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Experimental Advances in Intestinal Monitoring

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Gut Dysfunction in Critical Illness

Part of the book series: Update in Intensive Care and Emergency Medicine ((UICM,volume 26))

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Abstract

Assessment of splanchnic tissue perfusion, oxygenation and function has gained increased interest in intensive care research. Currently, no methods to directly measure splanchnic blood flow and oxygenation are routinely available. Indirect methods that have been introduced into clinical practice include the measurement of systemic indocyanine green clearance, the determination of the MEGX concentration, a metabolite of lignocaine, after a lignocaine bolus injection, and gastric tonometry [1]. This chapter will discuss two techniques which have recently been applied to assess gut and liver perfusion, oxygenation and metabolic performance. On the one hand, remission spectrophotometry using the Erlanger Micro-lightguide Phzotometer (EMPHO) allows to measure intracapillary hemoglobin O2 saturation and relative hemoglobin content, the latter being a mirror of capillary blood flow [2, 3]. On the other hand, the use of stable, non-radioactive isotope-labelled substrates in tracer amounts permits to obtain information on global systemic as well as organ specific metabolic performance [4–6].

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Authors
  1. P. Radermacher
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  2. M. Georgieff
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Editor information

Editors and Affiliations

  1. Department of Surgery, Pennsylvania University Hospital, 3400 Spruce Street, 19104, Philadelphia, PA, USA

    J. L. Rombeau

  2. Department of Intensive Care Critical Care Research Program, Kuopio University Hospital, FIN-70211, Kuopio, Finland

    J. Takala

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© 1996 Springer-Verlag Berlin Heidelberg

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Radermacher, P., Georgieff, M. (1996). Experimental Advances in Intestinal Monitoring. In: Rombeau, J.L., Takala, J. (eds) Gut Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80224-9_25

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  • DOI: https://doi.org/10.1007/978-3-642-80224-9_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80226-3

  • Online ISBN: 978-3-642-80224-9

  • eBook Packages: Springer Book Archive

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