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Polyethyleneimine Derivatives as Nucleic Acid Model and Interaction with DNA

  • Yoshiaki Inaki
  • Takehiko Wada
Conference paper

Abstract

Polyethyleneimine derivatives having nucleic acid bases and hydrophilic amino acids such as homoserine and serine were prepared as nucleic acid models. The polymers were found to interact with DNA accompanied by induction of conformational change. The induced conformation of DNA by interaction with the polymer containing uracil and homoserine (PEI-Hse-Ura) was concluded as super triple helical structure. The formation of the polymer complex, DNA: PEI-Hse-Ura, was found to be affected by the presence of metal ions such as Ca2+ and Cu2+.

Keywords

Polymer Complex Hydrophilic Amino Acid Double Helical Structure Type Conformation Specific Hydrogen Bonding 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • Yoshiaki Inaki
    • 1
  • Takehiko Wada
    • 1
  1. 1.Department of Applied Chemistry, Faculty of EngineeringOsaka UniversitySuita, OsakaJapan

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