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Eikosanoide: Intrazelluläre autokrine Regulatoren epithelialer Funktionen im Gastrointestinaltrakt

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Ökosystem Darm VII

Zusammenfassung

Der in den Jahren 1934 bis 1938 durch von Euler geführte Nachweis, daß die starke biologische Aktivität des humanen Spermas bzw. Samenblasenextraktes vom Schaf auf einen oder mehrere Faktoren mit fettsäureähnlichen Eigenschaften zurückzufuhren ist, war die Geburtsstunde einer neuen Gruppe natürlich vorkommender biologisch aktiver Substanzen [12–15].

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Literatur

  1. Adachi T, Nakashima S, Saji S, Nakamura T, Nozawa Y (1995) Roles of prostaglandin production and mitogen-activated protein kinase activation in hepatocyte growth factor- mediated rat hepatocyte proliferation. Hepatoplogy 21: 1668–1674

    CAS  Google Scholar 

  2. Barrett KE, Bigby TD (1993) Involvement of arachidonic acid in the chloride secretory response of intestinal epithelial cells. Am J Physiol 264: C446–C452

    PubMed  CAS  Google Scholar 

  3. Bergström S (1966) Isolation structure and action of the prostaglandins. In: Bergström S, Samuelsson B (eds) Prostaglandins: proceedings of the second nobel symposium. Wiley, New York, 21–30

    Google Scholar 

  4. Bergström S, Sjövall J (1957) The isolation of prostaglandins. Acta Chem Scand 11: 1086–1089

    Article  Google Scholar 

  5. Burstein S, Budrow J, Debatis M, Hunter SA, Subramanian A (1994) Phospholipase participation in cannabinoid-induced release of free arachidonic acid. Biochem Pharmacol 48: 1253–1264

    Article  PubMed  CAS  Google Scholar 

  6. Cybulsky AV, Goodyer PR, Cyr MD, McTavish AF (1992) Eicosanoids enhance epidermal growth factor receptor activation and proliferation in glomerular epithelial cells. Am J Physiol 262: F639–F646

    PubMed  CAS  Google Scholar 

  7. Dennis EA, Ackermann EJ, Deems RA, Reynolds LJ (1995) Multiple forms of phospholipase A2 in macrophages capable of arachidonic acid release for eicosanoid biosynthesis. Adv Prostaglandin Thromboxane Leukot Res 23: 75–80

    PubMed  CAS  Google Scholar 

  8. DuBois RN, Tsujii M, Bishop P, Awad JA, Makita K, Lanahan A (1994) Cloning and characterization of a growth factor-inducible cyclooxygenase gene from rat intestinal epithelial cells. Am J Physiol 266: G822–G827

    PubMed  CAS  Google Scholar 

  9. DuBois RN, Awad J, Morrow J, Roberts LJ, 2nd, Bishop PR (1994) Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor- alpha and phorbol ester. J Clin Invest 93: 493–498

    Article  PubMed  CAS  Google Scholar 

  10. Eliasson R (1959) Studies on prostaglandin. Occurrence, formation and biological actions. Acta Physiol Scand 46 (Suppl): 158–162

    Google Scholar 

  11. Escalante B, Erlij D, Falck JR, McGiff JC (1991) Effect of cytochrome P450 arachidonate metabolites on ion transport in rabbit kidney loop Henle. Science 251: 799–802

    Article  PubMed  CAS  Google Scholar 

  12. Euler von US (1934) Zur Erkenntnis der pharmakologischen Wirkungen von Nativsekreten und Extrakten männlicher accesorischer Geschlechtsdrüßen. Naunyn-Schniedeberg’s Arch Pharmak 175: 78–84

    Article  Google Scholar 

  13. Euler von US (1935) Über die spezifische blutdrucksenkende Substanz des menschlichen Prostata- und Samenblasensekretes. Klin Wschr 14: 1182–1183

    Article  Google Scholar 

  14. Euler von US (1936) On the specific vasodilating substances from accessory genital glands in man and certain animals (prostaglandin and vesiglandin). J Physiol Lond 88: 213–234

    Google Scholar 

  15. Euler von US (1938) Action of adrenaline, acetylcholine and substances on nerve-free vessels (human placenta). J Physiol Lond 93: 129–143

    Google Scholar 

  16. Exton JH (1994) Phosphatidylcholine breakdown and signal transduction. Biochim Biophys Acta 1212: 26–42

    PubMed  CAS  Google Scholar 

  17. Glaser KB (1995) Regulation of phospholipase A2 enzymes: selective inhibitors and their pharmacological potential. Adv Pharnacol 32: 31–66

    Article  CAS  Google Scholar 

  18. Glaser KB, Mobilio D, Chang JY, Senko N (1993) Phospholipase A2 enzymes: regulation and inhibition. Trends Pharmacol Sci 14: 92–98

    Article  PubMed  CAS  Google Scholar 

  19. Gronich J, Konieczkowski M, Gelb MH, Nemenoff RA, Sedor JR (1994) Interleukin 1 alpha causes rapid activation of cytosolic phospholipase A2 by phosphorylation in rat mesangial cells. J Clin Invest 93: 1224–1233

    Article  PubMed  CAS  Google Scholar 

  20. Hatzelmann A, Fruchtmann R, Möhrs KH, Raddatz S, Matzke M, Pleiss U, Keldenich J, Muller-Peddinghaus R (1994) Mode of action of the leukotriene synthesis (FLAP) inhibitor BAY X 1005: implications for biological regulation of 5-lipoxygenase. Agents Actions 43: 64–68

    Article  PubMed  CAS  Google Scholar 

  21. Isakson P, Hauser S, Zhang Y, Leahy K, Masferrer J, Scibert K (1994) Cytokine regulation of eicosanoid generation. Ann N Y Acad Sci 744: 181–183

    Article  PubMed  CAS  Google Scholar 

  22. LeDuc LE, McRoberts JA, Vidrich A (1994) Eicosanoid production by a differentiated canine colonic epithelial cell line, VNCC. Gastroenterol 106: 297–305

    Google Scholar 

  23. Ling BN, Webster CL, Eaton DC (1993) Eicosanoids modulate apical Ca2+ - dependent K+ channels in cultured rabbit principal cells. Am J Physiol 263: F116–F126

    Google Scholar 

  24. Macica C, Balazy B, Falck JR, Mioskowski C, Carrol MA (1993) Characterization of cytochrome P-450-dependent arachidonic acid metabolism in rabbit intestine. Am J Physiol 265: G735–G741

    PubMed  CAS  Google Scholar 

  25. McGiff JC (1981) Prostaglandins, prostacyglin and thromboxanes. Ann Rev Pharmacol Toxicol 21: 479–509

    Article  CAS  Google Scholar 

  26. Moncada S, Vane JR (1979) Pharmycology and endogenous roles of prostaglandin endo- peroxides, thromboxane A2 and prostacycline. Pharmac Rev 30: 293–331

    Google Scholar 

  27. Murakami M, Austen KF, Arm JP (1995) The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. J Exp Med 182: 197–206

    Article  PubMed  CAS  Google Scholar 

  28. Rao CV, Simi B, Wynn TT, Garr K, Reddy BS (1996) Modulating effect of amount and types of dietary fat on colonic mucosal phospholipase A2, phosphatidylinositol-specifk phospholipase C activities, and cyclooxygenase metabolite formation during different stages of colon tumor promotion in male F344 rats. Cancer Res 56: 532–537

    PubMed  CAS  Google Scholar 

  29. Riendeau D, Guay J, Weech PK, Laliberte F, Yergey J, Li C, Desmarais S, Perrier H, Liu S, Nicoll-Grifitth D et al. (1994) Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetrae- noic acid by calcium ionophore-challenged platelets. J Biol Chem 269: 15619–15624

    PubMed  CAS  Google Scholar 

  30. Rose DP, Hatala MA (1994) Dietary fatty acids and breast cancer invasion and metastasis. Nutr Cancer 21: 103–111

    Article  PubMed  CAS  Google Scholar 

  31. Sa G, Murugesan G, Jaye M, Ivashchenko Y, Fox PL (1995) Activation of cytosolic phospholipase A2 by basic fibroblast growth factor via a p42 mitogen-activated protein kinase-dependent phosphorylation pathway in endothelial cells. J Biol Chem 270: 2360–2366

    Article  PubMed  CAS  Google Scholar 

  32. Samuelsson B, Gangstrom E, Green K, Hamberg M (1971) Metabolism of prostaglandins. In: Ramwell PW, Shaw JE (eds) Prostaglandins. Ann N Y Acad Sci 180: 138–163

    Google Scholar 

  33. Samuelsson B, Borgeat P, Hammerström S, Murphy RC (1980) Leukotrienes: a new group of biologically activ compounds. In: Samuelsson B, Ramwell PW, Paoletti P (eds) Advances in Prostaglandines and thromboxane research. Raven Press, New York, (Vol 6 ) 1–18

    Google Scholar 

  34. Stein J, Uphoff K, Zeuzem S, Laube H (1994) Effects of prostaglandins and indomethacin on gastric emptying in the rat. Prostaglandins 47: 31–40

    Article  PubMed  CAS  Google Scholar 

  35. Stein J (1992) Gastrale Prostaglandine: Mucosale Synthese und ihre Wirkung auf die Magenentleerung der Ratte. Inaugural-Dissertation, Universität Gießen

    Google Scholar 

  36. Traber PG, Wang W, Yu L (1992) Differential regulation of cytochrome P-450 genes along rat intestinal crypt-villus axis. Am J Physiol 263: G215–G223

    PubMed  CAS  Google Scholar 

  37. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirinlike drugs. Nature 231: 232–235

    CAS  Google Scholar 

  38. Weller PF, Dvorak AM (1994) Lipid bodies: intracellular sites for eicosanoid formation. J Allergy Clin Immunol 94: 1151–1156

    Article  PubMed  CAS  Google Scholar 

  39. Triggiani M, Oriente A, De Crescenzo G, Rossi G, Maone G (1995) Biochemical functions of a pool of arachidonic acid associated with triglycerides in human inflammatory cells. Int Arch Allergy Immunol 107 (1-3): 261–263

    Article  PubMed  CAS  Google Scholar 

  40. Woods JW, Evans JF, Ethier D, Scott S, Vickers PJ, Hearn L, Heibein JA, Charleson S, Singer I (1993) 5-lipoxygenase-activating protein are localized in the nuclear envelope of activated human leucocytes. J Exp Med 178: 1935–1946

    Google Scholar 

  41. Xu XX, Rock CO, Qiu ZH, Leslie CC, Jackowski S (1994) Regulation of cytosolic phospholipase A2 phosphorylation and eicosanoid production by colony-stimulating factor 1. J Biol Chem 269: 31693–31700

    PubMed  CAS  Google Scholar 

  42. Yang VW (1996) Eicosanoids and inflammatory bowel disease. In: DuBois RN, Giardiello FM (eds) NSAIDs, eicosanoids, and the gastroenteric tract. Gastroenterol Clin N 25: 317–332

    Google Scholar 

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© 1996 Springer-Verlag Berlin Heidelberg

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Stein, J., Schröder, O. (1996). Eikosanoide: Intrazelluläre autokrine Regulatoren epithelialer Funktionen im Gastrointestinaltrakt. In: Kist, M., Caspary, W.F., Lentze, M.J. (eds) Ökosystem Darm VII. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80327-7_12

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  • DOI: https://doi.org/10.1007/978-3-642-80327-7_12

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