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General Considerations: Physiology

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Pancreatitis

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Abstract

The pancreas is composed of endocrine and exocrine elements. The endocrine pancreas is composed of only 2% of the mass of the pancreas. The exocrine pancreas comprises approximately 85%. The remainder of the pancreas is composed of connective tissue, nerves, and blood vessels. Recent studies have advanced our knowledge considerably regarding the physiology of the pancreas [1–16, 18–20, 22].

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References

  1. Adler G, Beglinger C, Braun U, Reinshagen M, Koop I, Schafmayer A, Rovati L, Arnold R (1991) Interaction of the cholinergic system and cholecystokinin in the regulation of endogenous and exogenous stimulation of pancreatic secretion in humans. Gastroenterology 100: 537–543

    PubMed  CAS  Google Scholar 

  2. Adler G, Nelson DK, Katschinski M, Beglinger C (1995) Neurohormonal control of human pancreatic exocrine secretion. Pancreas 10: 1–13

    Article  PubMed  CAS  Google Scholar 

  3. Brodish RJ, Kuvshinoff BW, McFadden DW, Fink AS (1995) Adrenergic pathways do not mediate peptide YY-induced inhibition of pancreatic exocrine secretion. Pancreas 10: 187–193

    Article  PubMed  CAS  Google Scholar 

  4. Brodish RJ, Kuvshinoff BW, McFadden DW, Fink AS (1995) Somatostatin inhibits cholecystokinin-induced pancreatic protein secretion via cholinergic pathways. Pancreas 10: 401–406

    Article  PubMed  CAS  Google Scholar 

  5. de Ondarza J, Hootman SR (1995) Regulation of cyclic AMP levels in guinea pig pancreatic ducts and cultured duct epithelial monolayers. Pancreas 11: 261–270

    Article  PubMed  Google Scholar 

  6. Gomez G, Upp JR Jr, Lluis F, Alexander RW, Poston GJ, Greeley GH Jr, Thompson JC (1988) Regulation of the release of cholecystokinin by bile salts in dogs and humans. Gastroenterology 94: 1036–1046

    PubMed  CAS  Google Scholar 

  7. Jin H, Cai L, Lee K, Chang T-M, Li P, Wagner D, Chey WY (1993) A physiological role of peptide YY on exocrine pancreatic secretion in rats. Gastroenterology 105: 208–215

    PubMed  CAS  Google Scholar 

  8. Jin HO, Song CW, Chang TM, Chey WY (1994) Roles of gut hormones in negative-feedback regulation of pancreatic exocrine secretion in humans. Gastroenterology 107: 1828–1834

    PubMed  CAS  Google Scholar 

  9. Kuvshinoff BW, Brodish RJ, James L, McFadden DW, Fink AS (1993) Somatostatin inhibits secretin-induced canine pancreatic response via a cholinergic mechanism. Gastroenterology 105: 539–547

    PubMed  CAS  Google Scholar 

  10. Kuvshinoff BW, Demar AR, James L, McFadden DW, Fink AS (1993) Effect of pancreatic denervation and atropine on the pancreatic response to secretin. Pancreas 8: 609–614

    Article  PubMed  CAS  Google Scholar 

  11. Li Y, Owyang C (1994) Endogenous cholecystokinin stimulates pancreatic enzyme secretion via vagal afferent pathway in rats. Gastroenterology 107: 525–531

    PubMed  CAS  Google Scholar 

  12. Lluis F, Gomez G, Fujimura M, Greeley GH Jr, Thompson JC (1988) Peptide YY inhibits pancreatic secretion by inhibiting cholecystokinin release in the dog. Gastroenterology 94: 137–144

    PubMed  CAS  Google Scholar 

  13. Marino CR (1993) Pancreatic duct cell physiology. Curr Opinion Gastroenterol 9: 740–746

    Article  Google Scholar 

  14. Miyasaka K, Sazaki N, Funakoshi A, Matsumoto M, Kitani K (1993) Two mechanisms of inhibition by bile on luminal feedback regulation of rat pancreas. Gastroenterology 104: 1780–1785

    PubMed  CAS  Google Scholar 

  15. Okumura T, Pappas TN, Taylor IL (1995) Pancreatic polypeptide microinjection into the dorsal motor nucleus inhibits pancreatic secretion in rats. Gastroenterology 108: 1517–1525

    Article  PubMed  CAS  Google Scholar 

  16. Owyang C (1993) Neurohormonal control of the exocrine pancreas. Curr Opinion Gastroenterol 9: 747–751

    Article  Google Scholar 

  17. Palade G (1975) Intracellular aspects of the process of protein synthesis. Science 189: 347–358

    Article  PubMed  CAS  Google Scholar 

  18. Rhodes RA, Skerven G, Chey WY, Chang T-M (1988) Acid-independent release of secretin and cholecystokinin by intraduodenal infusion of fat in humans. Pancreas 3: 391–398

    Article  PubMed  CAS  Google Scholar 

  19. Solomon TE (1995) Physiology of the exocrine pancreas. In: Haubrich WS, Schaffner F, Berk JE (eds) Bockus Gastroenterology, 5th edn. W.B. Saunders Comp., Philadelphia-London etc, pp 2821–2834

    Google Scholar 

  20. Soudah HC, Lu Y, Hasler WL, Owyang C (1992) Cholecystokinin at physiological levels evokes pancreatic enzyme secretion via a cholinergic pathway. Am J Physiol 263: G102 - G107

    PubMed  CAS  Google Scholar 

  21. Steer ML, Meldolesi J (1987) The cell biology of experimental pancreatitis. N Engl J Med 316: 144–150

    Article  PubMed  CAS  Google Scholar 

  22. Tomita H, Miyasaka K, Matsumoto M, Funakoshi A (1994) Direct, concentration-dependent inhibition by taurocholate of pancreatic exocrine secretion and CCK release in conscious rats. Dig Dis Sci 39: 1544–1549

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Medizinische Klinik, Städtisches Krankenhaus, Bögelstraße 1, D-21339, Lüneburg, Germany

    Prof. Dr. P. G. Lankisch

  2. Gastroenterology Division, Brigham and Women’s Hospital, 75 Francis Street, 02115, Boston, MA, USA

    Peter A. Banks M.D. (Associate Professor of Medicine, Harvard Medical School, Director, Clinical Gastroenterology Service)

Authors
  1. Prof. Dr. P. G. Lankisch
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  2. Peter A. Banks M.D.
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© 1998 Springer-Verlag Berlin Heidelberg

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Lankisch, P.G., Banks, P.A. (1998). General Considerations: Physiology. In: Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80320-8_3

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  • DOI: https://doi.org/10.1007/978-3-642-80320-8_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80322-2

  • Online ISBN: 978-3-642-80320-8

  • eBook Packages: Springer Book Archive

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