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Die isolierte hypertherme Extremitätenperfusion beim Malignen Melanom mit Melphalan und Tumornekrosefaktor

Isolated Hyperthermic Limb Perfusion for Malignant Melanoma with Melphaland and Tumor Necrosis Factor

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Wahrung des Bestandes, Wandel und Fortschritt der Chirurgie

Part of the book series: Langenbecks Archiv für Chirurgie ((KONGRESSBAND,volume 1996))

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Summary

Isolated limb perfusion (ILP) with tumor necrosis factor (TNF) and melphalan was carried out in 21 patients with regionally metastatic malignant melanoma of the limbs. The observed response rate was 65% complete and 15% partial remission. These results warrant further investigation of ILP with TNF and melphalan vs ILP with melphalan alone in a prospective randomised multicenter trial.

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Literatur

  1. Kettelhack C, Kraus T, Hupp T, Manner M., Schlag P (1990) Hyperthermic limb perfusion for malignant melanoma and soft tissue sarcoma. Eur J Surg Oncol 16:370–375

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  2. Lienard D, Eggermont AMM, Schraffordt Koops H, Kroon BBR, Rosenkaimer F, Autier P, Lejeune FJ (1994) Isolated perfusion of the limb with high-dose tumor necrosis factor-alpha (TNF-α), inter-feron-gamma (IFN-γ) and melphalan for melanoma stage III. Results of a multi-center pilot study. Melanoma Res 4 (S 1): 21–26

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  3. Lienard D, Ewalenko P, Delmotte JJ, Lejeune FJ (1992) High-dose recombinant tumor necrosis factor alpha in combination with interferon gamma and melphalan in isolation perfusion of the limbs for melanoma and sarcoma. J Clin Oncol 10:52–60

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Author information

Authors and Affiliations

  1. Virchow-Klinikum, Robert-Rössle-Klinik, Humboldt-Universität, Lindenberger Weg 80, D-13122, Berlin, Deutschland

    C. Kettelhack, P. Hohenberger & P. M. Schlag

Authors
  1. C. Kettelhack
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  2. P. Hohenberger
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  3. P. M. Schlag
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Editor information

Editors and Affiliations

  1. Deutschen Gesellschaft für Chirurgie, Steinhölzle 16, D-89197, Westerstetten-Vorderdenkental, Deutschland

    W. Hartel (Generalsekretär) (Generalsekretär)

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© 1996 Springer-Verlag Berlin Heidelberg

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Kettelhack, C., Hohenberger, P., Schlag, P.M. (1996). Die isolierte hypertherme Extremitätenperfusion beim Malignen Melanom mit Melphalan und Tumornekrosefaktor. In: Hartel, W. (eds) Wahrung des Bestandes, Wandel und Fortschritt der Chirurgie. Langenbecks Archiv für Chirurgie, vol 1996. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80295-9_25

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  • DOI: https://doi.org/10.1007/978-3-642-80295-9_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61617-7

  • Online ISBN: 978-3-642-80295-9

  • eBook Packages: Springer Book Archive

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