The Origins of the Central Nervous System
Understanding the developmental origins of the nervous sytem is important for two reasons. First, it is intellectually interesting as an example of the assembly of a multicellular system. Second, this knowledge will permit us to control the assembly and disassembly of this system in health and in disease. Of course the brain is an extraordinarily complex device and there are many steps in the assembly process. Following the advice given to Alice in Wonderland, we can begin at the beginning and ask what cells give rise to the nervous system.
KeywordsStem Cell Neuronal Differentiation Nestin Expression Multicellular System Direct Gene Expression
Unable to display preview. Download preview PDF.
- Amazan G, McKay RDG (1992) An oligodendrocyte precursor cell line from rat optic nerve. Brain Res 579:243–245Google Scholar
- Brustle O, Maskos U, McKay RDG (1995) Host-guided migration allows targeted introduction of neurons into the embryonic brain. Neuron, in pressGoogle Scholar
- Vicario-Abejon C, Cunningham M, McKay RDG (1995b) Cerebellar precursors transplanted to the neonatal dentate gyrus express features characteristic of hippocampal neurons. J Neurosci, in pressGoogle Scholar