Skip to main content
SpringerLink
Log in

Interaktionen zwischen Clostridium difficile und Saccharomyces boulardii

  • Conference paper
Book cover Ökosystem Darm VII

  • 27 Accesses

Zusammenfassung

Das klinische Management Clostridium difficile-assoziierter Diarrhöen ist nach wie vor mit Problemen behaftet. Die Modifikation der zu über 99% aus Anaerobiern bestehenden intestinalen Kolonisationsflora durch Antibiotika gilt als wesentlicher prädisponierender Faktor. Ein Absetzen der einmal begonnenen antibiotischen Therapie bzw. ein Umsetzen auf weniger begünstigende Substanzen ist aufgrund der klinischen Situation (z. B. Endokarditis) oft nicht möglich. Daneben ist ein ausgeprägter postantibiotischer Effekt zu beobachten, d.h. die physiologische Darmflora erholt sich nur langsam. Bei einzelnen Patienten traten die Durchfälle erst 6 Wochen nach Beendigung der antibiotischen Therapie auf [20].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Bartlett JG (1990) Clostridium difficile: clinical considerations. Rev Infect Dis 12, (suppl 2): 243–251

    Article  Google Scholar 

  2. Brugier S, Patte F (1975) Antagonisme in vitro entre l’ultra-levure et différents germes bactériens. Med Paris 45: 3–8

    Google Scholar 

  3. Bundesanzeiger (1994) Monographie: Trockenhefe aus Saccharomyces cerevisi HANSEN CBS 5926 (Synonym: Saccharomyces boulardii). Bundesanzeiger 71: 40491

    Google Scholar 

  4. Buts JP, Bernasconi P, van Craynest MP, Maldague P, de Mayer R (1986) Response of human and rat small intestinal mucosa to oral administration of Saccharomyces boulardii. Pediatr Res 20: 192–196

    Google Scholar 

  5. Buts JP, Bernasconi P, Vaerman JP, Dive C (1990) Stimulation of secretory IgA and secretory component of immunoglobulins in small intestine of rats treated with Saccharomyces boulardii. Dig Dis Sei 35: 251–256

    Article  CAS  Google Scholar 

  6. Buts JP, de Keyser N, de Raedemaeker L (1994) Saccharomyces boulardii enhances rat intestinal enzyme expression by endoluminal release of polyamines. Pediatr Res 36: 522–527

    Google Scholar 

  7. Corthier G, Dubos F, Ducluzeau R (1986) Prevention of Clostridium difficile induced mortality in gnotobiotic mice by Saccharomyces boulardii. Can J Microbiol 32: 894–896

    Article  PubMed  CAS  Google Scholar 

  8. Czerucka D, Nano JL, Bernasconi P, Rampal P (1989) Résponse à la toxine cholérique de deux lignées de cellules épithéliales intestinales. Effet de Saccaromyces boulardii. Gastro¬enterol Clin Biol 13: 383–384

    Google Scholar 

  9. Czerucka D, Nano JL, Bernasconi P, Rampal P (1991) Response aux toxines A et B de Clostridium difficile d’une lignée de cellules épithéliales intestinales de rat: IRD 98. Effet de Saccharomyces boulardii. Gastroenterol Clin Biol 15: 22–27

    Google Scholar 

  10. Elmer GW, McFarland LV (1987) Suppression by Saccharomyces boulardii of toxigenic Clostridium difficile overgrowth after Vancomycin treatment in hamsters. Antimicrob Agents Chemother 31: 129–131

    PubMed  CAS  Google Scholar 

  11. Elmer GW, Corthier G (1990) Modulation of Clostridium difficile induced mortality as a function of the dose and the viability of the Saccaromyces boulardii used as a preventative agent in gnotobiotic mice. Can J Microbiol 37: 315–317

    Article  Google Scholar 

  12. Elmer GW, Surawicz CM, McFarland LV (1996) Biotherapeutic agents. A neglected modality for the treatment and prevention of selected intestinal and vaginal infections. JAMA 275: 870–876

    Google Scholar 

  13. Fekety R, Shah AB (1993) Diagnosis and treatment of Clostridium difficile colitis. JAMA 269: 71–75

    Article  PubMed  CAS  Google Scholar 

  14. Gorbach SL, Chang TW, Goldin B (1987) Successful treatment of relapsing Clostridium difficile colitis with Lactobacillus GG. Lancet 2: 1519

    Article  PubMed  CAS  Google Scholar 

  15. Kelly CP, Pothoulakis C, LaMont T (1994) Clostridium difficile colitis. N Engl J Med 330: 257–262

    Article  PubMed  CAS  Google Scholar 

  16. Klein SM, Elmer GW, McFarland LV, Surawicz CM, Levy RH (1993) Recovery and elimination of the biotherapeutic agent, Saccharomyces boulardii, in healthy human volunteers. Pharm Res 10: 1615–1619

    Google Scholar 

  17. Krammer M, Karbach U (1993) Antidiarrheal action of the yeast Saccharomyces boulardii in the rat small and large intestine by stimulating chloride absorption. Z Gastroenterol 31 (suppl 4): 73–77

    Google Scholar 

  18. Loeschke K, Ruckdeschel G (1992) Durchfälle unter Antibiotika: Diagnostik und Therapie. Dt Ärztebl 89: B221–B224

    Google Scholar 

  19. McFarland LV, Surawicz CM, Greenberg RN, Fekety R, Elmer GW, Moyer KA, Melcher SA, Bowen KE, Cox JL, Noorani Z, Harrington G, Rubin M, Greenwald D (1994) A randomized placebo-controlled trial of Saccharomyces boulardii in combination with standard antibio¬tics for Clostridium difficile disease. JAMA 272: 1913–1918

    Article  Google Scholar 

  20. McFarland LV, Surawicz CM, Greenberg RN, Elmer GW, Moyer KA, Melcher SA, Bowen KE, Cox JL (1995) Prevention of ß-lactam-associated diarrhea by Saccharomyces boulardii compared with placebo. Am J Gastroenterol 90: 439–448

    PubMed  CAS  Google Scholar 

  21. Müller J, Remus N, Harms KH (1995) Mycoserological study of the treatment of paediatric cystic fibrosis patients with Saccharomyces boulardii (Saccaromyces cerevisiae Hansen CBS 5926). Mycoses 38: 119–123

    Article  PubMed  Google Scholar 

  22. Pothoulakis C, Kelly CP, Joshi MA, Gao N, O’Keane CJ, Castagliuolo I, LaMont T (1993) Saccaromyces boulardii inhibits Clostridium difficile Toxin A binding and enterotoxicity in rat ileum. Gastroenterol 104: 1108–1115

    CAS  Google Scholar 

  23. Salyers AA, Whitt DD (1994) Pseudomembranous colitis. In: Bacterial pathogenesis. A molecular approach. ASM Press, pp 282–289

    Google Scholar 

  24. Seal D, Borriello SP, Barclay F, Welch A, Piper M, Bonnycastle M (1987) Treatment of relapsing Clostridium difficile diarrhea by administration of a nontoxigenic strain. Eur J Clin Microbiol 6: 51–53

    Article  PubMed  CAS  Google Scholar 

  25. Surawicz CM, Elmer GW, Speelman P, McFarland LV, Chinn J, van Belle G (1989) Prevention of antibiotic-associated diarrhea by Saccharomyces boulardii: A prospective study. Gastroenterol 96: 981–988

    Google Scholar 

  26. Surawicz CM, McFarland LV, Elmer GW, Chinn I (1989) Treatment of recurrent Clostridium difficile colitis with Vancomycin and Saccharomyces boulardii. Am J Gastroenterol 84: 1285–1287

    PubMed  CAS  Google Scholar 

  27. Trede M, Rask-Madsen J (1989) Bacteriotherapy for chronic relapsing Clostridium difficile diarrhea in six patients. Lancet 1: 1156–1160

    Google Scholar 

  28. Vidon N, Huchet B, Rambaud JC (1986) Influence de Saccaromyces boulardii sur la sécrétion jéjunale induit chez le rat par le toxin cholérique. Gastroenterol Clin Biol 10: 13–16

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. H.-U. Schmidt
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie und Hygiene, Albert-Ludwigs-Universität, Hermann-Herder-Straße 11, D-79104, Freiburg i. Br., Germany

    Manfred Kist

  2. Schwerpunkte: Gastroenterologie/Hepatologie und Pneumologie/Allergologie, Medizinische Klinik, Universitätsklinikum, Theodor-Stern-Kai 7, D-60590, Frankfurt a.M., Germany

    Wolfgang F. Caspary

  3. Zentrum für Kinderheilkunde, Rheinische Friedrich-Wilhelms-Universität, Adenauerallee 119, D-53113, Bonn, Germany

    Michael J. Lentze

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Schmidt, HU. (1996). Interaktionen zwischen Clostridium difficile und Saccharomyces boulardii. In: Kist, M., Caspary, W.F., Lentze, M.J. (eds) Ökosystem Darm VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80327-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80327-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61817-1

  • Online ISBN: 978-3-642-80327-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation