Abstract
In pursuit of an ideal clinical monitor of tissue perfusion, attention has focused on the gastrointestinal (GI) tract. Its inner-most mucosal layer has a countercurrent system of arterioles and venules that improves absorptive function but makes it susceptible to reduced oxygen delivery (DO2) states. Splanchnic vasoconstriction is an early response to a reduction in global DO2 as blood is diverted to organs such as heart and brain. Whether due to myocardial failure and/or hypovolemia, the reduction in splanchnic blood volume is disproportionately greater than that seen in other beds [1]. There is also considerable evidence to suggest that splanchnic hypoperfusion may be a significant factor in the pathogenesis of the multiple organ dysfunction syndrome (MODS) [2].
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References
Lundgren O (1989) Physiology of the intestinal circulation. In: Marston A, Bulkley GB, Fiddian-Green RG, Haglund UH (eds) Splanchnic ischemia and multiple organ failure. Edward Arnold, London, pp 29–40
Mythen MG, Webb AR (1994) The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction. Intensive Care Med 20: 203–209
Fink MP (1991) Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Crit Care Med 19: 627–641
Uusaro A, Ruokonen E, Takala J (1995) Estimation of splanchnic blood flow by the Fick principle in man and problems in the use of indocyanine green. Cardiovasc Res 30:106–112
Nilson GE, Tenland T, Oberg PA (1980) Evaluation of laser Doppler flowmeter for measurement of tissue blood flow. IEE Trans Biomed Eng 27: 597–604
Ahn H, Ivarsson LE, Johansson K, et al (1988) Assessment of gastric blood flow with laser Doppler flowmetry. Scand J Gastroenterol 23: 1203–1210
Leung FW, Morishita T, Livingston EH (1987) Reflectance spectrophotometry for the assessment of gastroduodenal mucosal perfusion. Am J Physiol 252: G797–797G804
Larsen PN, Moesgaard F, Naver L, et al (1991) Gastric and colonic oxygen tension measured with a vacuum-fixed oxygen electrode. Scand J Gastroenterol 26: 409–418
Glenny RW, Bernard S, Brinkley M (1993) Validation of fluorescent labelled microspheres for measurement of regional organ perfusion. J Appl Physiol 74: 2585–2597
Murakami M, Moriga M, Miyake T, et al (1982) Contact electrode method in hydrogen gas clearance technique: A new method for determination of regional gastric mucosal blood flow in animals and humans. Gastroenterology 82: 457–467
Landow L, Phillips DA, Heard SO, Prevost D, Vandersalm TJ, Fink MP (1991) Gastric tonometry and venous oximetry in cardiac surgery patients. Crit Care Med 19: 1226–1233
Rasmussen I, Haglund U (1992) Early ischemia in experimental fecal peritonitis. Circ Shock 38: 22–28
De Nobile J, Guzzetta P, Patterson K (1990) Pulse oximetry as a means of assessing bowel viability. J Surg Res 48: 21–23
Gardner GP, LaMorte WW, Obi-Tabot ET, et al (1994) Transanal intracolonic pulse oximetry as a means of monitoring the adequacy of colonic perfusion. J Surg Res 57: 537–540
Mclver MA, Redfield AC, Benedict EB (1926) Gaseous exchange between the blood and the lumen of the stomach and intestines. Am J Physiol 76: 92–111
Bergofsky EH (1964) Determination of tissue O2 tension by hollow visceral tonometers: Effect of breathing enriched O2 mixtures. J Clin Invest 43: 193–200
Dawson AM, Trenchard D, Guz A (1965) Small bowel tonometry: Assesment of small gut mucosal oxygen tension in dog and man. Nature (London) 206: 943–944
Kivisaari J, Niinikoski J (1973) Use of silastic sampling tube and capillary sampling technic in the measurement of tissue PO2 and PCO2. Am J Surg 125:623–627
Fiddian-Green RG, Pittenger G, Whitehouse WM (1982) Back diffusion of CO2 and its influence on the intramural pH in gastric mucosa. J Surg Res 33: 39–48
Fiddian-Green RG, Baker S (1987) Predictive value of the stomach wall pH for complications after cardiac operations: Comparison with other monitoring. Crit Care Med 15: 153–156
Desai V, Weil MH, Tang W, Yang G, Bisera J (1993) Gastric intramural PCO2 during peritonitis and shock. Chest 104: 1254–1258
Nok M, Weil MH, Sun S, Gazmuri RJ, Tang W, Pakula JL (1993) Comparison of gastric wall PCO2 during hemorrhagic shock. Circ Shock 40: 194–199
Antonsson JB, Boyle CC, Kruithoff KL, et al (1990) Validity of tonometric measures of gut intramural pH during endotoxemia and mesenteric occlusion in pigs. Am J Physiol 259: G519–519G523
Grum CM, Fiddian-Green RG, Pittenger GL, Grant BJB, Rothman D, Dantzker DR (1984) Adequacy of tissue oxygenation in intact dog intestine. J Appl Physiol 56: 1065–1069
Fiddian-Green RG (1989) Studies in splanchnic ischemia and multiple organ failure. In: Marston A, Bulkely GB, Fiddian-Green RG, Haglund UH (eds) Splanchnic ischemia and multiple organ failure. Edward Arnold, London, pp 349–363
Heard SO, Helmsmoortel CM, Kent JC, Shahnarian A, Fink MP (1990) Gastric tonometry in healthy volunteers: Effect of ranitidine on calculated intramural pH. Crit Care Med 19: 271–274
Kolkman JJ, Groeneveld ABJ, Meuwissen SGM (1994) Effect of ranitidine on basal and bicarbonate enhanced intragastric PCO2: A tonometric study. Gut 35: 737–741
Higgins D, Mythen MG, Webb AR (1994) Low intramucosal pH is associated with failure to acidify the gastric lumen in response to pentagastrin. Intensive Care Med 20:105–108
Salzman AL, Strong KE, Wang H, Wollert PS, Vandermeer TJ, Fink MP (1994) Intraluminal “balloonless” air tonometry: A new method for determination of gastrointestinal mucosal carbon dioxide. Crit Care Med 22:126–134
Schlichtig R, Bowles SA (1994) Distinguishing between aerobic and anaerobic appearance of dissolved CO2 in intestine during low flow. J Appl Physiol 76: 2443–2451
Benjamin E, N-Fonayim JM, Hannon EM, et al (1992) Effects of systemic metabolic alkalosis on gastrointestinal tonometry. Crit Care Med 20 (Suppl): S65 (Abst)
Boyd O, Mackay CJ, Lamb G, Bland JM, Grounds RM, Bennett ED (1993) Comparison of clinical information gained from routine blood gas analysis and from gastric tonometry for intramural pH. Lancet 34: 142–146
Crispin C, Jones W, Daffurn K (1995) How consistently do RNs perform the procedure of collecting specimens for measurement of gastric pHi and CO2. Intensive Crit Care Nurs 11: 123–125
Takala J, Parviainen IMS, Ruokonen E, Hamalainen E (1994) Saline PCO2 is an important source of error in the assessment of gastric intramucosal pH. Crit Care Med 22: 1877–1879
Riddington D, Venkatesh B, Clutton BT, Bion J (1994) Measuring carbon dioxide tension in saline and alternative solutions: Quantification of bias and precision in two blood gas analyzers. Crit Care Med 22: 96–100
Doglio GR, Pusajo JF, Egurrola MA, et al (1991) Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 19: 1037–1040
Maynard N, Biahari D, Beale R, et al (1993) Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 270: 1203–1210
Gys T, Hubens A, Neels H, Ludo F, Lauwers F, Peeters R (1988) Prognostic value of gastric intramural pH in surgical intensive care patients. Crit Care Med 16: 1222–1224
Mohsenifar Z, Goldbach P, Tashkin DP (1983) Relationship between oxygen delivery and oxygen consumption in the adult respiratory distress syndrome. Chest 84: 267–271
Ivatury RR, Simon RJ, Havriliak D, Garcia G, Greenbarg J, Stahl WM (1995) Gastric mucosal pH and oxygen delivery and oxygen consumption indices in the assessment of adequacy of resuscitation after trauma: A prospective, randomized study. J Trauma 39: 128–136
Mythen MG, Webb AR (1995) Per-operative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 130: 423–429
Noone RB, Yen MHN, Leone BJ, Mythen MG (1996) In vitro validation of an automated gastrointestinal tonometer (the Tonocap). Intensive Care Med 22: S65 (Abst)
Noone RB, Yen MHN, Leone BJ, Mythen MG (1996) In vivo validation of an automated gastrointestinal tonometer (the Tonocap) in a canine haemorrhage model. Intensive Care Med 22: S66 (Abst)
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Mythen, M., Faehnrich, J. (1996). Monitoring Gut Perfusion. In: Rombeau, J.L., Takala, J. (eds) Gut Dysfunction in Critical Illness. Update in Intensive Care and Emergency Medicine, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80224-9_17
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DOI: https://doi.org/10.1007/978-3-642-80224-9_17
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