Abstract
Nausea and vomiting are common and familiar side-effects of opioid drugs, but surprisingly few data on the incidence and characteristics of this phenomenon in cancer patients can be found in the literature. In the few studies available the percentage of patients suffering opi-oid-related emesis varied from 2.7% [1] to 40% [2].
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References
Spector R: Analgesia. In: Spector R (ed) The Scientific Basis of Clinical Pharmacology. Little Brown, Boston 1986 pp 343–354
Mitchelson F: Pharmacological agents affecting emesis. A review (part I). Drugs 1992 (43):295–315
Campora E, Merlini L, Pace M, Bruzzone M, Luzzani M, Gottlieb A, Rosso R: The incidence of narcotic-induced emesis. J Pain Symptom Management 1991 (6):428–430
Walsh TD: Antiemetic drug combinations in advanced cancer. Lancet 1982 (i):1018
Jaffe JH and Martin WR: Opioid analgesics and antagonists. In: Goodman Gillman A et al (eds) The Pharmacological Basis of Therapeutics. 8th Ed. Pergamon Press, New York 1990 pp 485–521
Cousins MJ, Mather LE: Intrathecal and epidural administration of opioids. Anesthesiology 1984 (61): 276–310
Zenz M, Piepenbrock S, Tryba M: Epidural opiates: long-term experiences in cancer pain. Klin Wochenschr 1985 (63):225–229
Blancquaert JP, Lefebvre RA, Willems JL: Emetic and antiemetic effects of opioids in the dog. Eur J Pharmacol 1986 (128): 143–150
Chesselet MF, Chéramy A, Reisine TD, Glowinsky J: Morphine and δ-opiate agonists locally stimulate in vivo dopamine release in the cat caudate nucleus. Nature 1981 (291):320–322
Gupta YK, Bhandari P, Chugh A, Seth SD, Dixit KS, Bhargava KP: Role of endogenous opioids and histamine in morphine induced emesis. Indian J Exp Biol 1989 (27):52–54
Gottlieb A and Luzzani M: II problema della nausea e del vomito da oppiacei nel paziente neoplastico avanzato: nuovo approccio farmacologico con gli antagonisti dei recettori 5-HT3. Studio preliminare. In: Proceedings of the International Congress “II trattamento della nausea e del vomito da chemio-terapia antineoplastica: nuove acquisizioni sul ruolo dei 5-HT3 antagonisti”. Verona, 18 June 1991, pp 127–131
Thompson PI, Bingham S, Andrews PLR, Patel N, Joel SP, Slevin ML: Morphine 6-glucuronide: a metabolite of morphine with greater emetic potency than morphine in the ferret. Br J Pharmacol 1992 (106): 3–10
Wynn RL, Essien E, Thut PD: The effects of different antiemetic agents on morphine-induced emesis in ferrets. Eur J Pharmacol 1993 (241):47–54
Costello DJ and Borison HL: Naloxone antagonizes narcotic self-blockade of emesis in the cat. J Pharmacol Exp Ther 1977 (203):222–230
Harris AL: Cytotoxic-therapy-induced vomiting is mediated via enkephalin pathways. Lancet 1982 (i): 714–716
Osborne RJ, Slevin Ml, Joel SP, Trew DM, Thompson PI, Malpas JS: The analgesic activity and pharmacokinetics of morphine and morphine-6-glucuronide in man. Br J Cancer 1989 (60): 451
Hanks GW: Antiemetics for terminal cancer patients. Lancet 1982 (i): 1410
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© 1996 Springer-Verlag Berlin Heidelberg
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Roila, F., Ballatori, E., Del Favero, A. (1996). Antiemetic Therapy in Cancer Patients Submitted to Narcotic Analgesics. In: Tonato, M. (eds) Antiemetics in the Supportive Care of Cancer Patients. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80240-9_9
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