACD due to sesquiterpene lactones. A comparative study of human and animal sensitivity to a-methylene- y-butyrolactones and derivatives. Br J Dermatol 99:163–169
Paulsen E, Andersen KE, Hausen BM (1993) Results of routine testing with the sesquiterpene lactone mix supplemented with aimed patch testing with extracts ans sesquiterpene lactones of compositae plants. Contact Dermatitis 29:6–10
Lepoittevin J-P, Drieghe J, Dooms-Goossens A (1995) Studies in patients with corticosteroid contact allergy: Understanding cross-reactivity among different steroids. Arch Dermatol 131:31–37
Lauerma AI, Reitamo S (1994) Allergic reactions to topical and systemic corticosteroids. Eur J Dermatol 5:354–358
Coopman S, Degreef H, Dooms-Goossens A (1989) Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. Br J Dermatol 121:27 - 34
European Communities (1993) Annex IV to Commission Directive 93/21/EEC of 27 April 1993 adapting to technical progress for the 18th time Council Directive 67/548/EEC on the approximation of the laws, regulations and administrative provisions relating to the classification, packaging and labelling of dangerous substances. Official J Eur Communities 36:59
Barratt MD, Basketter DA, Chamberlain M, Admans GD, Langowski JJ (1994) An expert system rulebase for identifying contact allergens. Toxicol In Vitro 8:1053–1060
Basketter DA, Scholes EW, Chamnerlain M, Barratt MD (1995) An alternative strategy to the use of guinea pigs for the identification of skin sensitization hazard. Food Chem Toxicol 33:1051–1056
Riding JE, Barratt MD, Cary R, Earnshaw CG, Eggington CE, Ellis MK, Judson PN, Langowski JJ, Marchant CA, Payne MP, Watson WP, Yih TD (1996) Computer prediction of possible toxic from chemical structure: an update on the DEREK system. Toxicology 106:267–269
Basketter DA, Cookman G, Gerberick GF, Mamaide H, Potokar M (1997) Skin sensitiation thresholds: determination in predictive models. Food Chem Toxicol 35 (in press)
Basketter DA, Roberts DW, Cronin M, Scholes EW (1992) The value of the local lymph node assay in quantitative structure activity investigations. Contact Dermatitis 27:137–142
Roberts DW, Basketter DA (1990) A quantitative structure activity/dose response relationship for contact allergic potential of alkyl group transfer agents. Contact Dermatitis 23:331–335
Magee PS, Hostynek J J, Maibach HI (1994) A classification model of allergenic contact dermatitis. Quantitative structure activity relationships 13:22–33
Cronin MTD, Basketter DA (1994) Multivariate QSAR analysis of a skin sensitization database. SAR QSAR Environ Res 2:159–179
Gealy R, Graham C, Sussman NB, Macina OT, Rosenkranz HS, Karol MH (1996) Evaluating clinical case report data for SAR modeling of allergic contact dermatitis. Hum Exp Toxicol 15:489–493
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Goossens, A., Karlberg, AT., Basketter, D., Lepoittevin, JP. (1998). The Practical Approach. In: Lepoittevin, JP., Basketter, D.A., Goossens, A., Karlberg, AT. (eds) Allergic Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80331-4_9
Download citation
DOI: https://doi.org/10.1007/978-3-642-80331-4_9
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80333-8
Online ISBN: 978-3-642-80331-4
eBook Packages: Springer Book Archive