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Structure—Activity Relationships for Contact Hypersensitivity

  • Chapter
Allergic Contact Dermatitis

Abstract

Allergic contact dermatitis is caused by chemicals. These chemicals stimulate the immune system to produce an inflammatory response in the skin, and it is this reaction which both typifies the disease and which has been used as an indicator system in traditional predictive models such as the guinea pig maximisation test (GPMT) [1]. However, since it is the chemical which is the driving force, it is reasonable to examine to what extent it is possible to relate chemical structure with the propensity to behave as a skin sensitizer.

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Authors
  1. Martin D. Barratt
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  2. David A. Basketter
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  3. David W. Roberts
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Editor information

Editors and Affiliations

  1. Clinique Dermatologique, Laboratoire de Dermatochimie associé au CNRS, Université Louis Pasteur, 1, Place de l’Hôpital, F-67091, Strasbourg Cedex, France

    Jean-Pierre Lepoittevin D.Sc.

  2. Unilever Environmental Safety Laboratory, Colworth House, MK44 1LQ, Sharbrook, Bedford, UK

    David A. Basketter

  3. Department of Dermatology, Katholieke Universiteit Leuven, University Hospital, B-3000, Leuven, Belgium

    An Goossens Ph.D.

  4. Department of Occupational Dermatology, National Institute for Working Life, S-171 84, Solna, Sweden

    Ann-Therése Karlberg Ph.D.

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© 1998 Springer-Verlag Berlin Heidelberg

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Barratt, M.D., Basketter, D.A., Roberts, D.W. (1998). Structure—Activity Relationships for Contact Hypersensitivity. In: Lepoittevin, JP., Basketter, D.A., Goossens, A., Karlberg, AT. (eds) Allergic Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80331-4_8

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  • DOI: https://doi.org/10.1007/978-3-642-80331-4_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80333-8

  • Online ISBN: 978-3-642-80331-4

  • eBook Packages: Springer Book Archive

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