Advertisement

The Origins of the Central Nervous System

  • R. McKay
Conference paper
Part of the Research and Perspectives in Neurosciences book series (NEUROSCIENCE)

Abstract

Understanding the developmental origins of the nervous sytem is important for two reasons. First, it is intellectually interesting as an example of the assembly of a multicellular system. Second, this knowledge will permit us to control the assembly and disassembly of this system in health and in disease. Of course the brain is an extraordinarily complex device and there are many steps in the assembly process. Following the advice given to Alice in Wonderland, we can begin at the beginning and ask what cells give rise to the nervous system.

Keywords

Stem Cell Neuronal Differentiation Nestin Expression Multicellular System Direct Gene Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Amazan G, McKay RDG (1992) An oligodendrocyte precursor cell line from rat optic nerve. Brain Res 579:243–245Google Scholar
  2. Brustle O, Maskos U, McKay RDG (1995) Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron, in pressGoogle Scholar
  3. Cattaneo E, McKay RDG (1990) Nerve growth factor regulates proliferation and differentiation of neuronal stem cells. Nature 347:762–765PubMedCrossRefGoogle Scholar
  4. Frederiksen K, McKay R (1988) Proliferation and differentiation of rat neuroepithelial precursor cells in vitro. J Neurosci 8:1144–1151PubMedGoogle Scholar
  5. Hockfield S, McKay RDG. (1985) Identification of major cell classes in the developing mammalian nervous system. J Neurosci 5:3310–3328PubMedGoogle Scholar
  6. Lendahl U, Zimmerman L, McKay RDG (1990) CNS stem cells express a new class of intermediate filament proetin. Cell 60:585–595PubMedCrossRefGoogle Scholar
  7. Renfranz P, Cunningham M, McKay RDG (1991) Region-specific differentiation of the hippocampal stem cell line HiB5 upon implantation into the developing mammalian brain. Cell 66:713–729PubMedCrossRefGoogle Scholar
  8. Vicario-Abejon C, Johe K, Hazel TG, Collazo D, McKay RDG (1995a) Functions of basic fibroblast growth factor and neurotrophins in the differentiation of hippocampal neurons. Neuron 15:105–114PubMedCrossRefGoogle Scholar
  9. Vicario-Abejon C, Cunningham M, McKay RDG (1995b) Cerebellar precursors transplanted to the neonatal dentate gyrus express features characteristic of hippocampal neurons. J Neurosci, in pressGoogle Scholar
  10. Zimmerman LZ, Lendahl U, Cunningham M, McKay R, Parr B, Gavin B, Mann J, Vassileva G, McMahon A (1994) Independent regulatory elements in the nestin gene direct transgene expression to neural stem cells or muscle presursors. Neuron 12, 11–24PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1997

Authors and Affiliations

  • R. McKay

There are no affiliations available

Personalised recommendations