Pharmacology of Antimicrobial Agents in Preterm Infants

  • J. N. van den Anker
  • G. L. Kearns
  • R. de Groot
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 25)


Bacterial infections continue to be a major cause of morbidity and mortality in preterm infants admitted to neonatal intensive care units [1]. Nosocomial infections including septicemia, meningitis, pneumonia or urinary tract infection occur in approximately 18% of neonates with a very low (<1500 g) birth weight. Major pathogens responsible for bacterial infections during the first month of life are Staphylococcus aureus, coagulase-negative staphylococci, en- terococci, group B streptococcus, Escherichia coli, klebsiella, enterobacter, pseu- domonas and other gram-negative bacteria. The combination of prolonged hospitalization, multiple invasive procedures, prolonged positive pressure ventilation, parenteral nutrition, and an impaired host defence is largely responsible for the increased susceptibility of preterm infants for bacterial, viral and fungal infections.


Preterm Infant Neonatal Intensive Care Unit Patent Ductus Arteriosus Dose Interval Antimicrob Agent 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • J. N. van den Anker
  • G. L. Kearns
  • R. de Groot

There are no affiliations available

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