Skip to main content
SpringerLink
Log in

Neonatal Intensive Care and Neurodevelopmental Outcome

  • Chapter
Intensive Care in Childhood

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 25))

  • 158 Accesses

Abstract

The introduction of modern neonatal intensive care units (NICUs) and the technological advances, used in these NICUs, have markedly improved the survival rates for all neonates. Improved survival has been most dramatic for very low-birth-weight (VLBW, < 1500g) infants. During the last 20 years, the survival rate in our own neonatal intensive care unit increased from 60 to 90% for infants with birthweights of 1000 to 1500 grams and from 25 to 70% for infants with birthweights < 1000 grams (ELBW). New treatment techniques, like for example extracorporal membrane oxygenation (ECMO), have also been developed for the fullterm infant with intractable respiratory failure secondary to a variety of disorders that have common a high mortality rate (> 80%) and a potential for reversibility. Mortality has traditionally been the tool used to evaluate the success of NICU treatment. With the increasing survival rate the interest in the quality of survival was growing and consequently follow-up studies were undertaken. Adverse outcome in survivors was first mostly described in terms of major handicap and defined as “the presence of impairments that will prevent the child from leading a normal daily life”. Most major handicaps can be detected in the first year of life. Less severe impairments may go undetected until later in childhood, but may also be more amenable to intervention. Therefore, today both shortterm and longterm neurodevelopmental outcome must be evaluated in the NICU graduate.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Volpe J J (1995) Intracranial Haemorrhage: Geminal matrix-intra ventricular hemorrhage of the premature infant. In: Volpe JJ Neurology of the newborn, 3rd edition. Saunders Company, pp403–453.

    Google Scholar 

  2. de Vries LS, Eken P, Dubowitz LM (1992) The spectrum of leucomalacia using cranial ultrasound. Behav Brain Res 49(1): 1–6.

    Article  PubMed  Google Scholar 

  3. Volpe JJ (1995) Hypoxic-ischemic encephalopathy: Clinical aspects. In: Volpe JJ Neurology of the newborn, 3rd edition. Saunders Company, pp 315–367.

    Google Scholar 

  4. Veen S, Ens-Dokkum MH, Schreuder AM, Verloove-Vanhorick SP, Brand R, Ruys JH (1991) Impairments, disabilities, and handicaps of very preterm and very-low-birthweight infants at five years of age. The Lancet 338;33–36.

    Article  CAS  Google Scholar 

  5. Weisglas-Kuperus N, Baerts W, Fetter WP, Sauer PJ (1992) Neonatal cerebral ultrasound, neonatal neurology and perinatal conditions as predictors of neurodevelopmental outcome in very low birthweight infants. Early-Hum-De 31(2);131–48.

    Article  CAS  Google Scholar 

  6. Weisglas-Kuperus N, Baerts W, Sauer PJ (1993) Early assessment and neurodevelopmental outcome in very low-birth-weight infants: implications for pediatric practice. Acta-Pae- diatr. 82(5): 449–53.

    Article  CAS  Google Scholar 

  7. Weisglas-Kuperus N, Baerts W, Smrkovsky M, Sauer PJ (1993) Effects of biological and social factors on the cognitive development of very low birth weight children. Pediatrics 92(5):658–65.

    PubMed  CAS  Google Scholar 

  8. Weisglas-Kuperus N, Koot HM, Baerts W, Fetter WP, Sauer PJ (1993) Behaviour problems of very low-birthweight children. De. Med. Child Neurol. 35(5): 406–16.

    Article  CAS  Google Scholar 

  9. Brooks-Gunn J, Kato P, Liauw F, Spiker D (1993) Enhancing the outcome of low birth- weight premature infants; results from the Infant Health and Development Program. Child De. 64:736–53.

    Article  CAS  Google Scholar 

  10. Rauh VA, Nurcombe B, Achenbach T, Howell C (1990) The Mother-Infant Transaction Program: The Content and implications for the Mothers of Low-Birthweight Infants. Clinics in Perinatology 17: 31–47.

    PubMed  CAS  Google Scholar 

  11. Achenbach TM, Howell CT, Aoki MF (1993) Nine-Year Outcome of the Vermont Intervention Program for Low-Birthweight Infants. Pediatrics 91: 45–55.

    PubMed  CAS  Google Scholar 

  12. McCormick M, Gortmaker SL, Sobol AM (1990) Very low birthweight children: Behavior problems and school difficulty in a national sample. J Pediatr. 117:687–93.

    Article  PubMed  CAS  Google Scholar 

  13. Hall A, McLeod A, Counsell C, Thomson L, Mutch L (1996) School attainment, cognitive ability and motor function in a total scottish very-low-birthweight population at eight years: a controlled study.

    Google Scholar 

  14. Als H (1986) A synactive model of neonatal behavioral organization: Framework for the assessment and support of the neurobehavioral development of the premature infant and his parents in the environment of the neonatal intensive care unit. In J.K. Sweeney (Ed.), The high-risk neonate: Developmental therapy perspectives. Physical and Occupational Therapy in Pediatrics 6/(3/4): 3–55.

    Google Scholar 

  15. Als H (1991) Manual for the Naturalistic Observation of Newborn Behavior. The Children’s Hospital Boston, MA 02115.

    Google Scholar 

  16. Buehler DM, Als H, Duffy FH, McAnulty GB, Liederman J (1995) Effectiveness of Individualized developmental care for low risk preterm infants: behavioral and eletrophysiologic evidence. Pediatrics 96:923–938.

    PubMed  CAS  Google Scholar 

  17. Als H, Lawhon G, Duffy FH, McAnuity GB, Gibes-Grossman R, Blickman JG (1994) Individualized developmental care for the Very Low- Birth-Weight Preterm Infant. JAMA 272:853–858.

    Article  PubMed  CAS  Google Scholar 

  18. Sarnat HB, Sarnat MS (1976) Neonatal Encephalopathy Fetal Distress. A clinical and elec- troencephalographic study. Arch. Neurol. 33:696–705.

    PubMed  CAS  Google Scholar 

  19. Carter BS, Haverkamp AD, Merenstein GB (1993) The definition of acute perinatal asphyxia. Clinics in perinatology 20:287–304.

    PubMed  CAS  Google Scholar 

  20. Levene MI (1993) Management of the asphyxiated full term infant. Archives of disease in childhood 68:612–616.

    Article  PubMed  CAS  Google Scholar 

  21. Taylor MJ, Murphy WJ, Whyte HE (1992) Prognostic relaibility of somatosensory and visual evoked potentials of asphyxiated term infants. De. Med. Child Neurol. 34:507–15.

    Article  CAS  Google Scholar 

  22. Rutherford MA, Pennock JM, Scwieso JE, Cowan FM, Dubowitz LMS (1995) Hypoxic is- chaemic encephalopathy: Early magnetic resonance imaging findings and their evolution. Neuropediatrics 26:183–191.

    Article  PubMed  CAS  Google Scholar 

  23. Low J A (1993) The relationship of asphyxia in the mature fetus to long-term neurological function. Clinical obstetrics and gynecology 36(1): 82–90.

    Article  PubMed  CAS  Google Scholar 

  24. Robertson CMT, Finer NN (1993) Long-term follow-up of term neonates with perinatal asphyxia. Clinics in perinatology 20:287–304.

    Google Scholar 

  25. Volpe JJ (1995) Intracranial hemorrhage: Subdural, primary subarachnoid, intracerebellar, intraventricular (term infant), miscellaneous. In: Volpe JJ Neurology of the newborn, 3rd edition. Saunders Company, pp396–399.

    Google Scholar 

  26. Page J, Frisk V, Whyte H (1994) Developmental outcome of infants treated with extracorporal membrane oxygenation (ECMO) in the neonatal period: is the evidence all in? Pedi- atr Perinat Epidemiol 8(2): 123–139.

    Article  CAS  Google Scholar 

  27. Griffin MP, Minifee PK, Landry SH, Allison PL, Swischuk LE, Zwischenberger JP (1992) Neurodevelopmental outcome in neonates after extracorporal membrane oxygenation: cranial magnetic resonance imaging and ultrasonography correlation. J Pediatr Surgery 27 (1):33–35.

    Article  CAS  Google Scholar 

  28. Revenis ME, Glass P, Short BL (1992) Mortality and morbidity rates among lower birth weight infants (2000 to 2500 grams) treated with extracorporal membrane oxygenation. J Pediatrics 121:452–458.

    Article  CAS  Google Scholar 

  29. Glass P, Wagner AE, Papero PH, Rajasingham SR, Civitello LA, Kjaer MS, Coffman CE, Getson PR (1995) Neurodevelopmental status at age five years of neonates treated with extracorporal membrane oxygenation. J Pediatr 127 (3): 447–4457.

    Article  PubMed  CAS  Google Scholar 

  30. Bernbaum J, Schwartz IP, Gerdes M, D’ Agostino JA, Coburn CE, Polin RA (1995) Survivors of extracorporal membrane oxygenation at 1 year of age: The relationship of primary diagnosis with health and neurodevelopmental sequelae. Pediatrics 96 (5): 907–913.

    PubMed  CAS  Google Scholar 

  31. Kato T, Kanto K, Yoshino H, Hebiguchi T, Koyama K, Arakawa Y, Hishikawa Y (1993) Mental and intellectual development of neonatal surgical children in long-term follow-up. Journal of Pediatric Surgery 28 (2): 123–129.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. N. Weisglas-Kuperus
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dept. of Pediatric Surgery, Pediatric Surgical Intensive Care Unit, Sophia Children’s Hospital, University Hospital Rotterdam, Dr. Molewaterplein 60, NL-3015, GJ Rotterdam, The Netherlands

    Dick Tibboel

  2. Dept. of Pediatrics, Subdivision of Pediatric, Intensive Care, Sophia Children’s Hospital, University Hospital Rotterdam, Dr. Molewaterplein 60, NL-3015, GJ Rotterdam, The Netherlands

    Edwin van der Voort

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Weisglas-Kuperus, N. (1996). Neonatal Intensive Care and Neurodevelopmental Outcome. In: Tibboel, D., van der Voort, E. (eds) Intensive Care in Childhood. Update in Intensive Care and Emergency Medicine, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80227-0_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-80227-0_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80229-4

  • Online ISBN: 978-3-642-80227-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation