Abstract
Major progresses have been made in recent years in investigating fetal disorders. Echography now allows precise diagnosis of congenital malformations (such as digestive, urinary tract or cardiac abnormalities). Diagnosis of abnormal karyotype is possible with chorion biopsy, amniocentesis or fetal blood sampling. Such procedures have their own complications but their frequency is reduced in experienced hands. The therapeutic decision of whether to carry on pregnancy and to treat fetal diseases or to induce abortion is obviously a matter of individual cases and differences in legislation in various countries.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Ward RM (1995) Pharmacological treatment of the fetus. Clinical pharmacokinetic considerations. Clin Pharmacokinet 28:343–350.
Pacifici GM, Nottoli R (1995) Placental transfer of drugs administered to mothers. Clin Pharmacokinet 28:235–269.
Levy G (1981) Pharmacokinetics of fetal and neonatal exposure to drugs. Obstet Gynecol 58:9S-16S.
Azancot Benisty A, Jacqz Aigrain E, Guirgis NM, De Crepy A, Oury JF, Blot P (1992) Clinical and pharmacological study of fetal supraventricular tachyarrhythmias. J Pediatr 121:608–613.
Maxwell DJ, Crawford DC, Curry PVM, Tynan MJ, Allan LD (1988) Obstetric importance, diagnosis and management of fetal tachycardias. BMJ 297:107–110.
VanEngelen AD, Weijtens O, Brenner JI, Kleinman CS, Copel JA, Stoutenbeek P, Meijboom EJ (1994) Management outcome and follow-up of fetal tachycardia. J Am Coll Cardiol 24:1371–1375.
Dupouy Carnet J, Gavinet MF, Paugam A, Tourte-Schaefer C (1993) Mode de contamination, incidence et prevalence de la toxoplasmose. Med Mai Inf 23:139–147.
Wong SY, Remington JS (1994) Toxoplasmosis during pregnancy. Clin Infect Dis 18:853–862.
Hohfeld P, Daffos F, Costa JM, Thulliez P, Forestier F, Vidaud M (1994) Prenatal diagnosis of congenital toxoplasmosis with a polymerase chain reaction test on amniotic fluid. N Eng J Med 331:695–699.
Wilson CB (1990) Treatment of congenital toxoplasmosis during pregnancy. J Pediatr 116:1003–1004.
Couvreur J, Desmonts G, Thulliez P (1988) Prophylaxis of congenital toxoplasmosis: effects of spiramycin on placental infection. J Antimicrob Chemother 22:193–200.
Hohfeld P, Daffos F, Thulliez P, Aufrant C, Couvreur J, MacAleese J, Descombey D, Forestier F (1989) Fetal toxoplasmosis: outcome of pregnancy and infant follow-up after in utero treatment. J Pediatr 115:765–769.
Morel Y, Miller WL (1991) Clinical and molecular genetics of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Adv Hum Genet 20:1–68.
Forest MG, David M, Morel Y (1993) Prenatal diagnosis and treatment of 21-hydroxylase deficiency. J Steroid Biochem Mol Biol 45:75–82.
Forest MG, Dorr HG (1993) Prenatal treatment of congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency: European experience in 223 pregnancies at risk. Pediatr Res 33:S3.
Burrow GN, Fisher DA, Larsen PR (1994) Maternal and thyroid function. N Engl J Med 331:1072–1078.
Perelman AH, Johnson RL, Clemons RD, Finberg HJ, Clewell WH, Trujillo L (1990) Intrauterine diagnosis and treatment of fetal goitrous hypothyroidism. J Clin Endocrinol Metab 71:618–621.
Friedman SA (1988) Pre-eclampsia: a review of the role of prostaglandins. Obstet Gynecol 71:1.
Schiff E, Peleg E (1989) The use of aspirin to prevent pregnancy induced hypertension and lower the ratio of thromboxane A2 to prostacyclin in relatively high risk pregnancies. N Engl J Med 321:351–356.
Uzan S, Beaufils M (1989) Idiopathic recurrent fetal growth retardation and aspirin-dipy- ridamole therapy. Am J Obstet Gynecol 160:763–764.
Wallenburgh HCS, Rotmans N (1987) Prevention of recurrent idiopathic fetal growth retardation by low dose aspirin and dipyridamole. Am J Obstet Gynecol 157:1230–1235.
Spielberg SP, Strickler SM, Miller MA, Andermann E, Dansky LV, Seni MH (1985) Genetic predisposition to phenytoin-induced birth defects. Lancet pp: 746.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1996 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Aigrain, E.J. (1996). Fetal Pharmacology and Therapy. In: Tibboel, D., van der Voort, E. (eds) Intensive Care in Childhood. Update in Intensive Care and Emergency Medicine, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80227-0_31
Download citation
DOI: https://doi.org/10.1007/978-3-642-80227-0_31
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-80229-4
Online ISBN: 978-3-642-80227-0
eBook Packages: Springer Book Archive