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Polyethyleneimine Derivatives as Nucleic Acid Model and Interaction with DNA

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New Macromolecular Architecture and Functions

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Abstract

Polyethyleneimine derivatives having nucleic acid bases and hydrophilic amino acids such as homoserine and serine were prepared as nucleic acid models. The polymers were found to interact with DNA accompanied by induction of conformational change. The induced conformation of DNA by interaction with the polymer containing uracil and homoserine (PEI-Hse-Ura) was concluded as super triple helical structure. The formation of the polymer complex, DNA: PEI-Hse-Ura, was found to be affected by the presence of metal ions such as Ca2+ and Cu2+.

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Author information

Authors and Affiliations

  1. Department of Applied Chemistry, Faculty of Engineering, Osaka University, Suita, Osaka, 565, Japan

    Yoshiaki Inaki & Takehiko Wada

Authors
  1. Yoshiaki Inaki
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  2. Takehiko Wada
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Editor information

Editors and Affiliations

  1. Dept. of Macromolecular Science, Osaka University, 560, Toyonaka, Osaka, Japan

    Mikiharu Kamachi  & Akira Nakamura  & 

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© 1996 Springer-Verlag Berlin Heidelberg

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Inaki, Y., Wada, T. (1996). Polyethyleneimine Derivatives as Nucleic Acid Model and Interaction with DNA. In: Kamachi, M., Nakamura, A. (eds) New Macromolecular Architecture and Functions. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80289-8_9

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  • DOI: https://doi.org/10.1007/978-3-642-80289-8_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80291-1

  • Online ISBN: 978-3-642-80289-8

  • eBook Packages: Springer Book Archive

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