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Adeno-associated Virus Based Vectors As Antivirals

  • K. K. WongJr.
  • S. Chatterjee
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 218)

Abstract

Although great strides have been made in the treatment and prevention of human viral infections, antiviral drug therapy still remains problematic when compared to treatment of bacterial infections. The therapeutic toxicity/efficacy ratio of many antivirals is low, resulting in potential risks of regimen related toxicity. The number of effective antivirals is limited, and many important viral infections remain untreatable. In addition, currently used antivirals often suppress rather than cure infections, necessitating repeated, sometimes lifelong, therapy to prevent recurrences. Furthermore, the increasing use of antivirals has resulted in the selection or emergence of drug-resistant strains as has occurred following the widespread use of antibacterial (Field and Biron 1994). Finally, several medically important viruses, most notably human immunodeficiency virus (HIV), have been recalcitrant to either the development of curative chemotherapy or protective vaccines (Schnittman and Fauci 1994). Thus, novel approaches to the treatment or prevention of viral infections are constantly being sought.

Keywords

Human Immunodeficiency Virus Long Terminal Repeat Antisense Transcript Cystic Fibrosis Transmembrane Regulator Hammerhead Ribozyme 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • K. K. WongJr.
    • 1
  • S. Chatterjee
    • 2
  1. 1.Departments of Hematology and Bone Marrow Transplantation, Infectious DiseasesDuarteUSA
  2. 2.Division of Pediatrics, Beckman Research InstituteCity of Hope National Medical CenterDuarteUSA

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