Zusammenfassung
Diese Studie zur Photodynamischen Therapie (PDT) beschäftigte sich mit einem Photosensibilisator aus der Gruppe der Phthalocyanine [1, 2,3, 4, 5, 6, 7, 8, 11, 12, 13], dem Okta-α-butyloxy-Zinkphthalocyanin (8-α-bo-ZnPc). Untersucht wurde die Pharmakokinetik des Photosensibilisators am Lewis lung Tumormodell der Maus mit folgenden Fragestellungen:
-
1.
Bestimmung der Akkumulationsraten in ausgewählten Organen
-
2.
Ermittlung eines geeigneten Inkubationsintervalls für den Einsatz einer PDT
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Bown S.G., Tralau C.J., Colderidge-Smith P.D., Akdemir D., and Wiemann T.J., 1986. Photodynamic therapy with porphyrin and phtalocyanine sensitisation: Quantitativ studies in normal rat liver. Br.J.Cancer 54: 43–52
Panjehpour ML, Sneed R.E., Frazier D.L., Barnhill M.A., O’Brien S., Harb W., and Overholt B.F., et al., 1991. Quantification of phtalocyanine concentration in rat tissue using laser-induced fluorescence spectroscopy. Laser Surg.Med. 13: 23–30
Hünerbein M., Stern J., Graschew G., Friedrich E.A., Sinn H. und Schlag P, 1992. Wertigkeit von Spektroskopie und Laser-Fluoreszenz-Mikroskopie zum Nachweis von Photosensibilatoren in Gewebe. Lasermedizin 8: 153–158
Chan W.S., Marshall J.F., Svensen R, Bedwell J., and Hart I.R., 1990. Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminium phtalocyanine. Cancer Res. 50: 4533–4538
Chatlani P.T., Bedwell J., MacRobert A.J., Barr H., Boulos P.B., Krasner N., Phillips D., and Bown S.G., 1991. Comparison of distribution and photodynamic effects of di- and tetra-sulphonated aluminium phtalocyanines in normal rat colon. Photochem.Photobiol. 53: 745–751
Tralau C.J., MacRobert A.J., Coleridge-Smith P.D., Barr H., and Bown S.G., 1987. Photodynamic therapy with phthalocyanine sensitisation: quantitative studies in a transplantable rat fibrosarcoma. Br J.Cancer 55: 389–395
Reddi E., Lo Castro G., Biolo R., and Jori G., 1987. Pharmacokinetic studies with zinc II phthalocyanine in tumorbearing mice. Br J.Cancer 56: 597–600
Biolo R., et al., 1991. A comparison of fluorescence methods used in the pharmacokinetic studies of Zn II phtalocyanine in mice. Photochem. Photobioi 53: 113–118
Röder B, Dressier C., Hagemann R., Fuchs B., Berlien H.-P., Nowak C., and Moser J.G., 1994. The Pharmakokinetics of 132-hydroxy-bacteriopheophorbide a methylcstcr studied by fluorescence spectroscopy on Lewis lung carcinoma bearing mice. SPIE 2078: 349–359
Röder B., Zimmermann C., Herter R, 1994. Photophysical characterization of far-red absorbing photosensitizers in cyclodextrin solutions. SPIE 2325: 80–91
Dressier C, Ismail M.S., Nowak C., Herter R., Senz R.G., Hagemann R., Röder B., Berlien H.-P., 1994. On the Pharmacokinetics of the far red absorbing Okta-a-butyloxy-Zinkphthalocyanin in Lewis lung carcinoma bearing mice. SPIE 2325: 220–227
Daraio M.E., Aramendia P.F., San Roman E.A, Braslavsky S.E., 1991. Carboxylated zinc-phtalocyanines II dimerization and singlet molecular oxygen sensitization in hexadecyltrimethylammonium bromide micelles. Photochem.Photobiol. 54: 367–370
Rosenthal I, 1991. Phthalocyanines as photodynamic sensitizer. Photochem.Photobiol. 53: 859–870
Dressler C., Ismail M.S., Ströbele S., Nowak C., Herter R., Senz RG., Hagemann R.,Koeppe P., Röder B., Berlien H.-P., 1994. Absorption spectroscopic analysis of the pharmacokinetcs of Okta-α-butyloxy-Zinkphthalocyanin in Lewis lung carcinoma bearing mice. 5th. intertl Photodynamic Ass. Biennial Meeting, Sept. 1994 fin press).Tab.l zeigt die relevanten photodynamischen Parameter des 8-a-bo-ZnPc.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag, Berlin Heidelberg
About this paper
Cite this paper
Ströbele, S., Dressler, C., Ismail, M.S., Koeppe, P., Berlien, HP. (1996). Regressionsanalyse zur Pharmakokinetik des Okta-α-Butyloxy- Zinkphthalocyanin am Lewis lung Carcinom. In: Waidelich, W., Staehler, G., Waidelich, R. (eds) Laser in der Medizin / Laser in Medicine. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80264-5_18
Download citation
DOI: https://doi.org/10.1007/978-3-642-80264-5_18
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-61318-3
Online ISBN: 978-3-642-80264-5
eBook Packages: Springer Book Archive