Regulation of Gut Oxygen Delivery, Cellular Oxygen Supply and Metabolic Activity

  • P. T. Schumacker
Part of the Update in Intensive Care and Emergency Medicine book series (UICM, volume 26)


Over the past three decades, a large number of studies have examined the physiological regulation of blood flow, oxygen supply (DO2) and oxygen extraction (O2ER) in the gut using a wide variety of different models and experimental approaches. More recently, with a growing recognition of the potential significance of gut dysfunction in critical illness, investigators have explored the behavior of the gut under pathophysiological conditions, in terms of its regulation of cellular O2 supply and epithelial barrier function. In this review, we begin with a brief overview of the physiological regulation of intestinal blood flow and oxygen transport, and then proceed to examine the potential significance of these findings for the function of the gut during critical illness, and especially during sepsis.


Systemic Hemorrhage Intestinal Blood Flow Arteriovenous Anastomosis Mucosal Perfusion Perfuse Capillary Density 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer-Verlag Berlin Heidelberg 1996

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  • P. T. Schumacker

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