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Structure—Activity Relationships for Contact Hypersensitivity

  • Martin D. Barratt
  • David A. Basketter
  • David W. Roberts

Abstract

Allergic contact dermatitis is caused by chemicals. These chemicals stimulate the immune system to produce an inflammatory response in the skin, and it is this reaction which both typifies the disease and which has been used as an indicator system in traditional predictive models such as the guinea pig maximisation test (GPMT) [1]. However, since it is the chemical which is the driving force, it is reasonable to examine to what extent it is possible to relate chemical structure with the propensity to behave as a skin sensitizer.

Keywords

Contact Dermatitis Allergic Contact Dermatitis Skin Sensitisation Skin Penetration Skin Permeability 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1998

Authors and Affiliations

  • Martin D. Barratt
  • David A. Basketter
  • David W. Roberts

There are no affiliations available

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