The Primary Processes in Heme Protein Relaxation: The Coupled Reaction Coordinate Problem in Molecular Cooperativity

  • H.-L. Chiu
  • J. Deak
  • R. J. D. Miller
Conference paper
Part of the Springer Series in Chemical Physics book series (CHEMICAL, volume 62)


The phenomena of molecular cooperativity involves an interaction between two or more different protein moieties in which one protein’s function is controlled synergistically by its neighbor. Changes in state of the adjacent protein, such as changes in ligation of a receptor molecule, affect the reaction rate of its neighbor, often several nanometers away. Our current understanding of this process is based on structural changes at one site affecting the adjacent activation barrier. In order to affect a reaction coordinate at a distance, these structural changes must involve highly correlated atomic displacements coupling thousands of degrees of freedom. The key question then is what is the mechanism by which the reaction forces at one site propagate to adjacent sites, i.e., what is the communication pathway?


Reaction Coordinate Polarization Dependence Biophysical Journal Absorption Anisotropy Short Range Motion 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • H.-L. Chiu
    • 1
  • J. Deak
    • 1
  • R. J. D. Miller
    • 1
  1. 1.Departments of Chemistry and PhysicsUniversity of TorontoTorontoCanada

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