Abstract
Hapten-peptide-T cell receptor interactions play a pivotal role in the mechanism of contact allergy. It is at this stage that antigenic information is used by the immune system to select and activate a population of antigen-specific T lymphocytes, a process that will to a great extent determine the nature and selectivity of the resultant pathology.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Basketter D, Dooms-Goossens A, Karlberg A-T, Lepoittevin J-P (1995) The chemistry of contact allergy: why is a molecule allergenic? Contact Dermatitis 32:65–73
Kalish R S (1995) Antigen processing: the gateway to the immune response. J Am Acad Dermatol 32:640–652
Lepoittevin J-P, Benezra C (1992) 13C-Enriched methylalkanesulfonates: new lipophilic methylating agents for the identification of nucleophilic amino acids of protein by NMR. Tetrahedron Lett 33:3875–3878
Franot C, Benezra C, Lepoittevin J-P (1993) Synthesis and interaction studies of 13C labeled lactone derivatives with a model protein using 13C NMR. Bioorg Med Chem 1:389–397
Liberato DJ, Byers VS, Ennick RGD and Castagnoli N Jr (1981) Regiospecific attack of nitrogen and sulphur nucleophiles on quinones derived form poison oak/ivy catechols (urushiols) and analogues as models for urushiol-protein conjugate formation. J Med Chem 24:28–33
Stampf JL, Benezra C, Byers V and Castagnoli N Jr (1986) Induction of tolerance to poison ivy in the guinea pig by cutaneous application of the structural analog 5-methyl-3- n-pentadecylcatechol. J Invest Dermatol 5:535–538
Nazih A, Benezra C, Lepoittevin J-P (1993) Bihaptens with 5- and 6-methyl-substituted alkyl catechols and methylene lactone functional groups: tools for hapten (allergen or tolerogen)-protein interaction studies. Chem Res Toxicol 6:215–222
Hosken NA, Shibuya K, Heath AW, Murphy KM, O'Garra A (1995) The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-trans- genic model. J Exp Med 182:1579–1584
Kimber I, Gerberick GF, Loveren HV, House RV (1992) Symposium overview. Chemical allergy: molecular mechanisms and practical applications. Fund Appl Toxicol 19:479–483
Engelhard V (1994) La présentation des antigènes. Pour la Science 204:88–97
Martin S, Weltzien HU (1994) T cell recognition of haptens, a molecular view. Int Arch Allergy Immunol 104:10–16
Griem P, Panthel K, Kalbacher H, Gleichmann E (1996) Alteration of a model antigen by Au(III) leads to T cell sensitization to cryptic peptides. Eur J Immunol 26:279–287
Coopman S, Degreef H, Dooms-Goossens A (1989) Identification of cross-reaction patterns in allergic contact dermatitis from topical corticosteroids. Br J Dermatol 121:27–34
Lepoittevin J-P, Drieghe J, Dooms-Goossens A (1995) Studies in patients with corticosteroid contact allergy: understanding cross-reactivity among different steroids. Arch Dermatol 131:31–37
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lepoittevin, JP., Goossens, A. (1998). Molecular Basis for the Recognition of Haptens by T Lymphocytes. In: Lepoittevin, JP., Basketter, D.A., Goossens, A., Karlberg, AT. (eds) Allergic Contact Dermatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80331-4_7
Download citation
DOI: https://doi.org/10.1007/978-3-642-80331-4_7
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80333-8
Online ISBN: 978-3-642-80331-4
eBook Packages: Springer Book Archive