Abstract
There is no one generally accepted concept for explaining the pathophysiology of chronic pancreatitis. Four major hypotheses have been proposed, that may to some extent explain the development of chronic pancreatitis, but further studies are required.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Bordalo O, Baptista A, Dreiling D, Noronha M (1984) Early pathomorphological pancreatic changes in chronic alcoholism. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis–Concepts and Classification. Elsevier Science Publ., Amsterdam, pp 57–60
Bordalo O, Goncalves D, Noronha M, Cristina ML, Salgadinho A, Dreiling DA (1977) Newer concept for the pathogenesis of chronic alcoholic pancreatitis. Am J Gastroenterol 68: 278–285
Dagorn JC (1993) Lithostathine. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds) The Pancreas: Biology, Pathobiology, and Disease, 2nd edn. Raven Press, New York, pp 253–263
DiMagno EP, Layer P, Clain JE (1993) Chronic pancreatitis. In: Go VLW, DiMagno EP, Gardner JD, Lebenthal E, Reber HA, Scheele GA (eds) The Pancreas: Biology, Pathobiology, and Disease, 2nd edn. Raven Press, New York, pp 665–706
Freedman SD, Sakamoto K, Venu RP (1993) GP2, the homologue to the renal cast protein uromodulin, is a major component of intraductal plugs in chronic pancreatitis. J Clin Invest 92: 83–90
Fukuoka S-I, Freedman SD, Scheele GA (1991) A single gene encodes membrane-bound and free forms of GP-2, the major glycoprotein in pancreatic secretory (zymogen) granule membranes. Proc Natl Acad Sci USA 88: 2898–2902
Giorgi D, Bernard J-P, Rouquier S, Iovanna J, Sarles H, Dagorn J-C (1989) Secretory pancreatic stone protein messenger RNA. Nucleotide sequence and expression in chronic calcifying pancreatitis. J Clin Invest 84: 100–106
Hoops TC, Rindler MJ (1991) Isolation of the cDNA encoding glycoprotein-2 (GP-2), the major zymogen granule membrane protein. Homology to uromudulin/Tamm-Horsfall protein. J Biol Chem 266: 4257–4263
Klöppel G, Maillet B (1991) Pseudocysts in chronic pancreatitis: a morphological analysis of 57 resection specimens and 9 autopsy pancreata. Pancreas 6: 266–274
Klöppel G, Maillet B (1991) Chronic pancreatitis: evolution of the disease. Hepatogastroenterology 38: 408–412
Klöppel G, Maillet B (1992) The morphological basis for the evolution of acute pancreatitis into chronic pancreatitis. Virchows Arch [Pathol Anat] 420: 1–4
Klöppel G, von Gerkan R, Dreyer T (1984) Pathomorphology of acute pancreatitis. Analysis of 367 autopsy cases and 3 surgical specimens. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis–Concepts and Classification. Elsevier Science Publ., Amsterdam, pp 29–35
Layer P, Hotz J, Schmitz-Moormann HP, Goebell H (1982) Effects of experimental chronic hypercalcemia on feline exocrine pancreatic secretion. Gastroenterology 82: 309–316
Lohse J, Pfeiffer A (1984) Duodenal total and ionised calcium secretion in normal subjects, chronic alcoholics, and patients with various stages of chronic alcoholic pancreatitis. Gut 25: 874–880
Lohse J, Schmidt D, Sarles H (1983) Pancreatic citrate and protein secretion of alcoholic dogs in response to graded doses of caerulein. Pflügers Arch 397: 141–143
Multigner L, Sarles H, Lombardo D, de Caro A (1985) Pancreatic stone protein. II. Implication in stone formation during the course of chronic calcifying pancreatitis. Gastroenterology 89: 387–391
Noronha M, Baptista A, Bordalo O (1984) Sequential aspects of pathology in chronic alcoholic disease of the pancreas. In: Gyr KE, Singer MV, Sarles H (eds) Pancreatitis–Concepts and Classification. Elsevier Science Publ., Amsterdam, pp 61–65
Noronha M, Salgadinho A, Ferreira de Almeida MJ, Dreiling DA, Bordalo O (1981) Alcohol and the pancreas. I. Clinical associations and histopathology of minimal pancreatic inflammation. Am J Gastroenterol 76: 114–119
Planche NE, Palasciano G, Meullenet J, Laugier R, Sarles H (1982) Effects of intravenous alcohol on pancreatic and biliary secretion in man. Dig Dis Sci 27: 449–453
Reber HA, Roberts C, Way LW (1979) The pancreatic duct mucosal barrier. Am J Surg 137: 128–134
Renner IG, Rinderknecht H, Valenzuela JE, Douglas AP (1980) Studies of pure pancreatic secretions in chronic alcoholic subjects without pancreatic insufficiency. Scand J Gastroenterol 15: 241–244
Sahel J, Sarles H (1979) Modifications of pure human pancreatic juice induced by chronic alcohol consumption. Dig Dis Sci 24: 897–905
Sarles H (1975) Alcohol and the pancreas. Ann N Y Acad Sci 252: 171–182
Sarles H (1984) Epidemiology and physiopathology of chronic pancreatitis and the role of the pancreatic stone protein. Clin Gastroenterol 13: 895–912
Sarles H, Bernard JP, Johnson C (1989) Pathogenesis and epidemiology of chronic pancreatitis. Ann Rev Med 40: 453–468
Sarles H, Dagorn JC, Giorgi D, Bernard JP (1990) Renaming pancreatic stone protein as “lithostathine”. Gastroenterology 99: 900–901
Schmiegel W, Burchert M, Kalthoff H, Roeder C, Bützow G, Grimm H, Kremer B, Soehendra N, Schreiber H-W, Thiele H-G, Greten H (1990) Immunochemical characterization and quantitative distribution of pancreatic stone protein in sera and pancreatic secretions in pancreatic disorders. Gastroenterology 99: 1421–1430
Watanabe T, Yonekura H, Terazono K, Yamamoto H, Okamoto H (1990) Complete nucleotide sequence of human reg gene and its expression in normal and tumoral tissues. J Biol Chem 265: 7432–7439
Yamadera K, Moriyama T, Makino I (1990) Identification of immunoreactive pancreatic stone protein in pancreatic stone, pancreatic tissue, and pancreatic juice. Pancreas 5: 255–260
Author information
Authors and Affiliations
Rights and permissions
Copyright information
© 1998 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lankisch, P.G., Banks, P.A. (1998). Chronic Pancreatitis: Pathophysiology. In: Pancreatitis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80320-8_14
Download citation
DOI: https://doi.org/10.1007/978-3-642-80320-8_14
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80322-2
Online ISBN: 978-3-642-80320-8
eBook Packages: Springer Book Archive