Involvement of Bacteria/Endotoxin Translocation in the Development of Multiple Organ Failure

  • S. Bahrami
  • H. Redl
  • Y.-M. Yao
  • G. Schlag
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 216)


The progression of multiple organ failure (MOF) in patients with various underlying diseases continues to pose a life-threatening problem in intensive care units. Despite being the subject of an exponentially increasing number of experimental and clinical investigations during recent decades, the precise mechanisms leading to the development of MOF are not yet clearly understood. While several authors had earlier suggested that systemic sepsis due to uncontrolled infection is the leading cause of MOF (Baue 1975; Fry et al. 1980; Polk and Shields 1973), it has become increasingly clear that an infectious focus cannot be identified in all patients with MOF (Carrico et al. 1986; Faist et al. 1983; Goriset al. 1985).


Hemorrhagic Shock Bacterial Translocation Hypovolemic Shock Tumor Necrosis Factor Level Plasma Endotoxin 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1996

Authors and Affiliations

  • S. Bahrami
    • 1
  • H. Redl
    • 1
  • Y.-M. Yao
    • 1
  • G. Schlag
    • 1
  1. 1.Ludwig Boltzmann Institute for Experimental and Clinical TraumatologyViennaAustria

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