Zusammenfassung
Clostridium difficile, im Jahre 1935 als Bestandteil der Darmflora von Neugeborenen erstmals beschrieben [7], gilt heute als der einzige bekannte Erreger schwerer pseudomembranöser Colitiden während und nach Antibiotikabehandlungen und als wichtige Ursache der durch Antibiotika induzierten Diarrhöen überhaupt. Das ist seit der zweiten Hälfte der 70er Jahre bekannt, als es Bartlett und Tedesco mit ihren Arbeitsgruppen gelang, die Pathogenese der Clindamycin-assoziierten Kolitis zu klären, die damals aktuell war; die Geschichte dieser Entdeckung hat Bartlett kürzlich geschildert [2].
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Aronsson B, Möllby R, Nord CE (1985) Antimicrobial Agents and Clostridium difficile in acute enteric disease: Epidemiological data from Sweden, 1980–1982. J Infect Dis 151: 476–481
Bartlett JG (1994) Clostridium difficile: history of its role as an enteric pathogen and the current state of knowledge about the organism. Clin Infect Dis 18, Suppl 4: 265–272
Chang TW, Lauerman M, Bartlett JG (1979) Cytotoxicity assay in antibiotic-associated colitis. J Infect Dis 140: 765–770
Danninger M (1986) Untersuchungen zur Häufigkeit von Clostridium difficile in verschiedenen Altersklassen der gesunden Bevölkerung im Raum München - Vergleich verschiedener Nachweisverfahren. Med. Dissertation, Universität München
Ehret W, Turba M, Pfaller P, Heizmann W, Ruckdeschel G (1988) Computer-aided densitometric analysis of protein patterns of Clostridium difficile. Eur J Clin Microbiol Infect Dis 7: 285–290
George WL, Sutter VL, Citron D, Finegold SM (1979) Selective and differential medium for isolation of Clostridium difficile. J Clin Microbiol 9: 214–219
Hall IC, O’Toole E (1935) Intestinal flora in new-born infants with description of a new pathogenic organism Bacillus difficilis. Am J Dis Child 49: 390–402
Kelly WF, Wait KJ, Gilligan PH (1992) Evaluation of the latex agglutination test for detection of Clostridium difficile. Arch Pathol Lab Med 116: 517–520
Kelsey MC, Vince AJ (1979) Clostridia in neonatal faeces. Lancet 2: 100
Kim KH, Fekety FR, Batts DH, Brown D, Cudmore M, Silva J, Waters D (1981) Isolation of Clostridium difficile from the environment and contacts of patients with antibiotic-associated colitis. J Infect Dis 143: 42–50
Lyerly DM, Barroso LA, Wilkins TD (1991) Identification of the latex test-reactive protein of Clostridium difficile as glutamate dehydrogenase. J Clin Microbiol 29: 2639–2642
Mardh PA, Colleen HI, Oberg M, Holst E (1982) Clostridium difficile toxin in faecal specimens of healthy children with diarrhoe. Acta Paediatr Scand: 275–278
Marler LM, Siders JA, Wolters LC, Pettigrew Y, Skitt BL, Allen SD (1992) Comparison of five cultural procedures for isolation of Clostridium difficile from stools. J Clin Microbiol 30: 514–516
Möllby R, Aronsson B, Nord CE (1983) Ecological aspects on Clostridium difficile. 13th Int Congress Chemother, Abstract Nr. 45: 8 - 11
Nakamura S, Mikawa M, Nakashio S, Takabatake M, Okado I, Yamakawa K, Serikawa T, Okumura S, Nishida S (1981) Isolation of Clostridium difficile from the feces and the antibody in sera of young and elderly adults. Microbiol Immunol 25: 345–351
Ruckdeschel G (1992) Gattung Clostridium. In: Burkhardt F (Hrsg) Mikrobiologische Diagnostik. Thieme, Stuttgart New York, 223–237
Ruckdeschel G, Danninger M, Pfaller P (1984) Diagnostik und Epidemiologie von Clostridium difficile. Fortschr Antimikrob Antineoplast Chemother 3-4: 397–402
Shanholtzer CJ, Peterson LR (1987) Laboratory quality assurance testing of microbiologic media from commercial sources. Am J Clin Pathol 88: 210–215
Snyder ML (1940) The normal fecal flora of infants between two weeks and one year of age. J Infect Dis 66: 1–16
Stark PL, Lee A, Parsonage BD (1982) Colonization of the large bowel by Clostridium difficile in healthy infants: quantitative study. Infect Immun 35: 895–899
Svedham A, Kaijser B, McDowall I (1982) Intestinal occurence of Campylobacter fetus subspecies jejuni and Clostridium difficile in children in Sweden. Eur J Clin Microbiol 1: 29–32
Torres JF, Cedillo R, Sanchez J, Dillman C, Giono S, Munoz O (1984) Prevalence of Clostri¬dium difficile and its cytotoxin in infants in Mexico. J Clin Microbiol 20: 274–275
Viscidi R, Willey S, Bartlett JG (1981) Isolation rates and toxigenic potential of Clostridium difficile isolates from various patient populations. Gastroenterol 81: 5–9
Wilson KH, Kennedy MJ, Fekety R (1982) Use of sodium taurocholate to enhance spore recovery on a medium selective for Clostridium difficile. J Clin Microbiol 15: 443–446
Woods GL, Yam P (1988) Clinical comparison of latex agglutination and cytotoxin assay for detection of Clostridium diffìcile toxin in feces. Lab Med 19: 649–651
Wren B, Clayton C, Tabaqchali S (1990) Rapid identification of toxigenic Clostridium difficile by polymerase chain reaction. Lancet 1: 423 (Letter)
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Ruckdeschel, G., Lob, S., Schwarzenböck, A. (1996). Diagnostik und Epidemiologie der Clostridium difficile-Infektion. In: Kist, M., Caspary, W.F., Lentze, M.J. (eds) Ökosystem Darm VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80327-7_4
Download citation
DOI: https://doi.org/10.1007/978-3-642-80327-7_4
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-61817-1
Online ISBN: 978-3-642-80327-7
eBook Packages: Springer Book Archive